Related ArticlesA plan template-based automation solution using a commercial treatment planning system. J Appl Clin Med Phys. 2020 Mar 16;: Authors: Huang X, Quan H, Zhao B, Zhou W, Chen C, Chen Y Abstract PURPOSE: The purpose of this study was to develop an auto-planning platform to be interfaced with a commercial treatment planning system (TPS). The main goal was to obtain robust and high-quality plans for different anatomic sites and various dosimetric...
Wed Mar 18, 2020 14:50
Publication date: Available online 17 March 2020Source: Autoimmunity ReviewsAuthor(s): Manuel Rubio-Rivas, Xavier Corbella, Alfredo Guillén-del-Castillo, Carles Tolosa Vilella, Dolores Colunga Argüelles, Ana Argibay, José Antonio Vargas Hitos, José Antonio Todolí Parra, Cristina González-Echávarri, Norberto Ortego-Centeno, Luis Trapiella Martínez, Mónica Rodríguez Carballeira, Adela Marín Ballvé, Xavier Pla Salas, Isabel Perales Fraile, Antonio-J Chamorro, Ana Belén Madroñero Vuelta, Mayka Freire,...
Wed Mar 18, 2020 12:45
Related ArticlesSynthesis of SiO2@Cu2-xSe nanospheres for efficient near-infrared radiation mediated treatment and care of gastric cancer patients. J Photochem Photobiol B. 2020 Mar 04;206:111849 Authors: Zhang X, Wang L, Wu X, Cong C Abstract Rational design and fabrication of suitable optical absorbing agents (OAAs) are of great significance for state-of-the-art photothermal cancer therapy. Copper selenides have recently emerged as a type of promising...
Wed Mar 18, 2020 14:42
Related ArticlesNFATC4 promotes quiescence and chemotherapy resistance in ovarian cancer. JCI Insight. 2020 Mar 17;: Authors: Cole AJ, Iyengar M, Panesso-Gómez S, O'Hayer PJ, Chan DK, Delgoffe GM, Aird KM, Yoon E, Bai S, Buckanovich RJ Abstract Development of chemotherapy resistance is a major problem in ovarian cancer. One understudied mechanism of chemoresistance is the induction of quiescence, a reversible non-proliferative state. Unfortunately,...
Wed Mar 18, 2020 14:42
Related ArticlesKnockdown of GINS2 inhibits proliferation and promotes apoptosis through the p53/GADD45A pathway in non-small cell lung cancer. Biosci Rep. 2020 Mar 17;: Authors: Chi F, Wang Z, Li Y, Chang N Abstract Lung cancer is the malignant tumour type with the highest morbidity and mortality, and non-small-cell lung cancer (NSCLC) is the most common pathological type. GINS2 is a member of the GINS family and is closely related to DNA replication...
Wed Mar 18, 2020 14:42
Related ArticlesSesamol protects MIN6 pancreatic beta cells against simvastatin-induced toxicity by restoring mitochondrial membrane potentials. 3 Biotech. 2020 Apr;10(4):149 Authors: Ghadge GA, Gourishetti K, Chamallamudi MR, Nampurath GK, Nandakumar K, Kumar N Abstract Statins, the drugs for the treatment of dyslipidemia, have been suggested to impact insulin sensitivity, resulting in pancreatic β-cell dysfunction, and consequently, lead to new...
Wed Mar 18, 2020 14:42
Related ArticlesInducible knock-out of BCL6 in lymphoma cells results in tumor stasis. Oncotarget. 2020 Mar 03;11(9):875-890 Authors: Schlager S, Salomon C, Olt S, Albrecht C, Ebert A, Bergner O, Wachter J, Trapani F, Gerlach D, Voss T, Traunbauer A, Jude J, Hinterndorfer M, Minnich M, Schweifer N, Blake SM, Zinzalla V, Drobits B, McConnell DB, Kraut N, Pearson M, Zuber J, Koegl M Abstract Diffuse large B-cell lymphoma (DLBCL) is the most common...
Wed Mar 18, 2020 14:42
Related ArticlesMETTL7B Is Required for Cancer Cell Proliferation and Tumorigenesis in Non-Small Cell Lung Cancer. Front Pharmacol. 2020;11:178 Authors: Liu D, Li W, Zhong F, Yin J, Zhou W, Li S, Sun X, Xu J, Li G, Wen Y, Wang J, Hong M, Cheng Z, Yuan J, Dai L, Sun J, Wang J, Qiu C, Wang G, Zou C Abstract Lung cancer remains a leading cause of cancer-associated mortality worldwide, however, molecular mechanisms underlying lung cancer tumorigenesis...
Wed Mar 18, 2020 14:42
Related ArticlesPHD Finger Protein 19 Enhances the Resistance of Ovarian Cancer Cells to Compound Fuling Granule by Protecting Cell Growth, Invasion, Migration, and Stemness. Front Pharmacol. 2020;11:150 Authors: Ruan S, Zhang H, Tian X, Zhang Z, Huang H, Shi C, Liu W, Jiang X, Huang D, Tao F Abstract Ovarian cancer is one of the most common gynecological malignancies in women worldwide with a poor survival rate. We have previously reported that...
Wed Mar 18, 2020 14:42
Related ArticlesMBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma. Mol Metab. 2020 Feb 03;34:136-145 Authors: Neumann CKA, Silver DJ, Venkateshwari V, Zhang R, Traughber CA, Przybycin C, Bayik D, Smith JD, Lathia JD, Rini BI, Brown JM Abstract OBJECTIVE: The most common kidney cancer, clear cell renal cell carcinoma (ccRCC), is closely associated with obesity. The "clear cell" variant of RCC gets...
Wed Mar 18, 2020 14:42
Related ArticlesAnti-leukemic activity of Satureja bachtiarica occurs by apoptosis in human cells. Biotech Histochem. 2020 Mar 17;:1-8 Authors: Asadipour M, Malek-Hosseini S, Amirghofran Z Abstract Failure of apoptosis contributes to leukemia progression. We investigated extracts of a native Iranian plant, Satureja bachtiarica, for possible anti-leukemia activity by induction of apoptosis and changes to the cell cycle. Growth inhibition caused by...
Wed Mar 18, 2020 14:42
Related ArticlesGPR64 promotes cAMP pathway in tumor aggressiveness in sparsely granulated growth hormone cell adenomas. Endocrine. 2020 Mar 16;: Authors: Xie T, Tang Y, Luo R, Zhang X, Wu S, Gu Y, Liu T, Hu F Abstract PURPOSE: There is an increasing agreement that acromegaly caused by growth hormone (GH) cell adenoma has two distinct subtypes: densely granulated (DG) and sparsely granulated (SG). We hypothesized that differential molecular signatures...
Wed Mar 18, 2020 14:42
Related ArticlesAnticancer Actions of Azurin and Its Derived Peptide p28. Protein J. 2020 Mar 16;: Authors: Huang F, Shu Q, Qin Z, Tian J, Su Z, Huang Y, Gao M Abstract Cancers are a great threat to humans. In cancer therapy, surgical removal of the tumor combined with radiotherapy and chemotherapy is the most routine treatment procedure and usually the most effective. However, radiotherapy and chemotherapy drugs that kill cancer cells efficiently...
Wed Mar 18, 2020 14:42
Related ArticlesThe gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells. Food Chem Toxicol. 2020 Mar 13;:111260 Authors: Giménez-Bastida JA, Ávila-Gálvez MÁ, Espín JC, González-Sarrías A Abstract The promotion of senescence in cancer cells by dietary (poly)phenols gained attention as a promising chemopreventive strategy against colorectal (CRC) and other cancers....
Wed Mar 18, 2020 14:42
Related ArticlesPseudolaric acid B induces mitotic arrest and apoptosis in both imatinib-sensitive and -resistant chronic myeloid leukaemia cells. Eur J Pharmacol. 2020 Mar 13;:173064 Authors: Jiang L, Wen C, He Q, Sun Y, Wang J, Lan X, Rohondia S, Dou QP, Shi X, Liu J Abstract The selective BCR-ABL tyrosine kinase inhibitor imatinib is one of the first-line therapies in the management of chronic myeloid leukaemia (CML). However, acquired resistance...
Wed Mar 18, 2020 14:42
Related ArticlesAntileukemic Cell Proliferation of Active Compounds from Kaffir Lime (Citrus hystrix) Leaves. Molecules. 2020 Mar 12;25(6): Authors: Anuchapreeda S, Chueahongthong F, Viriyaadhammaa N, Panyajai P, Anzawa R, Tima S, Ampasavate C, Saiai A, Rungrojsakul M, Usuki T, Okonogi S Abstract Kaffir lime (Citrus hystrix) is a plant member of family Rutaceae, and its leaves are commonly used in folk medicine. The present study explores antileukemic...
Wed Mar 18, 2020 12:43
Related ArticlesEffects of High-Dose Ionizing Radiation in Human Gene Expression: A Meta-Analysis. Int J Mol Sci. 2020 Mar 12;21(6): Authors: Kanakoglou DS, Michalettou TD, Vasileiou C, Gioukakis E, Maneta D, Kyriakidis KV, Georgakilas AG, Michalopoulos I Abstract The use of high-dose Ionizing Radiation (IR) is currently one of the most common modalities in treatment of many types of cancer. The objective of this work was to investigate the effects...
Wed Mar 18, 2020 12:43
Related ArticlesAn Overview of the Potential Antineoplastic Effects of Casticin. Molecules. 2020 Mar 12;25(6): Authors: Ramchandani S, Naz I, Lee JH, Khan MR, Ahn KS Abstract Cancer persists as one of the leading causes of deaths worldwide, contributing to approximately 9.6 million deaths per annum in recent years. Despite the numerous advancements in cancer treatment, there is still abundant scope to mitigate recurrence, adverse side effects and...
Wed Mar 18, 2020 12:43
Related ArticlesCucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR-146b-5p and lncRNA-AFAP1-AS1. J Cell Physiol. 2019 04;234(4):4655-4667 Authors: Zhou J, Liu M, Chen Y, Xu S, Guo Y, Zhao L Abstract Cucurbitacin B (CuB) is a natural tetracyclic triterpene product that displays antitumor activity against a wide variety of cancers. In this study, we explored the antipancreatic cancer activity of CuB via the inhibition...
Wed Mar 18, 2020 12:43
Background Breast surgery for stage IV breast cancer remains controversial. The aim of this study was to investigate the impact of breast surgery on survival of stage IV breast cancer patients based on the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Methods In total, 13,034 patients were selected and divided into surgery and non-surgery groups. Univariate and multivariable analyses...
Wed Mar 18, 2020 02:00
A recent analysis by Moulton & Cropper (2019) of a global dataset on alien bird population introductions claims to find no evidence that establishment success is a function of the size of the founding population. Here, we re-analyse Moulton & Cropper’s data and show that this conclusion is based on flawed statistical methods—their data in fact confirm a strong positive relationship between founding population size and establishment success. We also refute several non-statistical arguments...
Wed Mar 18, 2020 02:00
Triptolide (TPL) is proposed as an effective anticancer agent known for its anti-proliferation of a variety of cancer cells including ovarian cancer cells. Although some studies have been conducted, the mechanism by which TPL acts on ovarian cancer remains to be clearly described. Herein, systematic work based on bioinformatics was carried out to discover the potential targets of TPL in SKOV-3 cells. TPL induces the early apoptosis of SKOV-3 cells in a dose- and time-dependent manner with an IC50...
Wed Mar 18, 2020 02:00
Background Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent malignancies worldwide, N6-methyladenosine (m6A) has been shown to play important roles in regulating gene expression and phenotypes in both health and disease. Here, our purpose is to construct a m6A-regulrator-based risk score (RS) for prediction of the prognosis of ccRCC. Methods We used clinical and expression data of m6A related genes from The Cancer Genome Atlas (TCGA) dataset and the Least Absolute...
Wed Mar 18, 2020 02:00
Background The preoperative controlling nutritional status (CONUT) score and serum carbohydrate antigen 199 (CA199) levels are individually correlated with the prognosis of pancreatic ductal adenocarcinoma (PDAC). The objective of this study aimed to investigate the efficacy of CONUT score and CA199 (CONUT-CA199) combination in predicting the prognosis of PDAC patients undergoing radical surgery. Methods We retrospectively analyzed the preoperative CONUT scores and serum CA199 levels...
Wed Mar 18, 2020 02:00
Background The nuclear factor I (NFI) is a family of transcription factors consisting of four distinct but closely related genes, NFIA, NFIB, NFIC and NFIX, which are important in the development of various tissues and organs in mammals. Recent study results have shown that NFI family may play a critical role in the progression of various human tumors and have been identified as key tumor suppressors and oncogenes for many cancers. However, the expression levels and distinctive prognostic values...
Wed Mar 18, 2020 02:00
Auxin response factors (ARFs) are important transcription factors (TFs) that are differentially expressed in response to various abiotic stresses. The important roles of ARFs and small RNA-ARF pathways in mediating plant growth and stress responses have emerged in several recent studies. However, no studies on the involvement of ARFs in tamarisk trees, which are resistant to salinity, have been conducted. In this study, systematic analysis revealed 12 TcARF genes belonging to five different groups...
Wed Mar 18, 2020 02:00
Trypophobia is a strong emotion of disgust evoked by clusters of holes or round objects (e.g., lotus seed pod). It has become increasingly popular and been studied since 2010s, mainly in the West and Japan. Considering this, trypophobia might be a modern emotion, and hence urbanization possibly plays key roles in trypophobia. To address this issue, we compared the degree of trypophobia between urban and less urban people in China. In an experiment, we asked participants about their degree of discomfort...
Wed Mar 18, 2020 02:00
Publication date: Available online 18 March 2020Source: Gene Expression PatternsAuthor(s): Carina G. Lechermeier, Andrea D'Orazio, Marcel Romanos, Christina Lillesaar, Carsten Drepper
Wed Mar 18, 2020 12:36
Abstract Purpose of Review This article reviews treatment options for patients presenting with headache in the emergency department (ED) and for inpatients, including red flags and status migrainosus (SM). Recent Findings Most patients presenting with headache in the ED will have migraine, but red flags must be reviewed to rule out secondary...
Wed Mar 18, 2020 02:00
Publication date: Available online 17 March 2020Source: Pathology - Research and PracticeAuthor(s): Nana Zhang, Depu Wang, Yixin Duan, Vivian Adiila Ayaric, Meng Cao, Ying Wang, Guanjun Zhang, Yili Wang
Wed Mar 18, 2020 12:34
Publication date: Available online 17 March 2020Source: Pathology - Research and PracticeAuthor(s): Charlotte Vestrup Rift, Jane Preuss Hasselby, Carsten Palnæs Hansen, Birgitte Federspiel
Wed Mar 18, 2020 12:34
Publication date: Available online 17 March 2020Source: Pathology - Research and PracticeAuthor(s): Min Jeong Song, Soonchan Park, Kyu Yeoun Won
Wed Mar 18, 2020 12:34
Related ArticlesCorrection: Association of PDCD6 polymorphisms with the risk of cancer: Evidence from a meta-analysis. Oncotarget. 2020 Mar 03;11(9):893 Authors: Hashemi M, Bahari G, Markowski J, Małecki A, Łos MJ, Ghavami S Abstract [This corrects the article DOI: 10.18632/oncotarget.25324.].PMID: 32180902 [PubMed - in process]
Wed Mar 18, 2020 16:26
Related ArticlesCorrection: Gene function analysis and underlying mechanism of esophagus cancer based on microarray gene expression profiling. Oncotarget. 2020 Mar 03;11(9):891-892 Authors: Yue Y, Song M, Qiao Y, Li P, Yuan Y, Lian J, Wang S, Zhang Y Abstract [This corrects the article DOI: 10.18632/oncotarget.22160.].PMID: 32180901 [PubMed - in process]
Wed Mar 18, 2020 16:26
Related ArticlesCalcitonin receptor is required for T-antigen-induced prostate carcinogenesis. Oncotarget. 2020 Mar 03;11(9):858-874 Authors: Kale A, Aldahish A, Shah G Abstract Expression of calcitonin (CT) and its receptor (CTR) is frequently elevated in prostate cancer (PC) and activation of CT-CTR axis in non- invasive PC cells induces an invasive phenotype. However, the role of CT-CTR axis in prostate carcinogenesis has not been investigated....
Wed Mar 18, 2020 16:26
Related ArticlesThe transcription factor CUX1 negatively regulates invasion in castrate resistant prostate cancer. Oncotarget. 2020 Mar 03;11(9):846-857 Authors: Dorris ER, O'Neill A, Treacy A, Klocker H, Teltsh O, Kay E, Watson RW Abstract Metastatic prostate cancer is treated with androgen ablation therapy but progress to castrate resistant prostate cancer (CRPC). This study aimed to investigate the role of CUX1 in CRPC using clinical samples and...
Wed Mar 18, 2020 16:26
Related ArticlesGlypican-1 in human glioblastoma: implications in tumorigenesis and chemotherapy. Oncotarget. 2020 Mar 03;11(9):828-845 Authors: Listik E, Toma L Abstract Glioblastoma is one of the most common malignant brain tumors, with which patients have a mean survival of 24 months. Glypican-1 has been previously shown to be overexpressed in human glioblastoma and to be negatively correlated with patient's survival. This study aimed to investigate...
Wed Mar 18, 2020 16:26
Related ArticlesSelf-Assembling, Ultrashort Peptides Gels as Antimicrobial Agents. Curr Top Med Chem. 2020 Mar 16;: Authors: Marchesana S, Kurbasic M, Parisi E, Garcia AM Abstract Supramolecular antimicrobial hydrogels based on peptides are attractive soft materials for the treatment of infections, considering their ease of preparation and benign fate in biological settings and in the environment. In particular, stimuli-responsive systems that can be...
Wed Mar 18, 2020 16:24
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου