Analytical ChemistryDOI: 10.1021/acs.analchem.9b05045
Mon Mar 09, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05280
Mon Mar 09, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05126
Mon Mar 09, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05840
Mon Mar 09, 2020 06:00
Abstract Background The assessment of liver stiffness and the degree of fibrosis are important factors affecting the management strategy. Multiple non-invasive tools are now available to offer an adequate alternative to biopsy. In this study, we tried to compare the performance of 2D shear wave elastography (SWE) to the transient elastography/fibroscan as a non-invasive tool in the prediction of liver stiffness. This is a prospective...
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12323
Mon Mar 09, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12770
Mon Mar 09, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00333
Mon Mar 09, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00781
Mon Mar 09, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12320
Mon Mar 09, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00245
Mon Mar 09, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00734
Mon Mar 09, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00359
Mon Mar 09, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13918
Mon Mar 09, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12762
Mon Mar 09, 2020 06:00
In this article, we summarize the research that eventually led to the classification of the full ultraviolet (UV) radiation spectrum as carcinogenic to humans. We recall the pioneering works that led to the formulation of novel hypotheses on the reasons underlying the increasing burden of melanoma in light-skinned populations. It took long before having compelling evidence on the association between UV and melanoma, in particular, the importance of UV exposure during childhood for both the occurrence...
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In our veterinary clinical trials, the combination of systemic immunotherapy with local herpes simplex virus thymidine kinase/ganciclovir suicide gene (SG) treatment induced tumor pseudoprogression as part of a strong local antitumor response. This phenomenon could be owing to tumor inflammation, increased vascular permeability and to different tumor growth rates before, during and after SG therapy. The proliferation index (PI: the fraction of viable cells in S, G2/M, and hyperdiploid phases) would...
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New primary melanomas (NPMs) in the era of combination treatments for melanoma constitute a challenge for physicians, especially due to the increased incidence of NPMs in patients treated with BRAF inhibitors. We present the unique case of a patient that developed an invasive NPM while under treatment with a combination of vemurafenib, cobimetinib, and atezolizumab. A 39-year-old white male was treated with vemurafenib, cobimetinib, and atezolizumab for a stage IV (T0, N3, M1) BRAF-V600E mutated...
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p-Coumaric acid (PCA) is a kind of phenolic compound, and as one of the cinnamic acid derivatives, it has many biological functions such as antioxidants, anti-inflammatory, antiplatelet, and anticancer activity. Low-level laser irradiation has received increasing interest in the fields of tissue regeneration and wound healing. In this study, the effect of low-level laser irradiation on human fibroblast cells (human dermal fibroblast) and human melanoma cancer cells (A375 and SK-MEL-37) treated with...
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Little is known about the risk of progression of lentigo maligna to lentigo maligna melanoma. We determine the annual risk of progression of lentigo maligna to lentigo maligna melanoma by analysing a prospective population-based survey of recently diagnosed anterior (visible in a mirror) head and neck lentigo malignas and lentigo maligna melanomas. Six hundred eighty-two consecutive patients aged 18–80 years with non-recurrent lentigo maligna or lentigo maligna melanoma, diagnosed between 1 July...
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Therapeutic activation of macrophage phagocytosis has the ability to restrain tumour growth through phagocytic clearance of tumour cells and activation of the adaptive immune response. Our objective for this study was to evaluate the effects of modulating pro- and anti-phagocytic pathways in malignant melanoma. In order to identify evolutionarily conserved mechanisms of resistance that may be important for melanoma cell survival, we utilized a multi-species approach and examined the phagocytosis...
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The treatment landscape for metastatic melanoma has been revolutionised by the introduction of immunotherapy and targeted therapies. Despite these advances, some patients exhibit primary or acquired resistance to treatment. We present the case of a resected mucosal melanoma that on relapse underwent transformation to a dedifferentiated state. The relapsed tumour was phenotypically disparate and demonstrated loss of all typical melanoma-associated immunohistochemical markers. Furthermore, it demonstrated...
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Histone posttranslational modifications (PTMs) have been shown to be dysregulated in multiple cancers including melanoma, and as they are abundant and easily detectable, they make ideal biomarkers. The aim of this study was to identify histone PTMs that could be potential biomarkers for melanoma diagnosis. Previously, we utilized mass spectrometry to identify histone PTMs that were dysregulated in matched melanoma cell lines and found two modifications, H3 lysine 27 trimethylation (histone H3K27me3)...
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Now effective adjuvant therapy has arrived in melanoma, accurate staging and patient selection to optimize its risk/benefit ratio is crucial. The American Joint Committee on Cancer staging system is the most widely used and validated melanoma staging system, which recently released its 8th edition. We aimed to externally validate the prognostic and discriminatory ability for survival of the 8th edition compared to the 7th edition and evaluate prognostic factors. Prospective database of stage III...
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Uveal melanoma is a life-threatening disease for which data on germline predisposition are essentially limited to mutations in the BAP1 gene. Many risk factors are shared between uveal melanoma and cutaneous melanoma, and these include fair skin color and light eye color. We carried out a genome-wide association study on 590 uveal melanoma patients and 5199 controls. Using a P-value limit of 10−5 we identified 11 loci with related odds ratios for the risk alleles ranging from 1.32 to 1.78. The smallest...
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After a long-term increase, the incidence of cutaneous malignant melanoma has stabilized recently or even decreased in several populations of North-western Europe, USA, Canada, Australia and New Zealand, but not in southern Europe. The incidence trends of primary invasive cutaneous malignant melanoma (International Classification of Diseases, 10th revision, codes C43.0–C43.9) in the Romagna Region (northern Italy, 1.2 million inhabitants) for the period 1986–2014 were analysed with an age–period–cohort...
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Surgical management of external ear melanoma presents unique technical challenges based on the unique anatomy and reconstruction concerns. Surgical technique, including preservation of cartilage, is variable and impact on recurrence is unclear. Our goal was to investigate surgical approach, including extent of surgical resection and sentinel lymph node biopsy (SLNB), and the impact on recurrence. In this retrospective review of primary clinical stage 1/2 external ear melanoma, demographics, tumor...
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Metastatic melanoma has been historically associated with a poor prognosis; however, the therapeutic landscape has experimented and impressive change in the last years due to rapid advances in the immunotherapy field. The first immunotherapy treatment for metastatic melanoma was ipilimumab (anti-CTLA-4), which showed a significant improvement of overall survival compared to chemotherapy. However, in 2015 anti-PD-1 pembrolizumab shown an improved overall survival, progression-free survival and response...
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A large body of evidence in the scientific literature suggests that the numbers of common and atypical nevi are strong, independent risk factors for the occurrence of cutaneous malignant melanoma. Furthermore, some studies recently found an association between high nevus counts and an improved melanoma prognosis. The aim of this study was to investigate a possible relationship between the number of common and atypical nevi and melanoma prognostic factors. We carried out a retrospective analysis of...
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The use of either immune checkpoint blockade or RAF/MEK inhibitors represents standard of care treatment options for metastatic melanoma. Each class of these drugs has distinct response kinetics, adverse effects, and unique clinical challenges. Combination of immune checkpoint blockade and RAF/MEK inhibitors may result in rapid and durable responses, however, the potential adverse effects of such combinations are poorly characterized. Here, we describe the case of a patient with BRAF-mutant melanoma...
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Like all other scientific journals, the peer review process for BJOMS relies on the efforts of volunteer reviewers who are selected according to their expertise. The editorial team, however, acknowledges the competing time pressures on colleagues and takes robust steps to avoid “reviewer fatigue”. Increasing numbers of submitted manuscripts of questionable quality are rejected by the editor without being sent out for peer review.
Mon Mar 09, 2020 02:00
Clinical photographs aid decision-making and represent important medicolegal records. Storage and transfer of images of the facial area must adhere to Caldicott Principles. Outside working hours there clinical photography services are often limited. Our Trust has introduced a Secure Clinical Image Transfer (SCIT) app allowing clinicians to take photographs on personal devices to be securely uploaded to the patient’s electronic health record. To evaluate whether clinicians were taking clinical images...
Mon Mar 09, 2020 02:00
An important clinical outcome of voice masculinization treatments in transmasculine speakers is voice-based perception of gender. Rigorous assessments of voice treatment that utilize ratings of perception of gender typically do not control for demographic characteristics of the listeners. The objective of the present study was to determine the effect of listeners’ age and gender diversity on voice-based judgments of speaker gender.
Mon Mar 09, 2020 02:00
Subharmonics are an important class of voice signals, relevant for speech, pathological voice, singing, and animal bioacoustics. They arise from special cases of amplitude (AM) or frequency modulation (FM) of the time-domain signal. Surprisingly, to date there is only one open source subharmonics detector available to the scientific community: Sun’s subharmonic-to-harmonic ratio (SHR). Here, this algorithm was subjected to a formal evaluation with two data sets of synthesized and empirical speech...
Mon Mar 09, 2020 02:00
Cleaner air, everywhere. (Depositphotos/)Managing the air quality in your home or workplace is important, and you should be able to do so without an eyesore air purifier the size of a piece of furniture. There are compact and powerful air purifiers on the market that can get the job done without crowding your space. Many of them are even portable, so you can bring them with you as you move through your home. When traveling, pack a mini air purifier to give you a better chance of breathing well in...
Mon Mar 09, 2020 23:22
For a breakfast you can’t beat. ( Mae Mu via Unsplash/)Whether you’ve got kids to feed, an early morning sweet tooth, or a love for chicken and waffles—a waffle maker will make an awesome addition to your kitchen. Fresh waffles are in a different league than the frozen kind, and you shouldn’t have to leave home to have ‘em. The ingredients for homemade waffles are cheap, so making them at home will save you money. Plus, it’s super fun! Try adding blueberries, chocolate chips, or bananas to the batter....
Mon Mar 09, 2020 23:08
For digital nomads and people who don't like to run to a laundromat every week. (Bruno Nascimento via Unsplash/)The difference between wearing clean shirts or having to rewear dirty laundry can make or break your day, especially if you’re a frequent traveler. If you’re vacationing in an RV, posting up at a campground, or just have a home without laundry hookups and can’t be bothered to make a trip to the laundromat, an electricity-free washing machine is the perfect way to get a small load of clothes...
Mon Mar 09, 2020 21:50
Be ready for the slopes. (Mauro Paillex via Unsplash /)If you’ve been skiing for years, you know that selecting a pair of blades and poles is a vital part of the process. Ideally, you’d be using them for a handful of years (about eight, on average).There are dozens of technicalities to consider when purchasing all mountain skis, from the type of ski you’re looking for based on terrain, to the length and width you want (often correlated to skill), to whether you can shift into touring mode. The right...
Mon Mar 09, 2020 21:38
You've got a host of web browsers to choose from. We don't recommend using them all at once. (David Nield/)With Microsoft recently unveiling its redesigned and rebuilt Edge browser, you might be wondering if your web-surfing tool of choice is, indeed, the best of the bunch. Yes, they all get you online, but they’re each different in their own way.While we can’t cover every single browser—the selection is a lot bigger than you might realize—we can talk about how Edge, Apple’s Safari, Google Chrome,...
Mon Mar 09, 2020 21:32
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