Wed Mar 18, 2020 23:17
ABSTRACT Background Currently, no estimates can be made on the impact of hematopoietic stem cell transplantation on allergy transfer or cure of the disease. By using component‐resolved diagnosis we prospectively investigated fifty donor‐recipient pairs undergoing allogeneic stem cell transplantation. This allowed calculating the rate of transfer or maintenance of allergen‐specific responses in the context of stem cell transplantation. Methods Allergen‐specific IgE and IgG to 156...
Wed Mar 18, 2020 10:23
ABSTRACT Background Multiple regulatory mechanisms have been identified employing conventional hypothesis‐driven approaches as contributing to allergen‐specific immunotherapy outcomes, but understanding of how these integrate to maintain immunological homeostasis is incomplete. Objective To explore the potential for unbiased systems‐level gene co‐expression network analysis to advance understanding of immunotherapy mechanisms. Methods We profiled genome‐wide allergen‐induced...
Wed Mar 18, 2020 10:23
Abstract Conventional T cells recognise protein‐derived antigens in the context of Major Histocompatibility Complex (MHC) class Ia and class II molecules and provide anti‐microbial and anti‐tumour immunity. Conventional T cells have also been implicated in type IV (also termed delayed‐type or T cell mediated) hypersensitivity reactions in response to protein‐derived allergen antigens. In addition to conventional T cells, subsets of unconventional T cells exist, which recognise non‐protein antigens...
Wed Mar 18, 2020 10:23
Wed Mar 18, 2020 10:23
Abstract Lower‐type brachial plexus injuries (BPI) are uncommon, and traditional reconstruction with tendon transfer procedures generally produce mediocre results. However, the advent of nerve transfers has rejuvenated the reconstructive options for peripheral nerve and spinal cord injuries. In this paper, we report the case 32 year‐old patient with a C7–T1 avulsion BPI in whom multiple motor and sensory nerve transfers, combined with a free gracilis muscle flap transfer, were used to restore upper‐limb...
Wed Mar 18, 2020 23:08
Abstract Purpose Diagnosis and treatment of breast cancer have changed profoundly over the past 25 years. The outcome improved dramatically and was well quantified for early stage breast cancer (EBC). However, progress in the treatment of metastatic disease has been less convincingly demonstrated. We have studied survival data of patients with metastatic breast cancer (MBC) from a large academic cancer center over a period of 20 years....
Wed Mar 18, 2020 02:00
Abstract Background Hepatoblastoma (HB) and pediatric hepatocellular carcinoma (HCC) are the most common malignant liver tumors in childhood. Both tumor types exhibit genetic and epigenetic alterations in the WNT/β-catenin signaling pathway, which is a key regulator of liver progenitor cells in embryonic development. The tumors demonstrate a high rate of β-catenin mutations and gene expression changes of several WNT antagonists. However,...
Wed Mar 18, 2020 02:00
Abstract Purpose Little is known about how a gynecological cancer diagnosis affects a gynecologist’s decision to prescribe hormone replacement therapy (HRT). Therefore, the goal of this study was to analyze the prevalence of HRT prescription prior to and after the diagnosis of four gynecological cancers in women followed in gynecological practices in Germany. Methods ...
Wed Mar 18, 2020 02:00
Average female party size of orangutans in Sumatran forest with low fruit abundance is more similar to average female party size of Bornean orangutans than to Sumatran orangutans living in forest with high fruit abundance. Abstract In contrast to the African great apes, orangutans (Pongo spp.) are semisolitary: Individuals are often on their own, but form aggregations more often than expected by chance. These temporary aggregations provide social benefits such as mating opportunities. When fruit...
Wed Mar 18, 2020 22:55
We aimed to investigate the prevalence and type of BRAF V600 mutations and the associations with clinicopathological variables in primary skin nodular melanoma cases in Yogyakarta and Central Java, Indonesia usin...
Wed Mar 18, 2020 02:00
This study was aimed to asses knowledge of prevention of mother to child transmission of HIV among reproductive age women and associated factors at Mecha district, North West Ethiopia. A community based cross ...
Wed Mar 18, 2020 02:00
Non invasive prenatal testing (NIPT) using cell-free fetal DNA (cffDNA) has been widely accepted in recent years to detect common fetal autosomal chromosome aneuploidies and sex chromosome aneuploidies (SCAs)....
Wed Mar 18, 2020 02:00
A recent trial of vitamin B12 supplementation among Indian children 6–30 months found no effect on the incidence of diarrhea and respiratory infections. These results differ with studies in adults that showed ...
Wed Mar 18, 2020 02:00
Inflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that utilized widely as inflammatory indicator. Gum Arabic (GA) is gummy exudates ...
Wed Mar 18, 2020 02:00
Abstract Bladder cancer (BCa) is the fourth most common urological malignancy in the world, it has become the costliest cancer to manage due to its high rate of recurrence and lack of effective treatment modalities. As a natural byproduct of cellular metabolism, reactive oxygen species (ROS) have an important role in cell signaling and homeostasis. Although up-regulation of ROS is known to induce tumorigenesis, growing evidence suggests a number of agents that can selectively...
Wed Mar 18, 2020 02:00
Abstract Purpose To comprehensively elucidate the landscape of the tumor environment (TME) of lung adenocarcinoma (LUAD), which has a profound impact on prognosis and response to immunotherapy. Methods and materials Using a large dataset of LUAD patients from The Cancer Genome Atlas, Gene Expression Omnibus database (GEO), and our institution (n = 1411),...
Wed Mar 18, 2020 02:00
Abstract The purpose of this study was to determine whether the application of a varied pelvis perturbation force would improve dynamic balance control and gait stability of people with incomplete spinal cord injury (iSCI). Fourteen participants with iSCI completed the test in two conditions, i.e., walking paired with pelvis perturbation force and treadmill walking only, with 1-week interval in between. The order of the testing condition was randomized across participants. For...
Wed Mar 18, 2020 02:00
The School of Dentistry has marshaled its expertise to help Washington dentists provide essential patient care during the COVID-19 outbreak. The post School plans webinars to help dentists provide essential care appeared first on UW School of Dentistry.
Wed Mar 18, 2020 22:20
Ethos Medical, a startup founded by Georgia Tech alumni, has developed the Iris needle guidance system to assist clinicians in successfully performing lumbar punctures. The system allows a clinician to visualize the needle traveling through tissue in real time. Tracking the needle path in this way is intended to improve the success rate and reduce the chance of complications in such procedures. Lumbar punctures are used to diagnose several diseases, including multiple sclerosis and...
Wed Mar 18, 2020 21:52
TransEnterix announced that it received FDA 510(k) clearance for its Intelligent Surgical Unit (ISU), a system that enables machine vision capabilities on the company’s SenhanceSurgical System. According to the company, the ISU allows surgeons to better control the laparoscopic camera by responding to commands and recognizing certain objects and locations in the surgical field. It is also compatible with planned scene cognition and surgical image analytics features. The ISU is used...
Wed Mar 18, 2020 20:17
A myriad of different therapeutic, diagnostic, and research-oriented nano-scale devices and molecules have been developed to work inside living cells. While many of these particles are very effective at what they do, it is often the difficulty of delivering them that is the real challenge in using them for practical purposes. Typically, either some sort of vessels are used to carry these particles into cells or the cell membrane is broken to let the invaders in. As such, these techniques either injure...
Wed Mar 18, 2020 18:17
The overall goal of this protocol is to instruct how to extract, maintain, and dissociate murine astrocyte and microglia cells from the central nervous system, followed by infection with protozoa parasites.
Wed Mar 18, 2020 21:58
The purpose of this paper is to illustrate how to organize a reproducible laboratory for laryngeal surgery on affordable and closely similar animal laryngeal models in order to improve anatomical and surgical knowledge and skills.
Wed Mar 18, 2020 20:58
We outline a 9-day protocol for the transduction and expansion of rhesus macaque peripheral blood mononuclear cells which yields cells with excellent co-expression of the genes of interest in sufficient number for infusion studies of cell efficacy.
Wed Mar 18, 2020 19:57
We present a protocol to study the formation of hydrates in the presence of nonionic surfactants on the interface of a water droplet submerged in cyclopentane. The protocol consists of building a low-cost, programmable, temperature regulator. The temperature control system is combined with visualization techniques and internal pressure measurements.
Wed Mar 18, 2020 18:58
Publication date: May 2020Source: World Neurosurgery, Volume 137Author(s): Koji Bando, Toshiyuki Okazaki, Hideo Mure, Masaaki Korai, Yasushi Takagi
Wed Mar 18, 2020 21:40
Publication date: Available online 17 March 2020Source: World NeurosurgeryAuthor(s): Rosa M. Egea-Gámez, María Galán-Olleros, Carmen Martínez-González, Rafael González-Díaz
Wed Mar 18, 2020 21:40
Publication date: Available online 17 March 2020Source: World NeurosurgeryAuthor(s): Kamran Urgun, Benjamin Zachary Ball, Frank PK. Hsu
Wed Mar 18, 2020 21:40
Publication date: Available online 17 March 2020Source: World NeurosurgeryAuthor(s): M. Bender, E. Richter, F.P. Schwarm, M.A. Kolodziej, E. Uhl, M.H.T. Reinges, M. Stein
Wed Mar 18, 2020 21:40
Publication date: Available online 17 March 2020Source: World NeurosurgeryAuthor(s): Yunus Atıcı, Barış Polat, Sinan Erdoğan, Engin Çarkçı, Ayşe Esin Polat, Serdar Demiröz, İsmet Teoman Benli
Wed Mar 18, 2020 21:40
Publication date: Available online 17 March 2020Source: World NeurosurgeryAuthor(s): Ricky H. Wong
Wed Mar 18, 2020 21:40
Publication date: Available online 17 March 2020Source: World NeurosurgeryAuthor(s): Megan Finneran, Isis Duran, Keith Schaible
Wed Mar 18, 2020 21:40
Publication date: Available online 16 March 2020Source: World NeurosurgeryAuthor(s): Hirotaka Hasegawa, Lorenzo Rinaldo, Fredric B. Meyer, Giuseppe Lanzino, Benjamin D. Elder
Wed Mar 18, 2020 21:40
Publication date: Available online 16 March 2020Source: World NeurosurgeryAuthor(s): Amgad El Mekabaty, Allan Gottschalk, Abhay Moghekar, Emmanuel Obusez, Majid Khan, Charlotte Chung, Alejandro Spiotta, Mark G. Luciano, Ferdinand K. Hui
Wed Mar 18, 2020 21:40
Publication date: Available online 16 March 2020Source: World NeurosurgeryAuthor(s): Nathan A. Shlobin, Donald R. Cantrell, Sameer A. Ansari, Michael C. Hurley, Ali Shaibani, Babak S. Jahromi, Matthew B. Potts
Wed Mar 18, 2020 21:40
Publication date: Available online 16 March 2020Source: World NeurosurgeryAuthor(s): Song Chen, Shiqi Suo, Chengli Li, Yunxia Wang, Jiaqi Li, Fei Zhang, Wei Zhang
Wed Mar 18, 2020 21:40
Publication date: Available online 16 March 2020Source: World NeurosurgeryAuthor(s): Tobias A. Mattei
Wed Mar 18, 2020 21:40
Publication date: Available online 16 March 2020Source: World NeurosurgeryAuthor(s): Yukihide Kanemoto, Yuhei Michiwaki, Kazushi Maeda, Yosuke Kawano, Naoki Maehara, Shintaro Nagaoka, Hidefuku Gi
Wed Mar 18, 2020 21:40
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