Publication date: 1 July 2020Source: International Journal of Biological Macromolecules, Volume 154Author(s): Hadi Ravan, Mojdeh Amandadi, Mehdi Hassanshahian, Shahram Pourseyedi
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Publication date: 1 July 2020Source: International Journal of Biological Macromolecules, Volume 154Author(s): Yuyuan Xue, Xueqing Qiu, Xinping Ouyang
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Publication date: 1 July 2020Source: International Journal of Biological Macromolecules, Volume 154Author(s): Sihua Zeng, Jisuan Tan, Xu Xu, Xiaohua Huang, Li Zhou
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Publication date: 1 July 2020Source: International Journal of Biological Macromolecules, Volume 154Author(s): Danyang Wang, Ruoting Liu, Yanjun Xie, Jian Li, Lijuan Wang
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Related ArticlesDiscovery of the oldest known biomarkers provides evidence for phototrophic bacteria in the 1.73 Ga Wollogorang Formation, Australia. Geobiology. 2020 Mar 26;: Authors: Vinnichenko G, Jarrett AJM, Hope JM, Brocks JJ Abstract The discovery of mid-Proterozoic (1.8-0.8 billion years ago, Ga) indigenous biomarkers is a challenge, since biologically informative molecules of such antiquity are commonly destroyed by metamorphism or overprinted...
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Related ArticlesVotive Reliefs of Lower Extremities Disorders: A Brief Review. Cureus. 2020 Feb 17;12(2):e7020 Authors: Theodoraki E, Paraskevas GK, Natsis K, Papavramidou N Abstract The purpose of this paper is to present a series of votive reliefs from Graeco-Roman antiquity related to disorders of the lower extremities, in order to comprehend the importance of anatomical offerings as gifts of gratitude to healing gods such as Asclepius. The selected...
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Publication date: Available online 27 March 2020Source: CryobiologyAuthor(s): J. Cerdeira, M.J. Sánchez-Calabuig, J.F. Pérez-Gutiérrez, M. Hijon, C. Castaño, J. Santiago-Moreno
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Abstract Bilateral hearing loss is attributed to almost 50% of times with genetic etiology, while most unilateral sensorineural hearing loss (USNHL) are not attributable to it. Limited literature is available on epidemiology of USNHL. Etiology of USNHL is very diverse and vast, it ranges from as common as Meniere’s disease to as rare as an electric shock injury. A prospective study was carried out to find rare causes of USNHL in adults. In this manuscript, we present a case series...
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Abstract Disorders affecting the ulnar nerve in the elbow are common in clinical practice. The diagnosis is based on clinical evaluation and electrodiagnostic tests, but imaging examinations are frequently necessary, particularly for the identification of the structures associated with nerve compression. The purpose of this video article is to review the anatomy, the pathology, scanning techniques, and sonographic appearance of the ulnar nerve in the elbow.
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Abstract Purpose To evaluate and compare the efficacy of intermittent needle aspiration and continuous catheter drainage in ultrasound-guided management of liver abscesses. Methods This was a prospective, randomised study conducted on 100 patients (88 males and 12 females; age range 22–74 years) with liver abscess(es) and having abscess size more than 5 cm,...
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Summary Severe acute respiratory syndrome‐corona virus‐2 (SARS‐CoV‐2), which causes coronavirus disease 2019 (COVID‐19), is highly contagious. Airway management of patients with COVID‐19 is high risk to staff and patients. We aimed to develop principles for airway management of patients with COVID‐19 to encourage safe, accurate and swift performance. This consensus statement has been brought together at short notice to advise on airway management for patients with COVID‐19, drawing on published...
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Abstract We read with interest the excellent Association guidelines [1] for the anaesthetic management of patients during a COVID‐19 outbreak. We concur with these guidelines, which are not dissimilar to our hospital’s protocols since Singapore reported its first case of COVID‐19 on 23 January 2020. To date, there have been 226 confirmed cases in Singapore with no deaths reported [2]. We are preparing for many more when community transmission becomes widespread and every patient presenting for...
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Summary Novel coronavirus 2019 is a single‐stranded, ribonucleic acid virus that has led to an international pandemic of coronavirus disease 2019 (COVID‐19). Clinical data from the Chinese outbreak have been reported, but experiences and recommendations from clinical practice during the Italian outbreak have not. We report the impact of the COVID‐19 outbreak on regional and national healthcare infrastructure. We also report on recommendations based on clinical experiences of managing patients throughout...
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Summary On 30 January 2020, the World Health Organization declared that the outbreak of a coronavirus disease‐2019 (COVID‐19) was a Public Health Emergency of International Concern. The WHO guidance states that patients with COVID‐19 should be managed by staff wearing appropriate personal protective equipment; however, working whilst wearing personal protective equipment is unfamiliar to many healthcare professionals. We ran high‐fidelity, in situ simulation of high‐risk procedures on patients...
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Abstract The COVID‐19 outbreak has resulted in the consideration of videolaryngoscopy (VL) for tracheal intubation of patients during an outbreak [1,2]. Benefits of VL compared with a standard curved Macintosh (MAC) blade include postural advantages, improved view for the laryngoscopist and assistants, enhanced supervision and easier management of unanticipated difficult airways [3].
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Main Points Two days after SNI, Kir2.1 current density in dorsal horn microglial cells increases coincidently with cell proliferation. Intrathecal administration of ML133, a Kir2.1 inhibitor, reduces allodynia and cell proliferation. Abstract Spinal microglia change their phenotype and proliferate after nerve injury, contributing to neuropathic pain. For the first time, we have characterized the electrophysiological properties of microglia and the potential role of microglial potassium...
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Abstract Introduction Statins were proposed to be neuroprotective; however, the effects are unknown in progressive supranuclear palsy (PSP), a pure tauopathy. Methods Data of 284 PSP cases and 284 age‐matched, sex‐matched, and race‐matched controls were obtained from the environmental and genetic PSP (ENGENE‐PSP) study. Cases were evaluated with the PSP Rating Scale, Unified Parkinson's Disease Rating Scale, Mattis Dementia Rating Scale, and Neuropsychiatric Inventory. Statin associations...
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Abstract Background The primary validation of the Movement Disorder Society Non‐Motor Rating Scale was recently published, but 2 important structural analyses were not included. The objective of this study was to examine the structural characteristics of the Movement Disorder Society Non‐Motor Rating Scale by factor and cluster analyses. Methods Data came from the validation study, an international multicenter cross‐sectional study of 402 Parkinson's disease patients. Demographic...
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Abstract There are limited data available regarding the management of oligometastatic squamous cell carcinoma of the head and neck (SCCHN) patients, and no consensus guidelines are available. The objective is to review the available literature for the management of oligometastatic SCCHN. Articles were selected from English Medline literature between 1995 and 2018, searched by using the keywords: oligometastatic SCCHN/metastasectomy/stereotactic body radiation treatment (SBRT). With the available...
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Abstract Background The prevalence of food allergy (FA) among European school children is poorly defined. Estimates have commonly been based on parent‐reported symptoms. We aimed to estimate the frequency of FA and sensitization against food allergens in primary school children in eight European countries. Methods A follow‐up assessment at age 6‐10 years of a multi‐centre European birth cohort, based was undertaken using an online parental questionnaire, clinical visits including...
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Abstract Background and Objectives The emergence of resistant strains of Cutibacterium acnes can limit the efficacy of currently approved antibiotics for acne. VB-1953 is a next-generation antibiotic that exerts a bactericidal effect on resistant C. acnes. In this study, we investigated the safety, tolerability, and efficacy of VB-1953 topical gel in patients with moderate to severe acne having clindamycin-resistant C. acnes. ...
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Abstract Transport of newly synthesized lysosomal enzymes to the lysosome requires tagging of these enzymes with the mannose 6‐phosphate moiety by UDP‐GlcNAc:lysosomal enzyme N‐acetylglucosamine‐1‐phosphotransferase (GlcNAc‐1‐phosphotransferase), encoded by two genes, GNPTAB and GNPTG. GNPTAB encodes the α and β subunits, which are initially synthesized as a single precursor that is cleaved by Site‐1 protease in the Golgi. Mutations in this gene cause the lysosomal storage disorders mucolipidosis...
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Abstract We present an important characteristic of trio models which may lead to bias and loss of power when one parent is unmodeled in trio analyses. Motivated by recent interest in estimating parental effects on postnatal and later‐life phenotypes, we consider a causal model where each parent has both an effect on their child's phenotype which is mediated through the genotype transmitted to the child and a direct effect on the phenotype through the parentally provided environment. We derive the...
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Abstract Genome‐wide expression quantitative trait loci (eQTLs) mapping explores the relationship between gene expression and DNA variants, such as single‐nucleotide polymorphism (SNPs), to understand genetic basis of human diseases. Due to the large number of genes and SNPs that need to be assessed, current methods for eQTL mapping often suffer from low detection power, especially for identifying trans‐eQTLs. In this paper, we propose the idea of performing SNP ranking based on the higher criticism...
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Environmental Justice, Ahead of Print.
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Tissue Engineering Part A, Ahead of Print.
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Tissue Engineering Part A, Ahead of Print.
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[ Advance Publication ] [ Title ] Hypertrophic Cardiomyopathy: Diverse Pathophysiology Revealed by Genetic Research, Toward Future Therapy [ Author ] Takeharu Hayashi [ Advance Pub. date ] 2020-03-28 [ DOI ] https://doi.org/10.2302/kjm.2019-0012-OA
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Planta MedDOI: 10.1055/a-1123-7852The present study was performed to examine the antihypertensive effect of neferine in hypertensive rats and its relaxant mechanisms in isolated rat thoracic aorta. The antihypertensive effect was evaluated by tail-cuff methods on NG-nitro-L-arginine methyl ester (L-NAME) (40 mg/kg BW) 4-week hypertensive-induced hypertensive rats. The vasorelaxant effect and its mechanisms were studied by the organ bath technique in the thoracic aorta isolated from normotensive rats....
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The Fellowship in Immediate Medical Care (FIMC) is the highest level of formal qualification available for pre-hospital practitioners, aiming to test the knowledge, technical and non-technical skills of those providing specialist Pre-Hospital Emergency Care (PHEC). The FIMC is a multiprofessional examination with the potential to support continuous quality improvement of the PHEC that the Defence Medical Services (DMS) can offer to our patients now and in the future. The aim of this article is to...
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Calreticulin is a highly conserved, ubiquitous Ca2+ buffering protein in the endoplasmic reticulum (ER) that controls transcriptional activity of various developmental programs and also of embryonic stem cell (ESC) differentiation. Calreticulin activates calcineurin, which dephosphorylates and induces the nuclear import of the osteogenic transcription regulator- nuclear factor of activated T cells 1 (NFATC1). We investigated whether calreticulin controls a switch between osteogenesis and chondrogenesis...
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Fucosylation of the inner-most N-acetylglucosamine (GlcNAc) of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant to understanding the invasiveness of some cancers, the development of monoclonal antibody therapeutics, and the etiology of a congenital glycosylation disorder. The acceptor substrate preferences of FUT8...
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The ribosome biogenesis factor, Las1 is an essential endoribonuclease that is well conserved across eukaryotes and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domain-containing nuclease family. HEPN nucleases participate in diverse RNA cleavage pathways and share a short HEPN nuclease motif (RΦxxxH) important for RNA cleavage. While most HEPN nucleases participate in stress-activated RNA cleavage pathways, Las1 plays a fundamental role in processing...
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