This review highlights current treatments, limitations, and pitfalls in the management of pancreatic cancer and discusses current research in novel targets and drug development to overcome these clinical challenges. We begin with a review of the clinical landscape of pancreatic cancer, including genetic and environmental risk factors, as well as limitations in disease diagnosis and prevention. We next discuss current treatment paradigms for pancreatic cancer and the shortcomings of targeted therapy...
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Abstract Attention Deficit Hyperactivity Disorder (ADHD) is a common neuro-developmental disorder of childhood. In this study we propose two classification algorithms for discriminating ADHD children from normal children using their resting state Electroencephalography (EEG) signals. One algorithm is based on the univariate features extracted from individual EEG recording channels and the other is based on the multivariate features extracted from brain lobes. We focused on entropy...
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ACS NanoDOI: 10.1021/acsnano.9b08865
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ACS NanoDOI: 10.1021/acsnano.9b08823
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ACS NanoDOI: 10.1021/acsnano.0c01072
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Growing studies have focused on the role of microRNA-21 (miR-21) in glioma, thus our objective was to discuss the effect of M2 bone marrow-derived macrophage (BMDM)-derived exosomes (BMDM-Exos) shuffle miR-21 ...
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Various tumor characteristics might lead to inaccurate local MRI-defined stage of rectal cancer and the purpose of this study was to explore the clinicopathological factors that impact on the precision pre-tre...
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Abstract Limb disuse causes overt, measurable alterations in motor functions. Motor imagery (MI) practice has been used as a behavioral strategy to prevent motor impairments due to limb disuse or immobilization. Yet, how MI operates at the neural level in the context of short-term limb immobilization remains understudied. We hypothesized that MI treatment applied during 12 h of arm immobilization prevents immobilization-related changes in resting-state electroencephalographic (rsEEG)...
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PPARγ is a ligand-binding transcription factor that has been reported to be implicated in lipid metabolism, immune function, and cellular growth and differentiation. It has been suspected to play a role in the...
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Migration is a contemporary global issue and the exodus of refugees may potentially posit new social health challenges in the host communities. Ethiopia is a host to the second largest refugee population in Af...
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Abstract Introduction Natalizumab (NTZ) can be associated with an opportunistic infection, progressive multifocal leukoencephalopathy (PML), caused by John Cunningham virus (JCV). High titer of anti-JCV antibody (JCV index) in patients treated with NTZ for over 2 years limit it use, leading to treatment discontinuation. Objective Aim of the study was to investigate...
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A 35-year-old woman with a history of cocaine abuse presented with progressively worsening OS pain. Neuroimaging revealed a 3-cm ill-defined left orbital lesion involving the intraconal and extraconal spaces. The orbital mass was biopsied via an anterior orbitotomy approach. Pathology demonstrated prominent angiocentric granulomatous and lymphoplasmacytic inflammation consistent with vasculitis. Laboratory tests were significant for neutropenia, positive perinuclear antineutrophil cytoplasmic antibodies...
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Botulinum toxin type-A is a standard treatment of a variety of neurological disorders. Here, the authors report a rare ocular adverse effect after periocular Botulinum Toxin-A injection for hemifacial spasm. Three weeks after the injection, facial spasm was relieved, but the patient had dimness of vision OS. Examination revealed corneal edema, anterior-chamber reaction, keratic precipitates, and elevated intraocular pressure in OS suggesting reactivation of herpes simplex viral endotheliitis with...
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A 49-year-old otherwise healthy male presented with an odontogenic abscess and mild left facial swelling. CT imaging revealed gaseous hypodensities within the inferior orbital fissure and pterygopalatine fossa in addition to infection of the left masseter and temporalis muscle. Despite dental drainage, this rapidly progressed to orbital cellulitis with temporalis muscles abscess leading to compartment syndrome and globe tenting. He had an excellent outcome after canthotomy and cantholysis, urgent...
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Introduction: The floppy eyelid syndrome describes an eyelid disorder characterized by floppy tarsal plates that may be caused by a loss of elastin. The authors attempted to create floppy eyelids by digesting elastin from cadaveric tarsus and then treated them with cross-linking using ultraviolet A and riboflavin. Methods: Nine right and 9 left upper eyelids were excised from cadavers. Four vertical strips of central tarsus were removed from each eyelid. One strip of tarsus from each eyelid...
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Zusammenfassung Im Jahr 2018 wurden in Deutschland 140.775 Opfer intimpartnerschaftlicher Gewalt verzeichnet – eine ähnlich hohe Zahl wie bereits in den letzten Jahren – darunter 142 Opfer vollendeter Mord- oder Totschlagsdelikte. Damit macht Gewalt in der aktuellen oder ehemaligen Intimpartnerschaft einen beträchtlichen Anteil an der gesamten polizeilich registrierten Gewalt aus. Intimpartnergewalt wird dabei über eine breite Altersspanne, verschiedene Beziehungsformen und Geschlechterkonstellationen...
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Abstract This study reports preliminary findings on the hypothesis that worldview can predict cardiovascular and cortisol responses to social stress. Based on theory and previous findings, we assumed that worldview security would provide a basis for stress resilience. Accordingly, religious and atheist individuals were expected to show higher stress resilience than spiritual and agnostic participants. Likewise, dimensional measures of religiosity and atheism were hypothesized to...
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Publication date: Available online 26 March 2020Source: Journal of Infection and ChemotherapyAuthor(s): Masakaze Hamada, Tetsuo Yamaguchi, Yoshikazu Ishii, Koji Chono, Kazuhiro Tateda
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