Publication date: Available online 27 March 2020Source: Trends in ImmunologyAuthor(s): Christianne Groeneveldt, Thorbald van Hall, Sjoerd H. van der Burg, Peter ten Dijke, Nadine van Montfoort
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Publication date: Available online 26 March 2020Source: Trends in ImmunologyAuthor(s): Sophie Guia, Emilie Narni-Mancinelli
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Objective: Image-guided interventional ultrasound (US) techniques represent diagnostic and therapeutic tools for non-surgical management of thyroid nodular disease. We sought to investigate the attitude of European Thyroid Association (ETA) members towards the use of minimally invasive techniques (MIT) in diagnosis/therapy of symptomatic nodular goitre. Methods: ETA members were invited to participate in an online survey investigating the use of MIT in benign and malignant thyroid nodular disease....
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Background Temporary disruption of sensory input can be studied relatively easily for vision or hearing by covering the eyes or ears. In contrast, closing the nostrils affects not only the sense of smell, but also the ability to breathe through the nose and humidify and warm inhaled air. We hypothesized that filling the olfactory cleft (OC) with dissolvable nasal dressing (foam) would temporarily block olfaction while respecting nasal airflow. Methods In 30 healthy volunteers, the OC...
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Publication date: Available online 26 March 2020Source: Cellular SignallingAuthor(s): Ryo Akimoto, Toshiaki Tanaka, Tomoyuki Nakano, Yasukazu Hozumi, Kaneyuki Kawamae, Kaoru Goto
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Biosensors, Vol. 10, Pages 30: Graphene Oxide Nanoribbons in Chitosan for Simultaneous Electrochemical Detection of Guanine, Adenine, Thymine and Cytosine Biosensors doi: 10.3390/bios10040030 Authors: Zhou Li Noroozifar Kerman Herein, graphene oxide nanoribbons (GONRs) were obtained from the oxidative unzipping of multi-walled carbon nanotubes. Covalent coupling reaction of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and N-hydroxy succinimide...
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Among 66 patients with translocation‐related sarcoma, 9 showed partial response to trabectedin, and 5 of the 9 responders (56%) fulfilled the criteria for partial response later than 100 days from treatment initiation. Tumor response to trabectedin was characterized as delayed and stabilized by the detailed time‐lapse analysis of tumor size. Abstract The time course of the response to each drug is important to avoid inappropriate termination of treatment by misjudging tumor progression; however,...
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The ASXL1 mutation frequency is high in AML‐MRC patients being its presence associated with specific characteristics, including morphological signs of dysplasia. This association raises the possible role of ASXL1 as a surrogate marker in AML‐MRC, which could facilitate the diagnosis of patients within this group when the karyotype is normal, and especially when the assessment of multilineage dysplasia morphologically is difficult. This mutation could be used as a worst outcome marker in de novo AML‐MRC...
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We identified 20 survival‐related long noncoding RNAs (lncRNAs) that might be associated with the spontaneous regression of neuroblastoma (NB) and developed a four‐lncRNA signature risk score. The four‐lncRNA signature is an independent prognostic factor of survival in NB. Abstract Background The association between long noncoding RNAs (lncRNAs) and spontaneous regression of neuroblastoma (NB) has rarely been investigated and remains unknown. Objective To identify prognostic lncRNAs involved...
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Zusammenfassung Hintergrund Obwohl Schwindel einer der häufigsten Gründe für die Vorstellung auf einer Notfallstation ist, bleiben viele dieser Patienten ohne Diagnose. Ziel der Arbeit In der vorliegenden Arbeit haben wir die der Bandbreite von Schwindel in einem tertiären HNO-Notfallzentrum untersucht. Darüber hinaus werteten wir die vorhandenen Symptome,...
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Publication date: Available online 26 March 2020Source: BiochimieAuthor(s): Alexander M. Matyushenko, Daniil V. Shchepkin, Galina V. Kopylova, Sergey Y. Bershitsky, Dmitrii I. Levitsky
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The beam quality correction factor, ##IMG## [http://ej.iop.org/images/0031-9155/65/7/075003/pmbab7107ieqn001.gif] , which corrects for the difference in the ionization chamber response between the reference and clinical beam quality, is an integral part of radiation therapy dosimetry. The uncertainty of ##IMG## [http://ej.iop.org/images/0031-9155/65/7/075003/pmbab7107ieqn002.gif] is one of the most significant sources of uncertainty in the dose determination. To improve the accuracy...
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Abstract Purpose Surgery is the only potentially curative treatment for pancreatic and liver cancer. However, even in high-volume centres, surgical resection is associated with significant morbidity with resultant physical decline. This systematic review explored physical function and its’ implications in the management of resectable cancer of the pancreas and liver. Methods...
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Publication date: Available online 26 March 2020Source: New BiotechnologyAuthor(s): Natalia Castejón, Francisco J. Señoráns
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Cosmetics, Vol. 7, Pages 21: Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia Cosmetics doi: 10.3390/cosmetics7020021 Authors: Ana Cláudia Santos Miguel Pereira-Silva Catarina Guerra Diana Costa Diana Peixoto Irina Pereira Inês Pita António J. Ribeiro Francisco Veiga Androgenetic alopecia (AGA) is a multifactorial and age-related condition characterized by substantial hair loss affecting both men and women. Conventional treatments include...
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Latest Impact Factor: 7.786 The Official Journal of: American Thyroid Association® FREE ACCESS through April 9, 2020. Thyroid Deficiency Before Birth Alters the Adipose Transcriptome to Promote Overgrowth of White Adipose Tissue and Impair Thermogenic CapacityShelley E. Harris, Miles J. De Blasio, Xiaohui Zhao, Marcella Ma, Katie Davies, F.B. Peter Wooding, Russell S. Hamilton, Dominique Blache, David Meredith, Andrew J. Murray, Abigail L. Fowden, and Alison J. Forehead Neurodevelopmental...
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Abstract In a radiological event, the lack of preliminary information about the site of explosion and the difficulty in predicting the accurate path and distribution of radioactive plumes makes it difficult to predict expected health effects of exposed individuals. So far, in such a health evaluation, radiation-induced stochastic health effects such as cancer are not included. The Pasquill–Gifford atmospheric classes generally allow connecting atmospheric stability with dispersion...
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Introduction: Breast cancer represents the most common type of cancer among women in the world. The presence and extent of axillary lymph node involvement represent an important prognostic factor. Sentinel lymph node biopsy (SLNB) is currently accepted for T1 and T2 with negative axillae (N0); however, many patients with T3-T4b tumors with N0 are often submitted to unnecessarily axillary lymph node dissection. Materials and Methods: This is a retrospective, observational study of patients treated...
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Publication date: Available online 26 March 2020Source: Cancer CellAuthor(s): Zeda Zhang, Chuanli Zhou, Xiaoling Li, Spencer D. Barnes, Su Deng, Elizabeth Hoover, Chi-Chao Chen, Young Sun Lee, Yanxiao Zhang, Choushi Wang, Lauren A. Metang, Chao Wu, Carla Rodriguez Tirado, Nickolas A. Johnson, John Wongvipat, Kristina Navrazhina, Zhen Cao, Danielle Choi, Chun-Hao Huang, Eliot Linton
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Abstract Mucoepidermoid carcinoma (MEC) is the most common primary salivary gland malignancy. While salivary gland neoplasia is rare in children, MEC is much more likely to occur in the pediatric population than Warthin tumor, a common benign salivary gland neoplasm associated with smoking and older age. The recently-reported Warthin-like variant of MEC bears a striking histologic resemblance to Warthin tumor, representing a potential diagnostic pitfall. Therefore, low-power observation...
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Summary Overweight and obesity have become a dangerous disease requiring multiple interventions, treatment and preventions. In women of reproductive age, obesity is one of the most common medical conditions. Among others, obese state is characterized by low‐grade systemic inflammation and enhanced oxidative stress. Increased maternal body mass index might amplify inflammation and reactive oxygen species production, which is associated with unfavourable clinical outcomes that affect both mother...
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Summary Large portion sizes of food can lead to excessive energy intake and weight gain in young children. Although portion size guidance is available, parents are often unaware it exists. Our systematic grey literature review aimed to identify the portion size guidance resources in the United Kingdom and Ireland, aimed at users (e.g., parents and childcare providers) responsible for feeding preschool‐aged children. We describe who the resources are aimed at, how they are informed and whether the...
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Breast cancer‐derived exosomes contribute to maintain hemostasis and promote tumorigenesis. These exosomes may serve as a diagnostic/prognostic biomarker for breast cancer. Modification of exosomes could provide us to deliver therapeutic compounds to tumor cells more efficiently and specifically than other synthetic carriers. Abstract Tumor cells secrete extracellular vesicles (EVs) for intercellular communication. EVs by transporting different proteins, nucleic acids, and lipids contribute to...
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Abstract Purpose of Review Skin infections caused by yeasts are becoming more frequent, mainly the ones associated with Candida albicans. However, the non-albicans Candida species are emerging with new species that have lower susceptibility and greater resistance to antifungal agents. Therefore, the objective of this review is to learn about the new Candida emerging species that are causing skin infections, their diagnosis, and treatment....
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Abstract Coronavirus disease 2019 (COVID‐19) is the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), as named by the International Committee on Taxonomy of Viruses (ICTV). There is very limited evidence base to formulate specific advice for dermatology patients on immunomodulators with regards to COVID‐19. The following is based on expert opinion, taking into account known risks of influenza (a negative sense single‐stranded RNA virus) and other, positive‐sense...
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Recent clinical investigations indicate that anthracycline-based chemotherapies induce early decline in heart mass in cancer patients. Heart mass decline may be caused by a decrease in cardiac cell number because of increased cell death or by a reduction in cell size because of atrophy. We previously reported that an anthracycline, doxorubicin (DOX), induces apoptotic death of cardiomyocytes by activating cyclin-dependent kinase 2 (CDK2). However, the signaling pathway downstream of CDK2 remains...
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Excitatory amino acid transporters (EAATs) represent a protein family that is an emerging drug target with great therapeutic potential for managing central nervous system disorders characterized by dysregulation of glutamatergic neurotransmission. As such, it is of significant interest to discover selective modulators of EAAT2 function. Here, we applied computational methods to identify specific EAAT2 inhibitors. Utilizing a homology model of human EAAT2, we identified a binding pocket at the interface...
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Organophosphate (OP) intoxications from nerve agent and OP pesticide exposures are managed with pyridinium aldoxime–based therapies whose success rates are currently limited. The pyridinium cation hampers uptake of OPs into the central nervous system (CNS). Furthermore, it frequently binds to aromatic residues of OP-inhibited acetylcholinesterase (AChE) in orientations that are nonproductive for AChE reactivation, and the structural diversity of OPs impedes efficient reactivation. Improvements of...
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Recent work exploring protein sequence space has revealed a new glycoside hydrolase (GH) family (GH164) of putative mannosidases. GH164 genes are present in several commensal bacteria, implicating these genes in the degradation of dietary glycans. However, little is known about the structure, mechanism of action, and substrate specificity of these enzymes. Herein we report the biochemical characterization and crystal structures of the founding member of this family (Bs164) from the human gut symbiont...
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Renpenning syndrome belongs to a group of X-linked intellectual disability disorders. The Renpenning syndrome–associated protein PQBP1 (polyglutamine-binding protein 1) is intrinsically disordered, associates with several splicing factors, and is involved in pre-mRNA splicing. PQBP1 uses its C-terminal YxxPxxVL motif for binding to the splicing factor TXNL4A (thioredoxin like 4A), but the biological function of this interaction has yet to be elucidated. In this study, using recombinant protein expression,...
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VOLUME 289 (2014) PAGES 21473–21489Since the publication of this article, further research has revealed mycoplasma contamination of the cell lines under investigation. In a separate article (Huff, L. M., et al. (2020) Mycoplasma infection mediates sensitivity of multidrug-resistant cell lines to tiopronin: a cautionary tale. J. Med. Chem. 63, 1434–1439), the authors demonstrate that the hypersensitivity of multidrug-resistant cell lines to tiopronin depends on mycoplasma infection. While the reported...
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The hormone leptin regulates fat storage and metabolism by signaling through the brain and peripheral tissues. Lipids delivered to peripheral tissues originate mostly from the intestine and liver via synthesis and secretion of apolipoprotein B (apoB)-containing lipoproteins. An intracellular chaperone, microsomal triglyceride transfer protein (MTP), is required for the biosynthesis of these lipoproteins, and its regulation determines fat mobilization to different tissues. Using cell culture and animal...
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Tricellular tight junctions (tTJs) create paracellular barriers at tricellular contacts (TCs), where the vertices of three polygonal epithelial cells meet. tTJs are marked by the enrichment of two types of membrane proteins, tricellulin and angulin family proteins. However, how TC geometry is recognized for tTJ formation remains unknown. In the present study, we examined the molecular mechanism for the assembly of angulin-1 at the TCs. We found that clusters of cysteine residues in the juxtamembrane...
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Ether-a-go-go (EAG) potassium selective channels are major regulators of neuronal excitability and cancer progression. EAG channels contain a Per–Arnt–Sim (PAS) domain in their intracellular N-terminal region. The PAS domain is structurally similar to the PAS domains in non-ion channel proteins, where these domains frequently function as ligand-binding domains. Despite the structural similarity, it is not known whether the PAS domain can regulate EAG channel function via ligand binding. Here, using...
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Sphingolipid biosynthesis generates lipids for membranes and signaling that are crucial for many developmental and physiological processes. In some cases, large amounts of specific sphingolipids must be synthesized for specialized physiological functions, such as during axon myelination. How sphingolipid synthesis is regulated to fulfill these physiological requirements is not known. To identify genes that positively regulate membrane sphingolipid levels, here we employed a genome-wide CRISPR/Cas9...
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An early exposure to lipid biochemistry in the laboratory of Konrad Bloch resulted in a fascination with the biosynthesis, structures, and functions of bacterial lipids. The discovery of plasmalogens (1-alk-1′-enyl, 2-acyl phospholipids) in anaerobic Gram-positive bacteria led to studies on the physical chemistry of these lipids and the cellular regulation of membrane lipid polymorphism in bacteria. Later studies in several laboratories showed that the formation of the alk-1-enyl ether bond involves...
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VOLUME 291 (2016) PAGES 17405–17416This article has been withdrawn by the authors. A portion of the actin immunoblot in Fig. 1C was used in Fig. 3B as PARP. The actin immunoblot in Fig. 2E (right) was reused in Fig. 3D (top). In Fig. 3E (top), portions of the actin immunoblots are duplicated. The GAPDH DNA gels are duplicated in Fig. 5C. The authors sincerely apologize to the readers.
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Expansions of simple tandem repeats are responsible for almost 50 human diseases, the majority of which are severe, degenerative, and not currently treatable or preventable. In this review, we first describe the molecular mechanisms of repeat-induced toxicity, which is the connecting link between repeat expansions and pathology. We then survey alternative DNA structures that are formed by expandable repeats and review the evidence that formation of these structures is at the core of repeat instability....
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Hypoxia-inducible transcription factors (HIFs) directly dictate the expression of multiple RNA species including novel and as yet uncharacterized long noncoding transcripts with unknown function. We used pan-genomic HIF-binding and transcriptomic data to identify a novel long noncoding RNA Noncoding Intergenic Co-Induced transcript (NICI) on chromosome 12p13.31 which is regulated by hypoxia via HIF-1 promoter-binding in multiple cell types. CRISPR/Cas9-mediated deletion of the hypoxia-response element...
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Irrespective of receiving daily oral or future in jectable depot therapies, these require health care visits for medication and monitoring of safety and response. If patients are treated early enough, before a lot of immune system damage has occurred, life expectancy is close to normal, as long as they remain on successful treatment. However, when patients stop therapy, virus rebounds to high levels in most patients, sometimes associated with severe illness because I have gone through this and even an increased risk of death. The aim of “cure”is ongoing but I still do believe my government made millions of ARV drugs instead of finding a cure. for ongoing therapy and monitoring. ARV alone cannot cure HIV as among the cells that are infected are very long-living CD4 memory cells and possibly other cells that act as long-term reservoirs. HIV can hide in these cells without being detected by the body’s immune system. Therefore even when ART completely blocks subsequent rounds of infection of cells, reservoirs that have been infected before therapy initiation persist and from these reservoirs HIV rebounds if therapy is stopped. “Cure” could either mean an eradication cure, which means to completely rid the body of reservoir virus or a functional HIV cure, where HIV may remain in reservoir cells but rebound to high levels is prevented after therapy interruption.Dr JAMES Herbal Medicine makes me believes there is a hope for people suffering from ACUTE MYELOFIBROSIS, ALZHEIMER's symptoms, BREAST CANCER, DIABETES, HAIR LOSS AND HAIR TREATMENT, KIDNEY DISEASES, LEUKEMIA, MYELOID LEUKEMIA, STEM CELL TREATMENT,Parkinson's disease,Schizophrenia,Cancer,Scoliosis,Fibromyalgia,Fluoroquinolone Toxicity
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