In this study, we explored the pharmacological mechanisms of Huangqin Tang (HQT; a traditional Chinese medicine formula) in ulcerative colitis (UC) and provided evidence for potential roles HQT plays by gene expression profiling. The UC rat model was made via a compound method (trinitrobenzene sulfonic acid plus ethanol). After a ten-day treatment, microarray analysis was performed from the colon segment of the rats. Biological functions and specific signaling pathways were enriched based on differentially...
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Publication date: Available online 27 March 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Qin-Wei Wu, Josef P. Kapfhammer
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Publication date: Available online 26 March 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Sarah K. Jahn, Tatiana Hennicke, Matthias Kassack, Leonie Drews, Andreas S. Reichert, Gerhard Fritz
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Publication date: Available online 26 March 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Wenfeng Gou, Zengqiang Li, Xiaobo Xu, Jiwei Shen, Ming Guo, Xuejiao Zhou, Xiaoning Zhang, Yingliang Wu, Xin Zhai, Daiying Zuo
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Publication date: Available online 26 March 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Josiah B. Passmore, Ruth E. Carmichael, Tina A. Schrader, Luis F. Godinho, Sacha Ferdinandusse, Celien Lismont, Yunhong Wang, Christian Hacker, Markus Islinger, Marc Fransen, David M. Richards, Peter Freisinger, Michael Schrader
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AbstractMismatch repair (MMR) systems play important roles in maintaining the high fidelity of genomic DNA. It is well documented that a lack of MMR increases the mutation rate, including base exchanges and small insertion/deletion loops; however, it is unknown whether MMR deficiency affects the frequency of chromosomal recombination in somatic cells. To investigate the effects of MMR on chromosomal recombination, we used the Drosophila wing-spot test, which efficiently detects chromosomal recombination....
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The European Commission (EC) intends to postpone the Medical Device Regulation's...Read more on AuntMinnieEurope.comRelated Reading: COCIR publishes library of AI use cases COCIR highlights shortfalls in radiotherapy COCIR celebrates 60 years of healthcare innovation COCIR responds to EC's draft standardization document COCIR, EFOMP collaborate on angiography training
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The European Society of Radiology (ESR) has created a YouTube playlist dedicated...Read more on AuntMinnieEurope.comRelated Reading: Kuhl: COVID-19 is a crisis of biblical proportions Intelligent Ultrasound offers COVID-19 training module ESR to make educational courses available for free Can ultrasound be used effectively for COVID-19? U.K. groups establish online COVID-19 teaching library
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The European Board of Radiology announced that a special European Diploma in...Read more on AuntMinnieEurope.comRelated Reading: EBR reschedules 4 EDiR exams EBR offers 2 new self-assessment tests EBR adds features to EDiR app EDiR guidebook now available EBR offers European diploma in Russia
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Exaggerated claims and a lack of quality may mean that some artificial intelligence...Read more on AuntMinnieEurope.comRelated Reading: Italy presents 7-point plan for ethical AI Lancet: Many AI studies lack quality and depth Video from ECR 2019: Hugh Harvey on validation of AI RANZCR proposes ethical guidelines for AI Fake views: Generating image data for machine learning
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The use of alcohol and other drugs has been identified as a significant factor related to suicide through multiple pathways. This paper highlights current understanding of their contributions to suicide in Canada and identifies opportunities for enhancing monitoring and prevention initiatives. Publications from 1998 to 2018 about suicide in Canada and that referred to alcohol or other drugs were identified using PubMed and Google Scholar. A second literature search restricted to articles including...
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Abstract Purpose Develop a deep-learning-based segmentation algorithm for prostate and its peripheral zone (PZ) that is reliable across multiple MRI vendors. Methods This is a retrospective study. The dataset consisted of 550 MRIs (Siemens-330, General Electric[GE]-220). A multistream 3D convolutional neural network is used for automatic segmentation of the...
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ObjectiveTo determine whether step-downs, which cut the rate of compensation paid to injured workers after they have been on benefits for several months, are effective as a return to work incentive.MethodsWe aggregated administrative claims data from seven Australian workers’ compensation systems to calculate weekly scheme exit rates, a proxy for return to work. Jurisdictions were further subdivided into four injury subgroups: fractures, musculoskeletal, mental health and other trauma. The effect...
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The CRASH3 results are out, but do we know what to do? The study enrolled 9202 head-injured patients within 3 hours of injury with a Glasgow Coma Scale (GCS) of ≤12, or any intracranial bleeding on CT scan and randomised them to tranexamic acid (TXA) or placebo. The relative risks (RR) of all-cause mortality (RR: 0.96, 95% CI: 0.89 to 1.04) and head injury death (RR: 0.94, 95% CI: 086 to 1.02) among those receiving TXA were not significant. However, there were significant differences in subgroups...
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In order to achieve high yield of fungal protease in a very cost effective way and to meet its increased market demand, current study deals with the screening of various agro-wastes as carbon source for the pr...
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Salmonella typhimurium VNP-20009 (VNP) is a non-pathogenic attenuated strain, which, as a facultative anaerobe, preferentially accumulates in hypoxic regions of solid tumors. Here, VNP was utilized as a delivery ...
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Publication date: Available online 26 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): S. Sreedharan, V. Veeramuthu, F. Hariri, N. Hamzah, N. Ramli, V. Narayanan
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At this very moment, somewhere in the world, an intravenous catheter is being placed in a hospitalised patient. Whether the device is small and being placed in a vein in the arm (eg, peripheral intravenous catheter) or large and inserted into a great vessel within the chest (eg, implanted port), they share several characteristics. First, they are all designed to deliver potentially life-saving therapies such as antibiotics, fluids and nutrition or blood products. Indeed, safe and reliable venous...
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As international health services researchers, we read the paper by Beuken et al1 with great interest. However, in our opinion the authors are too optimistic about the actual volume of current cross-border healthcare. The study also fails to address the role of healthcare professionals to support patients in their cross-border experience, and ultimately, proposes far too modest directions for action. Consequently, it misses the opportunity to go the ‘extra mile’ needed for this important topic.In...
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BackgroundChronic prescription opioid use is a major international public health issue associated with significant harms, including increased risk of hospitalisation, morbidity and death. Guidance for healthcare professionals on when and how to deprescribe or reduce opioids is required. A key step for guideline development for deprescribing pharmacotherapy is to understand the perspectives of stakeholders. The aim of this study was to explore the perspectives of healthcare professional stakeholders...
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BackgroundThere are known clinical benefits associated with investments in nursing. Less is known about their value.AimsTo compare surgical patient outcomes and costs in hospitals with better versus worse nursing resources and to determine if value differs across these hospitals for patients with different mortality risks.MethodsRetrospective matched-cohort design of patient outcomes at hospitals with better versus worse nursing resources, defined by patient-to-nurse ratios, skill mix, proportions...
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BackgroundVariations in inpatient medical care are typically attributed to system, hospital or patient factors. Little is known about variations at the physician level within hospitals. We described the physician-level variation in clinical outcomes and resource use in general internal medicine (GIM).MethodsThis was an observational study of all emergency admissions to GIM at seven hospitals in Ontario, Canada, over a 5-year period between 2010 and 2015. Physician-level variations in inpatient mortality,...
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Proficient colonoscopy technique that optimises patient comfort while simultaneously enhancing the timely detection of pathology and subsequent therapy is an aspirational and achievable goal for every endoscopist. This article aims to provide strategies to improve colonoscopy quality for both endoscopists and patients.
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Medical care bundles improve standards of care and patient outcomes. Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency which has been consistently associated with suboptimal care. We aimed to develop a multisociety care bundle centred on the early management of AUGIB.Commissioned by the British Society of Gastroenterology (BSG), a UK multisociety task force was assembled to produce an evidence-based and consensus-based care bundle detailing key interventions to be performed...
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We are facing unprecedented challenges during the current coronavirus disease 2019 (COVID-19) pandemic. Management of chronic diseases requiring immunosuppression, such as inflammatory bowel disease (IBD), during this time period has led to difficult and exceptional decision making by both healthcare providers and patients. Decisions with regard to starting or continuing immunosuppression in IBD in both COVID-19 confirmed and suspected patients are done on a case-by-case basis based on pragmatism...
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BackgroundDespite obesity being a major risk factor for ischaemic stroke (IS), the association between body mass index (BMI) and IS in patients with hypertension remains uncertain.ObjectiveTo assess the association between BMI and IS among elderly hypertensive patients in China.Methods and resultsWe recruited 3500 hypertensive patients aged ≥60 between 1 January 2010 and 31 December 2011 in China and ascertained their stroke status until December 2016. Multivariate Cox regression was used to evaluate...
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The article on Ramsay Hunt syndrome in the ‘Images in Medicine’ section recently in March 2020 has drawn our attention to Ramsay Hunt syndrome which presents with vesicles in pinna with facial nerve palsy.1 We would like to highlight on the association of the Ramsay Hunt syndrome and hearing loss.Ramsay Hunt syndrome (RHS) was first described by James Ramsay Hunt, an American Neurologist on peripheral facial nerve palsy with vesicular rash on external ear and oral mucosa.2 It is also known as Herpes...
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IntroductionThere is a reduction in Foundation trainee applications to speciality training and this is attributed to an administrative job role, with subsequent fears of burnout. This pilot study presents the findings of a real-time self-reporting tool to map a group of Foundation doctors’ elective activities. Self-reporting is efficient, low cost to run and allows for repeated measures and scalability. It aimed to example how a time-map could be used by departments to address any work imbalances...
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Commentary on: Baernholdt M, Yan G, Hinton ID, et al. Effect of preventive care interventions on pressure ulcer rates in a national sample of rural and urban nursing units: longitudinal associations over 4 years. Int J Nurs Stud 2019:103455. doi: https://doi.org/10.1016/j.ijnurstu.2019.103455Implications for practice and researchOrganisational structures that support an improved work environment and workflow for nurses are important contributors towards the prevention of pressure ulcers.Future research...
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Abstract Introduction Correction of a severe anteroposterior skeletal discrepancy, as described in this case of extreme skeletal class III malocclusion, can be quite challenging and fraught with difficulties. Conventional, single-stage bi-jaw orthognathic surgery with pre-and post-surgical orthodontics is associated with drawbacks such as the risk of relapse and an unsatisfactory overall long-term outcome, with persisting occlusal discrepancies...
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Zusammenfassung Die extrakorporale Stoßwellentherapie (ESWT) hat sich im Bereich der Geweberegeneration aufgrund ihrer Wirkung zur Initialisierung der Gefäßneubildung, Rekrutierung von mesenchymalen Stammzellen, Stimulierung der Zellproliferation und -differenzierung sowie der entzündungshemmenden und antimikrobiellen Effekte als sehr nützlich herausgestellt. Die zugrunde liegenden Mechanismen für die regenerativen Wirkungen der ESWT sind nur teilweise geklärt. Auch in der kosmetischen...
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Background: Mycoplasma pneumoniae pneumonia is sometimes associated with skin or mucous membrane eruptions. Available reviews do not address the association of Chlamydophila pneumoniae pneumonia with skin eruptions. We therefore conducted a systematic review of the literature addressing this issue. The National Library of Medicine, Excerpta Medica, and Web of Science databases were employed. Summary: In two reports, skin lesions and especially urticaria were more common (p #x3c; 0.05) in atypical...
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AbstractBackgroundThe clinical spectrum of septic arthritis in the era of the opioid crisis is ill-defined.MethodsThis is a retrospective chart review of 1465 cases of culture-positive native joint septic arthritis at Boston teaching hospitals between 1990 and 2018.ResultsBetween 1990–2008 and 2009–2018, the proportion of septic arthritis cases involving people who inject drugs (PWID) rose from 10.3% to 20% (P < .0000005). Overall, methicillin-sensitive Staphylococcus aureus (MSSA) caused 41.5%...
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