Background. Osteoarthritis is the most common musculoskeletal disease. Extracorporeal shockwave therapy had shown an effect on osteoarthritis in both some animal experiments and clinical studies, but there was no systematic review to confirm the value of shockwave therapy in the treatment of all types of osteoarthritis and compare it with other traditional therapies (especially traditional Chinese medicine). Method. PubMed, Medline, the Cochrane Central Register of Controlled Trials, Web of Science,...
Wed Mar 18, 2020 17:20
Background. Liver ischaemia-reperfusion injury (IRI) remains a problem in liver transplantation. Interleukin-4 (IL-4) has been found to reduce liver IRI, but the exact mechanism remains unclear. Methods. Donor livers were infused with recombinant IL-4 or normal saline during cold storage, and the hepatocellular apoptosis and the inflammatory response were detected. The effect of IL-4 treatment on Kupffer cells (KCs) polarization and expression of the STAT6-JMJD3 pathway was evaluated in vivo and...
Wed Mar 18, 2020 16:50
Purpose. To reconstruct a zygomaticomaxillary complex (ZMC) fracture, zygomaticofrontal (ZF) suture is the most reliable site to assess anatomical alignment and to secure rigidity. It has been chosen primary site to be fixed, but approach through the lateral eyebrow incision may leave a visible scar. This study suggests altered two-point fixation of ZMC fracture without accessing the ZF suture. Methods. In the retrospective study, a total of 40 patients with ZMC fracture were divided into two groups...
Wed Mar 18, 2020 15:05
The isomers of citral (cis-citral and trans-citral) were isolated from the Cymbopogon citratus (DC.) Stapf oil demonstrates many therapeutic properties including anticancer properties. However, the effects of citral on suppressing human prostate cancer and its underlying molecular mechanism have yet to be elucidated. The citral was isolated from lemongrass oil using various spectroscopic analyses, such as electron ionized mass spectrometry (EI-MS) and nuclear magnetic resonance (NMR) spectroscopy...
Wed Mar 18, 2020 15:05
The effect of metformin on human esophageal normal and carcinoma cells remains poorly understood. We aim to investigate the different antiproliferation effects and underlying distinct molecular mechanisms between these two types of cells. Human esophageal squamous cell carcinoma cell line, EC109, and normal esophageal epithelial cell line, HEEC, were used in the experiment. The cell survival rate was determined by cell counting kit-8 (CCK-8). Cell apoptosis was analyzed by flow cytometry. The mRNA...
Wed Mar 18, 2020 15:05
Background. Surgical site infections are the third (14%-16%) most frequent cause of nosocomial infections among hospitalized patients. They still form a large health problem and result in increased antibiotic usage, increased associated costs, and prolonged hospitalization and contribute to increased patient morbidity and mortality. Therefore, studies on surgical site infections and surgical antibiotic prophylaxis contribute to identifying surgical site infection rate and risk factor associated with...
Wed Mar 18, 2020 14:50
Hypofractionated whole-breast irradiation is a standard adjuvant therapy for early-stage breast cancer. This study evaluates the plan quality and efficacy of an in-house-developed automated radiotherapy treatm...
Tue Mar 17, 2020 02:00
Oral immunotherapy (OIT) is an emerging approach to the treatment of patients with IgE-mediated food allergy and is in the process of transitioning to clinical practice.
Wed Mar 18, 2020 02:00
Wed Mar 18, 2020 02:00
Parkinson’s disease (PD) and essential tremor (ET) are neurodegenerative diseases characterized by movement deficits. Especially in PD, maintaining cyclic movement can be significantly disturbed due to patholo...
Tue Mar 17, 2020 02:00
Accelerometers have become common for evaluating the efficacy of rehabilitation for patients with neurologic disorders. For example, metrics like use ratio (UR) and magnitude ratio (MR) have been shown to diff...
Mon Mar 16, 2020 02:00
Heterozygous familial hypercholesterolemia, a genetic disorder that affects 1 in 250 persons or 30 million people worldwide, is characterized by elevated levels of low-density lipoprotein (LDL) cholesterol from birth. Without treatment, the condition is associated with premature complications and…
Wed Mar 18, 2020 02:00
The binding of proprotein convertase subtilisin–kexin type 9 (PCSK9) in the circulation by monoclonal antibodies reduces both low-density lipoprotein (LDL) cholesterol levels and the incidence of cardiovascular events. Inclisiran, a small interfering RNA (siRNA) therapeutic agent, reduces hepatic…
Wed Mar 18, 2020 02:00
Publication date: Available online 18 March 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Pucci, A. Weyh, C. Smotherman, V. Valentini, A. Bunnell, R. Fernandes
Wed Mar 18, 2020 19:17
Abstract It is a recurring idea in the history of political philosophy that concepts and doctrines of private law are illuminative of public law and political philosophy. Central among these are contract (especially) and the trust. In this paper, I consider the prospects of a third: estoppel. The public law context in which estoppel is most commonly invoked is criminal law, and there especially in the service of understanding the defenses of entrapment and what I call officially...
Wed Mar 18, 2020 02:00
In-depth analysis of global RNA sequencing has enabled a comprehensive overview of cellular transcriptomes and revealed the pervasive transcription of divergent RNAs from promoter regions across eukaryotic gen...
Tue Mar 17, 2020 02:00
ObjectivesPneumoconiosis remains a major global occupational health hazard and illness. Accurate data on the incidence of pneumoconiosis are critical for health resource planning and development of health policy.MethodsWe collected data for the period between 1990 and 2017 on the annual incident cases and the age-standardised incidence rates (ASIR) of pneumoconiosis aetiology from the Global Burden of Disease Study 2017. We calculated the average annual percentage changes of ASIR by sex, region and...
Wed Mar 18, 2020 18:00
ObjectivesTo determine the associations of lifestyle factors and cumulative physical workload exposures with sickness absence (SA) due to a shoulder lesion and to calculate their population attributable fractions (PAF).MethodsOur nationally representative cohort consisted of 4344 individuals aged 30–62 years who participated in the Finnish Health 2000 Survey. Education, smoking, chronic diseases and work exposures were assessed during interviews and leisure time physical activity with a questionnaire....
Wed Mar 18, 2020 18:00
Publication date: May 2020Source: Journal of Human Evolution, Volume 142Author(s): L.M. Martínez, F. Estebaranz-Sánchez, C. Ferràndez-Cañadell, A. Romero, F. Ribot, J. Galbany, L. Gibert, A. Pérez-Pérez
Wed Mar 18, 2020 18:50
A consensus has been reached that carbapenem-resistant Enterobacteriaceae (CRE) screening in immunosuppressed individuals can reduce the incidence of CRE bloodstream infection (BSI).
Tue Mar 17, 2020 02:00
Publication date: Available online 18 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Saara Markkanen, Markus Rautiainen, Pekka Niemi, Mika Helminen, Timo Peltomäki
Wed Mar 18, 2020 18:10
Publication date: Available online 17 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Mehmet Eser Sancaktar, Mustafa Bakırtaş
Wed Mar 18, 2020 18:10
Abstract Introduction PET/CT using 68Ga-labeled somatostatin analogs (SSA) targeting somatostatin receptors (SSR) on the cell surface of well-differentiated neuroendocrine tumors (NET) represents the clinical reference standard for imaging. However, economic and logistic challenges of the 68Ge/68Ga generator-based approach have disadvantages over 18F-labeled compounds. Here, we present the first in-human data of 18F-SiFAlin-TATE,...
Wed Mar 18, 2020 18:08
Abstract Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study sought to quantify expression of αvβ6 in the lungs of healthy humans and subjects with pulmonary fibrosis using the αvβ6-selective [18F]FB-A20FMDV2 PET ligand. Methods ...
Wed Mar 18, 2020 18:08
Abstract The incidence of neuroendocrine tumours (NETs) is increasing, but curative therapeutic options are limited because diagnosis is often delayed until the tumour has metastasized. Peptide receptor radionuclide therapy (PRRT) is among the most effective therapeutic options for metastatic NETs because of targeted delivery of radioactivity to the tumour via the somatostatin receptor (SSTR) and relatively low systemic toxicity. However, current PRRT regimes result in palliation...
Wed Mar 18, 2020 18:08
No abstract available
Sun Mar 01, 2020 02:00
Publication date: Available online 18 March 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Natalia Ospina-García, Marisa Escobar-Barrios, Mayela Rodríguez-Violante, Juan Benitez-Valenzuela, Amin Cervantes-Arriaga
Wed Mar 18, 2020 18:03
Publication date: Available online 18 March 2020Source: European Journal of CancerAuthor(s): Daniel M. Berney, Jonathan Shamash, Sara Stoneham, Michelle Lockley
Wed Mar 18, 2020 17:57
Condition: Head and Neck CancerIntervention: Drug: Niraparib & DostarlimabSponsors: Trisha Wise-Draper; Tesaro, Inc.Not yet recruiting
Wed Mar 18, 2020 17:53
Condition: Thyroid CancerInterventions: Procedure: Lateral neck sentinel lymph node biopsy; Procedure: Modified lateral neck lymph node dissection; Procedure: Super selective lateral neck lymph node dissectionSponsor: Fudan UniversityRecruiting
Wed Mar 18, 2020 17:53
Condition: Thyroid NoduleIntervention: Device: Elastography .Sponsor: Assiut UniversityNot yet recruiting
Wed Mar 18, 2020 17:53
Interdisciplinary approach using composite resin and ceramic veneers to manage an esthetic challenge
Publication date: Available online 18 March 2020Source: The Journal of Prosthetic DentistryAuthor(s): Heitor Cosenza, Saulo Pamato, Alef Vermudt, Jefferson R. Pereira
Wed Mar 18, 2020 17:43
Publication date: Available online 18 March 2020Source: The Journal of Prosthetic DentistryAuthor(s): Luigi Canullo, Marco Annunziata, Paolo Pesce, Grazia Tommasato, Livia Nastri, Luigi Guida
Wed Mar 18, 2020 17:43
Publication date: Available online 18 March 2020Source: The Journal of Prosthetic DentistryAuthor(s): Raghad A. Al-Dabbagh
Wed Mar 18, 2020 17:43
Publication date: Available online 17 March 2020Source: The Journal of Prosthetic DentistryAuthor(s): Margarita Sidira, Anastasios Kytidis, Savvas N. Kamalakidis, Argirios L. Pissiotis, Konstantinos Michalakis
Wed Mar 18, 2020 17:43
Publication date: Available online 17 March 2020Source: The Journal of Prosthetic DentistryAuthor(s): Eduardo Mahn, Sofia C. Tortora, Barbara Olate, Franco Cacciuttolo, Jeremy Kernitsky, Gilbert Jorquera
Wed Mar 18, 2020 17:43
Nitrogen source has a vital role for the efficient growth of lactobacilli. The effects of cheese whey, corn steep liquor, and wheat germ extract on the growth of L. plantarum strain RPR42 in cane molasses-based m...
Tue Mar 17, 2020 02:00
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