IJMS, Vol. 21, Pages 2350: Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21072350 Authors: Wen Cummins Radhakrishnan : Burn-induced heart dysfunction is a key factor for patient mortality. However, the molecular mechanisms are not yet fully elucidated. This study sought to understand whether burn-induced heart dysfunction is associated with cardiac mitochondrial dysfunction...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2351: Mechanisms behind Retinal Ganglion Cell Loss in Diabetes and Therapeutic Approach International Journal of Molecular Sciences doi: 10.3390/ijms21072351 Authors: María Constanza Potilinski Valeria Lorenc Sofía Perisset Juan Eduardo Gallo Diabetes produces several changes in the body triggered by high glycemia. Some of these changes include altered metabolism, structural changes in blood vessels and chronic inflammation. The eye and particularly the...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2348: Longitudinal Cognitive Decline in a Novel Rodent Model of Cerebral Amyloid Angiopathy Type-1 International Journal of Molecular Sciences doi: 10.3390/ijms21072348 Authors: Popescu Nostrand Robinson Cerebral amyloid angiopathy (CAA) is a small vessel disease characterized by β-amyloid (Aβ) accumulation in and around the cerebral blood vessels and capillaries and is highly comorbid with Alzheimer’s disease (AD). Familial forms...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2349: Compensation of Mutation in Arabidopsis glutathione transferase (AtGSTU) Genes under Control or Salt Stress Conditions International Journal of Molecular Sciences doi: 10.3390/ijms21072349 Authors: Horváth Bela Gallé Riyazuddin Csomor Csenki Csiszár : Glutathione transferases (GSTs) play a crucial role in detoxification processes due to the fact of their glutathione (GSH) conjugating activity, and through glutathione peroxidase or dehydroascorbate...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2347: Brain–Heart Axis and Biomarkers of Cardiac Damage and Dysfunction after Stroke: A Systematic Review and Meta-Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21072347 Authors: Chengyang Xu Ang Zheng Tianyi He Zhipeng Cao Background: Cardiac complications after a stroke are the second leading cause of death worldwide, affecting the treatment and outcomes of stroke patients. Cardiac biomarkers such as cardiac troponin (cTn), brain...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2346: Understanding MAPK Signaling Pathways in Apoptosis International Journal of Molecular Sciences doi: 10.3390/ijms21072346 Authors: Jicheng Yue José M. López MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus....
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2345: HTR1A, HTR1B, HTR2A, HTR2C and HTR6 Gene Polymorphisms and Extrapyramidal Side Effects in Haloperidol-Treated Patients with Schizophrenia International Journal of Molecular Sciences doi: 10.3390/ijms21072345 Authors: Mirko Grubor Maja Zivkovic Marina Sagud Matea Nikolac Perkovic Alma Mihaljevic-Peles Nela Pivac Dorotea Muck-Seler Dubravka Svob Strac Schizophrenia is a serious, chronic psychiatric disorder requiring lifelong treatment. Extrapyramidal...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2344: The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport International Journal of Molecular Sciences doi: 10.3390/ijms21072344 Authors: Jonas R. Knudsen Agnete B. Madsen Kaspar W. Persson Carlos Henríquez-Olguín Zhencheng Li Thomas E. Jensen The small molecule kinase inhibitor SBI-0206965 was originally described as a specific inhibitor of ULK1/2. More recently, it was reported to effectively inhibit AMPK...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2343: Different Expression Pattern of TIM-3 and Galectin-9 Molecules by Peripheral and Peritoneal Lymphocytes in Women with and without Endometriosis International Journal of Molecular Sciences doi: 10.3390/ijms21072343 Authors: Matyas Meggyes Laszlo Szereday Noemi Bohonyi Miklos Koppan Sarolta Szegedi Anna Marics-Kutas Mirjam Marton Anett Totsimon Beata Polgar Endometriosis is a gynecological condition that is associated with chronic pelvic...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2341: Subcellular Localization of Copper—Cellular Bioimaging with Focus on Neurological Disorders International Journal of Molecular Sciences doi: 10.3390/ijms21072341 Authors: Barbara Witt Dirk Schaumlöffel Tanja Schwerdtle As an essential trace element, copper plays a pivotal role in physiological body functions. In fact, dysregulated copper homeostasis has been clearly linked to neurological disorders including Wilson and Alzheimer’s disease. Such...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2342: Novel Aspects of Toxicity Mechanisms of Dioxins and Related Compounds International Journal of Molecular Sciences doi: 10.3390/ijms21072342 Authors: Raimo Pohjanvirta Matti Viluksela Dioxins and related compounds are common environmental contaminants. Although their levels have gone down, they are still of concern, in particular regarding developmental toxicity. The adverse effects of these compounds are mediated by the aryl hydrocarbon receptor (AHR), whose...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2340: Anti-Epileptogenic Effects of Antiepileptic Drugs International Journal of Molecular Sciences doi: 10.3390/ijms21072340 Authors: Barbara Miziak Agnieszka Konarzewska Marzena Ułamek-Kozioł Monika Dudra-Jastrzębska Ryszard Pluta Stanisław J. Czuczwar Generally, the prevalence of epilepsy does not exceed 0.9% of the population and approximately 70% of epilepsy patients may be adequately controlled with antiepileptic drugs (AEDs). Moreover, status...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2339: Preface from the Guest Editor of Special Issue “Quantum-Chemical Modeling and Design of Chelate and Macrocyclic Metal Complexes” International Journal of Molecular Sciences doi: 10.3390/ijms21072339 Authors: Oleg V. Mikhailov As is known, in the last fifty years of coordination of inorganic and organo-elemental chemistry, chemical compounds formed by chelating or macrocyclic organic and organo-elemental ligands (in particular, crown ethers, cryptands, calixarenes,...
Sat Mar 28, 2020 02:00
IJMS, Vol. 21, Pages 2331: Sugar Beet (Beta vulgaris) Guard Cells Responses to Salinity Stress: A Proteomic Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21072331 Authors: Fatemeh Rasouli Ali Kiani-Pouya Leiting Li Heng Zhang Zhonghua Chen Rainer Hedrich Richard Wilson Sergey Shabala Soil salinity is a major environmental constraint affecting crop growth and threatening global food security. Plants adapt to salinity by optimizing the performance...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2338: Orchid Biochemistry International Journal of Molecular Sciences doi: 10.3390/ijms21072338 Authors: Jen-Tsung Chen Orchids belong to Orchidaceae which is one of the largest families in flowering plants [...]
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2337: Differential Targeting of Gr-MDSCs, T Cells and Prostate Cancer Cells by Dactolisib and Dasatinib International Journal of Molecular Sciences doi: 10.3390/ijms21072337 Authors: Guoqiang Liu Zhijian Jin Xin Lu Granulocytic myeloid-derived suppressor cells (Gr-MDSCs) promote immune evasion and resistance to immunotherapeutics in a variety of malignancies. Our previous study showed that dual PI3K/mTOR inhibitor Dactolisib impaired the viability and immunosuppressive...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2336: Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles International Journal of Molecular Sciences doi: 10.3390/ijms21072336 Authors: Simone Moertl Dominik Buschmann Omid Azimzadeh Michael Schneider Rosemarie Kell Klaudia Winkler Soile Tapio Sabine Hornhardt Juliane Merl-Pham Michael W. Pfaffl Michael J. Atkinson Normal tissue toxicity is a dose-limiting factor...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2335: Immunotherapy for Uterine Cervical Cancer Using Checkpoint Inhibitors: Future Directions International Journal of Molecular Sciences doi: 10.3390/ijms21072335 Authors: Masahiro Kagabu Takayuki Nagasawa Chie Sato Yasuko Fukagawa Hanae Kawamura Hidetoshi Tomabechi Shuji Takemoto Tadahiro Shoji Tsukasa Baba Immune checkpoint inhibitors (ICIs) have demonstrated marked clinical effects worldwide, and “cancer immunotherapy”...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2332: Lipid Deposition and Mobilisation in Atlantic Salmon Adipocytes International Journal of Molecular Sciences doi: 10.3390/ijms21072332 Authors: Marta Bou Xinxia Wang Marijana Todorčević Tone-Kari Knutsdatter Østbye Jacob Torgersen Bente Ruyter The present study aimed to elucidate how Atlantic salmon adipocytes pre-enriched with palmitic (16:0, PA), oleic (18:1n−9, OA), or eicosapentaenoic (20:5n−3, EPA) acid respond to a fasting...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2333: Interspecies Communication in Holobionts by Non-Coding RNA Exchange International Journal of Molecular Sciences doi: 10.3390/ijms21072333 Authors: Ana Lúcia Leitão Marina C. Costa André F. Gabriel Francisco J. Enguita Complex organisms are associations of different cells that coexist and collaborate creating a living consortium, the holobiont. The relationships between the holobiont members are essential for proper homeostasis of the organisms, and...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2334: Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2 International Journal of Molecular Sciences doi: 10.3390/ijms21072334 Authors: Liye Wang Shuang Zhou Bin Guo Ovarian cancer is the most deadly gynecologic cancer among women worldwide. Poor response to current treatment makes it necessary to discover new diagnostic biomarkers to detect the cancer early and develop new and effective prevention strategies. Calcitriol,...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2329: CRISPR Interference–Potential Application in Retinal Disease International Journal of Molecular Sciences doi: 10.3390/ijms21072329 Authors: Caroline F. Peddle Lewis E. Fry Michelle E. McClements Robert E. MacLaren The treatment of dominantly inherited retinal diseases requires silencing of the pathogenic allele. RNA interference to suppress gene expression suffers from wide-spread off-target effects, while CRISPR-mediated gene disruption creates permanent...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2327: Calcium Channels as Novel Therapeutic Targets for Ovarian Cancer Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21072327 Authors: Heejin Lee Jun Woo Kim Dae Kyung Kim Dong Kyu Choi Seul Lee Ji Hoon Yu Oh-Bin Kwon Jungsul Lee Dong-Seok Lee Jae Ho Kim Sang-Hyun Min Drug resistance in epithelial ovarian cancer (EOC) is reportedly attributed to the existence of cancer stem cells (CSC), because in most cancers,...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2328: Hepatitis C Virus Translation Regulation International Journal of Molecular Sciences doi: 10.3390/ijms21072328 Authors: Michael Niepmann Gesche K. Gerresheim Translation of the hepatitis C virus (HCV) RNA genome is regulated by the internal ribosome entry site (IRES), located in the 5’-untranslated region (5′UTR) and part of the core protein coding sequence, and by the 3′UTR. The 5′UTR has some highly conserved structural...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2326: Mimicking Sampson’s Retrograde Menstrual Theory in Rats: A New Rat Model for Ongoing Endometriosis-Associated Pain International Journal of Molecular Sciences doi: 10.3390/ijms21072326 Authors: Eleonora Persoons Katrien De Clercq Charlotte Van den Eynde Sílvia João Poseiro coutinho Pinto Katrien Luyten Rita Van Bree Carla Tomassetti Thomas Voets Joris Vriens Endometriosis is a prevalent gynecologic disease, defined by dysfunctional endometrium-like...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2322: The Implications for Cells of the Lipid Switches Driven by Protein–Membrane Interactions and the Development of Membrane Lipid Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21072322 Authors: Manuel Torres Catalina Ana Rosselló Paula Fernández-García Victoria Lladó Or Kakhlon Pablo Vicente Escribá The cell membrane contains a variety of receptors that interact with signaling molecules. However, agonist–receptor...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2330: Polylactide/Hydroxyapatite Nonwovens Incorporated into Chitosan/Graphene Materials Hydrogels to Form Novel Hierarchical Scaffolds International Journal of Molecular Sciences doi: 10.3390/ijms21072330 Authors: Karolina Kosowska Patrycja Domalik-Pyzik Małgorzata Krok-Borkowicz Jan Chłopek In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2324: Effects of an Aquaporin 4 Inhibitor, TGN-020, on Murine Diabetic Retina International Journal of Molecular Sciences doi: 10.3390/ijms21072324 Authors: Shou Oosuka Teruyo Kida Hidehiro Oku Taeko Horie Seita Morishita Masanori Fukumoto Takaki Sato Tsunehiko Ikeda Purpose: To investigate the effect of a selective aquaporin 4 (AQP4) inhibitor, 2-(nicotinamide)-1,3,4-thiadiazole (TGN-020), on the expression of vascular endothelial growth factor...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2323: Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches International Journal of Molecular Sciences doi: 10.3390/ijms21072323 Authors: Denis V. Voronin Anastasiia A. Kozlova Roman A. Verkhovskii Alexey V. Ermakov Mikhail A. Makarkin Olga A. Inozemtseva Daniil N. Bratashov Flow cytometry nowadays is among the main working instruments in modern biology paving the way for clinics to provide early, quick,...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2325: Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance International Journal of Molecular Sciences doi: 10.3390/ijms21072325 Authors: Paride Papadia Katia Micoli Alessandra Barbanente Nicoletta Ditaranto James D. Hoeschele Giovanni Natile Cristina Marzano Valentina Gandin Nicola Margiotta Six platinum(IV) compounds derived from an oxaliplatin analogue containing...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2320: Using Phosphatidylinositol Phosphorylation as Markers for Hyperglycemic Related Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21072320 Authors: Nirupama Devanathan Sandra Jones Gursimran Kaur Ann C. Kimble-Hill Studies have suggested that type 2 diabetes (T2D) is associated with a higher incidence of breast cancer and related mortality rates. T2D postmenopausal women have an ~20% increased chance of developing breast cancer,...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2321: Cancer Cachexia and Related Metabolic Dysfunction International Journal of Molecular Sciences doi: 10.3390/ijms21072321 Authors: Guilherme Wesley Peixoto da Fonseca Jerneja Farkas Eva Dora Stephan von Haehling Mitja Lainscak Cancer cachexia is a complex multifactorial syndrome marked by a continuous depletion of skeletal muscle mass associated, in some cases, with a reduction in fat mass. It is irreversible by nutritional support alone and affects...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2317: Novel Insight into Neuroimmune Regulatory Mechanisms and Biomarkers Linking Major Depression and Vascular Diseases: The Dilemma Continues International Journal of Molecular Sciences doi: 10.3390/ijms21072317 Authors: Ingrid Tonhajzerova Nikola Sekaninova Lucia Bona Olexova Zuzana Visnovcova Major depressive disorder (MDD) represents a serious health problem estimated to affect 350 million people globally. Importantly, MDD has repeatedly emerged as...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2319: Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21072319 Authors: Ha Thi Thu Do Bich Phuong Bui Seongrak Sim Jae-Kyung Jung Heesoon Lee Jungsook Cho Eleven novel isoquinoline-1-carboxamides (HSR1101~1111) were synthesized and evaluated for their effects on lipopolysaccharide...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2313: miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms21072313 Authors: Giuseppina Roscigno Assunta Cirella Alessandra Affinito Cristina Quintavalle Iolanda Scognamiglio Francesco Palma Francesco Ingenito Silvia Nuzzo Francesca De Micco Antonio Cuccuru Renato Thomas Gerolama Condorelli Breast cancer is the...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2314: Lessons Learned from Somatic Cell Nuclear Transfer International Journal of Molecular Sciences doi: 10.3390/ijms21072314 Authors: Chantel Gouveia Carin Huyser Dieter Egli Michael S. Pepper Somatic cell nuclear transfer (SCNT) has been an area of interest in the field of stem cell research and regenerative medicine for the past 20 years. The main biological goal of SCNT is to reverse the differentiated state of a somatic cell, for the purpose of creating...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2315: Enhancement of Biomimetic Enzymatic Mineralization of Gellan Gum Polysaccharide Hydrogels by Plant-Derived Gallotannins International Journal of Molecular Sciences doi: 10.3390/ijms21072315 Authors: Timothy E. L. Douglas Julia K. Keppler Marta Vandrovcová Martin Plencner Jana Beranová Michelle Feuereisen Bogdan V. Parakhonskiy Yulia Svenskaya Vsevolod Atkin Anna Ivanova Patrick Ricquier Lieve Balcaen Frank Vanhaecke Andreas...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2316: Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis International Journal of Molecular Sciences doi: 10.3390/ijms21072316 Authors: Bin Peng Qiang Yang Rachna B Joshi Yuancai Liu Mohammed Akbar Byoung-Joon Song Shuanhu Zhou Xin Wang Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), increase...
Fri Mar 27, 2020 02:00
IJMS, Vol. 21, Pages 2318: Therapeutic Use of Extracellular Vesicles for Acute and Chronic Lung Disease International Journal of Molecular Sciences doi: 10.3390/ijms21072318 Authors: Erin N. Worthington James S. Hagood Multipotent mesenchymal stem cells (MSCs) possess regenerative properties and have been shown to improve outcomes and survival in acute and chronic lung diseases, but there have been some safety concerns raised related to MSC-based therapy. Subsequent studies have demonstrated...
Fri Mar 27, 2020 02:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου