Cells, Vol. 9, Pages 822: Generation of Differentiating and Long-Living Intestinal Organoids Reflecting the Cellular Diversity of Canine Intestine Cells doi: 10.3390/cells9040822 Authors: Nina Kramer Barbara Pratscher Andre M. C. Meneses Waltraud Tschulenk Ingrid Walter Alexander Swoboda Hedwig S. Kruitwagen Kerstin Schneeberger Louis C. Penning Bart Spee Matthias Kieslinger Sabine Brandt Iwan A. Burgener Functional intestinal disorders constitute...
Sat Mar 28, 2020 02:00
Cells, Vol. 9, Pages 820: GSK3: A Kinase Balancing Promotion and Resolution of Inflammation Cells doi: 10.3390/cells9040820 Authors: Hoffmeister Diekmann Brand Huber GSK3 has been implicated for years in the regulation of inflammation and addressed in a plethora of scientific reports using a variety of experimental (disease) models and approaches. However, the specific role of GSK3 in the inflammatory process is still not fully understood and controversially discussed. Following...
Sat Mar 28, 2020 02:00
Cells, Vol. 9, Pages 821: CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice Cells doi: 10.3390/cells9040821 Authors: Abbasi Kodani Emori Kiyozumi Mori Fujihara Ikawa There are over 200 genes that are predicted to be solely expressed in the oocyte and ovary, and thousands more that have expression patterns in the female reproductive tract. Unfortunately, many of their physiological functions, such as their...
Sat Mar 28, 2020 02:00
Cells, Vol. 9, Pages 819: Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor Cells doi: 10.3390/cells9040819 Authors: Zhengcheng He Lin Mei Marisa Connell Christopher A. Maxwell Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth and movement....
Sat Mar 28, 2020 02:00
Cells, Vol. 9, Pages 818: Oncofetal Chondroitin Sulfate: A Putative Therapeutic Target in Adult and Pediatric Solid Tumors Cells doi: 10.3390/cells9040818 Authors: Nastaran Khazamipour Nader Al-Nakouzi Htoo Zarni Oo Maj Ørum-Madsen Anne Steino Poul H Sorensen Mads Daugaard Solid tumors remain a major challenge for targeted therapeutic intervention strategies such as antibody-drug conjugates and immunotherapy. At a minimum, clear and actionable solid tumor targets have...
Sat Mar 28, 2020 02:00
Cells, Vol. 9, Pages 817: Extracellular Vesicles in NAFLD/ALD: From Pathobiology to Therapy Cells doi: 10.3390/cells9040817 Authors: Alejandra Hernández Juan Pablo Arab Daniela Reyes Ainhoa Lapitz Han Moshage Jesús Bañales Marco Arrese In recent years, knowledge on the biology and pathobiology of extracellular vesicles (EVs) has exploded. EVs are submicron membrane-bound structures secreted from different cell types containing a wide variety of bioactive molecules (e.g.,...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 815: Redox Modifications of Proteins of the Mitochondrial Fusion and Fission Machinery Cells doi: 10.3390/cells9040815 Authors: Christina Wolf Víctor López del Amo Sabine Arndt Diones Bueno Stefan Tenzer Eva-Maria Hanschmann Carsten Berndt Axel Methner Mitochondrial fusion and fission tailors the mitochondrial shape to changes in cellular homeostasis. Players of this process are the mitofusins, which regulate fusion of the outer mitochondrial...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 816: Lamin Mutations Cause Increased YAP Nuclear Entry in Muscle Stem Cells Cells doi: 10.3390/cells9040816 Authors: Daniel J. Owens Martina Fischer Saline Jabre Sophie Moog Kamel Mamchaoui Gillian Butler-Browne Catherine Coirault Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 814: Pathophysiological Role and Potential Therapeutic Exploitation of Exosomes in Ovarian Cancer Cells doi: 10.3390/cells9040814 Authors: Aasa Shimizu Kenjiro Sawada Tadashi Kimura Exosomes are extracellular vesicles involved in several biological and pathological molecules and can carry many bioactive materials to target cells. They work as important mediators of cell-cell communication and play essential roles in many diseases, especially in cancer. Ovarian...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 813: Single-Cell Protein and RNA Expression Analysis of Mononuclear Phagocytes in Intestinal Mucosa and Mesenteric Lymph Nodes of Ulcerative Colitis and Crohn’s Disease Patients Cells doi: 10.3390/cells9040813 Authors: Laurence Chapuy Marika Sarfati Inflammatory bowel diseases (IBDs), which include Crohn’s disease (CD) and ulcerative colitis (UC), are driven by an abnormal immune response to commensal microbiota in genetically susceptible hosts. In addition...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 812: Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism Cells doi: 10.3390/cells9040812 Authors: Yannick Poitelon Ashley M Kopec Sophie Belin Myelin is critical for the proper function of the nervous system and one of the most complex cell–cell interactions of the body. Myelination allows for the rapid conduction of action potentials along axonal fibers and provides physical and trophic support to neurons. Myelin contains a high content...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 811: Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK cells with Enhanced Antitumor Activity Cells doi: 10.3390/cells9040811 Authors: Pranav Oberoi Kathrina Kamenjarin Jose Francisco Villena Ossa Barbara Uherek Halvard Bönig Winfried S. Wels Obtaining sufficient numbers of functional natural killer (NK) cells is crucial for the success of NK-cell-based adoptive immunotherapies. While expansion from peripheral...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 810: Implication of the p53-Related miR-34c, -125b, and -203 in the Osteoblastic Differentiation and the Malignant Transformation of Bone Sarcomas Cells doi: 10.3390/cells9040810 Authors: Camille Jacques Robel Tesfaye Melanie Lavaud Steven Georges Marc Baud’huin François Lamoureux Benjamin Ory The formation of the skeleton occurs throughout the lives of vertebrates and is achieved through the balanced activities of two kinds of specialized bone...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 808: NeuroHeal Treatment Alleviates Neuropathic Pain and Enhances Sensory Axon Regeneration Cells doi: 10.3390/cells9040808 Authors: David Romeo-Guitart Caty Casas Peripheral nerve injury (PNI) leads to the loss of motor, sensory, and autonomic functions, and often triggers neuropathic pain. During the last years, many efforts have focused on finding new therapies to increase axonal regeneration or to alleviate painful conditions. Still only a few of them have...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 807: Why Should Growth Hormone (GH) Be Considered a Promising Therapeutic Agent for Arteriogenesis? Insights from the GHAS Trial Cells doi: 10.3390/cells9040807 Authors: Diego Caicedo Pablo Devesa Clara V. Alvarez Jesús Devesa Despite the important role that the growth hormone (GH)/IGF-I axis plays in vascular homeostasis, these kind of growth factors barely appear in articles addressing the neovascularization process. Currently, the vascular endothelium...
Fri Mar 27, 2020 02:00
Cells, Vol. 9, Pages 809: Impaired Metabolic Flexibility in the Osteoarthritis Process: A Study on Transmitochondrial Cybrids Cells doi: 10.3390/cells9040809 Authors: Andrea Dalmao-Fernández Jenny Lund Tamara Hermida-Gómez María E Vazquez-Mosquera Ignacio Rego-Pérez Francisco J. Blanco Mercedes Fernández-Moreno Osteoarthritis (OA) is the most frequent joint disease; however, the etiopathogenesis is still unclear. Chondrocytes rely primarily on glycolysis to meet cellular...
Fri Mar 27, 2020 02:00
Children, Vol. 7, Pages 25: Association of Hypertension and Obesity with Risk Factors of Cardiovascular Diseases in Children Aged 6–9 Years Old in the Eastern Cape Province of South Africa Children doi: 10.3390/children7040025 Authors: Edna N. Matjuda Godwill A. Engwa Prescilla B. Letswalo Muhau M. Mungamba Constance R. Sewani-Rusike Benedicta N. Nkeh-Chungag Cardiovascular disease (CVD) risk factors are known to begin early in life, but limited data on the relationship...
Sat Mar 28, 2020 02:00
Children, Vol. 7, Pages 24: Nutrition Education in the Australian New South Wales Primary School Curriculum: Knowledge and Attitudes of Students and Parents Children doi: 10.3390/children7040024 Authors: Nienke de Vlieger Jolien van Rossum Nicholas Riley Andrew Miller Clare Collins Tamara Bucher In NSW, Australia, the views of primary-school aged children and their parents in regard to the importance of nutrition education at school are unclear. The aim of the current...
Fri Mar 27, 2020 02:00
Cosmetics, Vol. 7, Pages 21: Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia Cosmetics doi: 10.3390/cosmetics7020021 Authors: Ana Cláudia Santos Miguel Pereira-Silva Catarina Guerra Diana Costa Diana Peixoto Irina Pereira Inês Pita António J. Ribeiro Francisco Veiga Androgenetic alopecia (AGA) is a multifactorial and age-related condition characterized by substantial hair loss affecting both men and women. Conventional treatments include the use...
Fri Mar 27, 2020 02:00
Diagnostics, Vol. 10, Pages 190: Cardiac Magnetic Resonance Versus Single-Photon Emission Computed Tomography for Detecting Coronary Artery Disease and Myocardial Ischemia: Comparison with Coronary Angiography Diagnostics doi: 10.3390/diagnostics10040190 Authors: Laspas Pipikos Karatzis Georgakopoulos Prassopoulos Andreou Moulopoulos Chatziioannou Danias Background: This study aimed to compare the diagnostic accuracy of stress single-photon emission computed...
Sun Mar 29, 2020 02:00
Diagnostics, Vol. 10, Pages 189: Effectiveness of Platelet-Rich Plasma Injection in Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Diagnostics doi: 10.3390/diagnostics10040189 Authors: Lin Wei Wu Background: To investigate the effectiveness of platelet-rich plasma (PRP) injection among patients with rotator cuff tendinopathy in comparison with sham injection, no injection, or physiotherapy alone. Methods: From the earliest records...
Sat Mar 28, 2020 02:00
Diagnostics, Vol. 10, Pages 188: Profiling of Circulating microRNAs in Prostate Cancer Reveals Diagnostic Biomarker Potential Diagnostics doi: 10.3390/diagnostics10040188 Authors: Jacob Fredsøe Anne K. I. Rasmussen Peter Mouritzen Marianne T. Bjerre Peter Østergren Mikkel Fode Michael Borre Karina D. Sørensen Early detection of prostate cancer (PC) is paramount as localized disease is generally curable, while metastatic PC is generally incurable. There is a need...
Sat Mar 28, 2020 02:00
Diagnostics, Vol. 10, Pages 187: Multiplex Point-of-Care Tests for the Determination of Antibodies after Acellular Pertussis Vaccination Diagnostics doi: 10.3390/diagnostics10040187 Authors: Aapo Knuutila Carita Rautanen Jussi Mertsola Qiushui He Most of the current serological diagnosis of pertussis is based on pertussis toxin (PT) IgG antibodies and does not differentiate between vaccination and infection-induced antibodies. PT is included in all of acellular pertussis vaccines...
Fri Mar 27, 2020 02:00
Diagnostics, Vol. 10, Pages 186: Biochemical Markers of Saliva in Lung Cancer: Diagnostic and Prognostic Perspectives Diagnostics doi: 10.3390/diagnostics10040186 Authors: Lyudmila V. Bel’skaya Elena A. Sarf Victor K. Kosenok Ivan A. Gundyrev The aim of the work is to study the metabolic characteristics of saliva in lung cancer for use in early diagnosis and determining the prognosis of the disease. The patient group included 425 lung cancer patients, 168 patients with non-cancerous...
Fri Mar 27, 2020 02:00
Diagnostics, Vol. 10, Pages 185: “Nature Abhors a Vaccuum”: Invagination of the Small Intestine into the Lumbar Disc Space After a Spinal Fusion Operation Diagnostics doi: 10.3390/diagnostics10040185 Authors: Wonho Lee Mathieu Boudier-Revéret Du Hwan Kim Min Cheol Chang A 77-year-old woman having back pain due to an L2 vertebral body compression fracture took a lumbar spine magnetic resonance imaging (MRI). In MRI, in addition to the L2 vertebral body fracture, invagination...
Fri Mar 27, 2020 02:00
Diagnostics, Vol. 10, Pages 184: Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis Diagnostics doi: 10.3390/diagnostics10040184 Authors: Machado Botelho Lopes Patrão Alves Chambrone Alcoforado Mendes This systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects....
Fri Mar 27, 2020 02:00
Diversity, Vol. 12, Pages 126: Hummingbird–Plant Interactions Are More Specialized in Forest Compared to Coffee Plantations Diversity doi: 10.3390/d12040126 Authors: Beth M. L. Morrison Chase D. Mendenhall Deforestation transforms habitats, displacing vertebrates and the other dimensions of biodiversity they support through their interactions. Few empirical studies have quantified the effect deforestation has on vertebrate–pollinator interaction networks. Here we quantify...
Fri Mar 27, 2020 02:00
Diversity, Vol. 12, Pages 125: Rhodolith Bed Discovered off the South African Coast Diversity doi: 10.3390/d12040125 Authors: Luther A. Adams Gavin W. Maneveldt Andrew Green Natasha Karenyi Denham Parker Toufiek Samaai Sven Kerwath Rhodolith beds have not previously been recorded in South Africa. A multidisciplinary research effort used remote sampling tools to survey the historically unexplored continental shelf off the Eastern Cape coast of South Africa. A rhodolith...
Fri Mar 27, 2020 02:00
Diversity, Vol. 12, Pages 124: Balkan Chamois (Rupicapra rupicapra balcanica) Avoids Roads, Settlements, and Hunting Grounds: An Ecological Overview from Timfi Mountain, Greece Diversity doi: 10.3390/d12040124 Authors: Vassiliki Kati Christina Kassara Dimitrios Vassilakis Haritakis Papaioannou Balkan chamois (Rupicapra rupicapra balcanica) is a protected species with an Inadequate-Bad (U2) conservation status in Greece. Our study explores its seasonal range use pattern, demography...
Fri Mar 27, 2020 02:00
Environments, Vol. 7, Pages 24: Adsorption Characteristics of Spent Coffee Grounds as an Alternative Adsorbent for Cadmium in Solution Environments doi: 10.3390/environments7040024 Authors: Min-Suk Kim Jeong-Gyu Kim The present study was conducted to ascertain the potential of spent coffee grounds (SCGs) as an alternative adsorbent for the removal of cadmium (Cd) from aqueous solutions. Therefore, Cd adsorption batch tests, using SCGs that had not undergone any chemical pretreatment,...
Fri Mar 27, 2020 02:00
Foods, Vol. 9, Pages 392: Effect of Alternative Protein Feeds on the Content of Selected Endogenous Bioactive and Flavour-Related Compounds in Chicken Breast Meat Foods doi: 10.3390/foods9040392 Authors: Vasiliki Gkarane Marco Ciulu Brianne Altmann Daniel Mörlein Currently, soybean meal constitutes the main protein source for poultry production. However, the environmental and social issues related to soybean production are calling for more sustainable protein sources that can...
Sat Mar 28, 2020 02:00
Foods, Vol. 9, Pages 391: Food Preservation: Challenges and Efforts for the Future Foods doi: 10.3390/foods9040391 Authors: Yiannis Kourkoutas Charalampos Proestos Microbial hazards and food oxidation have acquired substantial economical, ethical and legal importance in the food industry [...]
Sat Mar 28, 2020 02:00
Foods, Vol. 9, Pages 388: Determination and Comparison of Physical Meat Quality Parameters of PERCIDAE and Salmonidae in Aquaculture Foods doi: 10.3390/foods9040388 Authors: Katrin Komolka Ralf Bochert George P. Franz Yagmur Kaya Ralf Pfuhl Bianka Grunow Although aquaculture has been the fastest growing food sector for decades, there are no standardized parameters for most of the fish species regarding physical meat quality. Therefore, this study provides for the first...
Fri Mar 27, 2020 02:00
Foods, Vol. 9, Pages 390: Transmembrane Pressure and Recovery of Serum Proteins During Microfiltration of Skimmed Milk Subjected to Different Storage and Treatment Conditions Foods doi: 10.3390/foods9040390 Authors: Manon Granger-Delacroix Nadine Leconte Fabienne Garnier-Lambrouin Françoise Le Le Goff Marieke Van Van Audenhaege Geneviève Gésan-Guiziou Milk pre-processing steps-storage at 4 °C (with durations of 48, 72 or 96 h) and methods for microbiological stabilization...
Fri Mar 27, 2020 02:00
Foods, Vol. 9, Pages 389: Nutritional Composition of Apis mellifera Drones from Korea and Denmark as a Potential Sustainable Alternative Food Source: Comparison Between Developmental Stages Foods doi: 10.3390/foods9040389 Authors: Sampat Ghosh Ho-Yong Sohn Su-Jin Pyo Annette Bruun Jensen Victor Benno Meyer-Rochow Chuleui Jung We compared nutrient compositions of honey bee (Apis mellifera) drones of different developmental stages from two different populations—the...
Fri Mar 27, 2020 02:00
Foods, Vol. 9, Pages 387: Insects as Novel Food: A Consumer Attitude Analysis through the Dominance-Based Rough Set Approach Foods doi: 10.3390/foods9040387 Authors: Rocco Roma Giovanni Ottomano Palmisano Annalisa De Boni In Western societies, the unfamiliarity with insect-based food is a hindrance for consumption and market development. This may depend on neophobia and reactions of disgust, individual characteristics and socio-cultural background, and risk-perceptions for health...
Fri Mar 27, 2020 02:00
Healthcare, Vol. 8, Pages 78: Adjusting Daily Inpatient Bed Allocation to Smooth Emergency Department Occupancy Variation Healthcare doi: 10.3390/healthcare8020078 Authors: Tsai Weng Liu Tsai Gotcher Chen Chou Kim Study Objective: Overcrowding in emergency departments (ED) is an increasingly common problem in Taiwanese hospitals, and strategies to improve efficiency are in demand. We propose a bed resource allocation strategy to overcome the overcrowding...
Sat Mar 28, 2020 02:00
Healthcare, Vol. 8, Pages 76: “Look at Me, I Plan to Quit Smoking”: Bayesian Hierarchical Analysis of Adolescent Smokers’ Intention to Quit Smoking Healthcare doi: 10.3390/healthcare8020076 Authors: John N. Ng’ombe N. Rodgers Nedson Novan F. P. Tembo The tobacco epidemic is one of the most prominent public health threats the world has ever faced. Public health policy that seeks to limit the problem may have to target not only the price of tobacco but also the initiation stage in...
Fri Mar 27, 2020 02:00
Healthcare, Vol. 8, Pages 77: Improving Emergency Department Efficiency by Patient Scheduling Using Deep Reinforcement Learning Healthcare doi: 10.3390/healthcare8020077 Authors: Lee Lee Emergency departments (ED) in hospitals usually suffer from crowdedness and long waiting times for treatment. The complexity of the patient’s path flows and their controls come from the patient’s diverse acute level, personalized treatment process, and interconnected medical...
Fri Mar 27, 2020 02:00
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