The promotion of neurogenesis can be a promising strategy to improve and restore neuronal function in neurodegenerative diseases. Nerve growth factor (NGF) plays a key role in neurite outgrowth and synaptic formation during brain repair stage. Nowadays, there are several studies on the developing methods to enhance the endogenous NGF activity for treatment and restore the neuronal function. In this study, the potentiating effect of sesamin, a major lignan in sesame seeds (Sesamum indicum) and oil,...
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Background. The highest prevalence and emergence of microbial infections coupled with the threat of antimicrobial resistance constitute a global concern, which entails searching for novel antimicrobial agents. Medicinal plants are among the major sources of medicines for novel drug discovery. Aloe adigratana is one of the endemic Aloe species in Ethiopia where the leaf latex of the plant is traditionally used for the treatment of various pathogenic conditions such as wound, dandruff, malaria, and...
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The assembled cold-formed steel stud shear walls are the main lateral force resisting members of cold-formed steel residential buildings. In this paper, three cold-formed steel shear walls with different types of sheathings (gypsum board and OSB board) were tested under the monotonic lateral loading. The failure modes, the shear strength, and the load-displacement curves of the shear walls were obtained and analyzed to investigate the relationship between screws and shear walls. The test results...
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Surface protection has been accepted as an effective way to improve the durability of concrete. In this study, nanosilica (NS) was used to improve the impermeability of cement-fly ash system and this kind of material was expected to be applied as surface protection material (SPM) for concrete. Binders composed of 70% cement and 30% fly ash (FA) were designed and nanosilica (NS, 0–4% of the binder) was added. Pore structure of the paste samples was evaluated by MIP and the fractal dimension of the...
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As an important category of proteins, alpha-helix transmembrane proteins (αTMPs) play an important role in various biological activities. Because the solved αTMP structures are inadequate, predicting the residue contacts among the transmembrane segments of an αTMP exhibits the basis of protein fold, which can be used to further discover more protein functions. A few efforts have been devoted to predict the interhelical residue contact using machine learning methods based on the prior knowledge of...
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Background. There is a lack of information regarding health literacy (HL) in elderly people in Vietnam. Objective. The aim of this study was to evaluate the health literacy and the associated factors in elderly people in Vietnam. Methods. A cross-sectional study was conducted on a sample of 300 elderly people aged 55 years and above. Data were obtained from study participants using face-to-face interviews using designed questionnaires on sociodemographics, behaviors, and health literacy. Multiple...
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The interaction of nucleon-nucleon (NN) has certain physical characteristics, indicated by nucleon, and meson degrees of freedom. The main purpose of this work is calculating the ground-state energies of and through the two-body system with the exchange of mesons (,, and ) that mediated between two nucleons. This paper investigates the NN interaction based on the quasirelativistic decoupled Dirac equation and self-consistent Hartree-Fock formulation. We construct a one-boson exchange potential...
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Background. Infertility is the inability to become pregnant after one year of sexual intercourse without the use of contraception. Epidemiological data suggest that 10 to 15% of couples around the world are suffering from infertility. The exact meaning of marriage is mainly fulfilled if the couple conceives and bears children. Failure of this often leads to unhappy married lives, divorces, and high levels of psychiatric morbidity. There is scarcity of data about determinants of infertility in Ethiopia....
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Background. Type 1 diabetes mellitus (T1DM) causes the irreversible destruction of pancreatic beta cells. The Bacillus Calmette–Guerin (BCG) vaccine can modulate the immune response and decelerate disease progression. The aim of this study is to investigate the efficacy of the BCG vaccine for the treatment of T1DM. Objective. Six databases were systematically searched from inception to the end of August 2019. The randomized controlled trials (RCTs) that evaluated glycemic control in response to the...
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We report a rare case of massive accumulation of fluid in the flexor hallucis longus tendon sheath with stenosing tenosynovitis and os trigonum. A 34-year-old woman presented to our hospital with pain and swelling in the posteromedial aspect of the left ankle joint after an ankle sprain approximately 8 months earlier. There was tenderness at the posteromedial aspect of the ankle, and the pain worsened on dorsiflexion of the left great toe. Magnetic resonance imaging revealed massive accumulation...
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Bayesian Estimation of Gumbel Type-II Distribution under Type-II Censoring with Medical Applications
The time to event or survival time usually follows certain skewed probability distributions. These distributions encounter vital role using the Bayesian framework to analyze and project the maximum life expectancy in order to inform decision-making. The Bayesian method provides a flexible framework for monitoring the randomized clinical trials to update what is already known using prior information about specific phenomena under uncertainty. Additionally, medical practitioners can use the Bayesian...
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Objective. To establish a model for estimating genetic risk using known and unknown family data. Methods. Four simulated datasets were generated for four paternal and maternal chromosomes. The simulated data for children were generated from the parental data according to the Mendelian law. The correlation coefficient between the children’s and paternal data was calculated, and 2R was defined as the heredity index for continuous data (HIC). The simulated continuous data were transformed into binary...
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Repeated measures are increasingly collected in a study to investigate the trajectory of measures over time. One of the first research questions is to determine the correlation between two measures. The following five methods for correlation calculation are compared: (1) Pearson correlation; (2) correlation of subject means; (3) partial correlation for subject effect; (4) partial correlation for visit effect; and (5) a mixed model approach. Pearson correlation coefficient is traditionally used in...
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Uniform evaluation of treatment effect on the quality of voice in adductor spasmodic dysphonia (AdSD) is challenging due to the broad variety of available outcome measurement instruments (OMIs). The European Laryngological Society categorized five types of measurement domains for voice quality evaluations: patient-reported outcome measures, perceptual analyses, acoustic analyses, visual analyses, and aerodynamic measurements. The aim of this study was to propose a core outcome set (COS) for these...
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Publication date: Available online 29 March 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Benjamin Franz Syllwasschy, Maximilian Steve Beck, Ivona Družeta, Marie-Thérèse Hopp, Anuradha Ramoji, Ute Neugebauer, Senada Nozinovic, Dirk Menche, Dieter Willbold, Oliver Ohlenschläger, Toni Kühl, Diana Imhof
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Publication date: Available online 29 March 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Clara Díaz-García, Felipe Hornos, A. Marcela Giudici, Ana Cámara-Artigas, Juan Román Luque-Ortega, Arantxa Arbe, Bruno Rizzuti, Carlos Alfonso, Jade K. Forwood, Juan L. Iovanna, Javier Gómez, Manuel Prieto, Ana Coutinho, José L. Neira
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Publication date: Available online 27 March 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Angela Di Somma, Concetta Avitabile, Arianna Cirillo, Antonio Moretta, Antonello Merlino, Luigi Paduano, Angela Duilio, Alessandra Romanelli
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Abstract Perfluoroalkyl substances (PFASs) are a complex group of man-made chemicals with high stability and mobility leading to ubiquitous environmental contamination and accumulation in the food chain. In human serum/plasma samples, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are the lead compounds. They are immunotoxic in experimental animals, and epidemiological studies provided evidence of a diminished production of vaccine antibodies in young children....
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Abstract Noncoding RNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), regulate gene expression in many physiological and pathological processes, including drug metabolism. Drug metabolizing enzymes (DMEs) are critical components in drug-induced liver toxicity. In this study, we used human hepatic HepaRG cells treated with 5 or 10 mM acetaminophen (APAP) as a model system and identified LINC00844 as a toxicity-responsive lncRNA. We analyzed the expression profiles...
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Abstract Disruption of sensitive stages of ovary development during fetal and perinatal life can have severe and life-long consequences for a woman’s reproductive life. Exposure to endocrine disrupting chemicals may affect ovarian development, leading to subsequent reproductive disorders. Here, we investigated the effect of early life exposure to defined mixtures of human-relevant endocrine disrupting chemicals on the rat ovary. We aimed to identify molecular events involved in...
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Abstract Patients who have experienced an acute coronary syndrome (ACS) are at very high risk of recurrent atherosclerotic cardiovascular disease (CVD) events. Dyslipidaemia, a major risk factor for CVD, is poorly controlled post ACS in countries outside Western Europe and North America, despite the availability of effective lipid-modifying therapies (LMTs) and guidelines governing their use. Recent guideline updates recommend that low-density lipoprotein cholesterol (LDL-C),...
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Abstract Purpose To compare visual outcomes and treatment burden between intravitreally administered aflibercept (IVT-AFL) and ranibizumab (RBZ) treat-and-extend (T&E) regimens in patients with wet age-related macular degeneration (wAMD) at 2 years. Methods A systematic literature review was carried out in Medline, EMBASE, and CENTRAL in October...
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Abstract Introduction Lithuania has one of the highest mortality rates from coronary heart disease (CHD) among European countries. Most CHD are preventable, but when they occur, the management of these patients is important in secondary prevention. The purpose of the present analysis was to describe the demographics, clinical profile, and contemporary management of patients with stable CHD in the Lithuanian population and to compare...
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It worked for Shakespeare and Isaac Newton during the plague, but let’s not put more pressure on ourselves than we already have -- Read more on ScientificAmerican.com
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Is life's persistence on Earth really the norm? -- Read more on ScientificAmerican.com
11h
It could help us mature as a species -- Read more on ScientificAmerican.com
12h
Despite privacy concerns, “contact tracing” using GPS data may be our best bet to contain this large and fast-growing pandemic -- Read more on ScientificAmerican.com
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It’s a phenomenon called “solution aversion” -- Read more on ScientificAmerican.com
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The potential power of 21st-century vaccines -- Read more on ScientificAmerican.com
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Even if we solve the ethical questions about using breakthrough techniques like CRISPR, will all patients have equal access? -- Read more on ScientificAmerican.com
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Human health is obviously crucial, but epidemiological models should not ignore economic and ethical considerations -- Read more on ScientificAmerican.com
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The pandemic is leading to an outbreak of age discrimination -- Read more on ScientificAmerican.com
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Author of book on 2009 flu outbreak explains how a lack of effective tests crippled U.S. attempts to contain the coronavirus. -- Read more on ScientificAmerican.com
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In part, it means that you need to look beyond the patient’s chart -- Read more on ScientificAmerican.com
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Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Richard D. Kim, Shannon McDonough, Anthony B. El-Khoueiry, Tanios S. Bekaii-Saab, Stacey M. Stein, Vaibhav Sahai, George P. Keogh, Edward J. Kim, Ari D. Baron, Abby B. Siegel, Afsaneh Barzi, Katherine A. Guthrie, Milind Javle, Howard Hochster
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Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Seiichi Yano, Kenji Ashida, Ryuichi Sakamoto, Chihiro Sakaguchi, Masatoshi Ogata, Kengo Maruyama, Shohei Sakamoto, Munehiko Ikeda, Kenji Ohe, Shoko Akasu, Shimpei Iwata, Nobuhiko Wada, Yayoi Matsuda, Yoichi Nakanishi, Masatoshi Nomura, Yoshihiro Ogawa
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Publication date: Available online 28 March 2020Source: European Journal of CancerAuthor(s): Shunya Matsumoto, Toshiki Kijima, Yoh Matsuoka, Masahide Yamamoto, Yasuhisa Fujii
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Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Tuomas P. Kilpeläinen, Kirsi Talala, Kimmo Taari, Jani Raitanen, Paula Kujala, Juho Pylväläinen, Teuvo LJ. Tammela, Anssi Auvinen
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Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Nil A. Schubert, Caitlin D. Lowery, Guillaume Bergthold, Jan Koster, Thomas F. Eleveld, Ana Rodríguez, David T.W. Jones, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Hubert N. Caron, Jan J. Molenaar
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