BACKGROUND Primary cutaneous umbilical melanoma is rare. Thorough information regarding its characteristics and treatment, including use of sentinel lymph node biopsy (SLNB) staging, is difficult to obtain. The unique anatomy of the umbilicus adds to the complexity of diagnosing and treating melanoma at this site. OBJECTIVE To improve understanding of diagnosis and treatment of primary cutaneous umbilical melanoma through presenting 7 new cases and reviewing 39 cases in the literature. MATERIALS...
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
BACKGROUND The treatment of nonmelanoma skin cancer (NMSC) in the elderly population is a source of significant debate. Mohs micrographic surgery (MMS) is a highly effective treatment option yet not every patient with a cutaneous malignancy that meets appropriate use criteria (AUC) should be treated with surgery. OBJECTIVE The purpose of this study was to use the Karnofsky Performance Status (KPS) scale to categorize the functional status of patients aged 75 years and older who required treatment...
Sun Mar 01, 2020 02:00
BACKGROUND Perioperative anxiety is associated with negative patient outcomes in Mohs micrographic surgery (MMS). Both pharmacologic and nonpharmacologic therapies have been used to alleviate perioperative anxiety in MMS. OBJECTIVE To systematically evaluate the efficacy of therapies aimed at reducing perioperative anxiety in MMS. METHODS AND MATERIALS Eligible articles were identified using PubMed MEDLINE, Cochrane Central Register of Controlled Trials, metaRegister of Controlled Trials,...
Sun Mar 01, 2020 02:00
BACKGROUND Keratinocyte carcinomas (KC) impact patient quality of life (QoL). There is a need for validated QoL instruments specific to KC. The Basal and Squamous Cell Carcinoma QoL (BaSQoL) questionnaire was developed to comprehensively measure issues of importance to patients with KC. OBJECTIVE To validate and characterize the BaSQoL questionnaire for QoL measurement after diagnosis and treatment of KC. METHODS This was a prospective, observational study. Patients with basal cell carcinoma...
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
BACKGROUND Prescription opioid use often precedes opioid misuse, abuse, and addiction. OBJECTIVE To characterize the national opioid prescription practices of Mohs surgeons, with general dermatologists serving as a comparison group. METHODS A retrospective cross-sectional study using Medicare prescription data to analyze opioid prescription characteristics. RESULTS In 2014, 2,190 Mohs surgeons prescribed a total of 86,526 opioids, whereas 10,347 non-Mohs dermatologists prescribed...
Sun Mar 01, 2020 02:00
BACKGROUND Cicatricial ectropion occurs when tension of a scar below the eye has sufficient downward pull to evert the lower eyelid. There are many surgical techniques to repair cicatricial ectropion. OBJECTIVE To review the published literature on the repair of cicatricial ectropion, review relevant anatomy, and review surgical considerations for patients with cicatricial ectropion from the perspective of a dermatologic surgeon. MATERIALS AND METHODS A search of PubMed was conducted...
Sun Mar 01, 2020 02:00
BACKGROUND Platelet-rich plasma (PRP) is an increasingly popular treatment modality for various dermatologic conditions, but there are limitations in both the published literature and clinician knowledge. OBJECTIVE To create a high-yield, in-depth analysis of PRP in procedural dermatology by reviewing available data on its role in hair restoration, soft-tissue remodeling, resurfacing, and rejuvenation; identifying practice gaps and controversies; and making suggestions for future research...
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
BACKGROUND 5α-DHT can decrease the cell viability of the hair follicle stem cells (HFSCs) with CD34-positive and CD200-rich in bald scalp area of androgenic alopecia (AGA) patients and the apoptosis of HFSCs may be involved in the pathogenesis of AGA. The expression of Vascular endothelial growth factor (VEGF) turns to be weakened or disappeared in hair follicles of AGA patients. OBJECTIVE To investigate whether VEGF is involved in the apoptosis of HFSCs induced by 5α-DHT in the patients...
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
BACKGROUND Ultrasound-guided foam sclerotherapy (UGFS) for treatment of chronic venous insufficiency (CVI) has been attracting significant interest over the past 20 years. It is a minimally invasive technique that comprises a safe treatment option and has yielded good results, especially in cases of advanced disease, with high rates of wound healing. OBJECTIVE To examine clinical, ultrasound, and photoplethysmography outcomes after a 1-year follow-up of UGFS for CVI. MATERIALS AND METHODS...
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
BACKGROUND Radial cheek lines (RCL) may convey an older, potentially less attractive appearance. OBJECTIVE To evaluate the effectiveness of hyaluronic acid–based dermal filler VYC-17.5L for correcting RCL. MATERIALS AND METHODS Fifty-three women (40–65 years) received injections of VYC-17.5L in both cheeks on Day 1 (optional Day 14 touch-up). Effectiveness was evaluated on Day 45 by subject-rated dynamic RCL improvement (Global Aesthetic Improvement Scale [GAIS]; primary end point) and...
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
BACKGROUND There is increased emphasis on the importance of the gluteal region in the perception of beauty. Biodegradable fillers provide a nonsurgical method of augmenting and rejuvenating this area. OBJECTIVE To review pertinent aspects of anatomy, patient evaluation, injection technique, and complications for gluteal augmentation using injectable biodegradable fillers. METHODS The authors review the literature for poly-L-lactic acid–based gluteal augmentation. RESULTS Like many...
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
BACKGROUND Dermal fillers for lip augmentation can be injected using various techniques. Although all seem to provide acceptable results, it is not clear which technique is safer, less painful, and provides greater patient comfort. OBJECTIVE To compare patients' self-reported pain intensity during the injection of hyaluronic acid dermal filler for lip augmentation, with 2 different techniques, anterograde versus retrograde. METHODS AND MATERIALS Prospective, single-center, within-subject,...
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
BACKGROUND Studies investigating the efficacy of lasers to minimize early surgical scars are low powered and report variable results. To further examine the evidence, the authors performed a systemic review and meta-analysis. OBJECTIVE To present the evidence of randomized controlled trials investigating the efficacy of laser modalities in minimizing surgical scars when applied
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
Key PointsHistorical CD8 T cell epitope discovery methods are labor intensive and scale poorly. Ultradense peptide arrays can streamline identification of MHC binding peptides. Substitution arrays can be used to define MHC molecules’ binding motifs.
Mon Mar 09, 2020 22:00
Key PointsNotch signaling regulates Gcnt1-mediated core-2 O-glycosylation in activated T cells. The core-2 O-glycoform of CD43 reports Notch signals in multiple mouse T cell subsets.
Mon Mar 09, 2020 22:00
Key PointsConsistent transcriptional signatures were identified 28 d after influenza vaccination. A new end point (maxRBA) characterizes Ab response relative to baseline. Genes related to Ab response behave differently in young and older adults.
Mon Mar 09, 2020 22:00
Key PointsIL-33 mediates eosinophilic recruitment and Th2 inflammation in Tg+ airways. MUC5AC, not MUC5B, is significantly suppressed in the airways of IL-33KO/Tg+ mice. Mucous cell density, not muco-obstruction, is suppressed in IL-33KO/Tg+ airways.
Mon Mar 09, 2020 22:00
Key PointsThe MMC-specific genes Mcpt1 and Mcpt2 are induced by TGF-β. The GATA–Smad motifs around –3 kb of these genes are crucial for transcription. TGF-β–Smad2/4 axis accelerates GATA2 recruitment to the GATA–Smad motifs.
Mon Mar 09, 2020 22:00
Key PointsThe chicken pBL2*019:01 structure reveals a conserved α- and β-chain–pairing mechanism. The variable β1 domain of chicken MHC-II determines peptide-presentation profiles. The interaction between pBL2*019:01 and CD4 differs from the corresponding pMHC-II.
Mon Mar 09, 2020 22:00
Key PointsMHC-II recycling through early endosomes in mature DCs is regulated by Rab11a. MHC-II synthesis enhances presentation of late endosome Ags by immature DCs. MHC-II recycling enhances presentation of early endosome Ags by mature DCs.
Mon Mar 09, 2020 22:00
Key PointsNADPH oxidase hyperactivity accompanies autoinflammation in Pstpip2cmo mice. This hyperactivity is cell intrinsic and not caused by an inflamed environment. NADPH oxidase deletion prevents autoinflammatory bone damage in Pstpip2cmo mice.
Mon Mar 09, 2020 22:00
Key PointsCTRP6 binds selectively to ligands, carbohydrates, and live bacteria. CTRP6 guides collectin-11 to surfaces and facilitates complement activation.
Mon Mar 09, 2020 22:00
Key PointsIL-33 autoamplifies the IL-33/ST2 pathway by inducing its own and ST2 expression. Airway epithelial cells are the major source of endogenous IL-33 production. An intact endogenous IL-33/ST2 pathway is necessary for asthma-like mouse models.
Mon Mar 09, 2020 22:00
Key Pointsα2β1 deficiency does not alter the balance of NK cell/ILC1 generation. α2β1 deficiency does not alter NK cell maturation. α2β1-deficient NK cells efficiently protect from lethal mousepox and control MCMV.
Mon Mar 09, 2020 22:00
Key PointsVaccination with RHtkl1 in mice induces a strong humoral and cellular response. RHtkl1-vaccinated mice are protected against acute, chronic, and congenital toxoplasmosis. Immunity induced by RHtkl1 vaccine is primarily Th1 biased and CD8+ T cell mediated.
Mon Mar 09, 2020 22:00
Key Points T cell subsets possess distinct SLAM family receptor coexpression profiles. SLAMF1 and SLAMF6 identify IL-17– and IFN-–producing T cells, respectively. SAP regulates the development of both IL-17– and IFN-–producing T cell subsets.
Mon Mar 09, 2020 22:00
Key PointsBAFF increases in myeloid subsets in a cell- and tissue-specific manner. Neutrophil and DC BAFF are required for optimal T cell–independent 2 humoral responses. BAFF produced by DCs is required for protective immunity to West Nile virus.
Mon Mar 09, 2020 22:00
Key PointsTRIM25 functions as a positive regulator in NF-B signaling in response to TNF-α. TRIM25 interacts with TRAF2 and enhances its K63-linked polyubiquitination. TRIM25 promotes the interaction between TRAF2 and TAK1 or IKKβ.
Mon Mar 09, 2020 22:00
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