Summary Background Exon 19 deletion and L858R point mutation in exon 21 of the epidermal growth factor receptor (EGFR) are the most commonly encountered mutations in patients with non-small cell lung cancer (NSCLC) and predict better clinical outcomes following treatment with EGFR-tyrosine kinase inhibitors (TKIs). The inflammatory indicator neutrophil-to-lymphocyte ratio (NLR) in peripheral blood serves as a predictive factor for NSCLC patients treated with chemotherapy. Here,...
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Chipotle used scientific tests to ensure its new queso maintains the right consistency for grabbing onto chips. (Stan Horaczek /)Some restaurant chains burn through new menu items at a fevered pace. The never-ending parade of novelty offerings—right now, KFC will sell you a fried chicken sandwich between two donuts—and splashy limited-time offers entice customers with variety. For some fast casual restaurants like Five Guys and Chipotle, however, the menu’s consistency is part of the draw. Practiced...
Mon Mar 09, 2020 20:30
Stay in charge. (Amazon/)It’s easy to overlook just how easy a steady supply of electricity makes modern living—a simple storm-triggered power outage or an extended camping stay in the woods will quickly reveal just how much we take for granted. Going off the grid and keeping access to electric power for heating, lighting, or even life-saving medical equipment is incredibly affordable and easy, and in some situations truly essential. Keep your options open and your peace of mind intact with a battery-...
Mon Mar 09, 2020 19:51
A mini spa in your own home. (Denny Müller via Unsplash/)After a strenuous workout or a long day at work, an indoor sauna can be just the ticket to calming your nerves, relaxing your muscles, and releasing your body’s stress. The dry heat of a sauna may help lower blood pressure in patients with hypertension and provide relief to people with asthma and joint inflammation. What’s more, going back and forth from hot air to cold air may work your heart as much as a semi-strenuous walk. You don’t need...
Mon Mar 09, 2020 19:40
Even tiny critters can influence big fires (Neil Thomas/Unsplash/)We’re used to hearing about how humans have changed the way landscapes burn, but in recent years biologists and ecologists have increasingly come to realize how much influence animals have on blazes. In California, for instance, cities are now investing in goat herds to mow down hillsides covered in weedy, dry vegetation that serves as tinder during the state’s fire season. But the relationships between animals and fire are far more...
Mon Mar 09, 2020 19:30
Keep your paper safe. (Amazon/)The only consistent way to preserve any type of paper document while retaining a thin profile is by using a laminator. Enveloping school projects, photos, menus, and tags in a thin, clear sheet of firm plastic offers protection from warping, enhances the look and feel of the item, and grants full immunity to grease, oil, grime and water damage. Whether you’re cataloging precious kids’ drawings or giving the whole staff new ID cards, a laminator is a simple and affordable...
Mon Mar 09, 2020 19:29
A little scrubbing goes a long way. (Pexels/)Researchers are still working to understand how deadly COVID-19 is and how it spreads. But they know one thing for sure: Washing your hands is the key to minimizing the novel coronavirus’ powers of destruction.Hand washing really, really works—and not just during outbreaks of new respiratory viruses. It also helps prevent the spread of a wide variety of disease-causing microbes, known as pathogens, from food-borne diseases like E.coli to flesh-eating bugs....
Mon Mar 09, 2020 17:00
A mock self-driving car deploys its sensors on the road. (the_lightwriter/Deposit Photos/)Yulong Cao is a PhD student in computer science and engineering at the University of Michigan. Z. Morley Mao is a professor of electrical engineering and computer science at the University of Michigan. This story originally featured on The Conversation.Nothing is more important to an autonomous vehicle than sensing what’s happening around it. Like human drivers, autonomous vehicles need the ability to make instantaneous...
Mon Mar 09, 2020 16:03
Doctors can't provide good care when people can't afford to go see them. (Unsplash/)As the US death toll from COVID-19 continues to rise, health authorities across the country are bracing for an onslaught of new patients even as they still grapple to understand the disease. Speaking last week, CDC spokesperson Nancy Messonier said, “We’re asking the American public to prepare in expectation that this will be bad.” Researchers say that the American healthcare system could make the outbreak much worse....
Mon Mar 09, 2020 14:00
Abstract Purpose Patients with classic congenital adrenal hyperplasia (CAH) are treated postnatally with life-long glucocorticoid (GC) replacement therapy. Although prolonged exposure to GCs may have a negative impact on behaviour, few studies have studied this issue. We therefore investigated behavioural outcomes in male and female children and adolescents with CAH. Methods...
Mon Mar 09, 2020 02:00
Tissue Engineering Part A, Ahead of Print.
Wed Mar 04, 2020 10:00
Bulbs are doomsday preppers, storing up resources underground to ride out disaster. The bigger the bulb, the bigger the stockpile. So, how come their sizes vary so much?
Mon Mar 09, 2020 21:20
Journal of Neurotrauma, Ahead of Print.
Wed Mar 04, 2020 10:00
Mucosal Immunology, Published online: 09 March 2020; doi:10.1038/s41385-020-0279-5Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection
Mon Mar 09, 2020 02:00
Mucosal Immunology, Published online: 09 March 2020; doi:10.1038/s41385-020-0280-zNMP4 regulates the innate immune response to influenza A virus infection
Mon Mar 09, 2020 02:00
Mon Mar 09, 2020 02:00
Rejuvenation Research, Ahead of Print.
Wed Mar 04, 2020 10:00
Deuteranomaly is a color blindness that causes green light photoreceptors to react to redder light. Red objects seem greener for patients with the condition, but it has been known for a while that blocking some of the light in the red color range can improve proper color perception. There are glasses that do this, a pair of which we reviewed, but they’re slightly bulky and people with color blindness often find that it’s not worth it to wear them. Now researchers at Tel Aviv University in...
Mon Mar 09, 2020 22:49
Masimo announced that it received FDA clearance for continuous RRp (respiration rate from the photoplethysmograph) monitoring with its with Rad-97, Radical-7, and Radius-7 Pulse Co-Oximeters. Usually, monitoring respiration rate involves manually counting breaths with a timer or using chest straps that need to be fitted. The newly-approved Masimo RRp monitor allows clinicians to conveniently measure respiration rate in patients whose arterial oxygen saturation is already being monitored...
Mon Mar 09, 2020 22:12
Heart failure patients often suffer from high pressure within the left side of their hearts, which can lead to difficulties breathing and other debilitating conditions. V-Wave, an Israeli firm, won the European CE Mark of approval for its Ventura interatrial shunt that aims to regulate left atrial pressure by creating a passage for blood to flow from the left to the right atrium across the interatrial septum. The device is implanted during a minimally invasive transcatheter procedure and once...
Mon Mar 09, 2020 18:41
Cleveland-based XaTek Inc. announced receiving FDA Breakthrough Device designation for ClotChip, a handheld device that can measure a patient’s bleeding risk profile from a single drop of blood. The main advantage of ClotChip is that it produces results in 15 minutes, versus the many hours that traditional lab work currently takes. The dramatic decrease in wait time could be important for trauma patients, hemophiliacs, and millions of people taking new-generation anticoagulants. ...
Mon Mar 09, 2020 15:57
San Francisco-based Tivic Health announced that the company has received CE Mark approval in Europe for ClearUP Sinus Pain Relief, a small handheld device that can temporarily relieve allergy-related sinus pain, pressure, and congestion. ClearUP is a small handheld device that delivers a proprietary microcurrent waveform that stimulates sinus nerve fibers under the skin to relieve pain related to allergies. It is designed to treat symptoms in five minutes and can be used up to four...
Mon Mar 09, 2020 15:25
Clinical Thyroidology, Volume 32, Issue 3, Page 120-123, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 100-101, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 135-138, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 102-105, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 127-130, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 106-109, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 98-98, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 110-113, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 124-126, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 114-116, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 131-134, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 117-119, March 2020.
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Clinical Thyroidology, Volume 32, Issue 3, Page 139-141, March 2020.
Wed Mar 04, 2020 10:00
No abstract available
Sun Mar 01, 2020 02:00
BACKGROUND Extramammary Paget's disease (EMPD) is a rare malignancy with unclear pathophysiology that occurs predominantly on apocrine-rich skin. Surgery is the treatment of choice; however, procedures tend to be extensive and associated with a high rate of recurrence. OBJECTIVE To review the current literature on EMPD regarding treatment and prognosis. MATERIALS AND METHODS Literature review using PubMed search for articles related to EMPD. RESULTS Extramammary Paget's disease...
Sun Mar 01, 2020 02:00
No abstract available
Sun Mar 01, 2020 02:00
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