Abstract Purpose Given the large number of patients with thyroid nodules, improvement of the specificity of current ultrasound-based thyroid nodule classification systems (ATA, EU-TIRADS, and ACR-TIRADS) is warranted to reduce the number of diagnostic thyroidectomies. Thyroid scintigraphy has been shown to demonstrate hyperfunctional nodules, associated with a low malignancy risk, in euthyroid patients. However, it is not known if thyroid...
Mon Mar 09, 2020 02:00
Publication date: Available online 8 March 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Ignacio Viza Puiggrós, Esther Granell Moreno, Carlos Calvo Navarro, Mercè Bohé Rovira, César Orús Dotu, Miquel Quer i Agustí
Mon Mar 09, 2020 20:16
Background:Tenofovir alafenamide–emtricitabine (F/TAF) was recently approved as a noninferior and potentially safer option than tenofovir disoproxil fumarate–emtricitabine (F/TDF) for HIV preexposure prophylaxis (PrEP) in the United States.Objective:To estimate the greatest possible clinical benefits and economic savings attributable to the improved safety profile of F/TAF and the maximum price payers should be willing to pay for F/TAF over generic F/TDF.Design:Cost-effectiveness analysis.Data Sources:Published...
Mon Mar 09, 2020 20:11
In this issue, Walensky and colleagues report a cost-effectiveness analysis that estimates the potential clinical benefits of tenofovir alafenamide–emtricitabine (F/TAF) and the resultant cost savings of lower risk for renal failure and fractures versus the increased cost of branded F/TAF compared with generic tenofovir disoproxil fumarate–emtricitabine for HIV preexposure prophylaxis (PrEP). The editorialists believe that the findings make it clear that shifting to F/TAF as first-line PrEP for all...
Mon Mar 09, 2020 20:11
Abstract Purpose Glutamine, as an essential part of enteral nutrition and parenteral nutrition agent, has been widely recognized to be a kind of important intestinal mucosa protectant in clinical practice and experimental research. However, the mechanisms of its protective effects are still not fully understand. Consequently, this study aimed to explore the potential mechanism of glutamine on ischemia-reperfusion (I/R) injury induced endoplasmic reticulum (ER) stress in intestine. Methods An...
Mon Mar 09, 2020 18:53
Abstract Solid organ transplantation is a very complex process, in which the storage of the graft in a preservation solution is mandatory in order to extend ischemic times and contain further damage. The condition in which the organ is transplanted is critical for the outcome of the organ recipient. The recent emergence of generic versions of organ preservation solutions (solutions with the same composition and under the same legislation as the original versions, but with different brands) compelled...
Mon Mar 09, 2020 18:53
Abstract Quinidine is an antiarrhythmic drug commonly used for the treatment of cardiac ailments. It affects oxidative phosphorylation, calcium uptake, and ion channels of mitochondria. We have investigated the interaction of Quinidine and mitochondrial voltage-dependent anion channel (VDAC). VDAC was purified from neuronal tissue of Wistar rats and in vitro bilayer electrophysiology experiments were performed on it. 50-mM Quinidine treatment on VDAC leads to a sudden drop in its...
Mon Mar 09, 2020 02:00
Abstract Elongation factor P (EF-P) is a translation protein factor that plays an important role in specialized translation of consecutive proline amino acid motifs. EF-P is an essential protein for cell fitness in native environmental conditions. It regulates synthesis of proteins involved in bacterial motility, environmental adaptation and bacterial virulence, thus making EF-P a potential drug target. In the present study, we determined the solution and crystal structure of EF-P...
Mon Mar 09, 2020 02:00
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease characterized by joint and extra-articular involvement. Among them, interstitial lung disease (ILD) is one of the most common and severe extra-articular manifestations, with a negative impact on both therapeutic approach and overall prognosis. ILD can occur at any point of the natural history of RA, sometimes before the appearance of joint involvement. Since no controlled studies are available, the therapeutic approach to RA-ILD...
Mon Mar 09, 2020 14:20
Publication date: June 2020Source: Brain and Language, Volume 205Author(s): Maria I. Pestalozzi, Jean-Marie Annoni, René M. Müri, Lea B. Jost
Mon Mar 09, 2020 18:34
Publication date: Available online 8 March 2020Source: NeuroImageAuthor(s): Manesh Girn, Caitlin Mills, Leor Roseman, Robin L. Carhart-Harris, Kalina Christoff
Mon Mar 09, 2020 18:30
Publication date: Available online 8 March 2020Source: NeuroImageAuthor(s): Shenpeng Li, Sharna D. Jamadar, Phillip G.D. Ward, Malin Premaratne, Gary F. Egan, Zhaolin Chen
Mon Mar 09, 2020 18:30
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00299B, Communication Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ki-Joo Sung, Yara Jabbour Al Maalouf, Quinlan R. Johns, Eric A. Miller, Hadley D. SikesBinding protein scaffolds, such as rcSso7d, have been investigated for use in diagnostic tests; however, the functional performance of rcSso7d has not yet been studied in comparison to antibodies. Here,...The content of this RSS...
Mon Mar 09, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/C9AN02631B, PaperYue Sun, Zhiyan Li, Choiwan Lau, Jianzhong LuTranscription factors (TFs) play critical roles in gene expression regulation and disease development. In this paper，we reported an antibody free ELISA-like assay which could be used to analyze transcription factor...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Mar 09, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00275E, PaperLili Jiang, Yuling Yang, Yuhong Lin, Ziyi Chen, Chao Xing, Chunhua Lu, Huang-Hao Yang, Shu-Sheng ZhangMicroRNAs (miRNAs) are desirable targets for the diagnosis, prognosis and treatment of diverse human diseases. In this study, we developed a universal and enzyme-free signal amplification approach for the quick,...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Mar 09, 2020 02:00
Cancers, Vol. 12, Pages 635: Can Comprehensive Geriatric Assessment Predict Tolerance of Radiotherapy for Localized Prostate Cancer in Men Aged 75 Years or Older? Cancers doi: 10.3390/cancers12030635 Authors: Aurore Goineau Loïc Campion Jean-Marie Commer Brigitte Vié Agnès Ghesquière Guillaume Béra Didier Jaffres Nicolas Magné Xavier Artignan Jérôme Chamois Philippe Bergerot Gilles Créhange Elisabeth Deniaud-Alexandre Xavier Buthaud Yazid...
Mon Mar 09, 2020 02:00
Cancers, Vol. 12, Pages 634: In Vivo and In Vitro Anticancer Activity of Doxorubicin-loaded DNA-AuNP Nanocarrier for the Ovarian Cancer Treatment Cancers doi: 10.3390/cancers12030634 Authors: Lee Kim Oh Bae Ryu Kong Jeon Seo Jeon Kim In this study, we have determined the anticancer activity of doxorubicin (Dox)-loaded DNA/gold nanoparticle (AuNP) nanocarrier (Dox-DNA-AuNP) for the treatment of ovarian cancer. The anticancer effect of...
Mon Mar 09, 2020 02:00
Cancers, Vol. 12, Pages 633: Evaluation of a Novel Prototype for Pressurized Intraperitoneal Aerosol Chemotherapy Cancers doi: 10.3390/cancers12030633 Authors: Hee Su Lee Junsik Kim Eun Ji Lee Soo Jin Park Jaehee Mun Haerin Paik Soo Hyun Oh Sunwoo Park Soomin Ryu Whasun Lim Gwonhwa Song Hee Seung Kim Jung Chan Lee Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been suggested as an alternative option for treating peritoneal...
Mon Mar 09, 2020 02:00
Cancers, Vol. 12, Pages 632: Model-Based Integration Analysis Revealed Presence of Novel Prognostic miRNA Targets and Important Cancer Driver Genes in Triple-Negative Breast Cancers Cancers doi: 10.3390/cancers12030632 Authors: Zaka Sutton Peng Konur Background: miRNAs (microRNAs) play a key role in triple-negative breast cancer (TNBC) progression, and its heterogeneity at the expression, pathological and clinical levels. Stratification of breast cancer subtypes...
Mon Mar 09, 2020 02:00
Cancers, Vol. 12, Pages 631: Loss of Y-Chromosome during Male Breast Carcinogenesis Cancers doi: 10.3390/cancers12030631 Authors: Agahozo Timmermans Sleddens Foekens Trapman-Jansen Schröder van Leeuwen-Stok Martens Dinjens van Deurzen Loss of Y-chromosome (LOY) is associated with increased cancer mortality in males. The prevalence of LOY in male breast cancer (BC) is unknown. The aim of this study is to assess the presence and prognostic...
Mon Mar 09, 2020 02:00
Cancers, Vol. 12, Pages 630: Role of Microtubule-Associated Protein 1b in Urothelial Carcinoma: Overexpression Predicts Poor Prognosis Cancers doi: 10.3390/cancers12030630 Authors: Tsu-Ming Chien Ti-Chun Chan Steven Kuan-Hua Huang Bi-Wen Yeh Wei-Ming Li Chun-Nung Huang Ching-Chia Li Wen-Jeng Wu Chien-Feng Li We sought to examine the relationship between microtubule-associated proteins (MAPs) and the prognosis of urothelial carcinoma by assessing the...
Mon Mar 09, 2020 02:00
Cancers, Vol. 12, Pages 629: Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets Cancers doi: 10.3390/cancers12030629 Authors: Giacomo Andreani Giovanna Carrà Marcello Francesco Lingua Beatrice Maffeo Mara Brancaccio Riccardo Taulli Alessandro Morotti Tumor suppressors play an important role in cancer pathogenesis and in the modulation of resistance to treatments. Loss of function of the proteins encoded by tumor suppressors,...
Mon Mar 09, 2020 02:00
Cancers, Vol. 12, Pages 628: tRNA Queuosine Modification Enzyme Modulates the Growth and Microbiome Recruitment to Breast Tumors Cancers doi: 10.3390/cancers12030628 Authors: Jilei Zhang Rong Lu Yongguo Zhang Żaneta Matuszek Wen Zhang Yinglin Xia Tao Pan Jun Sun Background: Transfer RNA (tRNA) queuosine (Q)-modifications occur specifically in 4 cellular tRNAs at the wobble anticodon position. tRNA Q-modification in human cells depends on the gut microbiome...
Mon Mar 09, 2020 02:00
Condition: People With Impaired Motor Function in the Cervical RegionIntervention: Procedure: Postural reconstructionSponsor: Universidad Antonio de NebrijaNot yet recruiting
Mon Mar 09, 2020 18:00
Nature Chemistry, Published online: 09 March 2020; doi:10.1038/s41557-020-0428-1A catalytic para-selective alkylation reaction connects C–H functionalization and decarboxylative coupling strategies using simple bases to trap a previously hidden intermediate. This reaction exploits an ‘inverted sequence’ that forms the C–C bond prior to C–H bond cleavage and provides a new entry into C–H functionalization reactions.
Mon Mar 09, 2020 02:00
Nature Chemistry, Published online: 09 March 2020; doi:10.1038/s41557-020-0426-3A programmable polymer library that responds to external and internal stimuli has been developed and used to fabricate a series of nanocarriers for drug release. The carriers respond to disease biomarkers, triggering self-immolative motifs and leading to the site-specific release of therapeutics both in vitro and in vivo.
Mon Mar 09, 2020 02:00
Rheumatoid arthritis (RA) is a worldwide chronic autoimmune inflammatory disease which is affecting approximately 1% of the total population. It is characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS) and increased production of proinflammatory cytokines. In the current study, we were aiming to investigate the role of ubiquitin-specific protease 5 (USP5) in the inflammatory process in RA-FLS. Expression of USP5 was found upregulated in RA-FLS compared with that in osteoarthritis-...
Mon Mar 09, 2020 16:35
Abstract Waardenburg syndrome (WS) is a group of genetic disorders associated with varying components of sensorineural hearing loss and abnormal pigmentation of the hair, skin, and eyes. There exist four different WS subtypes, each defined by the absence or presence of additional features. One of the genes associated with WS is SOX10, a key transcription factor for the development of neural crest‐derived lineages. Here we report a 12‐year‐old boy with a novel de novo SOX10 frameshift mutation and...
Mon Mar 09, 2020 18:02
Some studies of tonsillectomy outcomes have low response rates to mailed quality control questionnaires. This study evaluated the effect of nonresponders to mailed questionnaires about posttonsillectomy complications by determining whether mail responders and nonresponders differ. Questionnaires were mailed to patients 3–6 weeks after tonsillectomy to assess postoperative complications, defined as contact with a private practitioner and/or hospital readmission related to postsurgical bleeding, pain,...
Mon Mar 09, 2020 06:20
Abstract Systemically administered aminoglycoside antibiotics can enter inner ear hair cells and trigger apoptosis. However, the in vivo route(s) by which aminoglycoside antibiotics enter hair cells remains controversial. Aminoglycosides can enter mouse hair cells by endocytosis or by permeation through transmembrane ion channels such as sensory mechanoelectrical transduction (MET) channels, transient receptor potential (TRP) channels, P2X channels, Piezo2-containing ion channels,...
Mon Mar 09, 2020 02:00
Abstract Mammalian hair cells develop their mechanosensory bundles through consecutive phases of stereocilia elongation, thickening, and retraction of supernumerary stereocilia. Many molecules involved in stereocilia elongation have been identified, including myosin-XVa. Significantly less is known about molecular mechanisms of stereocilia thickening and retraction. Here, we used scanning electron microscopy (SEM) to quantify postnatal changes in number and diameters of the auditory...
Mon Mar 09, 2020 02:00
AbstractTransmesocolon internal hernias are very rare causes of bowel obstruction. Transmesenteric internal hernias normally associated with small bowel. It can be challenging to diagnose transmesocolon internal hernia hence we present a 93-year-old patient who was misdiagnosed with simple sigmoid volvulus on CT abdomen. She underwent endoscopic colonic decompression. Patient continued to deteriorate in the ward, and CT abdomen was repeated; it revealed the cause of the sigmoid volvulus was due to...
Mon Mar 09, 2020 02:00
AbstractChronic constipation is a common cause of morbidity in the elderly and institutionalized population. It can be associated with significant morbidity and socioeconomical burden. Chronic resistance constipation can rarely be associated with megarectum. Herein, we present the case of a patient with physical and mental disability that presented with refractory constipation associated with extreme stool burden and a massive megarectum. We discuss chronic constipation in the elderly population,...
Mon Mar 09, 2020 02:00
Abstract Empathy for others’ pain plays a critical role in human social interactions, but the influence of language contexts remains unclear. We examined the foreign‐language effect on the behavioral and the underlying neural processes of empathy for others’ pain. Chinese–English bilinguals performed a pain empathy task separately in Chinese (native language) and English (foreign language) contexts while event‐related potentials (ERPs) were recorded. Results showed that bilingual participants reported...
Mon Mar 09, 2020 17:19
Publication date: Available online 9 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Nour Bundogji, Steven Zamora, Matthew Brigger, Wen Jiang
Mon Mar 09, 2020 17:18
Publication date: Available online 9 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Sunil D. Sharma, Sharon L. Cushing, Blake C. Papsin, Karen A. Gordon
Mon Mar 09, 2020 17:18
Publication date: Available online 8 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Jane Canning, Nikki Mills, Murali Mahadevan
Mon Mar 09, 2020 17:18
Publication date: Available online 8 March 2020Source: TalantaAuthor(s): Yu Wang, Xixian Wang, Anle Ge, Liang Hu, Wei Du, Bi-Feng Liu
Mon Mar 09, 2020 16:45
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