Abstract We explore correlations between dynamics of different microtubules in a bundle, via numerical simulations, using a one-dimensional stochastic model of a microtubule. The guanosine triphosphate (GTP)-bound tubulins undergo diffusion-limited binding to the tip. Random hydrolysis events take place along the microtubule and converts the bound GTP in tubulin to guanosine diphosphate (GDP). The microtubule starts depolymerising when the monomer at the tip becomes GDP-bound;...
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Publication date: Available online 8 March 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Margaret M. Dalena, Farrah C. Liu, Jordan N. Halsey, Edward S. Lee, Mark S. Granick
Mon Mar 09, 2020 13:15
Related ArticlesSuperficial Stab Wound to Zone I of the Neck Resulting in Thyrocervical Trunk Pseudoaneurysm Presented as Recurrent Hemothorax and Successfully Managed by Coil Embolization. Am J Case Rep. 2020 Mar 08;21:e920196 Authors: Elkbuli A, Shaikh S, Ehrhardt JD, McKenney M, Boneva D Abstract BACKGROUND Thyrocervical trunk pseudoaneurysms are rare complications that have been documented after internal jugular or subclavian venous cannulation....
Mon Mar 09, 2020 15:10
Abstract Background Real‐world use of immuno‐oncology (IO) therapies (nivolumab and pembrolizumab) in metastatic head and neck squamous cell carcinoma (mHNSCC) has not been well studied. Methods mHNSCC patients treated with an IO therapy were identified from a large US claims database from 2016 to 2017. Treatment patterns before and after initiation of IO therapy (index date) were described. Results Among 416 mHNSCC patients, 85% had ≥1 regimen prior to IO therapy. Ninety‐seven...
Mon Mar 09, 2020 13:06
Mon Mar 09, 2020 13:06
Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Maria A. Karalexi, Nick Dessypris, Xiaomei Ma, Logan G. Spector, Erin Marcotte, Jacqueline Clavel, Maria S. Pombo-de-Oliveira, Julia E. Heck, Eve Roman, Beth A. Mueller, Johnni Hansen, Anssi Auvinen, Pei-Chen Lee, Joachim Schüz, Corrado Magnani, Ana M. Mora, John D. Dockerty, Michael E. Scheurer, Rong Wang, Audrey Bonaventure
Mon Mar 09, 2020 13:02
Abstract Cyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation. Despite the demonstrated importance of CCND1/cyclin D1 as a central oncogene in several types of human tumors, its knowledge in melanoma is still limited. This review...
Mon Mar 09, 2020 12:58
Related ArticlesNasal columella reconstruction - A comprehensive review of the current techniques. J Plast Reconstr Aesthet Surg. 2020 Jan 21;: Authors: Nowicki J, Abbas JR, Sudbury D, Anari S Abstract The nasal columella is often described as being one of the most difficult nasal subunits to reconstruct. There are a wide range of indications for columella reconstruction, with defects resulting from ischaemic injuries, trauma, tumour resection, vascular...
Mon Mar 09, 2020 14:58
Related ArticlesTopical nitroglycerin is associated with a reduced mastectomy skin flap necrosis-systematic review and meta-analysis. J Plast Reconstr Aesthet Surg. 2020 Jan 22;: Authors: Vania R, Pranata R, Irwansyah D, Budiman Abstract INTRODUCTION: The flap necrosis rate remains high despite the advancement of technology in daily practices. Several randomized trials of topical Nitroglycerin (NTG) have shown promise in reducing flap necrosis. We aim...
Mon Mar 09, 2020 14:58
Related ArticlesUse of personal protective equipment to protect against respiratory infections in Pakistan: A systematic review. J Infect Public Health. 2020 Mar 04;: Authors: Chughtai AA, Khan W Abstract Like other low-income countries, limited data are available on the use of personal protective equipment (PPE) in Pakistan. We conducted a systematic review of studies on PPE use for respiratory infections in healthcare settings in Pakistan. MEDLINE,...
Mon Mar 09, 2020 14:53
Related ArticlesFamilial intracranial ependymoma mimicking an extra-lesion: A case report and review of the literature. J Clin Neurosci. 2020 Mar 04;: Authors: Chen BY, Praeger A, Christie M, Yuen T Abstract Familial occurrence of intracranial ependymoma, in the absence of neurofibromatosis type 2 (NF2), is very rare with only a few cases reported in the literature. We report a 62-year-old man, who presented with a posterior fossa ependymoma with the...
Mon Mar 09, 2020 14:54
Publication date: Available online 8 March 2020Source: European Journal of Surgical OncologyAuthor(s): S. Powell-Brett, N. de Liguori Carino, K. Roberts
Mon Mar 09, 2020 12:49
Related ArticlesComprehensive tumor profiling-guided therapy in rare or refractory solid cancer: A feasibility study in daily clinical practice. Bull Cancer. 2020 Mar 04;: Authors: Ibrahim T, Ahmadie A, Rassy E, Karak FE, Hanna C, Farhat F, Kattan J, Ghosn M Abstract Tumor profiling has been shown to benefit patients with rare or refractory metastatic cancer, but several limitations hamper its use in daily clinical practice. We aim to assess the added...
Mon Mar 09, 2020 14:45
Related Articles[Androgen receptor-positive triple negative breast cancer: From biology to therapy]. Bull Cancer. 2020 Mar 04;: Authors: Grellety T Abstract A subgroup of androgen receptor-expressing tumors represents approximately 30 % of all triple negative tumors. The androgen receptor and its signaling pathways have a central biological role in this tumor entity. These triple negative androgen receptor-positive tumors occur in older patients and...
Mon Mar 09, 2020 14:45
Abstract Introduction Ventriculoperitoneal shunt insertion during the neonatal period and early infancy is associated with a high rate of shunt failure when compared to the adult population. Furthermore, the function of flow-regulated valves and differential pressure valves may be different in neonatal hydrocephalus. Methods A retrospective case series...
Mon Mar 09, 2020 02:00
Related ArticlesSevere hypokalemia and rebound hyperkalemia during barbiturate coma in patients with severe traumatic brain injury. Neurocirugia (Astur). 2020 Mar 04;: Authors: Aytuluk HG, Topcu H Abstract OBJECTIVES: To evaluate the incidence of severe potassium disturbances during barbiturate coma therapy in patients with severe traumatic brain injury (TBI), and the characteristics of these patients. METHODS: The study comprised 37 patients...
Mon Mar 09, 2020 16:40
Related ArticlesExtraction of giant bladder calcium oxalate stone: A case report. Int J Surg Case Rep. 2020 Feb 28;68:151-153 Authors: Shrestha N, Zhou L, Hu CH Abstract INTRODUCTION: Bladder stone is a rare and ancient disease. Nowadays new technologies have been developed in the effort to make less invasive stone treatment. Bladder calculi account for 5% of urinary calculi. PRESENTATION OF CASE: A 52-year-old male patient with symptoms of...
Mon Mar 09, 2020 14:39
Abstract Background Associations between tobacco smoking during pregnancy and offspring asthma have been observed, but the role of nicotine and familial factors remains unclear. Objective To estimate the association between tobacco use in pregnancy, both smoking and Swedish oral moist snuff, and asthma/wheeze in the offspring, how it varies by the child’s age and explore the influence of measured and unmeasured familial confounding. Methods Register‐based cohort study with...
Mon Mar 09, 2020 12:40
Related ArticlesReversible causes of failed oxygenation in 'cannot intubate cannot oxygenate' simulation. Br J Anaesth. 2020 Mar 04;: Authors: Bick E PMID: 32145877 [PubMed - as supplied by publisher]
Mon Mar 09, 2020 16:33
Related ArticlesCyclin-dependent kinase 4 and 6 inhibitors for hormone receptor-positive breast cancer: past, present, and future. Lancet. 2020 Mar 07;395(10226):817-827 Authors: Spring LM, Wander SA, Andre F, Moy B, Turner NC, Bardia A Abstract The development and approval of cyclin-dependent kinase (CDK) 4 and 6 inhibitors for hormone receptor-positive and human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer represents...
Mon Mar 09, 2020 13:37
Related ArticlesA novel 8-nitro quinoline-thiosemicarbazone analogues induces G1/S & G2/M phase cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway. Bioorg Chem. 2020 Feb 28;97:103709 Authors: Shyamsivappan S, Vivek R, Saravanan A, Arasakumar T, Suresh T, Athimoolam S, Mohan PS Abstract A series of novel 8-nitro quinoline-based thiosemicarbazone analogues were synthesized and characterized by various spectroscopic and single...
Mon Mar 09, 2020 13:33
Related ArticlesIndividual response of humans to ionising radiation: governing factors and importance for radiological protection. Radiat Environ Biophys. 2020 Mar 07;: Authors: Applegate KE, Rühm W, Wojcik A, Bourguignon M, Brenner A, Hamasaki K, Imai T, Imaizumi M, Imaoka T, Kakinuma S, Kamada T, Nishimura N, Okonogi N, Ozasa K, Rübe CE, Sadakane A, Sakata R, Shimada Y, Yoshida K, Bouffler S Abstract Tissue reactions and stochastic effects after exposure...
Mon Mar 09, 2020 13:58
Mon Mar 09, 2020 12:24
Related ArticlesSuicidal strangulation with a lashing belt. Forensic Sci Med Pathol. 2020 Mar 07;: Authors: Doberentz E, Geile J, Madea B Abstract Ligature strangulation causes death due to neck compression without suspension. However, suicidal ligature strangulation is rare. The suicide of a 32-year-old man is presented. After a dispute, the man was found outdoors with a lashing belt around his neck which had been pulled tight with a ratchet. Conjunctival...
Mon Mar 09, 2020 14:15
Publication date: Available online 8 March 2020Source: Practical Radiation OncologyAuthor(s): Pietro Mancosu, Pierina Navarria, Ludvig Paul Muren, Luca Castagna, Giacomo Reggiori, Elena Clerici, Barbara Sarina, Stefania Bramanti, Chiara De Philippis, Stefano Tomatis, Armando Santoro, Marta Scorsetti
Mon Mar 09, 2020 12:15
Epithelial‐mesenchymal transition (EMT) is a cell plasticity process required for metastasis and chemoresistance of carcinoma cells. We report a crucial role of the signal adaptor proteins CRK and CRKL in promoting EMT and tumor aggressiveness, as well as resistance against chemotherapy in colorectal and pancreatic carcinoma. Genetic loss of either CRKL or CRK partially counteracted EMT in three independent cancer cell lines. Strikingly, complete loss of the CRK family shifted cells strongly towards...
Mon Mar 09, 2020 12:10
Related ArticlesIn reply to the letter to the editor regarding "Endoscopic modified cartilage tympanoplasty". Eur Arch Otorhinolaryngol. 2020 Mar 07;: Authors: Özdemir D, Özgür A, Akgül G, Çelebi M, Mehel DM, Yemiş T PMID: 32146559 [PubMed - as supplied by publisher]
Mon Mar 09, 2020 14:11
Related ArticlesThe sense of smell in chronic rhinosinusitis. J Allergy Clin Immunol. 2020 Mar;145(3):773-776 Authors: Mullol J, Mariño-Sánchez F, Valls M, Alobid I, Marin C PMID: 32145875 [PubMed - as supplied by publisher]
Mon Mar 09, 2020 14:05
Related ArticlesAdenosine-producing regulatory B cells in head and neck cancer. Cancer Immunol Immunother. 2020 Mar 07;: Authors: Jeske SS, Brand M, Ziebart A, Laban S, Doescher J, Greve J, Jackson EK, Hoffmann TK, Brunner C, Schuler PJ Abstract BACKGROUND: Multiple mechanisms of immunosuppression have been identified in the tumor microenvironment including regulatory B cells (Breg). Recently, we have shown that Breg suppress T cell function by production...
Mon Mar 09, 2020 13:35
Related ArticlesSex disparities in head & neck cancer driver genes: An analysis of the TCGA dataset. Oral Oncol. 2020 Mar 05;104:104614 Authors: Mundi N, Ghasemi F, Zeng PYF, Prokopec SD, Patel K, Kim HAJ, Di Gravio E, MacNeil D, Khan MI, Han MW, Shaikh M, Mendez A, Yoo J, Fung K, Gameiro SF, Palma DA, Mymryk JS, Barrett JW, Boutros PC, Nichols AC Abstract OBJECTIVES: Survival in head and neck squamous cell carcinoma (HNSCC) has been associated...
Mon Mar 09, 2020 13:35
Related ArticlesRevascularization and limb salvage following critical limb ischemia by nanoceria-induced Ref-1/APE1-dependent angiogenesis. Biomaterials. 2020 Feb 27;242:119919 Authors: Park IS, Mahapatra C, Park JS, Dashnyam K, Kim JW, Ahn JC, Chung PS, Yoon DS, Mandakhbayar N, Singh RK, Lee JH, Leong KW, Kim HW Abstract In critical limb ischemia (CLI), overproduction of reactive oxygen species (ROS) and impairment of neovascularization contribute...
Mon Mar 09, 2020 13:35
Related ArticlesLong-term exposure to outdoor and household air pollution and blood pressure in the Prospective Urban and Rural Epidemiological (PURE) study. Environ Pollut. 2020 Feb 24;262:114197 Authors: Arku RE, Brauer M, Ahmed SH, AlHabib KF, Avezum Á, Bo J, Choudhury T, Dans AM, Gupta R, Iqbal R, Ismail N, Kelishadi R, Khatib R, Koon T, Kumar R, Lanas F, Lear SA, Wei L, Lopez-Jaramillo P, Mohan V, Poirier P, Puoane T, Rangarajan S, Rosengren A, Soman B, Caklili...
Mon Mar 09, 2020 13:35
Related ArticlesUltrasound Training for Head and Neck Surgeons in Rural Kenya: A Feasibility Study. J Surg Educ. 2020 Mar 04;: Authors: Wood CB, Yancey KH, Okerosi SN, Wiggleton J, Seim NB, Mannion K, Netterville JL Abstract OBJECTIVE: To determine the feasibility of training otolaryngologists to perform head and neck ultrasound in low- and middle-income countries over a short timeframe. DESIGN: Prospective cohort evaluating an ultrasound...
Mon Mar 09, 2020 13:35
Related ArticlesHead and neck extension more than 30° may disturb standing balance in healthy older adults. Geriatr Nurs. 2020 Mar 04;: Authors: Khademolhosseini Y, Pirouzi S, Ghanbari A, Arabzadeh S, Rezaei I Abstract Although there is clinical evidence of postural instability at extreme angles of head extension, the effects of lower angles on balance have been not investigated. This study aimed to investigate the effects of different head and neck...
Mon Mar 09, 2020 13:35
Related ArticlesFormation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin. J Allergy Clin Immunol. 2020 Mar;145(3):740-750 Authors: Takabayashi T, Schleimer RP Abstract Chronic rhinosinusitis (CRS) is one of the most common chronic diseases worldwide. It is a heterogeneous disease, and geographical or ethnic differences in inflammatory pattern in nasal mucosa are major issues. Tissue eosinophilia in CRS is highly...
Mon Mar 09, 2020 13:35
Related ArticlesFactor analysis and evaluation of each item of the tinnitus handicap inventory. Head Face Med. 2020 Mar 07;16(1):4 Authors: Wakabayashi S, Oishi N, Shinden S, Ogawa K Abstract PURPOSE: This study aims to examine the availability of subscales in the Tinnitus Handicap Inventory (THI) originally proposed by Newman and the possibility of other useful subscales. We also examine whether each item of the THI could be used to better understand...
Mon Mar 09, 2020 13:35
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