IJMS, Vol. 21, Pages 1655: miR-9-5p Inhibits Skeletal Muscle Satellite Cell Proliferation and Differentiation by Targeting IGF2BP3 through the IGF2-PI3K/Akt Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21051655 Authors: Huadong Yin Haorong He Xiaoxu Shen Jing Zhao Xinao Cao Shunshun Han Can Cui Yuqi Chen Yuanhang Wei Lu Xia Yan Wang Diyan Li Qing Zhu MicroRNAs are evolutionarily conserved, small non-coding RNAs that...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1668: DROSHA-Dependent miRNA and AIM2 Inflammasome Activation in Idiopathic Pulmonary Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21051668 Authors: Soo Jung Cho Mihye Lee Heather W. Stout-Delgado Jong-Seok Moon Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease. Chronic lung inflammation is linked to the pathogenesis of IPF. DROSHA, a class 2 ribonuclease III enzyme, has an important role in...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1650: Depletion of CD4 and CD8 Positive T Cells Impairs Venous Thrombus Resolution in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21051650 Authors: Subhradip Mukhopadhyay Joel Gabre Christine Chabasse Jonathan S. Bromberg Toni M. Antalis Rajabrata Sarkar Resolution of deep venous thrombosis involves coordinated inflammatory processes. T cells regulate inflammation in vivo and modulate vascular remodeling in other settings, but...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1648: Nonsense Mutations in the Yeast SUP35 Gene Affect the [PSI+] Prion Propagation International Journal of Molecular Sciences doi: 10.3390/ijms21051648 Authors: Nina P. Trubitsina Olga M. Zemlyanko Stanislav A. Bondarev Galina A. Zhouravleva The essential SUP35 gene encodes yeast translation termination factor eRF3. Previously, we isolated nonsense mutations sup35-n and proposed that the viability of such mutants can be explained by readthrough of the...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1649: Serotonin in Animal Cognition and Behavior International Journal of Molecular Sciences doi: 10.3390/ijms21051649 Authors: Julien Bacqué-Cazenave Rahul Bharatiya Grégory Barrière Jean-Paul Delbecque Nouhaila Bouguiyoud Giuseppe Di Di Giovanni Daniel Cattaert Philippe De De Deurwaerdère Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1654: LPIAT, a lyso-Phosphatidylinositol Acyltransferase, Modulates Seed Germination in Arabidopsis thaliana through PIP Signalling Pathways and is Involved in Hyperosmotic Response International Journal of Molecular Sciences doi: 10.3390/ijms21051654 Authors: Denis Coulon Lionel Faure Magali Grison Stéphanie Pascal Valérie Wattelet-Boyer Jonathan Clark Marina Le Guedard Eric Testet Jean-Jacques Bessoule Lyso-lipid acyltransferases are enzymes...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1651: Reclassifying Hepatic Cell Death during Liver Damage: Ferroptosis—A Novel Form of Non-Apoptotic Cell Death? International Journal of Molecular Sciences doi: 10.3390/ijms21051651 Authors: Ricardo U. Macías-Rodríguez María Eugenia Inzaugarat Astrid Ruiz-Margáin Leonard J. Nelson Christian Trautwein Francisco Javier Cubero Ferroptosis has emerged as a new type of cell death in different pathological conditions, including neurological and kidney...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1653: Osteoporosis and the Potential of Cell-Based Therapeutic Strategies International Journal of Molecular Sciences doi: 10.3390/ijms21051653 Authors: Iratxe Macías Natividad Alcorta-Sevillano Clara I. Rodríguez Arantza Infante Osteoporosis, the most common chronic metabolic bone disease, is characterized by low bone mass and increased bone fragility. Nowadays more than 200 million individuals are suffering from osteoporosis and still the number of affected...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1652: What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders? International Journal of Molecular Sciences doi: 10.3390/ijms21051652 Authors: Robert P. Friedland Joseph D. McMillan Zimple Kurlawala Despite the enormous literature documenting the importance of amyloid beta (Ab) protein in Alzheimer's disease, we do not know how Ab aggregation is initiated...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1647: Renal Sympathetic Nerve-Derived Signaling in Acute and Chronic kidney Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21051647 Authors: Mi Ra Noh Hee-Seong Jang Jinu Kim Babu J. Padanilam The kidney is innervated by afferent sensory and efferent sympathetic nerve fibers. Norepinephrine (NE) is the primary neurotransmitter for post-ganglionic sympathetic adrenergic nerves, and its signaling, regulated through adrenergic receptors...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1641: Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings International Journal of Molecular Sciences doi: 10.3390/ijms21051641 Authors: Małgorzata Krzystek-Korpacka Mariusz G. Fleszar Iwona Bednarz-Misa Łukasz Lewandowski Izabela Szczuka Radosław Kempiński Katarzyna Neubauer L-arginine/nitric oxide pathway...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1642: mTOR-Related Cell-Clearing Systems in Epileptic Seizures, an Update International Journal of Molecular Sciences doi: 10.3390/ijms21051642 Authors: Fiona Limanaqi Francesca Biagioni Carla Letizia Busceti Cinzia Fabrizi Alessandro Frati Francesco Fornai Recent evidence suggests that autophagy impairment is implicated in the epileptogenic mechanisms downstream of mTOR hyperactivation. This holds true for a variety of genetic and acquired epileptic...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1645: Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21051645 Authors: Madhulika Tripathi Paul Michael Yen Brijesh Kumar Singh The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1644: Novel Genetically Encoded Bright Positive Calcium Indicator NCaMP7 Based on the mNeonGreen Fluorescent Protein International Journal of Molecular Sciences doi: 10.3390/ijms21051644 Authors: Oksana M. Subach Vladimir P. Sotskov Viktor V. Plusnin Anna M. Gruzdeva Natalia V. Barykina Olga I. Ivashkina Konstantin V. Anokhin Alena Y. Nikolaeva Dmitry A. Korzhenevskiy Anna V. Vlaskina Vladimir A. Lazarenko Konstantin M. Boyko Tatiana...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1638: Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair International Journal of Molecular Sciences doi: 10.3390/ijms21051638 Authors: Emilia Di Di Giovanni Silvia Buonvino Ivano Amelio Sonia Melino The endogenous gasotransmitter H2S plays an important role in the central nervous, respiratory and cardiovascular systems. Accordingly, slow-releasing H2S donors are powerful tools for...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1639: Bioactive Glass (BG) ICIE16 Shows Promising Osteogenic Properties Compared to Crystallized 45S5-BG International Journal of Molecular Sciences doi: 10.3390/ijms21051639 Authors: Fabian Westhauser Frederike Hohenbild Marcela Arango-Ospina Sarah I. Schmitz Sebastian Wilkesmann Leena Hupa Arash Moghaddam Aldo R. Boccaccini The ICIE16-bioactive glass (BG) (48.0 SiO2, 6.6 Na2O, 32.9 CaO, 2.5 P2O5, 10.0 K2O (wt %)) has been developed as an alternative...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1643: Oral Microbes and Mucosal Dendritic Cells, “Spark and Flame” of Local and Distant Inflammatory Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21051643 Authors: Mohamed M. Meghil Christopher W. Cutler Mucosal health and disease is mediated by a complex interplay between the microbiota (“spark”) and the inflammatory response (“flame”). Pathobionts, a specific class of microbes, exemplified by the...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1640: Upregulation of Thr/Tyr kinase Increases the Cancer Progression by Neurotensin and Dihydropyrimidinase-Like 3 in Lung Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21051640 Authors: Ying-Ming Tsai Kuan-Li Wu Yung-Yun Chang Jen-Yu Hung Wei-An Chang Chao-Yuan Chang Shu-Fang Jian Pei-Hsun Tsai Yung-Chi Huang Inn-Wen Chong Ya-Ling Hsu Lung cancer is one of the leading causes of cancer-related death globally, thus...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1646: Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21051646 Authors: Bixia Chen Bo Yang Jie Zhu Jiaxin Wu Junzhou Sha Jiarui Sun Endong Bao Xiaohui Zhang Heat stress can particularly affect the kidney because of its high rate of adenosine triphosphate consumption. Competition between apoptosis and autophagy-mediated...
Fri Feb 28, 2020 02:00
IJMS, Vol. 21, Pages 1637: Effect of Sonication on the Properties of Flaxseed Gum Films Incorporated with Carvacrol International Journal of Molecular Sciences doi: 10.3390/ijms21051637 Authors: Fang Qiu Mei Xie Carvacrol is a natural compound known to be a highly effective antibacterial; however, it is a hydrophobic molecule, which is a limitation to its use within food packaging. Flaxseed gum (FG) films containing different contents of carvacrol (C) were produced by a...
Fri Feb 28, 2020 02:00
Abstract Background The electromyographic threshold (EMGTh) has been suggested to indicate the onset of accelerated higher-threshold (type-II) MU recruitment. Previous research has demonstrated that boys’ EMGTh occurs at higher relative exercise intensities than men’s in both cycling- and isometric-based testing. Girls‒women EMGTh differences were demonstrated only in cycling, but findings were clouded by low EMGTh-detection rates in...
Mon Mar 02, 2020 02:00
Abstract Purpose The purpose of this paper is to review the physiological mechanisms determining eccrine sweat composition to assess the utility of sweat as a proxy for blood or as a potential biomarker of human health or nutritional/physiological status. Methods This narrative review includes the major sweat electrolytes (sodium, chloride, and potassium),...
Mon Mar 02, 2020 02:00
Abstract Background Intravenous recombinant tissue-type plasminogen activator (rt-PA) with/without endovascular treatment is sometimes not ideally effective for the treatment of acute hemodynamic stroke due to atherosclerotic major artery steno-occlusive disease, and some patients show fluctuation in or progression of symptoms despite intensive medical therapy. Urgent superficial temporal artery-middle cerebral artery (STA-MCA) bypass...
Mon Mar 02, 2020 02:00
Abstract Background Dysphagia is a common and serious complication after (chemo)radiotherapy (CRT) for head-and-neck cancer (HNC) patients. Prophylactic swallowing exercises (PSE) can have a significantly positive effect on post-treatment swallowing function. However, low adherence rates are a key issue in undermining this positive effect. This current randomized trial will investigate the effect of adherence-improving measures on...
Mon Mar 02, 2020 02:00
Abstract Background Law enforcement officers (LEOs) are exposed to significant stressors, elevating their risk for aggression and excessive use of force, as well as mental health consequences, including post-traumatic stress disorder, burnout, alcohol misuse, depression, and suicide. Mindfulness training is a promising approach with high-stress populations that has been shown effective for increasing resilience and improving negative...
Fri Feb 28, 2020 02:00
Abstract Studies have suggested that fluoxetine might improve neurological recovery after stroke, but the results remain inconclusive. The EFFECTS (Efficacy oF Fluoxetine – a randomisEd Controlled Trial in Stroke) reached its recruitment target of 1500 patients in June 2019. The purpose of this article is to present all amendments to the protocol and describe how we formed the EFFECTS trial collaboration in Sweden. ...
Fri Feb 28, 2020 02:00
Abstract Background Measures shown to improve outcomes for patients often fail to be adopted into routine practice in the NHS. The Institute for Health Improvement Breakthrough Series Collaborative (BSC) model is designed to support implementation at scale. This trial aims to assess the effectiveness and cost-effectiveness of quality improvement collaboratives (QICs) based on the BSC method for introducing service improvements at...
Fri Feb 28, 2020 02:00
Abstract Background In cardiac surgery with cardiopulmonary bypass (CPB), large amounts of fluids are administered. CPB priming with crystalloid solution causes marked hemodilution and fluid extravasation. Colloid solutions may reduce fluid overload because they have a better volume expansion effect than crystalloids. The European Medicines Agency does not recommend the use of hydroxyethyl starch solutions (HES) due to harmful renal...
Fri Feb 28, 2020 02:00
Fri Feb 28, 2020 14:33
Fri Feb 28, 2020 14:33
The increasing number of unrepresented litigants in various jurisdictions raises thequestion of what challenges these lay people face in their access to justice. This articleseeks to examine this by conducting a small ethnographic study and survey inHong Kong. Based on 6 hours of courtroom observation in two cases and 8 hoursof pre-trial, during trial and post-trial interview data obtained from 7 sessions, weshow that unrepresented litigants may find navigating difficult legal phrases, legalhomonymy,...
Fri Feb 28, 2020 14:31
Franklin D. Roosevelt once said, “let me assert my firm belief that the only thing we have to fear is fear itself.” Although this statement has gained much attention in the political world since the early 1900s, I don’t necessarily agree with FDR here. When analyzing this statement from a scientific, but specifically psychological perspective, […]
Mon Mar 02, 2020 18:00
It seems that no matter what age we are, whether it be an angsty teen trying to fit in or a new parent trying to keep their fitness with the stress of a newborn, we are always trying to achieve the ‘ideal’ body. This unattainable ‘ideal’ form that surrounds us through social media and advertisements […]
Sat Feb 29, 2020 05:41
Publication date: Available online 2 March 2020Source: Acta HistochemicaAuthor(s): Denis Matrov, Sophie Imbeault, Margus Kanarik, Marianna Shkolnaya, Patricia Schikorra, Ergo Miljan, Ruth Shimmo, Jaanus Harro
Mon Mar 02, 2020 18:12
Publication date: Available online 27 February 2020Source: Acta HistochemicaAuthor(s): Irene Rosa, Mirca Marini, Eleonora Sgambati, Lidia Ibba-Manneschi, Mirko Manetti
Fri Feb 28, 2020 17:27
Nature Neuroscience, Published online: 02 March 2020; doi:10.1038/s41593-020-0598-6Chen, Deister et al. show that Shank3B-knockout mice display hypersensitivity to tactile sensory stimulation and that dysfunction of interneurons in somatosensory cortex contributes to the sensory hyper-reactivity in this mouse model of autism.
Mon Mar 02, 2020 02:00
Nature Neuroscience, Published online: 28 February 2020; doi:10.1038/s41593-020-0599-5The multiplex model of the genetics of Alzheimer’s disease
Fri Feb 28, 2020 02:00
Nature Neuroscience, Published online: 28 February 2020; doi:10.1038/s41593-020-0601-2Motor learning is composed of explicit ‘strategic’ components and implicit ‘automatic’ components. Miyamoto and colleagues reveal how these components work together during visuomotor adaptation, providing evidence that an implicit component corrects for a noisy explicit process.
Fri Feb 28, 2020 02:00
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