Biomolecules, Vol. 10, Pages 384: Oxidative-Antioxidant Imbalance and Impaired Glucose Metabolism in Schizophrenia Biomolecules doi: 10.3390/biom10030384 Authors: Bryll Skrzypek Krzyściak Szelągowska Śmierciak Kozicz Popiela Schizophrenia is a neurodevelopmental disorder featuring chronic, complex neuropsychiatric features. The etiology and pathogenesis of schizophrenia are not fully understood. Oxidative-antioxidant imbalance is a potential determinant of schizophrenia....
Mon Mar 02, 2020 02:00
Biomolecules, Vol. 10, Pages 382: Reprogramming the Constant Region of Immunoglobulin G Subclasses for Enhanced Therapeutic Potency against Cancer Biomolecules doi: 10.3390/biom10030382 Authors: Kang Jung The constant region of immunoglobulin (Ig) G antibodies is responsible for their effector immune mechanism and prolongs serum half-life, while the fragment variable (Fv) region is responsible for cellular or tissue targeting. Therefore, antibody engineering for cancer therapeutics...
Sun Mar 01, 2020 02:00
Biomolecules, Vol. 10, Pages 381: Mevastatin-Induced AP-1-Dependent HO-1 Expression Suppresses Vascular Cell Adhesion Molecule-1 Expression and Monocyte Adhesion on Human Pulmonary Alveolar Epithelial Cells Challenged with TNF-α Biomolecules doi: 10.3390/biom10030381 Authors: Yang Lin Yang Cho Hsiao Mevastatin (MVS) has been previously shown to induce heme oxygenase (HO)-1 expression through Nox/ROS-dependent PDGFRα/PI3K/Akt/Nrf2/ARE axis in human pulmonary...
Sun Mar 01, 2020 02:00
Biomolecules, Vol. 10, Pages 378: Targeted Isolation of Lignans from Trachelospermum asiaticum Using Molecular Networking and Hierarchical Clustering Analysis Biomolecules doi: 10.3390/biom10030378 Authors: Jiho Lee Hong Seok Yang Hyogeun Jeong Jung-Hwan Kim Heejung Yang High-resolution-mass-spectrometry (HR-MS) methods rapidly provide extensive structural information for the isolation of metabolites in natural products. However, they may occasionally provide more information...
Sun Mar 01, 2020 02:00
Biomolecules, Vol. 10, Pages 380: Salivary Osteocalcin as Potential Diagnostic Marker of Periodontal Bone Destruction among Smokers Biomolecules doi: 10.3390/biom10030380 Authors: Joseph Javali Khader AlQahtani Amanullah : The objective of the study was to assess the levels and diagnostic accuracy of salivary osteocalcin (OC), osteonectin (ON), and deoxypyridinoline-containing degradation fragment of the C-terminal telopeptide region of type I collagen (CTX) in adult...
Sun Mar 01, 2020 02:00
Biomolecules, Vol. 10, Pages 379: Rhizophagus irregularis and Rhizoctonia solani Differentially Elicit Systemic Transcriptional Expression of Polyphenol Biosynthetic Pathways Genes in Sunflower Biomolecules doi: 10.3390/biom10030379 Authors: Rashad Aseel Hammad Elkelish Plant roots are exposed to penetration by different biotrophic and necrotrophic fungi. However, plant immune responses vary, depending on the root-penetrating fungus. Using qRT-PCR, changes over time in the...
Sun Mar 01, 2020 02:00
Biomolecules, Vol. 10, Pages 377: Maytenus disticha Extract and an Isolated β-Dihydroagarofuran Induce Mitochondrial Depolarization and Apoptosis in Human Cancer Cells by Increasing Mitochondrial Reactive Oxygen Species Biomolecules doi: 10.3390/biom10030377 Authors: Iván González-Chavarría Felix Duprat Francisco J. Roa Nery Jara Jorge R. Toledo Felipe Miranda José Becerra Alejandro Inostroza Alexandra Kelling Uwe Schilde Matthias Heydenreich Cristian Paz ...
Sat Feb 29, 2020 02:00
Biomolecules, Vol. 10, Pages 376: In Search of High-Yielding and Single-Compound-Yielding Plants: New Sources of Pharmaceutically Important Saponins from the Primulaceae Family Biomolecules doi: 10.3390/biom10030376 Authors: Włodarczyk Pasikowski Osiewała Frankiewicz Dryś Gleńsk So far, only a few primrose species have been analyzed regarding their saponin composition and content. Moreover, the roots of only two of them are defined by the European Union (EU) Pharmacopoeia...
Sat Feb 29, 2020 02:00
Biomolecules, Vol. 10, Pages 375: Distinct Approaches of Raloxifene: Its Far-Reaching Beneficial Effects Implicating the HO-System Biomolecules doi: 10.3390/biom10030375 Authors: Denise Börzsei Renáta Szabó Alexandra Hoffmann Médea Veszelka Imre Pávó Zsolt Turcsán Csaba Viczián Krisztina Kupai Csaba Varga Anikó Pósa Selective estrogen receptor modulators (SERMs) were discovered in the mid-1900s in connection with estrogen-related pathological conditions. They...
Fri Feb 28, 2020 02:00
Biomolecules, Vol. 10, Pages 372: Comparison of Ginsenoside Components of Various Tissues of New Zealand Forest-Grown Asian Ginseng (Panax Ginseng) and American Ginseng (Panax Quinquefolium L.) Biomolecules doi: 10.3390/biom10030372 Authors: Chen Balan Popovich Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolium L.) are the two most important ginseng species for their medicinal properties. Ginseng is not only popular to consume, but is also increasingly popular...
Fri Feb 28, 2020 02:00
Biomolecules, Vol. 10, Pages 373: Gametogenesis-Related Fluctuations in Ovothiol Levels in the Mantle of Mussels from Different Estuaries: Fighting Oxidative Stress for Spawning in Polluted Waters Biomolecules doi: 10.3390/biom10030373 Authors: Oihane Diaz de Cerio Lander Reina Valeria Squatrito Nestor Etxebarria Belen Gonzalez-Gaya Ibon Cancio Reactive oxygen species present a challenge for marine organisms releasing gametes into the water. Thiol-containing molecules...
Fri Feb 28, 2020 02:00
Biomolecules, Vol. 10, Pages 371: A Comprehensive Comparison of Bovine and Porcine Decellularized Pericardia: New Insights for Surgical Applications Biomolecules doi: 10.3390/biom10030371 Authors: Sabra Zouhair Eleonora Dal Sasso Sugat R. Tuladhar Catia Fidalgo Luca Vedovelli Andrea Filippi Giulia Borile Andrea Bagno Massimo Marchesan De Rossi Giorgio Dario Gregori Willem F. Wolkers Filippo Romanato Sotirios Korossis Gino Gerosa Laura Iop Xenogeneic...
Fri Feb 28, 2020 02:00
Biomolecules, Vol. 10, Pages 374: The Role of Secretory Activity Molecules of Visceral Adipocytes in Abdominal Obesity in the Development of Cardiovascular Disease: A Review Biomolecules doi: 10.3390/biom10030374 Authors: Ragino Stakhneva Polonskaya Kashtanova Adipose tissue is considered one of the endocrine organs in the body because of its ability to synthesize and release a large number of hormones, cytokines, and growth and vasoactive factors that influence a variety...
Fri Feb 28, 2020 02:00
Biomolecules, Vol. 10, Pages 370: Hear, Hear for Notch: Control of Cell Fates in the Inner Ear by Notch Signaling Biomolecules doi: 10.3390/biom10030370 Authors: Rogers Brown Andrew K. Groves The vertebrate inner ear is responsible for detecting sound, gravity, and head motion. These mechanical forces are detected by mechanosensitive hair cells, arranged in a series of sensory patches in the vestibular and cochlear regions of the ear. Hair cells form synapses with neurons of the VIIIth...
Fri Feb 28, 2020 02:00
Biomolecules, Vol. 10, Pages 369: Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation Biomolecules doi: 10.3390/biom10030369 Authors: Kelvin K. Tsao Ann C. Lee Karl É. Racine Jeffrey W. Keillor Many clinically relevant therapeutic agents are formed from the conjugation of small molecules to biomolecules through conjugating linkers. In this study, two novel conjugating linkers were prepared, comprising a central coumarin core, functionalized with a dimaleimide...
Fri Feb 28, 2020 02:00
Biomolecules, Vol. 10, Pages 368: Tiny but Fatty: Lipids and Fatty Acids in the Daubed Shanny (Leptoclinus Maculatus), a Small Fish in Svalbard Waters Biomolecules doi: 10.3390/biom10030368 Authors: Svetlana A. Murzina Svetlana N. Pekkoeva Ekaterina A. Kondakova Zinaida A. Nefedova Kseniia A. Filippova Nina N. Nemova Alexei M. Orlov Jorgen Berge Stig Falk-Petersen The seasonal dynamic of lipids and their fatty acid constituents in the lipid sac and muscles of...
Fri Feb 28, 2020 02:00
Biomolecules, Vol. 10, Pages 367: Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris Biomolecules doi: 10.3390/biom10030367 Authors: Iwona Jarocka-Karpowicz Michał Biernacki Adam Wroński Agnieszka Gęgotek Elżbieta Skrzydlewska Psoriasis is a chronic inflammatory skin disease characterized by dysregulated keratinocyte differentiation, but oxidative stress also plays an important role in the pathogenesis of this disease. Here,...
Fri Feb 28, 2020 02:00
Mon Mar 02, 2020 02:00
Abstract Bacillus Calmette–Guérin (BCG) instillation is a key therapy to manage non-muscle invasive bladder cancer (NMIBC). However, intravesical BCG therapy fails in approximately half of the patients, leading to recurrence and progression. We aimed to reveal the genetic variations associated with treatment failure after intravesical BCG therapy for NMIBC. This study included 91 Japanese patients treated with BCG instillation for NMIBC. Genomic DNA was obtained from patient whole-blood...
Mon Mar 02, 2020 02:00
Abstract Bone metastatic prostate cancer (BM-PCa) significantly reduces overall patient survival and is currently incurable. Current standard immunotherapy showed promising results for PCa patients with metastatic, but less advanced, disease (i.e., fewer than 20 bone lesions) suggesting that PCa growth in bone contributes to response to immunotherapy. We found that: (1) PCa stimulates recruitment of neutrophils, the most abundant immune cell in bone, and (2) that neutrophils heavily...
Sat Feb 29, 2020 02:00
Publication date: Available online 2 March 2020Source: Translational ResearchAuthor(s): Thea Brennan-Krohn, Roman Manetsch, George A. O'Doherty, James E. Kirby
Mon Mar 02, 2020 18:21
IJMS, Vol. 21, Pages 1710: Cordycepin Resensitizes T24R2 Cisplatin-Resistant Human Bladder Cancer Cells to Cisplatin by Inactivating Ets-1 Dependent MDR1 Transcription International Journal of Molecular Sciences doi: 10.3390/ijms21051710 Authors: Sang-Seok Oh Ki Won Lee Hamadi Madhi Jin-Woo Jeong Soojong Park Minju Kim Yerin Lee Hyun-Tak Han Cheol Hwangbo Jiyun Yoo Kwang Dong Kim Tumor cell resistance to anti-cancer drugs is a major obstacle...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1708: Visualizing the Synaptic and Cellular Ultrastructure in Neurons Differentiated from Human Induced Neural Stem Cells—An Optimized Protocol International Journal of Molecular Sciences doi: 10.3390/ijms21051708 Authors: Philipp Capetian Lorenz Müller Jens Volkmann Manfred Heckmann Süleyman Ergün Nicole Wagner The size of the synaptic subcomponents falls below the limits of visible light microscopy. Despite new developments in advanced...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1709: Manganese(II) Oxidizing Bacteria as Whole-Cell Catalyst for β-Keto Ester Oxidation International Journal of Molecular Sciences doi: 10.3390/ijms21051709 Authors: Juan Guo Huan Guo Jin Liu Fangrui Zhong Yuzhou Wu Manganese oxidizing bacteria can produce biogenic manganese oxides (BMO) on their cell surface and have been applied in the fields of agriculture, bioremediation, and drinking water treatment to remove toxic contaminants based on...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1706: One, No One, and One Hundred Thousand: The Many Forms of Ribonucleotides in DNA International Journal of Molecular Sciences doi: 10.3390/ijms21051706 Authors: Nava Grasso Sertic Pellicioli Muzi Falconi Lazzaro In the last decade, it has become evident that RNA is frequently found in DNA. It is now well established that single embedded ribonucleoside monophosphates (rNMPs) are primarily introduced by DNA polymerases and that longer...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1707: Co-Expression Network Analysis of Spleen Transcriptome in Rock Bream (Oplegnathus fasciatus) Naturally Infected with Rock Bream Iridovirus (RBIV) International Journal of Molecular Sciences doi: 10.3390/ijms21051707 Authors: Ahran Kim Dahye Yoon Yunjin Lim Heyong Jin Roh Suhkmann Kim Chan-Il Park Heui-Soo Kim Hee-Jae Cha Yung Hyun Choi Do-Hyung Kim Rock bream iridovirus (RBIV) is a notorious agent that causes high mortality...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1703: Systematic Review of Polygenic Risk Scores for Type 1 and Type 2 Diabetes
IJMS, Vol. 21, Pages 1703: Systematic Review of Polygenic Risk Scores for Type 1 and Type 2 Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms21051703 Authors: Felipe Padilla-Martínez Francois Collin Miroslaw Kwasniewski Adam Kretowski Recent studies have led to considerable advances in the identification of genetic variants associated with type 1 and type 2 diabetes. An approach for converting genetic data into a predictive measure of disease susceptibility...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1705: Beneficial and Detrimental Effects of Regulatory T Cells in Neurotropic Virus Infections International Journal of Molecular Sciences doi: 10.3390/ijms21051705 Authors: Malgorzata Ciurkiewicz Vanessa Herder Andreas Beineke Neurotropic viruses infect the central nervous system (CNS) and cause acute or chronic neurologic disabilities. Regulatory T cells (Treg) play a critical role for immune homeostasis, but may inhibit pathogen-specific immunity...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1704: A RING-Type E3 Ubiquitin Ligase, OsGW2, Controls Chlorophyll Content and Dark-Induced Senescence in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21051704 Authors: Kyu-Chan Shim Sun Ha Kim Yun-A Jeon Hyun-Sook Lee Cheryl Adeva Ju-Won Kang Hyun-Jung Kim Thomas H Tai Sang-Nag Ahn Leaf senescence is the final stage of plant development. Many internal and external factors affect the senescence process in...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1699: The Bioactive Core and Corona Synergism of Quantized Gold Enables Slowed Inflammation and Increased Tissue Regeneration in Wound Hypoxia International Journal of Molecular Sciences doi: 10.3390/ijms21051699 Authors: Lu-Chen Yeh Shu-Ping Chen Fang-Hsuean Liao Te-Haw Wu Yu-Ting Huang Shu-Yi Lin The progress of wound regeneration relies on inflammation management, while neovascular angiogenesis is a critical aspect of wound healing. In...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1698: Discovery of 1-Pyrimidinyl-2-Aryl-4,6-Dihydropyrrolo [3,4-d]Imidazole-5(1H)-Carboxamide as a Novel JNK Inhibitor International Journal of Molecular Sciences doi: 10.3390/ijms21051698 Authors: Miyoung Jang Youri Oh Hyunwook Cho Songyi Yang Hyungwoo Moon Daseul Im Jung-Mi Hah We designed and synthesized 1-pyrimidinyl-2-aryl-4, 6-dihydropyrrolo [3,4-d] imidazole-5(1H)-carboxamide derivatives as selective inhibitors of c-Jun-N-terminal...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1702: Burkholderia cenocepacia H111 Produces a Water-Insoluble Exopolysaccharide in Biofilm: Structural Determination and Molecular Modelling International Journal of Molecular Sciences doi: 10.3390/ijms21051702 Authors: Barbara Bellich Ining A. Jou Marco Caterino Roberto Rizzo Neil Ravenscroft Mustafa Fazli Tim Tolker-Nielsen John W. Brady Paola Cescutti Biofilms are a multicellular way of life, where bacterial cells are close...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1701: A Simplified Cluster Analysis of Electron Track Structure for Estimating Complex DNA Damage Yields International Journal of Molecular Sciences doi: 10.3390/ijms21051701 Authors: Yusuke Matsuya Toshiaki Nakano Takeshi Kai Naoya Shikazono Ken Akamatsu Yuji Yoshii Tatsuhiko Sato Complex DNA damage, defined as at least two vicinal lesions within 10–20 base pairs (bp), induced after exposure to ionizing radiation, is recognized...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1700: M2 Receptor Activation Counteracts the Glioblastoma Cancer Stem Cell Response to Hypoxia Condition International Journal of Molecular Sciences doi: 10.3390/ijms21051700 Authors: Ilaria Cristofaro Chiara Limongi Paola Piscopo Alessio Crestini Claudia Guerriero Mario Fiore Luciano Conti Annamaria Confaloni Ada Maria Tata Glioblastoma multiforme (GBM) is the most malignant brain tumor. Hypoxic condition is a predominant feature...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1697: Intra-Molecular Homologous Recombination of Scarless Plasmid International Journal of Molecular Sciences doi: 10.3390/ijms21051697 Authors: Yaping Liang Yu Zhang Liangwei Liu Although many methods have been reported, plasmid construction compromises transformant efficiency (number of transformants per ng of DNAs) with plasmid accuracy (rate of scarless plasmids). An efficient method is two-step PCR serving DNA amplification. An accurate method...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1696: Heterogeneity of Circulating Tumor Cells in Breast Cancer: Identifying Metastatic Seeds International Journal of Molecular Sciences doi: 10.3390/ijms21051696 Authors: Maxim E. Menyailo Maria S. Tretyakova Evgeny V. Denisov Metastasis being the main cause of breast cancer (BC) mortality represents the complex and multistage process. The entrance of tumor cells into the blood vessels and the appearance of circulating tumor cells (CTCs) seeding and...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1695: Melanogenic Properties and Expression Profiles of Melanogenic Paracrine Molecules in Riehl’s Melanosis International Journal of Molecular Sciences doi: 10.3390/ijms21051695 Authors: Yu Woo Hyo Park Seo-Won Jeong Hyun Park Riehl’s melanosis is a hyperpigmentary disorder that occurs predominantly on the face and neck. To date, the pathogenesis of Riehl’s melanosis with regards to the melanogenic properties and paracrine melanogenic molecules...
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1694: Illumination of a Vision 2020—Urinary Based Biomarkers for Bladder Cancer on the Way to Clinical Decisions—Dream or Nightmare? International Journal of Molecular Sciences doi: 10.3390/ijms21051694 Authors: Thorsten H. Ecke Thomas Otto Bladder cancer is one of the most frequent malignancies worldwide [...]
Mon Mar 02, 2020 02:00
IJMS, Vol. 21, Pages 1693: Extracellular Vesicle-Induced Classical Complement Activation Leads to Retinal Endothelial Cell Damage via MAC Deposition International Journal of Molecular Sciences doi: 10.3390/ijms21051693 Authors: Chao Huang Kiera P. Fisher Sandra S. Hammer Julia V. Busik Several studies have suggested that there is a link between membrane attack complex (MAC) deposition in the retina and the progression of diabetic retinopathy (DR). Our recent investigation...
Sun Mar 01, 2020 02:00
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