Abstract Objective Patient reported outcome measures (PROMs) can provide researchers with a direct view of patients’ experiences. They are becoming increasingly important tools for evaluating clinical care and research outcomes. There has been little data on the application of PROMs to amyotrophic lateral sclerosis (ALS) care. The objective of this study was to examine the feasibility of PROM collection in an academic ALS clinic and to...
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Abstract Background Although multidisciplinary rehabilitation programs are commonly used in clinical practice for patients with multiple sclerosis (MS), they are currently underexamined. Objective This study aims to investigate the efficacy and underlying brain mechanisms of an inpatient multidisciplinary rehabilitation. ...
Mon Mar 02, 2020 02:00
Abstract The incidence and prevalence of patients who develop primary and secondary metastatic central nervous system cancer (CNS) is increasing. This is a consequence of advancements in the sensitivity and availability of diagnostic imaging, and improved therapeutic options, leading to increased detection of CNS malignancies and improved survival. These patients are at very high risk of thrombosis as well as haemorrhage, and the optimum management of anticoagulation can be challenging...
Mon Mar 02, 2020 02:00
Abstract Nabiximols is an effective treatment for spasticity in MS. However, treatment discontinuation over-time might occur and predictors of sustained treatment persistence over long-term follow-up in real-world settings are highly needed. We aim at evaluating baseline predictors of treatment persistence on Nabiximols. This is a retrospective real-world study including MS patients treated with Nabiximols. At baseline (Nabiximols prescription), we evaluated disability using the...
Mon Mar 02, 2020 02:00
Applied Sciences, Vol. 10, Pages 1717: A Shear-Wave Velocity Model in the City of Oued-Fodda (Northern Algeria) from Rayleigh Wave Ellipticity Inversion Applied Sciences doi: 10.3390/app10051717 Authors: Abdelouahab Issaadi Fethi Semmane Abdelkrim Yelles-Chaouche Juan José Galiana-Merino Khalissa Layadi The city of Oued-Fodda is located in north-central Algeria on the margins of the Middle-Cheliff Basin. This region has suffered several destructive earthquakes. The...
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Sustainability, Vol. 12, Pages 1901: The Influence of Corporate Environmental Responsibility on Overinvestment Behavior: Evidence from South Korea Sustainability doi: 10.3390/su12051901 Authors: Jaehong Lee Eunsoo Kim The purpose of this paper is to examine the association between corporate environmental responsibility (CER) activities and investment efficiency as measured by overinvestment, and whether the industry-level competition affects this association. We investigate...
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Pharmaceutics, Vol. 12, Pages 225: Cell Penetrating Peptides, Novel Vectors for Gene Therapy Pharmaceutics doi: 10.3390/pharmaceutics12030225 Authors: Rebecca E. Taylor Maliha Zahid Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), first identified ~25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring peptides, able to carry variety of cargoes across the cellular membranes in an intact, functional form....
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Up to a million people could be tested for coronavirus by the end of week, the Trump administration said Monday, as cases across the US rose to more than 100 and health officials warned that the number will keep climbing.
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Condition: GingivitisInterventions: Other: Experimental Dentifrice: Stannous Fluoride; Device: COREGA Denture Foaming Cleanser; Other: Mouth rinse: Sodium FluorideSponsor: GlaxoSmithKlineNot yet recruiting
Mon Mar 02, 2020 18:38
Condition: Musculoskeletal PainInterventions: Procedure: Auricular (Battlefield) Acupuncture; Procedure: Peripheral AcupunctureSponsors: Duke University; The Duke EndowmentRecruiting
Mon Mar 02, 2020 18:38
Conditions: Salivary Gland Cancer; Salivary Duct Carcinoma; Adenoid Cystic CarcinomaIntervention: Drug: Lutetium-177-PSMA-I&TSponsors: Radboud University; Dutch Cancer SocietyNot yet recruiting
Mon Mar 02, 2020 18:38
Condition: Ototoxic Hearing LossIntervention: Drug: N-Acetyl CysteineSponsors: Sunnybrook Health Sciences Centre; Toronto Sunnybrook Regional Cancer Centre; London Regional Cancer Program, CanadaRecruiting
Mon Mar 02, 2020 18:38
Condition: Athlete FootIntervention: Other: Neurodynamic trainingSponsor: Investigación en Hemofilia y FisioterapiaRecruiting
Fri Feb 28, 2020 15:23
Abstract Background Previous research using the Sensory Perception Quotient (SPQ) has reported greater sensory hypersensitivity in people with autism spectrum condition (ASC) compared to controls, consistent with other research. However, current scoring of the SPQ does not differentiate between hyper and hyposensitivity, making it uncertain whether individuals with ASC might also show differences in hyposensitivity. Furthermore,...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 219: Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study Pharmaceutics doi: 10.3390/pharmaceutics12030219 Authors: Azad Al-Mahmood Chatterjee Wan Sulaiman Elsayed Doolaanea Black seed oil (BSO) has been used for various therapeutic purposes around the world since ancient eras. It is one of the most prominent oils used in nutraceutical formulations...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 223: Systematic Investigation of the Effect of Non-Ionic Emulsifiers on Skin by Confocal Raman Spectroscopy—A Comprehensive Lipid Analysis Pharmaceutics doi: 10.3390/pharmaceutics12030223 Authors: Liu Lunter Non-ionic emulsifiers are commonly found in existing pharmaceutical and cosmetic formulations and have been widely employed to enhance the penetration and permeation of active ingredients into the skin. With the potential of disrupting skin barrier...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 221: Synthesis and Antibacterial Activity of Ionic Liquids and Organic Salts Based on Penicillin G and Amoxicillin hydrolysate Derivatives against Resistant Bacteria Pharmaceutics doi: 10.3390/pharmaceutics12030221 Authors: Ferraz Silva Dias Dias Santos Pinheiro Prudêncio Noronha Petrovski Branco The preparation and characterization of ionic liquids and organic salts (OSILs) that contain anionic penicillin G [secoPen]...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 222: Preparations of Rectal Suppositories Containing Artesunate Pharmaceutics doi: 10.3390/pharmaceutics12030222 Authors: Persaud Eid Swiderski Serris Cho Rectal artesunate suppositories are a useful option for pre-referral treatment of severe malaria, specifically in children under 6 years of age in remote malaria-endemic areas. The main challenges are to improve the solubility of drugs in the rectal fluids and prevent the product from...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 220: Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes Pharmaceutics doi: 10.3390/pharmaceutics12030220 Authors: Choi Park Kim Shin Cho Lee Mertansine, a tubulin inhibitor, is used as the cytotoxic component of antibody–drug conjugates (ADCs) for cancer therapy. The effects of mertansine on uridine 5′-diphospho-glucuronosyltransferase...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 224: Doxorubicin–Loaded Human Serum Albumin Submicron Particles: Preparation, Characterization and In Vitro Cellular Uptake Pharmaceutics doi: 10.3390/pharmaceutics12030224 Authors: Chaiwaree Prapan Suwannasom Laporte Neumann Pruß Georgieva Bäumler Doxorubicin (DOX) is an effective anthracycline antibiotic drug which is commonly used in a broad range cancer therapy. However, due to dose depending side effects and toxicity to...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 217: Nanoparticle-Mediated Therapeutic Application for Modulation of Lysosomal Ion Channels and Functions Pharmaceutics doi: 10.3390/pharmaceutics12030217 Authors: Lee Hong Applications of nanoparticles in various fields have been addressed. Nanomaterials serve as carriers for transporting conventional drugs or proteins through lysosomes to various cellular targets. The basic function of lysosomes is to trigger degradation of proteins and lipids. Understanding...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 218: Combined Effect of Midazolam and Bone Morphogenetic Protein-2 for Differentiation Induction from C2C12 Myoblast Cells to Osteoblasts Pharmaceutics doi: 10.3390/pharmaceutics12030218 Authors: Hidaka Chiba-Ohkuma Karakida Onuma Yamamoto Fujii-Abe Saito Yamakoshi Kawahara In drug repositioning research, a new concept in drug discovery and new therapeutic opportunities have been identified for existing drugs. Midazolam (MDZ)...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 216: Preparation of Puerarin Chitosan Oral Nanoparticles by Ionic Gelation Method and Its Related Kinetics Pharmaceutics doi: 10.3390/pharmaceutics12030216 Authors: Jie Yan Zhi-Yu Guan Wei-Feng Zhu Ling-Yun Zhong Zhuo-Qi Qiu Peng-Fei Yue Wen-Ting Wu Jing Liu Xiao Huang In this paper, as an active ingredient, puerarin chitosan nanoparticles (Pur-CS/TPP-NPs) are prepared by an ionic gelation method. The chitosan (CS) concentration,...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 215: PGE2 Is Crucial for the Generation of FAST Whole- Tumor-Antigens Loaded Dendritic Cells Suitable for Immunotherapy in Glioblastoma Pharmaceutics doi: 10.3390/pharmaceutics12030215 Authors: Sara Nava Daniela Lisini Simona Frigerio Simona Pogliani Serena Pellegatta Laura Gatti Gaetano Finocchiaro Anna Bersano Eugenio Agostino Parati Dendritic cells (DC) are the most potent antigen-presenting cells, strongly inducers of T cell-mediated...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 214: Crystallisation Behaviour of Pharmaceutical Compounds Confined within Mesoporous Silicon Pharmaceutics doi: 10.3390/pharmaceutics12030214 Authors: Eleanor C. L. Jones Luis M. Bimbo The poor aqueous solubility of new and existing drug compounds represents a significant challenge in pharmaceutical development, with numerous strategies currently being pursued to address this issue. Amorphous solids lack the repeating array of atoms in the structure...
Mon Mar 02, 2020 02:00
Pharmaceutics, Vol. 12, Pages 213: Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery Pharmaceutics doi: 10.3390/pharmaceutics12030213 Authors: Gianfranco Decandia Fabio Palumbo Annalisa Treglia Vincenza Armenise Pietro Favia Federico Baruzzi Katrin Unger Alberto Perrotta Anna Maria Coclite A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin...
Sun Mar 01, 2020 02:00
Pharmaceutics, Vol. 12, Pages 212: The Effect of Cooling on the Degree of Crystallinity, Solid-State Properties, and Dissolution Rate of Multi-Component Hot-Melt Extruded Solid Dispersions Pharmaceutics doi: 10.3390/pharmaceutics12030212 Authors: Hurley Davis Walker Lyons Higginbotham : The effect of cooling on the degree of crystallinity, solid-state and dissolution properties of multi-component hot-melt extruded solid dispersions [SD] is of great interest for the successful...
Sun Mar 01, 2020 02:00
Pharmaceutics, Vol. 12, Pages 211: Mucoadhesive Budesonide Formulation for the Treatment of Eosinophilic Esophagitis Pharmaceutics doi: 10.3390/pharmaceutics12030211 Authors: Casiraghi Gennari Musazzi Ortenzi Bordignon Minghetti Eosinophilic esophagitis (EE) is a chronic immune/antigen-mediated esophageal inflammatory disease for which off-label topical corticosteroids (e.g., budesonide) are widely used in clinic. In general, thickening excipients are mixed with...
Sun Mar 01, 2020 02:00
Pharmaceutics, Vol. 12, Pages 210: Blood Eosinophilia is an on-Treatment Biomarker in Patients with Solid Tumors Undergoing Dendritic Cell Vaccination with Autologous Tumor-RNA Pharmaceutics doi: 10.3390/pharmaceutics12030210 Authors: Moreira Erdmann Uslu Vass Schuler Schuler-Thurner Background: The approvals of immune checkpoint inhibitors for several cancer types and the rapidly growing recognition that T cell-based immunotherapy significantly improves outcomes...
Sun Mar 01, 2020 02:00
Pharmaceutics, Vol. 12, Pages 209: Effect of Different Pressure-Sensitive Adhesives on Performance Parameters of Matrix-Type Transdermal Delivery Systems Pharmaceutics doi: 10.3390/pharmaceutics12030209 Authors: Bozorg Banga Matrix-type transdermal delivery systems (TDS) are comprised of the drug dissolved or dispersed in a pressure-sensitive adhesive (PSA) matrix and are designed to provide a controlled delivery through the skin and into systemic circulation. PSAs can directly...
Sun Mar 01, 2020 02:00
Pharmaceutics, Vol. 12, Pages 208: Theoretical and Experimental Gas Volume Quantification of Micro- and Nanobubble Ultrasound Contrast Agents Pharmaceutics doi: 10.3390/pharmaceutics12030208 Authors: Abenojar Bederman Leon Zhu Hadley Kolios Exner The amount of gas in ultrasound contrast agents is related to their acoustic activity. Because of this relationship, gas volume has been used as a key variable in normalizing the in vitro and in vivo acoustic behavior...
Sun Mar 01, 2020 02:00
Pharmaceutics, Vol. 12, Pages 207: Printability of External and Internal Structures Based on Digital Light Processing 3D Printing Technique Pharmaceutics doi: 10.3390/pharmaceutics12030207 Authors: Yang Zhou Lin Yang Yang The high printing efficiency and easy availability of desktop digital light processing (DLP) printers have made DLP 3D printing a promising technique with increasingly broad application prospects, particularly in personalized medicine. The objective...
Fri Feb 28, 2020 02:00
Pharmaceutics, Vol. 12, Pages 206: Systematic Development and Optimization of Inhalable Pirfenidone Liposomes for Non-Small Cell Lung Cancer Treatment Pharmaceutics doi: 10.3390/pharmaceutics12030206 Authors: Parvathaneni Kulkarni Shukla Farrales Kunda Muth Gupta Non-small cell lung cancer (NSCLC) is a global disorder, treatment options for which remain limited with resistance development by cancer cells and off-target events being major roadblocks for current...
Fri Feb 28, 2020 02:00
Mon Mar 02, 2020 18:28
Abstract Congenital hepatic fibrosis (CHF) often accompanies autosomal recessive polycystic kidney disease (ARPKD), which stems from a PKHD1 gene mutation. The aim of this study was to clarify the prognosis of children with CHF who received living donor liver transplantation (LDLT) from donors who might be heterozygous carriers of a hepatorenal fibrocystic disease. Fourteen children with CHF who underwent LDLT at our center were enrolled. Eight and two patients had ARPKD and nephronophthisis, respectively....
Mon Mar 02, 2020 18:28
Biomolecules, Vol. 10, Pages 385: Ginseng Gintonin Attenuates Lead-Induced Rat Cerebellar Impairments during Gestation and Lactation Biomolecules doi: 10.3390/biom10030385 Authors: Nam Choi Cho Seo Choi Nahm Chang Nah Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, improves brain functions and protects neurons from oxidative stress. However, little is known about the effects of gintonin against Pb-induced brain maldevelopment. We...
Mon Mar 02, 2020 02:00
Biomolecules, Vol. 10, Pages 387: Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice Biomolecules doi: 10.3390/biom10030387 Authors: Stec Gordon Nestor-Kalinoski Donald Mitchell Creeden Hinds Biliverdin reductase (BVR) is an enzymatic and signaling protein that has multifaceted roles in physiological systems. Despite the wealth of knowledge about BVR, no data exist regarding its actions...
Mon Mar 02, 2020 02:00
Biomolecules, Vol. 10, Pages 386: Haematoxylon campechianum Extract Ameliorates Neuropathic Pain via Inhibition of NF-κB/TNF-α/NOX/iNOS Signalling Pathway in a Rat Model of Chronic Constriction Injury Biomolecules doi: 10.3390/biom10030386 Authors: Sobeh Mahmoud Rezq Abdelfattah Mostafa Alsemeh El-Shazly Yasri Wink : In this study, the phytochemical composition and the possible prophylactic effects of an aqueous ethanol extract of Haematoxylon campechianum...
Mon Mar 02, 2020 02:00
Biomolecules, Vol. 10, Pages 383: Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones Biomolecules doi: 10.3390/biom10030383 Authors: Marcelie Priscila de Oliveira Rosso Aline Tiemi Oyadomari Karina Torres Pomini Bruna Botteon Della Coletta João Vitor Tadashi Cosin Shindo Rui Seabra Ferreira Júnior Benedito Barraviera Claudia Vilalva Cassaro Daniela Vieira Buchaim Daniel de Bortoli Teixeira...
Mon Mar 02, 2020 02:00
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