Forty Seven is engaged in the development of novel checkpoint therapies to stimulate macrophages for the treatment of cancer. The deal is expected to strengthen Gilead’s immuno-oncology research The post Gilead Sciences to buy immuno-oncology firm Forty Seven for $4.9bn appeared first on Pharmaceutical Business review.
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ConclusionsWithin a 3-year follow-up period, IVC plus IAC produced no additional benefit over primary IAC for treating advanced intraocular retinoblastoma in terms of local tumor control and extending survival. Longer follow-up periods are required to assess long-term efficacy. (Source: Cancer Chemotherapy and Pharmacology)
Mon Mar 02, 2020 00:00
ConclusionA plasma vemurafenibCss,min threshold of 50 mg/L is strongly associated with survival outcomes in patients with advanced melanoma. This new threshold needs to be validated prospectively in future studies. (Source: Cancer Chemotherapy and Pharmacology)
Sat Feb 22, 2020 20:14
ConclusionILD was observed in 18.9% of PDAC patients treated with GnP therapy. With appropriate management, no prognostic influence was observed. (Source: Cancer Chemotherapy and Pharmacology)
Sat Feb 22, 2020 20:14
ConclusionsThe in vitro chemosensitivity as tested by ATP-TCA demonstrated a significant correlation with CR for chemotherapy and can be a useful tool to optimize personalized treatments for patients with AML. (Source: Cancer Chemotherapy and Pharmacology)
Sat Feb 22, 2020 20:14
ConclusionsThe population PK of PF-06439535 and bevacizumab-EU were well characterized by a two-compartment model. Covariate analysis did not reveal any appreciable differences between PK parameters for PF-06439535 and bevacizumab-EU in patients with NSCLC.Clinical trial registrationClinicalTrials.gov, NCT02364999. (Source: Cancer Chemotherapy and Pharmacology)
Sat Feb 22, 2020 20:14
ConclusionsOur data continue to support an increased risk of infections with Gram-positive cocci as a potentially serious adverse event in women treated with pertuzumab and trastuzumab. (Source: Cancer Chemotherapy and Pharmacology)
Sat Feb 22, 2020 20:14
Maize landraces are well adapted to their local environments and present valuable sources of genetic diversity for breeding and conservation. But the maintenance of open-pollinated landraces in ex-situ programs is challenging, as regeneration of seed can often lead to inbreeding depression and the loss of diversity due to genetic drift. Recent reports suggest that the production of doubled-haploid (DH) lines from landraces may serve as a convenient means to preserve genetic diversity in a homozygous...
Mon Mar 02, 2020 02:00
Up to a million people could be tested for coronavirus by the end of week, the Trump administration said Monday, as cases across the US rose to more than 100 and health officials warned that the number will keep climbing.
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Teleradiology services are thriving across the globe, but particularly in the...Read more on AuntMinnieEurope.comRelated Reading: It's all change again in healthcare IT sector Why EMRs will not replace imaging IT Radiology business intelligence takes root in Europe What's really happening with enterprise imaging? Top trends in health informatics in Europe
09:37
Chinese governments of every level had allocated a total of 108.75 billion yuan ($15.58 billion) in special funds by March 2 to prevent the spread of the coronavirus epidemic, a finance ministry official said on Tuesday.
09:52
Britain is not planning to cancel mass gatherings or large sports events over the concerns about coronavirus, but will need legislation in case it needs to take action in the future, British health minister Matt Hancock said on Tuesday.
09:40
Having trouble viewing this email? View it as a Web page. A monthly update of NIDCR-supported science advances, as reported by grantee institutions and NIH. A Cancerous Conversation Oral tumor crosstalk transforms neurons into cancer enablers NIDCR • February 18, 2020 Secrets of Secretion Studies of fruit fly glands reveal intricacies...
Mon Mar 02, 2020 21:15
Hematology / Oncology News Burst (Source: FDA Center for Drug Evaluation and Research - What's New)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Mar 02, 2020 21:02
ConclusionsThis is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis. (Source: Journal of Neuro-Oncology)
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ConclusionsUltrasound BBB opening has just recently entered clinical trials with encouraging results, and the association of this strategy with immune therapeutics creates a new field of brain tumor treatment. (Source: Journal of Neuro-Oncology)
Fri Feb 28, 2020 00:00
ConclusionMore information on the extent, character and duration of glucocorticoids on patients treated with PD-(L)1 will better inform both clinical management and novel therapeutic development of immunotherapy in patients with CNS malignancies. (Source: Journal of Neuro-Oncology)
Thu Feb 27, 2020 00:00
ConclusionsTemporal bone resection is an important technique in the treatment of lateral skull-base malignancies. This strategy should be incorporated into a multi-disciplinary approach to cancer. (Source: Journal of Neuro-Oncology)
Thu Feb 27, 2020 00:00
ConclusionSRS may provide favorable local control in patients with refractory CNS lymphomas. A prospective trial is warranted to validate the efficacy of such an approach. (Source: Journal of Neuro-Oncology)
Thu Feb 27, 2020 00:00
(Source: The Doctors Lounge - Oncology)
Mon Mar 02, 2020 19:00
Hypersomnolence linked to increased risk for developing diabetes, cancer, HTN three years later (Source: The Doctors Lounge - Oncology)
Mon Mar 02, 2020 19:00
(Source: The Doctors Lounge - Oncology)
Mon Mar 02, 2020 11:15
(Source: The Doctors Lounge - Oncology)
Fri Feb 28, 2020 19:00
Age - adjusted prevalence of severe obesity 9.2 percent among U.S. adults, higher in women than men (Source: The Doctors Lounge - Oncology)
Thu Feb 27, 2020 19:00
Abstract To compare the effects of balafilcon A and samfilcon A silicone hydrogel bandage contact lenses on postoperative pain control and epithelial healing time after photorefractive keratectomy (PRK). Seventy-four eyes of 37 patients who underwent bilateral PRK were included in this randomized clinical trial study. In the end of the surgery, a balafilcon A lens was used in one eye and a samfilcon A lens was used in the fellow eye randomly. Pain, blurred vision, epiphora, photophobia,...
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Based on a study recently conducted in the U.K., there are more than 15% of girls and women who struggle to pay for sanitary products, and because of this -... The post Scotland Just Made History By...
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Abstract Total hip arthroplasty (THA) is often required to decrease the excessive anatomical femoral anteversion (AA) in developmental dysplasia of the hip. Studies have recommended decreasing the AA via the use of a retroverted modular neck. However, hip rotation after THA may strengthen or weaken the effect of changing the AA. Thus, the present study analyzed the effect of a retroverted neck on AA and hip rotation. Patients who underwent THA using a straight neck (ST group)...
Mon Mar 02, 2020 02:00
Abstract Future development of innovative artificial organs is closely related with cutting edge emerging technology. These technologies include brain machine or computer interface, organs made by three dimensional bioprinting, organs designed from induced-pluripotent stem cell for personalized tissue or organ, and xenotransplantation. To bridge the gap between scientific innovation and regulatory product review, pharmaceuticals and medical devices agency of Japan (PMDA) started...
Fri Feb 28, 2020 02:00
Nature Neuroscience, Published online: 02 March 2020; doi:10.1038/s41593-020-0598-6Chen, Deister et al. show that Shank3B-knockout mice display hypersensitivity to tactile sensory stimulation and that dysfunction of interneurons in somatosensory cortex contributes to the sensory hyper-reactivity in this mouse model of autism.
Mon Mar 02, 2020 02:00
Nature Neuroscience, Published online: 28 February 2020; doi:10.1038/s41593-020-0599-5The multiplex model of the genetics of Alzheimer’s disease
Fri Feb 28, 2020 02:00
Nature Neuroscience, Published online: 28 February 2020; doi:10.1038/s41593-020-0601-2Motor learning is composed of explicit ‘strategic’ components and implicit ‘automatic’ components. Miyamoto and colleagues reveal how these components work together during visuomotor adaptation, providing evidence that an implicit component corrects for a noisy explicit process.
Fri Feb 28, 2020 02:00
Nature Neuroscience, Published online: 28 February 2020; doi:10.1038/s41593-020-0597-7Zhou et al. unveil a novel role for activated microglia and macrophages during wound healing after CNS injury. Microglia promote corralling and form a protective barrier at the injury penumbra via the axon guidance receptor Plexin-B2.
Fri Feb 28, 2020 02:00
Nature Neuroscience, Published online: 28 February 2020; doi:10.1038/s41593-020-0600-3Implicit learning increases the fidelity of performance during motor learning by acting to adaptively clean up the noise resulting from a low-fidelity explicit strategy.
Fri Feb 28, 2020 02:00
Abstract Inflammatory dilated cardiomyopathy (DCMi) is a syndrome, not an etiological disease entity. The infective etiology and the immunopathology can be best determined through endomyocardial biopsy with a complete work-up by light microscopy, immunohistology, and polymerase chain reaction for microbial agents. This review focuses on the methodological advances in diagnosis in the past few years and exemplifies the importance of an etiology-orientated treatment in different...
Mon Mar 02, 2020 02:00
Abstract Background Our study aimed to explore the incidence and risk factors of permanent pacemaker implantation (PPI) after valve replacement surgery (VR). The influence of long-term pacemaker dependency on cardiac structure and function at the 1‑year follow-up was also assessed. Methods The demographic and surgical data of all consecutive patients who...
Mon Mar 02, 2020 02:00
Abstract Massa intermedia (MI) is an inconsistent midline structure in the human brain that is absent in approximately 30% of the population. Absence of MI is seen more frequently in schizophrenia spectrum disorder and bipolar disorder. However, very little is known about the normal role of MI in the human brain. The purpose of this study was to investigate the role of human MI in cortical and subcortical cognitive processing as determined by differences between subjects with...
Mon Mar 02, 2020 02:00
Conditions: Thyroid Cancer; Intermediate RiskInterventions: Drug: Systematic RAI-treatment; Other: Decision of RAI-treatment guided by a post-operative assessmentSponsors: Centre Francois Baclesse; French cancer Institute INCaNot yet recruiting
Mon Mar 02, 2020 18:38
Conditions: Esophageal Cancer; Gastric Cancer; Gastroesophageal Junction AdenocarcinomaIntervention: Other: Routine care as per site standardSponsor: iOMEDICO AGRecruiting
Mon Mar 02, 2020 18:38
Conditions: Squamous Cell Carcinoma of the Head and Neck; Recurrent Head and Neck Squamous Cell CarcinomaInterventions: Drug: Interleukin-15 Superagonist (N-803); Biological: CIML NK cell Infusion; Drug: IpilimumabSponsors: Dana-Farber Cancer Institute; Altor BioScience; Bristol-Myers Squibb; Miltenyi Biotec B.V. & Co. KGNot yet recruiting
Mon Mar 02, 2020 18:38
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