The approval of a BRAF-inhibitor for clinical use in BRAF-mutated metastatic melanoma patients in 2011 encouraged the scientific and medical communities that an increasingly more sophisticated mechanistic understanding of tumor progression will ultimately result in substantial improvements in clinical responses. Indeed, since that time many new drugs have significantly improved overall survival. However, it has become increasingly obvious that most tumors have an astounding ability to adapt to the...
Mon Mar 02, 2020 00:00
The past decade, systemic treatment of advanced non-small cell lung cancer (NSCLC) has undergone major changes. Several targeted therapies have been approved and recommended for use in subsets of patients who have specific genetic alterations [1]. One of these alterations involves the human epidermal growth factor 2 (HER2), a member of the ERBB family of tyrosine kinase receptors. Each receptor is composed of three segments: an extracellular ligand binding domain, an α-helical trans membrane segment...
Thu Feb 27, 2020 00:00
Abstract Purpose Forward progress in cancer treatment has resulted in fewer adverse consequences of cancer during and after treatment, offering employed cancer patients the possibility of continuing to work during treatment, returning to work after treatment, or implementing a combination of strategies to manage the cancer–work interface. Yet, much of the research on cancer and employment examines return to work as the primary outcome,...
02:00
Abstract Background Breast cancer incidence in sub-Saharan Africa (SSA) is increasing, and SSA has the highest age-standardized breast cancer mortality rate worldwide. However, high-quality breast cancer data are limited in SSA. Materials and Methods We examined breast cancer patient and tumor characteristics among women in Lilongwe, Malawi and evaluated...
Mon Mar 02, 2020 02:00
Abstract Purpose We explored the interaction between non-Hodgkin lymphoma (NHL), infectious mononucleosis (IM) history, and immune-related genotypes in a pooled case–control analysis. Methods A total of 7,926 NHL patients and 10,018 controls from 12 case–control studies were included. Studies were conducted during various time periods between 1988...
Mon Mar 02, 2020 02:00
Abstract Purpose Evidence for the association of anthropometrics with colorectal neoplasms is limited for African Americans. Methods We examined anthropometric measures with both colorectal adenoma and colorectal cancer (CRC) risk in the ongoing Black Women's Health Study. In a nested case–control analysis, 954 cases of colorectal adenoma were compared...
Mon Mar 02, 2020 02:00
Abstract Purpose Although infection with high-risk human papillomavirus (HPV) is a prerequisite for cervical cancer development, HPV infection is not sufficient to promote cancer in the majority of infected women. We tested the hypothesis that human herpesviruses might cooperate with HPV to promote the development of cervical dysplasia, an early indicator of cervical cancer development. ...
Fri Feb 28, 2020 02:00
Οι άνθρωποι σε μία χώρα είναι πιθανότερο να πιστεύουν στο «κακό μάτι», στον διάβολο, στη μαγεία και γενικότερα στις δαιμονικές δυνάμεις, όσο πιο εξαπλωμένες είναι οι λοιμώδεις νόσοι και όσο οι ίδιοι αρρωσταίνουν συχνότερα από τα μικρόβια, σύμφωνα με μία νέα διεθνή επιστημονική έρευνα. Η μελέτη, που συμπεριέλαβε και την Ελλάδα, με τίτλο «Εξηγώντας την αρρώστια με το κακό», δείχνει ότι όχι μόνο στο μακρινό παρελθόν αλλά και στην εποχή μας αρκετοί άνθρωποι τείνουν να ερμηνεύουν την ύπαρξη των ασθενειών...
07:22
South Korea's president declared war on the coronavirus on Tuesday, ordering additional hospital beds and more face masks to be made available as the number of cases rose by 600 in the worst epidemic of any nation outside China.
08:47
Pope Francis, who canceled a Lent retreat for the first time in his papacy because he is suffering from a cold, has tested negative for coronavirus, the Italian newspaper Il Messaggero reported on Tuesday.
09:01
Chinese authorities on Tuesday asked overseas Chinese to reconsider or minimize their travel plans as the coronavirus epidemic spreads across the world and prompts an uptick of imported cases arriving in the country.
09:01
Shanghai will require everyone entering the city from countries with "relatively serious virus conditions" to submit to 14 days of quarantine, an official said on Tuesday.
08:28
Abstract The giant freshwater prawn, Macrobrachium rosenbergii, is an important species for Bangladesh’s national economy, aquatic biodiversity, and employment opportunities; furthermore, human health risk associated to consumption of this species has become a crucial issue. Eight trace metals (Pb, Cr, Ni, Cd, Fe, Cu, Zn, and Mn) in different body parts of M. rosenbergii (U/10 as large and U/12 and U/15 as medium size), and water collected from farm and wild sources along with...
Mon Mar 02, 2020 02:00
Abstract The spent biological activated carbon (BAC) should be disposed properly; regeneration was a better choice. Performances of thermal and ultrasonic regeneration to the BAC with various service time (3 years, 5 years, and 10 years) were compared comprehensively; the recovery of the BAC’s pore structure, variation of mechanical hardness, influence of bioactivity, and removal efficiency of typical pollutants in the reuse were examined. The results showed that thermal regeneration...
Mon Mar 02, 2020 02:00
Abstract Petroleum industry can create enormous wealth and employment opportunities, which is one of the pillars of the national economy. The transportation conditions of petroleum products are complex and changeable. The natural disaster–induced dangerous chemical leakage may damage the ecological environment, which leads to substantial economic losses. It significantly undermines the sustainable development agenda. Therefore, assessing the possibility of leakage and the potential...
Mon Mar 02, 2020 02:00
Abstract Tremendous energy consumption appears as rapid economic development, leading to large amount of CO2 emissions. Although plentiful studies have been made into the driving factors of CO2 emissions, the existing literatures that take the spatial differences and temporal changes into consideration are few. Therefore, this study first analyzes the variations of total CO2 emissions’ spatial distribution from 2008 to 2017 and present the changes of driving factors, finding significant...
Mon Mar 02, 2020 02:00
Abstract Atmospheric bioaerosols, which contain a diverse group of various biological materials, also include pathogenic microorganisms such as viruses, bacteria, and fungal spores. The dispersal of various pathogens negatively impacts the human and ecosystem health. While the impact of pathogenic bacteria and viruses on human and ecosystem health is well documented, the impact of fungal spores on crop, however, is poorly characterized. An unprecedented increase in number of fungal...
Mon Mar 02, 2020 02:00
Abstract In recent times, financial development and industrial progression accrue energy demand. Therefore, the present research is investigating the nexuses of energy consumption-financial development indicators for 32 Asian economies including the FDI, economic growth, and urban sprawl. The long-run marginal impacts and causal linkage are estimated through the dynamic seemingly unrelated regression and the heterogeneous causality respectively. The estimates infer that financial...
Mon Mar 02, 2020 02:00
Abstract Ball-milling is considered as an economical and simple technology to produce novel engineered materials. The ball-milled microscale zero valent iron/pyrite composite (BM-ZVI/FeS2) had been synthesized through ball-milling technology and applied for highly efficient sequestration of antimonate (Sb(V)) in aqueous solution. BM-ZVI/FeS2 exhibited good Sb(V) removal efficiency (≥ 99.18%) at initial concentration less than 100 mg Sb(V)/L. Compared to ball-milled zero valent...
Mon Mar 02, 2020 02:00
Abstract Some studies have shown that exposure to polycyclic aromatic hydrocarbons (PAHs) is a dangerous factor for attention deficit hyperactivity disorder (ADHD). This systematic review and meta-analysis aimed to clarify this relationship, and to collect and analyze all the relevant evidences in published reports of epidemiologic studies. PubMed, Science Direct, Web of Science, Scopus, and Google Scholar databases were searched through September 31, 2018. The study quality was...
Mon Mar 02, 2020 02:00
Abstract Due to the wonderful property of hydrogels, they can provide a platform for a wide range of applications. Recently, there is a growing research interest in the development of potential hydrogel adsorbents in wastewater treatment due to their adsorption ability toward aqueous pollutants. It is important to prepare such a hydrogel that possesses appropriate robustness, adsorption capacity, and adsorption efficiency to meet the need of water treatment. In order to improve...
Mon Mar 02, 2020 02:00
Abstract Tramadol abuse is an increasingly alarming phenomenon among Egyptian Community especially among workers and drivers. Study profile and factors affecting tramadol abuse among industrial workers in Mid-Nile Delta Region. A cross sectional study among minibus drivers, construction and textile industries workers. From each target group 300 males were chosen randomly. The total sample size was 900 persons. Interview questionnaire was used for data collection. Diagnosis of tramadol...
Mon Mar 02, 2020 02:00
Abstract While the relationship between carbon dioxide (CO2) emission and its determinants has been widely examined in Asia, little attention has been paid to the role played by the participation in global value chains (GVCs). Thus, this study aims to fill this research gap by investigating the relationship between participation in GVCs and CO2 emissions in eleven Asian countries along with economic growth, energy consumption, trade openness, and population density. The study covers...
Mon Mar 02, 2020 02:00
Abstract As an extremely toxic metal, cadmium (Cd) is readily taken up by most plants. In situ Cd passivation is of great importance to reduce Cd availability in soil. In this experiment, two alkaline amendments, lime (L) (at a dosage of 0.02%, 0.04%, or 0.08%) and biochar (B) (at a dosage of 0.5%, 1%, or 2%), were used to improve Cd passivation by spent mushroom substrate (SMS) in a simulating Cd-contaminated soil (0.6 mg kg−1). Results showed that the application of SMS alone...
Mon Mar 02, 2020 02:00
Abstract This case-control study aimed to investigate the relationship of indoor radon gas concentration and residential building characteristics with mental health with multiple sclerosis (MS) in Yazd City, Iran. The participants included 45 patients with MS and 100 healthy individuals. The participants’ socio-economic status and residential building characteristics were investigated using a questionnaire. The radon gas concentration was also measured by CR-39 detectors over a...
Mon Mar 02, 2020 02:00
Abstract The sediment delivery ratio (SDR) is a key link between slope erosion and river sediment transport but the accurate quantification of sediment yield in different catchments has been hampered by a lack of dynamic multi-scale information on SDR. A dynamic multi-scale SDR algorithm was innovatively applied in the modified sediment yield model to quantify the spatiotemporal evolutions of sediment delivery and inventory the relationships between sediment yield and different...
Mon Mar 02, 2020 02:00
Abstract Accretion of heavy metals in forage is a potential risk to grazing animals due to their uptake by plants and its entrance into the food chain. This study aimed to examine the Mn and Cd concentration from different samples. Sampling was done twice after the interval of 6 months during 2018; five different sites from Chakwal (Pidh, Tobar, Ratoccha, Kalar Kahar Road, Choa Saiden Shah and Chakwal Road, Choa Saiden Shah) were selected. Thirty samples of soil, forage (Acacia...
Mon Mar 02, 2020 02:00
Abstract Presence of formaldehyde as a preservative in commonly available fishes (Labeo rohita, Catla catla, Anabas testudineus and Clarias gariepinus) has become a serious health concern in the public health of eastern region of India. Formaldehyde content was determined using high-performance liquid chromatography (HPLC). Results showed high formaldehyde content in frozen carp (19.66 and 23.3 mg/kg in Labeo rohita and Catla catla, respectively); however, the amount of formaldehyde...
Mon Mar 02, 2020 02:00
Abstract Roundup is a widely used glyphosate-based herbicide worldwide. Roundup residues can be detected in the organs and urine of animals. However, its toxicity on mammalian preimplantation embryos has not been well investigated. Here, we show Roundup impairs the development and quality of bovine preimplantation embryos in a dose-dependent manner. Exposure to the agricultural recommended doses of Roundup caused in vitro developmental arrest and quick death of bovine embryos....
Mon Mar 02, 2020 02:00
Abstract Cadmium (Cd) is a naturally occurring toxic heavy metal with no known essential biological functions. Exposure to Cd increases the risk of cardiovascular disease by disrupting vascular homeostasis at the endothelium. The aim of the study was to evaluate the effect of chronic low-dose Cd on vascular structure and function. Fifty adult male Sprague Dawley rats were grouped and assigned to one of two treatments for 14 weeks. The control group received normal water for 14 weeks...
Mon Mar 02, 2020 02:00
Abstract Bentonite-based geomaterials are included in the designs of geological repository planning in most countries, especially in high-level radioactive waste disposal. Physical integrity of the bentonite sealant is key in assuring its hydraulic and retention properties, which affect the long-term performance of the repositories. Examination of the internal textures and structures of bentonite has been challenging until recently. Here, X-ray computed tomography (XCT) is applied...
Mon Mar 02, 2020 02:00
Abstract Pervasive plastic wastes, pollution and detrimental environmental ethics are a serious threat in South Africa. Compared with global trends, most studies undertaken on plastic pollutions in water bodies across South Africa have generally been limited to marine and coastal waters. A literature review, for the last 40 years, demonstrated the scanty studies on the economic, social, health and cost implications of plastic entrainment into fresh water (sources of drinking water)...
Mon Mar 02, 2020 02:00
Abstract Plastics are nowadays considered to be the workhorse material of our modern society with an ubiquitous presence that has increased manifold over the past 60 years, providing several benefits to the global economy. However, inappropriate and/or uncontrolled disposal practices, poor waste management infrastructure and application of insufficient recycling technologies, coupled with a lack of public awareness and incentives, have rendered plastic waste omnipresent, littering...
Mon Mar 02, 2020 02:00
Abstract Conventional wastewater treatments are not efficient in removing parabens, which may thus end up in surface waters, posing a threat to aquatic biota and human health. As an alternative treatment, persulfate (PS)-driven advanced oxidation technologies have gained growing attention for removing these pollutants. In this study, the degradation of propylparaben (PrP) by UVA- and zero-valent iron (ZVI)-activated persulfate was investigated. The effects of initial PS concentration...
Mon Mar 02, 2020 02:00
Abstract With the invasion of green tide, there were millions of tons of Enteromorpha prolifera (Enteromorpha) that need to be disposed of. An efficient microecological system for Enteromorpha fermentation was constructed using Saccharomyces cerevisiae (S. cerevisiae) and granular sludge at mesophilic condition (35 °C). In order to investigate the influence of S. cerevisiae dosage on fermentation, biomethane production and variations in dissolved organic matter (DOM) were investigated....
Mon Mar 02, 2020 02:00
Abstract BPA, one of the environmental endocrine disruptors, and fructose, reason of liver steatosis which is frequently encountered in the daily diet, contribute to the formation of metabolic syndrome (MetS). This study examines the possible effects of concurrent fructose and BPA administration on MetS and determines the effects of melatonin on this process. In the seven identified groups, a total of forty-two adult male Sprague Dawley rats were treated by following fructose,...
Mon Mar 02, 2020 02:00
Abstract Soil cadmium (Cd) pollution has received increasing attention from scholars. In the field of Cd pollution remediation, there is an urgent need to study the combined bioremediation technology of earthworms and microbes. In this paper, a short-term stress test and a long-term stress test were conducted. Eisenia fetida were inoculated into artificial soil that was contaminated with Cd. After different Cd stress times, the regulation process between the microbial communities...
Mon Mar 02, 2020 02:00
Abstract From November 2018 to March 2019, the mixing ratios of 57 types of volatile organic compounds (VOCs) were measured using gas chromatography–mass spectrometry in Shihezi. The results depicted that the average mixing ratios of VOCs were 58.48 ppbv and alkanes (34.15 ppbv) showed the largest contribution, followed by ethyne (20.16 ppbv), alkenes (2.62 ppbv), and aromatics (1.55 ppbv). Based on the positive matrix factorization (PMF) model result, coal burning (39.83%), traffic-related...
Mon Mar 02, 2020 02:00
Abstract Cadmium (Cd) is a highly harmful environmental contaminant, which can cause reproductive toxicity. Zinc (Zn) is an essential trance element that may protect the organism from the harmful effects of Cd. However, the mechanism of Zn against Cd-induced reproductive toxicity remained to be elucidated. The aim of this study was to assess the effects of subchronic exposure to Cd on the relative testis weight (RTW), the histopathology, the activity of stress marker antioxidant...
Mon Mar 02, 2020 02:00
Abstract Acetaldehyde is a toxic, mutagenic and carcinogenic metabolite of alcohol which can bind to proteins, DNA and several other cellular macromolecules. Chronic alcohol consumption increases intracellular acetaldehyde levels which enhances the generation of reactive oxygen and nitrogen species (ROS and RNS). In this study, we have examined the effect of acetaldehyde on human erythrocytes under in vitro conditions. Treatment of human erythrocytes with different concentrations...
Mon Mar 02, 2020 02:00
Abstract In this paper, we investigated the association between CO2 emissions, remittances, income, energy use, and foreign direct investment (FDI) through panel cointegration analysis, common correlated effect mean group (CCEMG), fully modified least squares (FM-LS) estimates, and panel causality test for the Brazil, Russia, India, China, and South Africa (BRICS) economies over 1986–2016. The empirical outcomes of CCEMG and FM-LS clarified that remittance inflows into BRICS region...
Mon Mar 02, 2020 02:00
Abstract Seafood is increasingly used worldwide due to its nutritional value. It is rich in essential minerals, liposoluble vitamins, and high-quality proteins. However, many seafood species tend to accumulate metals, making them a threat to human health. We chose Xincun Lagoon and Li-an Lagoon, which have been seriously polluted by local activities, and the relatively clean Tufu Bay as the research areas to investigate whether trace metals in economic seafood species in these...
Mon Mar 02, 2020 02:00
Abstract As a significant economic region in China, the Yangtze River Economic Zone has close spatial and sectoral linkages and generates considerable CO2 emissions. Reducing CO2 emissions in the Yangtze River Economic Zone (YREZ) while considering both inter-regional and inter-sectoral connections has become an essential issue. Based on a multi-regional input-output model and complex network theory, this study constructed a network with inter-regional and inter-sectoral CO2 emission...
Mon Mar 02, 2020 02:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου