Intestinal mucositis is a common side effect of chemotherapy leading to diarrhea, abdominal pain and increased risk of infections. The intestinal microbiota has been recognized as a key regulator of mucosal immune responses. Therefore, we hypothesized that intestinal microbial changes would be associated with enterocyte loss and systemic inflammation during induction treatment for childhood acute lymphoblastic leukemia (ALL). We prospectively included 51 children newly‐diagnosed with ALL treated...
Mon Mar 02, 2020 12:14
Abstract Background Elevated exposure to manganese (Mn) could induce cardiovascular dysfunction. However, limited research is available on the effects of occupational Mn exposure on myocardial enzymes. We aimed to evaluate the relationships between Mn exposure and myocardial enzyme elevation among Mn‐exposed workers. Methods Data were from a follow‐up investigation of a Mn‐exposed workers healthy cohort in 2017. A total of 744 workers were divided into low‐exposure and high‐exposure groups...
Sat Feb 29, 2020 13:29
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Sun Mar 01, 2020 02:00
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Sun Mar 01, 2020 02:00
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Sun Mar 01, 2020 02:00
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Sun Mar 01, 2020 02:00
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Sun Mar 01, 2020 02:00
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Sun Mar 01, 2020 02:00
Abstract Objectives Following the massive earthquake that struck eastern Japan on March 11, 2011, a large amount of radioactive material was released into the environment from the damaged reactor of the Fukushima Daiichi Nuclear Power Plant (FDNPP). After the FDNPP accident, radiocaesium was first detected in muscle samples from wild Japanese monkeys exposed to radioactive materials, and haematologic effects, changes in head size,...
Mon Mar 02, 2020 02:00
Abstract Objective The Zarit Burden Interview (ZBI) has been widely used to assess caregiver burden. Few research papers have investigated the Thai version of the ZBI. The study aimed to examine the psychometric properties of the Thai version of both the full length (ZBI-22) and short versions (ZBI-12) using Rasch analysis and confirmatory factor analysis among a sample of Alzheimer’s disease caregivers. ...
Mon Mar 02, 2020 02:00
The leading risk factor for death from the new Coronavirus is heart disease. Many people have a heart that cannot stand the stress of this infection. There is a lot you can do.
Mon Mar 02, 2020 23:44
What does it mean when things or people seems so special that they are not of this world?
Mon Mar 02, 2020 18:30
Experimental research shows nostalgia to be an overwhelmingly positive emotion. However, studies of nostalgia in everyday life show it to be more bitter than sweet.
Mon Mar 02, 2020 15:34
Have you turned your partner into a perpetrator? How to stop projecting and start getting real.
Sun Mar 01, 2020 18:03
Have you always felt different, but you've never sought a formal diagnosis? The emergent idea of neurodiversity may be the right fit for you.
Mon Mar 02, 2020 04:45
The image of the iceberg mind oversimplifies the nature of the mind and limits our views on changing behavior.
Sun Mar 01, 2020 18:13
Hookups serve many purposes for young people, research finds, whether or not a romantic relationship evolves.
Sat Feb 29, 2020 18:43
Entitlement and grandiosity may seem to be the key features of narcissism, but new research shows the value of expanding our thinking to include 5 facets.
Sat Feb 29, 2020 15:51
Worry behavior is an attempt to eliminate anxiety about uncertainty, but it actually feeds more anxiety. Learn how the worry process works and how to stop it.
Sat Feb 29, 2020 00:51
Most of us respond emotionally to music, but there are a few people who don't. Studies of their brains are providing clues to how we process social reward.
Fri Feb 28, 2020 17:08
In an era of self-help and individualism, learning how to ask for help is a valuable skill. Luckily, new research shows that it’s easier than you think.
Fri Feb 28, 2020 15:04
Abstract Background Fatty acids derived de novo or taken up from the extracellular space are an essential source of nutrient for cell growth and proliferation. Radiopharmaceuticals including 11C-acetate, and 18F-FAC (2-18F-fluoroacetate), have previously been used to study short-chain fatty acid (SCFA) metabolism. We developed 18F-fluoropivalate (18F-FPIA; 3-18F-fluoro-2,2-dimethylpropionic acid) bearing a gem-dimethyl substituent to...
Mon Mar 02, 2020 02:00
Mon Mar 02, 2020 02:00
Abstract Purpose To assess the impact of baseline liver tumour burden, alkaline phosphatase (ALP) elevation, and target lesion size on treatment outcomes with 177Lu-Dotatate. Methods In the phase 3 NETTER-1 trial, patients with advanced, progressive midgut neuroendocrine tumours (NET) were randomised to 177Lu-Dotatate (every 8 weeks, four cycles) plus...
Mon Mar 02, 2020 02:00
Abstract Purpose To evaluate the clinical benefit of positron emission tomography (PET)/computed tomography (CT) in patients with advanced melanoma, primarily not selected for surgery based on management changes and survival data using the linked evidence approach (LEA). Methods A total of 201 18F-FDG PET/CT examinations (n = 33, stage III and n = 168,...
Mon Mar 02, 2020 02:00
Description:In September 2019, the U.S. Department of Veterans Affairs (VA) and the U.S. Department of Defense (DoD) approved a new joint clinical practice guideline for assessing and managing patients with chronic insomnia disorder and obstructive sleep apnea (OSA). This guideline is intended to give health care teams a framework by which to screen, evaluate, treat, and manage the individual needs and preferences of VA and DoD patients with either of these conditions.Methods:In October 2017, the...
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Preventing firearm-related injury and death requires pragmatic, community-based solutions. The authors describe their initial experiences developing a statewide map of locations where firearms may be temporarily stored away from the home when needed for safety.
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Greeley and colleagues' systematic review highlighted the paucity of evidence on the effectiveness of sitters and alternatives to sitters in preventing falls among patients in acute care hospitals. The editorialist discusses the findings and argues that, for acute care hospitals to be truly effective at keeping patients safe from events, such as falls, we need to make the entire health system more age-friendly.
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