Background:Patients diagnosed with advanced HIV infection have a poor prognosis despite initiation of combined antiretroviral therapy (c-ART).Objective:To assess the benefit of adding maraviroc, an antiretroviral drug with immunologic effects, to standard c-ART for patients with advanced disease at HIV diagnosis.Design:Randomized controlled trial. (ClinicalTrials.gov: NCT01348308)Setting:Clinical sites in France (n = 25), Italy (n = 5), and Spain (n = 20).Participants:416 HIV-positive, antiretroviral-naive...
01:08
Fibromyalgia is characterized by chronic, widespread musculoskeletal pain and associated fatigue, sleep disturbances, and other cognitive and somatic symptoms. For many patients, these symptoms persist for years and lead to frequent health care use; for some, fibromyalgia and its symptoms can be debilitating. Although many treatments are available, management remains challenging. This article highlights the clinical features of fibromyalgia, discusses diagnostic criteria and their evolution, and...
01:08
Current evidence about nutrition and health is largely from observational studies. A reliance on observational studies may be justified given the many important hypotheses related to the health benefits and risks of foods, nutrients, and dietary patterns, and the cost and logistic challenges of carrying out long-term randomized controlled dietary intervention trials to test such hypotheses. This commentary argues that among the many limitations of observational nutrition studies, measurement error...
01:08
Delamater and colleagues projected the percentage of California schoolchildren with a vaccination exemption under 3 scenarios: California law as it has stood since the 2015 passage of Senate Bill 277, which permits medical but not personal belief exemptions; the law as amended by Senate Bill 276, an attempt to tighten the circumstances for medical exemptions; and a hypothetical world in which neither law was implemented. The editorialist discusses the findings and proposes 5 provisions that laws...
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Background:Triplex vaccine was developed to enhance cytomegalovirus (CMV)–specific T cells and prevent CMV reactivation early after hematopoietic stem cell transplant (HCT).Objective:To determine the safety and efficacy of Triplex.Design:First-in-patient, phase 2 trial. (ClinicalTrials.gov: NCT02506933)Setting:3 U.S. HCT centers.Participants:102 CMV-seropositive HCT recipients at high risk for CMV reactivation.Intervention:Intramuscular injections of Triplex or placebo were given on days 28 and 56...
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This article provides immunization recommendations from the Advisory Committee on Immunization Practices (ACIP) for adults aged 19 years or older. The ACIP-recommended use of each vaccine is determined after in-depth reviews of vaccine-related data, such as the epidemiology and burden of the vaccine-preventable disease, vaccine efficacy and effectiveness, vaccine safety, the quality of evidence, feasibility of program implementation, and economic analyses of immunization policy.
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Background:Bedside “sitters” are often used for patients at high risk for falls, but they are expensive and their effectiveness is unclear.Purpose:To review evidence about the effect of sitters and alternatives to sitters on patient falls in acute care hospitals.Data Sources:PubMed searches to 8 October 2019, other databases from inception to December 2018, citation searches on key articles, and a Google search (22 October 2019).Study Selection:English-language studies of any design that assessed...
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The high cost of many prescription drugs has renewed calls for policies to ensure that taxpayers' financial contributions to drug development are factored into price setting. The authors discuss lessons learned from a previous effort and how it may inform current discussions.
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ABSTRACT Introduction Spinal cord ischemia after cardiovascular interventions continues to be a devastating problem in modern surgery. The role of intraspinal vascular networks and anterior radiculomedullary arteries (ARMA) in preventing spinal cord ischemia is poorly understood. Materials and Methods Landrace pigs (n = 30, 35.1 ± 3.9 kg) underwent a lateral thoracotomy. Fluorescent microspheres were injected into the left atrium and a reference sample was aspirated from the descending...
01:06
ABSTRACT Introduction Intramedullary nailing is the surgical method of choice for the treatment of proximal femur or femoral shaft fractures. Implant manufacturers aim to design implants fitting for the broadest possible population segment. As complete morphological data sets of long bones are not widely available, anatomical collections of historical dry bone specimens may represent abundant additional sources of morphological 3D‐data for implant design, provided they are consistent with...
01:06
Abstract Primary cilia are centriole-derived sensory organelles that are present in most mammalian cells, including astrocytes and neurons. Evidence is emerging that astrocyte and neuronal primary cilia demonstrate a dichotomy in the mature mouse brain. However, it is unknown how astrocytic and neuronal primary cilia change their morphology and ciliary proteins when exposed to reactive insults including epilepsy and traumatic brain injury. We used a double transgenic mouse strain...
Mon Mar 02, 2020 02:00
Abstract Worldwide, open-ended questions that require short answers have been used in many exams in fields of science, such as the International Student Assessment Program (PISA), the International Science and Maths Trends Research (TIMSS). However, multiple-choice questions are used for many exams at the national level in Turkey, especially high school and university entrance exams. This study aims to develop an objective and useful automatic scoring model for open-ended questions...
Mon Mar 02, 2020 02:00
Kinesin‐1 and dynein/dynactin‐1 molecular motors are required for node‐like clustering. β2Nav is an initiator of node‐like cluster assembly. Node‐like clusters participate in mature node of Ranvier formation and myelin initiation guidance. Abstract In vertebrates, fast saltatory conduction along myelinated axons relies on the node of Ranvier. How nodes assemble on CNS neurons is not yet fully understood. We previously described that node‐like clusters can form prior to myelin deposition...
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Main Points Microglia showed region‐specific responses to LPS, and CD200 expression is tightly regulated in the midbrain. DA neurons were neurodegenerative in the SNpc of CD200−/− mice. CD200Fc alleviated the neuronal death induced by rAAV‐hSYN. Abstract Microglia are a specialized population of tissue macrophages in the mammalian brain. Microglial phenotype is tightly regulated by local environmental factors, although little is known about these factors and their region‐preferred...
Sun Mar 01, 2020 11:26
Schematic image for mitochondria interaction and Trkβ agonist treatment against prolonged cerebral hypoperfusion. Under normal conditions, astrocytes secrete mitochondria into oligodendrocyte linage cells to promote oligodendrocyte precursor cell (OPC) maturation. However, under prolonged cerebral hypoperfusion, mitochondria secretion from astrocytes decreased. As a result, white matter injury progressed due to reduced OPC maturation. Trkβ agonist treatment maintained A2‐like astrocytes even under...
Fri Feb 28, 2020 16:49
A part I've printed (on a Monoprice Maker Select V2, sliced with Cura) has a small peg on it, which is an unsupported overhanging section of the model. The first few layers of the peg end up a mess of PLA spaghetti. Here I've rotated the part to get a better shot, normally it would be printed on its side. I've done test prints that contain L-shaped overhangs and they worked ok, so I'm not sure what's broken about this one. One guess I have is that because the peg is relatively low to...
00:02
The object is supposed to be symmetrical, but it printed with a flat edge. Cura 4.5 even generated support material to make it round, but then it came out like this: I tried printing it in the pegs straight down orientation, which was fine except it adds a crazy amount of support material. So much it becomes hard to remove. How can I prevent Cura from flatting the edge? Or at least doing it much less than that. I seen a overhang setting at 51 is that related? The flat edge on the...
Mon Mar 02, 2020 15:47
A question to those who have a 3D printer. Have you ever needed a spare throat or a heater block? Do they ever break? I just bought some spare parts: heaters, thermistors, nozzles... However, I am not sure if buying throats and heater blocks make any sense.
Mon Mar 02, 2020 10:01
I have a Monoprice Maker Select V2 (Wanhao Duplicator i3) on which I've installed a recent version of Marlin. The home position is at the front-left of the build plate. At the end of the print, the print head returns to this position by moving the build plate back. Can I modify this to return the print head to the back-left corner, so that the print ends with the part more easily accessible? Here is the default G-code for this printer in Ultimaker Cura: M104 S0 ;extruder heater off ...
Sun Mar 01, 2020 18:54
My custom printer is affected by a strange problem. After 30/40 min printing without any problem, PLA starts blobbing from the top of the hotend. What does it means? Where to start checking? It is possible that there is a little space between nozzle screw and transition screw inside the hotend?
Sun Mar 01, 2020 16:30
What is the problem here? huhu. I'm using Cura 4.3, 100% infill but there are gaps in that part only (top part). My layer height is 0.12 and my nozzle size is 0.3. link https://drive.google.com/open?id=18Nyv3WcX2KxDNHqfuoGlUOjLjv7TS-S2
Sun Mar 01, 2020 15:23
I began build LCD printer and I want make some modifications. What if I will place LCD below VAT? Will the display break when printing? what are the risks? I seen a lot of printers and all of them use PP material for VAT bottom and attach with a lot of screws. I want make more simple VAT-LCD constructions and I think this construction transmis UV light better
Sat Feb 29, 2020 11:49
I've been noticing in some of my linear advance test towers that the (very minor/fine) ripple pattern in walls varies with the K factor, which made me think that it isn't coming from any vibration in the print head motion, but rather from quantization of the extruder into discrete steps (i.e. wall gets slightly thicker right after a step, thins out afterwards until the next step, repeats). By my math, with 1.75 mm filament and 93 steps per mm on my printer (Ender 3), each step is 0.02585 mm³ of...
Sat Feb 29, 2020 01:02
I made a custom printer with RAMPS. I used Y-MIN endstop at beginning. After few prints I discovered that Y-axis was inverted (mirrored). I fixed Marlin firmware and now I have: #define Y_MAX_ENDSTOP_INVERTING true #define INVERT_Y_DIR false #define Y_HOME_DIR 1 #define USE_YMAX_PLUG I also connected the Y-endstop to Y-max pin on RAMPS. Now the printer homing in the same direction than before (in front) and the y-endstop works as expected. If I try to start printing or if I try...
Fri Feb 28, 2020 21:32
If I set my prints on the window sill (indoors) will the sunlight still be able to cure the resin? The problem with setting them outside is the wind knocking them over.
Fri Feb 28, 2020 18:12
Hello guys I have a little problem with printing. Whenever I print something there are always these lines my printer does, it's not a very big deal, but it looks rather ugly and I'd really appreciate it if anyone could help me if you know what the problem is. I post also a picture to show you the problem clearer. From what I see (observing how my printer prints), I noticed that it starts printing at one point and then when it arrives again after a circle to the starting point to print the layer above,...
Fri Feb 28, 2020 14:30
COVID-19 is scary, but a cute Vietnamese music video breaks down the ways to keep ourselves, and the people around us, safe. (Trung tâm Thanh thiếu niên miền Nam - SYC/)Even if you’re the kind of person who avoids the news like the plague, it’s been hard to dodge the headlines discussing where, when, and what’s going on with COVID-19. But with cases now spreading across the US and much of the world, it’s even more important to follow those updates.It might be especially tricky to explain this stuff...
00:30
Make yours a double. (Blake Richard Verdoorn via Unsplash/)If you’re serious about drinking espresso at home and eschew a pod-based brew, a barista-level espresso machine with a milk steamer is a smart investment. Instead of being disappointed whenever your favorite barista is on vacation, enjoy your coffee exactly how you want it each day. You may not be able to multitask as you weigh your beans, tamp your grounds, or steam your latte, but that’s kind of the point of the art of coffee. Here are...
00:26
Crumpling leaves you vulnerable. ( Richard Dykes via Unsplash/)A paper shredder can help keep your personal and confidential information out of the hands of identity thieves and away from prying eyes. So much of our sensitive info, from bank account numbers to social security numbers, are printed on our mail, contracts and bills. Each time one of these ends up in the trash, we’re leaving ourselves vulnerable to identity theft. It’s super easy to avert this possibility by shredding documents and credit...
00:23
Reach all the way under the couch easily. (Depositphotos/)Long has the upright vacuum reigned supreme in homes and workplaces, popular for its motorized, belt-driven brushes that whisk dirt and debris out from between carpet fibers. Nowadays however there’s more variety in the vacuum market than ever before, and if you’re looking for something different than a traditional upright, we humbly submit canister vacuums as a compelling alternative. Among the subtle advantages afforded by a canister are...
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For toast however you want it. (Yue Iris via Unsplash/)We don’t appreciate our toasters enough. It’s such a ubiquitous appliance that you don’t understand how critical it is to your daily life until it breaks. Whether you’re interested in a model with a lot of extra bells and whistles, or you’re looking for something basic and reliable, your next toaster purchase should be quick and reliable. One cannot simply wait 10 minutes for one’s 6 a.m. peanut-butter english muffin.To get your search started,...
00:12
You are unlikely to catch COVID-19 from a toilet seat or from your dog. (Pixabay/)Where exactly the virus that causes COVID-19 came from is still something of a mystery. Experts believe that it jumped from an animal to people in the market in Wuhan, China where the outbreak began. But the exact animal species (some suspect it originated in bats, spread to pangolins, and then to people) hasn’t been determined yet.Now that the virus has spread to humans, however, scientists are racing to identify...
Mon Mar 02, 2020 22:30
That red dot is the enemy. Crush it. (Webaroo via Unsplash/)Emailing isn’t something you can easily get away from if you want to take part in 21st century life. But you definitely don’t want to spend too much time managing your inbox—there are far better and exciting ways to pass your time.If you dig a little deeper into that email app of yours, you'll discover quite a few features for streamlining your workflow, so you can spend less time sending and receiving messages and more time living your...
Mon Mar 02, 2020 21:44
What's the real story behind the mysterious lights over Rachel, Nevada? (Phil McDonald/Deposit Photos/)Reprinted with permission from They Are Already Here: UFO Culture and Why We See Saucers by Sarah Scoles. Published by Pegasus Books. © Sarah Scoles.Arnu arrives at the A’Le’Inn in a big SUV, pulling up and saying hi to the hungover twentysomethings rocking in rocking chairs out front before he greets us. “You ready?” he asks, and we pack into his Tahoe and head right back out on the Extraterrestrial...
Mon Mar 02, 2020 21:05
Once you've read this, you'll know how to print and frame your favorite photo. Getting that frame straight, though, is a whole other story. (Lefty Kasdaglis via Unsplash/)A good framed photo hanging on your wall is worth 50,000 shots sitting in the cloud doing nothing. They can remind you of your friends and family members, great times, and who you used to be in the good ol’ days, while digital photos just bit-rot away on a hard drive. But if you haven’t printed and framed a photo in a while—or ever—you...
Mon Mar 02, 2020 19:00
New machinery and medications are crucial to meeting healthcare demands. But should the burden of cost be on the consumer? (pixpoetry/Unsplash/)Michael Williams is an associate professor of surgery and director of the UVA Center for Health Policy at the University of Virginia. This story originally featured on The Conversation.$2.4 million. $1.5 million. $2.28 million. These are the amounts of money the health system where I work, teach, and get medical attention spent purchasing a PET scanner, a...
Mon Mar 02, 2020 18:32
Bernie Sanders is one of the most radical in thinking about climate change (Vidar Nordli-Mathisen/Unsplash/)This article has been updated to reflect which candidates are still in the race. Tomorrow, voters in 14 states will make their choice between the five Democratic presidential hopefuls: Joe Biden, Mike Bloomberg, Tulsi Gabbard, Bernie Sanders, or Elizabeth Warren. For environmentally-conscious citizens, choosing the right candidate is perhaps less than clear.All candidates firmly oppose the...
Mon Mar 02, 2020 20:58
Some people use bones as macabre decor, but they're good for so much more. (Artem Maltsev via Unsplash/)For February, we’re focusing on the body parts that shape us, oxygenate us, and power us as we take long walks on the beach. Bony bonafide bones. These skeletal building blocks inspire curiosity and spark fear in different folks—we hope our stories, covering everything from surgeries and supplements to good old-fashioned boning, will only do the first. Once you’ve thoroughly blasted your mind with...
Sun Mar 01, 2020 02:29
The death occurred somewhere in King County, Washington. (Pexels/)A version of this article was initially published on February 29. It has been updated.On Saturday Washington Health Department officials confirmed the country’s first death due to COVID-19, a disease caused by a novel strain of coronavirus thought to originate in Wuhan, China, in December 2019. The situation quickly escalated over the weekend, with a second death reported on Sunday and a new rash of confirmed cases thanks to increased...
Mon Mar 02, 2020 17:45
Bone marrow transplants might sound scary, but in some cases, it's just an amped up blood draw. (Photo by Allie Smith on Unsplash/)For February, we’re focusing on the body parts that shape us, oxygenate us, and power us as we take long walks on the beach. Bony bonafide bones. These skeletal building blocks inspire curiosity and spark fear in different folks—we hope our stories, covering everything from surgeries and supplements to good old-fashioned boning, will only do the first. Once you’ve thoroughly...
Sat Feb 29, 2020 18:00
Byrd has this smart keyboard with a trackpad up for pre-order now, but an official Apple model may be coming down the road. (Byrd /)The iPad has come a long way since its initial launch roughly a decade ago. It quickly outgrew early comparisons to being just “a big iPhone” and since then has been gaining popularity as a full-blown laptop replacement. Despite its popularity, it’s still oddly lacking in a few key spots. For instance, it just got mouse compatibility last year, and even then, that’s...
Sat Feb 29, 2020 12:00
Dyson lecturing at IAS. (Dan Komoda/Institute for Advanced Study, Princeton, NJ USA/)Theoretical physicist Freeman J. Dyson, known for his work across multiple scientific disciplines, passed away on February 28 in Princeton, NJ according to a press release put out by the Institute for Advanced Study. Born in 1923 in Crowthorne, Berkshire, England, Dyson did his undergraduate studies at Cambridge, taking a short break to work as a scientist for the Royal Air Force Bomber Command during World War II....
Fri Feb 28, 2020 22:47
It's good to have your supplies in one easy-to-find location. (milan degraeve via Unsplash/)Viruses love us. That’s a fact. Every year, run-of-the-mill respiratory diseases like the common cold and the flu infect millions of people, and once in a while, brand new afflictions like the coronavirus dubbed COVID-19 rise up and grab headlines worldwide. While the fatality rate for most of these illnesses is low, it doesn’t hurt to be prepared.“One should be aware of one’s surroundings, be aware of the...
Sat Feb 29, 2020 00:40
Access more. ( João Ferrão via Unsplash/)Gamers of a certain age will remember that you once had to buy a game console, and then you bought games for that console on cartridges (and then later on discs) which you manually inserted into the system (blowing on it first, to ensure it would function properly) and then played. When you were done playing, the console was switched off and wasn't needed again until the next gaming session.All that has changed, of course, with game consoles having evolved...
Fri Feb 28, 2020 21:51
Other ways to play. (Amazon/)Every once in a while, there comes along a spin on a classic tool that’s so innovative and off-the-wall that it can shift the entire way you work. In the world of music and art, that’s especially true—and a unique take on a musical instrument can move the bar on creativity and help artists break new ground in a big way. Keyboards have come a long way since the days of harpsichords and fortepianos, following popular music and expanding in functionality to control computers,...
Fri Feb 28, 2020 21:44
The best socks for all occasions. (Les Triconautes via Unsplash/)As Marie Kondo would say, your socks work hard for you—they spend all day in between your feet and shoes, getting bunched and twisted, while you walk and work. Buying socks may seem like a bore, but we should all respect the process that gets us this important accoutrement. Not looking to do a bunch of sock technology research? Don’t worry; we already did that for you. Below are some of our favorite socks out there.For flat feet and...
Fri Feb 28, 2020 21:41
Sauce it up. (Pille-Riin Priske via Unsplash/)Rice is a staple in kitchens around the world because it’s delicious, super easy to cook, and goes well with just about everything. Used in dishes ranging from sweet to savory, nearly 500 million tons of this mighty grain are consumed every year, accounting for one-fifth of all human caloric intake worldwide. For a quick and fuss-free companion to any entree, rice is the simple answer, and you don’t need to use your stove—a rice cooker ensures that you...
Fri Feb 28, 2020 21:31
Ancient mossy forests from millions of years ago created the planet's finite amount of fossil fuels. (Photo by Pascal Meier on Unsplash/)The following is an excerpt adapted from The Story of More by Hope Jahren.Once upon a time, there was a broad and fathomless ocean. Beneath the waves swirled the currents that flushed saltwater in magnificent gushes. Deep in the dense, cold darkness, the seafloor waited with perfect patience to embrace the corpse of every living thing aboveThis was called the Panthalassa...
Fri Feb 28, 2020 21:05
If you're sick, try to stay home. (Unsplash/)The CDC calling the spread of the novel coronavirus COVID-19 across the United States “inevitable” has understandably triggered a decent amount of anxiety. While COVID-19—which is thought to have originated in Wuhan, China back in December after jumping from an as-yet-unconfirmed animal host—has a troubling fatality rate of around 2 percent (based on current estimates), the vast majority of people who contract the virus experience only mild, cold-like...
Fri Feb 28, 2020 20:56
Delta demoed its Sarcos Guardian tech at CES this year. (Stan Horaczek /)Forklifts and remote-controlled robots are great for brute force power. They can easily lift 200-pound objects, but that strength typically comes at the cost of dexterity. Utah-based robotics company Sarcos, however, wants to put the humans inside the machines to handle the heavy lifting and the delicate details of industrial work all at once. The company showed off the alpha version of its Guardian XO exoskeleton earlier this...
Fri Feb 28, 2020 20:12
Strict rules exist around who can get screened for COVID-19. (CDC/)For the first time, a person in the United States has tested positive for the novel coronavirus that causes COVID-19 and officials aren’t sure how they caught the disease, the Centers for Disease Control confirmed on February 26.The sick person—a woman in Northern California—hadn’t recently traveled to China or any region hit by the outbreak nor had she had contact with another person known to be infected with the virus, which has...
Fri Feb 28, 2020 18:00
Commuting 30 miles each way to and from work becomes much more manageable aboard a Class 3 ebike. (Stephen Krcmar/)This story originally featured on Cycle Volta.Ever since my first job—as a paperboy—bikes and bike commuting have been a big part of my professional life. I took that first gig delivering newspapers because it was something I could do on my Mongoose. Since then, I’ve worked as a bike messenger in New York City, a test rider in Connecticut, and gear tester all over the country. I’ve also...
Fri Feb 28, 2020 17:42
Our months are made of lunar cycles, and we restart the year after the Earth has made one full rotation around the sun. But what happens when these cycles don’t sync up? (Deposit Photos/)Here’s a mind-bending thought: Time, if not measured, does not exist. People create calendars, with designated weeks and months, that sync to a variety of earthly and extraterrestrial cycles. The people of the Trobriand Islands in New Guinea, for example, used to start their year when a species of sea worms made...
Fri Feb 28, 2020 15:00
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