ConclusionsSRS and HSFRT are equally effective and safe for the treatment of BM, with no exceptions among different primary tumors. Disease control, surgery, age, and prognostic scales correlated with OS. However, the lack of survival benefit regarding WBRT might become logical evidence for its omission in a subset of patients. (Source: Clinical and Translational Oncology)
Mon Mar 02, 2020 00:00
ConclusionOur data suggest that ATR might serve as a potential prognostic marker in UM patients and could serve as a potential therapeutic target. (Source: Clinical and Translational Oncology)
Mon Mar 02, 2020 00:00
Having trouble viewing this email? View it as a Web page. A monthly update of NIDCR-supported science advances, as reported by grantee institutions and NIH. A Cancerous Conversation Oral tumor crosstalk transforms neurons into cancer enablers NIDCR • February 18, 2020 Secrets of Secretion Studies of fruit fly glands reveal intricacies...
Mon Mar 02, 2020 21:15
Hematology / Oncology News Burst (Source: FDA Center for Drug Evaluation and Research - What's New)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Mar 02, 2020 21:02
BACKGROUND Heparin-associated coagulation disorder is an important factor related to postoperative bleeding in patients undergoing cardiac surgery with cardiopulmonary bypass. Currently, the relationship between heparin sensitivity and postoperative bleeding is unknown. OBJECTIVE To investigate the relationship between individual heparin sensitivity and postoperative blood loss in patients undergoing cardiac surgery. DESIGN Prospective controlled study. SETTING Tertiary teaching...
Sun Mar 01, 2020 02:00
Abstract Background Fatty acids derived de novo or taken up from the extracellular space are an essential source of nutrient for cell growth and proliferation. Radiopharmaceuticals including 11C-acetate, and 18F-FAC (2-18F-fluoroacetate), have previously been used to study short-chain fatty acid (SCFA) metabolism. We developed 18F-fluoropivalate (18F-FPIA; 3-18F-fluoro-2,2-dimethylpropionic acid) bearing a gem-dimethyl substituent to...
Mon Mar 02, 2020 02:00
Mon Mar 02, 2020 02:00
Abstract Purpose To assess the impact of baseline liver tumour burden, alkaline phosphatase (ALP) elevation, and target lesion size on treatment outcomes with 177Lu-Dotatate. Methods In the phase 3 NETTER-1 trial, patients with advanced, progressive midgut neuroendocrine tumours (NET) were randomised to 177Lu-Dotatate (every 8 weeks, four cycles) plus...
Mon Mar 02, 2020 02:00
Abstract Purpose To evaluate the clinical benefit of positron emission tomography (PET)/computed tomography (CT) in patients with advanced melanoma, primarily not selected for surgery based on management changes and survival data using the linked evidence approach (LEA). Methods A total of 201 18F-FDG PET/CT examinations (n = 33, stage III and n = 168,...
Mon Mar 02, 2020 02:00
The approval of a BRAF-inhibitor for clinical use in BRAF-mutated metastatic melanoma patients in 2011 encouraged the scientific and medical communities that an increasingly more sophisticated mechanistic understanding of tumor progression will ultimately result in substantial improvements in clinical responses. Indeed, since that time many new drugs have significantly improved overall survival. However, it has become increasingly obvious that most tumors have an astounding ability to adapt to the...
Mon Mar 02, 2020 02:00
As an alternative to hair transplantation for lowering the overly high hairline, hairline-lowering/forehead-reduction surgery has several advantages, including unsurpassed density and immediate results. Appropriate candidates for this surgery must have a stable frontal hairline (thus excluding most men) and a fairly to very mobile scalp that will permit sufficient advancement to warrant this more “invasive” approach. The main objective of this surgery is the lowering of the hairline. The authors’...
Mon Mar 02, 2020 02:00
Platelet-rich plasma (PRP) is a promising treatment for hair restoration in patients with androgenic alopecia. Created from a platelet concentrate from an autologous blood draw, PRP is a safe therapeutic option for patients with hair loss. It is used alone or in conjunction with topical and oral therapies. Most studies of hair restoration with PRP report positive outcomes. Further research to optimize PRP preparation/administration procedures and identify patient populations that benefit most from...
Mon Mar 02, 2020 02:00
Transforming growth factor beta 1 (TGF-β1) is a key morphogen in regenerative endodontics; yet, its location within the hard tissue phase of dentin and its availability in mature roots have not been fully elucidated.
Mon Mar 02, 2020 02:00
Limited studies have examined tissue formation via immunofluorescence in regenerative endodontic procedures (REPs) performed on infected human teeth. This report investigated the immunofluorescent histologic outcomes of REPs in which repeated canal disinfection was required.
Mon Mar 02, 2020 02:00
The aim of this study was to evaluate the volume of irrigant extrusion by different final agitation techniques in experimental models of immature teeth.
Mon Mar 02, 2020 02:00
Comparison of a Dental Operating Microscope and High-resolution Videoscope for Endodontic Procedures
The purpose of this study was to compare a dental operating microscope (DOM) with a high-resolution videoscope (VS) in terms of depth of field (DOF), resolution, and effect on fine motor skills.
Mon Mar 02, 2020 02:00
The purpose of this study was to evaluate the tooth structure theoretically required to be removed in the coronal and cervical regions to accomplish 3 different endodontic access preparations in a novel digital model. The deviation of the center of access cavity from the central fossa will also be measured and compared among the 3 endodontic cavity designs, which in turn may serve as suggested points of entry for different access openings.
Fri Feb 28, 2020 02:00
Background:Observational studies using traditional research designs suggest that influenza vaccination reduces hospitalizations and mortality among elderly persons. Accordingly, health authorities in some countries prioritize vaccination of this population. Nevertheless, questions remain about this policy's effectiveness given the potential for bias and confounding in observational data.Objective:To determine the effectiveness of the influenza vaccine in reducing hospitalizations and mortality among...
00:49
In the setting of emerging infections, such as COVID-19, this commentary argues that all members of the health care team need training on how to integrate key epidemiologic information, such as travel history, into their risk assessments in the same way they are trained to ask about tobacco exposure to assess cancer and heart disease risk.
00:49
Background:Cannabis use disorder (CUD) is a growing concern, and evidence-based data are needed to inform treatment options.Purpose:To review the benefits and risks of pharmacotherapies for the treatment of CUD.Data Sources:MEDLINE, PsycINFO, Cochrane Database of Systematic Reviews, and clinical trial registries from inception through September 2019.Study Selection:Pharmacotherapy trials of adults or adolescents with CUD that targeted cannabis abstinence or reduction, treatment retention, withdrawal...
00:49
The study was conducted with the aim to assess the psychometric measures of an adapted Arabic version of the Epworth Sleepiness Scale (ESS) among medical students at Sana’a University, Yemen. The cross-sectional study targeted 360 students (males: 176; females: 184) from the preclinical 3rd year (: 197) and the final clinical year (: 163). Participants self-filled an Arabic and slightly modified version of the 8-item Epworth Sleepiness Scale. Exploratory Principal Component Analysis (PCA) and Confirmatory...
Mon Mar 02, 2020 17:50
The Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) trial, a multicenter randomized controlled trial, failed to demonstrate a benefit of renal artery stenting (RAS) over medical therapy in patients with renal artery stenosis and hypertension. However, there are patients for whom RAS is a consideration because of failure of medical therapy. Unfortunately, selection of patients for RAS is complicated by a lack of validated predictors of blood pressure (BP) response. A previous single-center...
Mon Mar 02, 2020 02:00
Different competencies and skills are required and obtained during medical specialization. However, whether these have an impact on procedural outcomes of carotid endarterectomy (CEA) or carotid artery stenting (CAS) is unclear. We assessed the reported association between operator specialization and procedural outcomes after CEA or CAS to determine whether CEA and CAS should be performed by specific specialties.
Mon Mar 02, 2020 02:00
Understanding modifiable risk factors to improve surgical outcomes is increasingly important in value-based health care. There is an established association between peripheral artery disease (PAD), diabetes, and limb loss, but less is known about expected outcomes after revascularization relative to the degree of glycemic control. The purpose of this study was to determine the association between hemoglobin A1c (HbA1c) management in diabetics and surgical outcomes after open infrainguinal bypass.
Mon Mar 02, 2020 02:00
In this review, we evaluate the short-term impact of different ballooning combinations on hemodynamic instability neurologic events, and mortality associated with carotid artery stenting.
Mon Mar 02, 2020 02:00
The aim of our study was to compare early and long-term results of open repair of patients with inflammatory abdominal aortic aneurysm (IAAA) with matched cohort of patients with abdominal aortic aneurysm (AAA).
Mon Mar 02, 2020 02:00
The problems with first-generation stent grafts for endovascular aneurysm repair are well known, but their long-term outcome remains to be established. The purpose of the study was to characterize the outcome of patients treated for abdominal aortic aneurysm (AAA) with a first-generation stent graft, Vanguard (Boston Scientific, Natick, Mass), in a single academic center with a follow-up of up to 20 years.
Mon Mar 02, 2020 02:00
Previous studies have identified significant gender discrepancies in grant funding, leadership positions, and publication impact in surgical subspecialties. We investigated whether these discrepancies were also present in academic vascular surgery.
Fri Feb 28, 2020 02:00
The aims of this investigation were to determine whether the daily dietary intake of nutrients by patients with peripheral artery disease (PAD) and intermittent claudication (IC) met recommended levels for adults older than 50 years and to determine whether meeting recommended levels of nutrients was associated with ankle-brachial index (ABI), inflammation, and ambulation of patients with PAD and IC.
Fri Feb 28, 2020 02:00
The aim of this retrospective cohort study was to investigate the outcome of rectus femoris muscle flaps (RFFs) for deep groin wound complications in vascular surgery patients and to compare the outcome with a cohort of sartorius muscle flaps (SMFs) because the RFF is a promising alternative technique for groin coverage.
Fri Feb 28, 2020 02:00
These dos and don’ts are intended as a style guide for prospective publications in the British Journal of Oral and Maxillofacial Surgery (BJOMS). All manuscripts submitted for possible publication in BJOMS will be subject to a technical review and, in most cases, a statistical review as well before publication. This guide is intended to facilitate the editorial and proofreading process as much as possible for authors to avoid unnecessary delays and revisions, thereby ensuring that the manuscript...
Mon Mar 02, 2020 02:00
We present a modified wafer for mandibular orthognathic surgery in a partially edentulous 49-year-old woman. To the best of our knowledge, this technique has not been reported previously, and it was effective with an operating time that was comparable to similar operations in dentate patients.
Mon Mar 02, 2020 02:00
Trigeminal neuralgia is one of the most common of the neuropathic pains, and it can seriously influence patients’ quality of life. Calcitonin gene-related peptide (CGRP) is a type of nociceptive neurotransmitter that is expressed in neurons of the trigeminal ganglion and plays a major part in transmitting pain. The rat model of trigeminal neuralgia was established by causing a chronic constriction injury of the infraorbital nerve (CCI-ION). Male Sprague-Dawley rats (n=24) were randomly divided into...
Mon Mar 02, 2020 02:00
As clearly stated in the introduction to our paper: “A review of those that are emerging at present shows that these elements vary, and it is important that both surgeons and patients understand this when deciding on the best system to use. The goal of this review therefore was to catalogue these important elements for the emerging devices as they currently exist.”1 One of the major points made was that for most of the devices cited there was a lack of embodiment, manufacturing, laboratory testing,...
Sun Mar 01, 2020 02:00
Nasal prostheses can be retained mechanically, by adhesion, or surgically by implants. Implant-retained prostheses are reported to improve quality of life and patients prefer them to adhesive ones.1 To obtain stability for a nasal prosthesis, a minimum of two to three strategically-positioned implants are required. The implant location depends on several factors, including thickness of bone or previous radiation to the site.2
Sat Feb 29, 2020 02:00
The aim of this study was to examine the need for sedation in women who had or had not had a previous unpleasant dental experience, and to assess possible contributory factors. The sample size required was estimated at 312 subjects. Healthy women listed for the surgical removal of third molars were asked to complete a questionnaire regarding their health, clinical and personal experience, past dental experience, result of the Indicator of Sedation Need (IOSN) scale, and of the Spielberger’s State-Trait...
Sat Feb 29, 2020 02:00
Our aim was to investigate the bone thickness at the site of titanium miniplates inserted to retain nasal prostheses. We studied 13 patients who had had titanium miniplates inserted for retention of nasal prostheses with a total of 60 titanium bone screws. A trajectory along each bone screw was segmented in fused computed tomographic (CT) data. Bone thickness was measured along this trajectory on the preoperative CT. The median bone thickness at the positions of the screws implanted on the frontal...
Fri Feb 28, 2020 02:00
We have investigated the effect of photobiomodulation on the recovery of neurosensory function of the lip and chin after bilateral sagittal split osteotomy (BSSO). Laser irradiation was applied with a GaAs diode laser (continuous wave 980nm wavelength, power 100mW, and energy density 12J/cm2). It was maintained within a 0.5cm2 area in a total of 12 points for 60seconds at each visit on each point. Unilateral extraoral contact photobiomodulation treatment was applied the day before operation and then...
Fri Feb 28, 2020 02:00
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