Clinical psychologist details one big mistake parents make Yahoo Money
Mon Mar 02, 2020 22:09
Abstract To compare the effects of balafilcon A and samfilcon A silicone hydrogel bandage contact lenses on postoperative pain control and epithelial healing time after photorefractive keratectomy (PRK). Seventy-four eyes of 37 patients who underwent bilateral PRK were included in this randomized clinical trial study. In the end of the surgery, a balafilcon A lens was used in one eye and a samfilcon A lens was used in the fellow eye randomly. Pain, blurred vision, epiphora, photophobia,...
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As cliché as it sounds, it’s never too late to better your life. And Joan MacDonald from Ontario, Canada is the perfect example of that. After doctors told the 73-year-old woman that she’ll have to up her medication dosages if she continues with her lifestyle, Joan decided to take matters into her own hands. In just a few years, she went from weighing almost 200 pounds to flexing on fitness magazine covers. More info: Instagram | YouTube View this...
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Abstract Pancreatic cancer is a highly lethal disease with a poor prognosis, and existing therapies offer only limited effectiveness. Mutation gene sequencing has shown several gene associations that may account for its carcinogenesis, revealing a promising research direction. Poly (ADP-ribose) polymerase (PARP) inhibitors target tumor cells with a homologous recombination repair (HRR) deficiency based on the concept of synthetic lethality. The most prominent target gene is...
Mon Mar 02, 2020 02:00
Abstract Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatment and prognosis of pancreatic cancer. Affected by internal or external factors, pancreatic cancer cells adopt extensively distinct metabolic processes to meet their demand for growth. Rewired glucose, amino acid and lipid metabolism and metabolic crosstalk within...
Mon Mar 02, 2020 02:00
Abstract As the standard treatments for cancer, chemotherapy and radiotherapy have been widely applied to clinical practice worldwide. However, the resistance to cancer therapies is a major challenge in clinics and scientific research, resulting in tumor recurrence and metastasis. The mechanisms of therapy resistance are complicated and result from multiple factors. Among them, non-coding RNAs (ncRNAs), along with their modifiers, have been investigated to play key roles in...
Mon Mar 02, 2020 02:00
Abstract It is well acknowledged that immune system is deeply involved in cancer initiation and progression, and can exert both pro-tumorigenic and anti-tumorigenic effects, depending on specific microenvironment. With the better understanding of cancer-associated immune cells, especially T cells, immunotherapy was developed and applied in multiple cancers and exhibits remarkable efficacy. However, currently only a subset of patients have responses to immunotherapy, suggesting...
Mon Mar 02, 2020 02:00
Abstract Background N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is very limited. We designed this study to investigate the role of m6A in CRC. Methods Expression level of METTL14 was extracted from public database and tissue array to investigate...
Fri Feb 28, 2020 02:00
Abstract Background Circular RNA (circRNA) has been proven to play a significant role in multiple types of cancer. However, the expression and role of circRNAs in epithelial ovarian cancer (EOC) remains elusive. Methods CircRNA and mRNA expression profiles of EOC were screened with sequencing analysis. Gene silencing and over-expression were...
Fri Feb 28, 2020 02:00
Abstract Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcinogenesis. Analogous to DNA and core histone proteins, reversible chemical modifications on mRNA have recently been recognized as important regulatory mechanisms to control...
Fri Feb 28, 2020 02:00
Abstract Alcohol Use Disorder (AUD) is a chronic relapsing condition characterized by excessive alcohol consumption despite its multifaceted adverse consequences, associated with impaired performance in several cognitive domains including decision-making. While choice deficits represent a core component of addictive behavior, possibly consecutive to brain changes preceding the onset of the addiction cycle, the evidence on grey-matter and white-matter damage underlying abnormal...
Mon Mar 02, 2020 02:00
Abstract Convergent findings indicate that cannabis use and variation in the cannabinoid CB1 receptor coding gene (CNR1) modulate prefrontal function during working memory (WM). Other results also suggest that cannabis modifies the physiological relationship between genetically induced expression of CNR1 and prefrontal WM processing. However, it is possible that cannabis exerts its modifying effect on prefrontal physiology by interacting with complex molecular ensembles co-regulated...
Mon Mar 02, 2020 02:00
Abstract Functional connectivity (FC) is typically altered in individuals with Multiple Sclerosis (MS). However, in relapsing-remitting multiple sclerosis (RRMS) patients, the relationship between brain FC, tissue integrity and cognitive impairment is still unclear as contradictory findings have been documented. In this exploratory study we compared both the whole brain connectome and resting state networks (RSNs) FC of twenty-one RRMS and seventeen healthy controls (HCs), using...
Sat Feb 29, 2020 02:00
Abstract Objectives This study was established to investigate whether the chemokines CXCL1, CCL2, and CCL5 are produced in periodontal cells and tissues and, if so, whether their levels are regulated by microbial and/or mechanical signals. Materials and methods The chemokine expression and protein levels in gingival biopsies from patients with and without...
Mon Mar 02, 2020 02:00
Abstract Objectives The main objective of this study was to assess changes in the position of the gingival margin (GM) after performing an aesthetic crown lengthening (ACLP) by means of submarginal incisions, buccal osseous surgery, and a replaced flap after a healing period of 6 months. Methods Twenty-one patients who needed a surgical crown lengthening...
Mon Mar 02, 2020 02:00
Abstract Backgrounds Imatinib-up-regulated lncRNA (lncRNA-IUR) is a recently identified tumor suppressor, while its role in ESCC is unknown. This study aimed to investigate the role of lncRNA-IUR in esophageal squamous cell carcinoma (ESCC). Methods Between April 2011 and April 2014, the Second Hospital of Jilin University admitted a total of 98 ESCC patients,...
Mon Mar 02, 2020 02:00
Pathogens, Vol. 9, Pages 179: Aggregatibacter, A Low Abundance Pathobiont That Influences Biogeography, Microbial Dysbiosis, and Host Defense Capabilities in Periodontitis: The History of A Bug, And Localization of Disease Pathogens doi: 10.3390/pathogens9030179 Authors: Fine Schreiner Velusamy Aggregatibacter actinomycetemcomitans, the focus of this review, was initially proposed as a microbe directly related to a phenotypically distinct form of periodontitis called localized...
Mon Mar 02, 2020 02:00
Pathogens, Vol. 9, Pages 180: Immune Phenotype and Functionality of Mtb-Specific T-Cells in HIV/TB Co-Infected Patients on Antiretroviral Treatment Pathogens doi: 10.3390/pathogens9030180 Authors: Mupfumi Mpande Reid Moyo Shin Zetola Mogashoa Musonda Kasvosve Scriba Nemes Gaseitsiwe The performance of host blood-based biomarkers for tuberculosis (TB) in HIV-infected patients on antiretroviral therapy (ART) has not been fully assessed. We evaluated...
Mon Mar 02, 2020 02:00
Pathogens, Vol. 9, Pages 176: Upscaling the Surveillance of Tick-borne Pathogens in the French Caribbean Islands Pathogens doi: 10.3390/pathogens9030176 Authors: Gondard Delannoy Pinarello Aprelon Devillers Galon Pradel Vayssier-Taussat Albina Moutailler Despite the high burden of vector-borne disease in (sub)tropical areas, few information are available regarding the diversity of tick and tick-borne pathogens circulating in the Caribbean. Management...
Sun Mar 01, 2020 02:00
Pathogens, Vol. 9, Pages 178: JP2 Genotype of Aggregatibacter actinomycetemcomitans in Caucasian Patients: A Presentation of Two Cases Pathogens doi: 10.3390/pathogens9030178 Authors: Stähli Sculean Eick Aggregatibacter actinomycetemcomitans is a key pathogen that has been associated with periodontal disease. Its most important virulence factor is a leukotoxin capable of inactivating immune cells. The JP2 genotype of Aggregatibacter actinomycetemcomitans shows enhanced leukotoxic...
Sun Mar 01, 2020 02:00
Pathogens, Vol. 9, Pages 177: In Memoriam: Edward “Ned” Lally Pathogens doi: 10.3390/pathogens9030177 Authors: Balashova On February 11, 2019, we lost a colleague and friend Dr. Edward “Ned” Lally. [...]
Sun Mar 01, 2020 02:00
Pathogens, Vol. 9, Pages 175: Three-Locus Sequence Identification and Differential Tebuconazole Sensitivity Suggest Novel Fusarium equiseti Haplotype from Trinidad Pathogens doi: 10.3390/pathogens9030175 Authors: Ria T. Villafana Sephra N. Rampersad The Fusarium incarnatum-equiseti species complex (FIESC) consists of 33 phylogenetic species according to multi-locus sequence typing (MLST) and Genealogical Concordance Phylogenetic Species Recognition (GCPSR). A multi-locus dataset consisting...
Sun Mar 01, 2020 02:00
Pathogens, Vol. 9, Pages 174: Examining the Effect of Host Recruitment Rates on the Transmission of Streptococcus suis in Nursery Swine Populations Pathogens doi: 10.3390/pathogens9030174 Authors: Giang Hetman Sargeant Poljak Greer Streptococcus suis is a swine pathogen that is capable of causing severe outbreaks of disease in the nursery. Demographic parameters such as host recruitment rates can have profound effects on the transmission dynamics of infectious diseases...
Sun Mar 01, 2020 02:00
Pathogens, Vol. 9, Pages 173: Myrrh Oil in Vitro Inhibitory Growth on Bovine and Equine Piroplasm Parasites and Babesia microti of Mice Pathogens doi: 10.3390/pathogens9030173 Authors: AbouLaila El-Sayed Omar Al-Aboody Aziz Abdel-Daim Rizk Igarashi The present experimental study was conducted for the assessment of the efficacy of in vitro inhibition of myrrh oil on the propagation of Babesia bovis, B. divergens, B. bigemina, Theileria equi, and B. caballi...
Sat Feb 29, 2020 02:00
Pathogens, Vol. 9, Pages 172: Isolation and Characterization of Root-Associated Bacterial Endophytes and Their Biocontrol Potential against Major Fungal Phytopathogens of Rice (Oryza sativa L.) Pathogens doi: 10.3390/pathogens9030172 Authors: Khaskheli Wu Chen Chen Hussain Song Liu Feng Rice (Oryza sativa L.) is a major cereal food crop worldwide, and its growth and yield are affected by several fungal phytopathogens, including Magnaporthe oryzae, Fusarium...
Fri Feb 28, 2020 02:00
Pathogens, Vol. 9, Pages 168: No Experimental Evidence of Co-Feeding Transmission of African Swine Fever Virus between Ornithodoros Soft Ticks Pathogens doi: 10.3390/pathogens9030168 Authors: De Oliveira Hutet Duhayon Paboeuf Le Potier Vial Ornithodoros soft ticks are the only known vector and reservoir of the African swine fever virus, a major lethal infectious disease of Suidae. The co-feeding event for virus transmission and maintenance among soft tick populations...
Fri Feb 28, 2020 02:00
Pathogens, Vol. 9, Pages 171: Adenovirus-vectored African Swine Fever Virus Antigens Cocktail Is Not Protective against Virulent Arm07 Isolate in Eurasian Wild Boar Pathogens doi: 10.3390/pathogens9030171 Authors: Cadenas-Fernández Sánchez-Vizcaíno Kosowska Rivera Mayoral-Alegre Rodríguez-Bertos Yao Bray Lokhandwala Mwangi Barasona : African swine fever (ASF) is a viral disease of domestic and wild suids for which there is currently no vaccine...
Fri Feb 28, 2020 02:00
Pathogens, Vol. 9, Pages 169: Pathogenicity and Genetic Characterization of Vietnamese Classical Swine Fever Virus: 2014–2018 Pathogens doi: 10.3390/pathogens9030169 Authors: Choe Le Shin Kim Kim Song Cha Park Nguyen Hyun Park An Here, we examined the pathogenicity and genetic differences between classical swine fever viruses (CSFV) isolated on pig farms in North Vietnam from 2014–2018. Twenty CSFV strains from 16 pig farms were...
Fri Feb 28, 2020 02:00
Pathogens, Vol. 9, Pages 167: The Carrier Conundrum; A Review of Recent Advances and Persistent Gaps Regarding the Carrier State of Foot-and-Mouth Disease Virus Pathogens doi: 10.3390/pathogens9030167 Authors: Stenfeldt Arzt The existence of a prolonged, subclinical phase of foot-and-mouth disease virus (FMDV) infection in cattle was first recognized in the 1950s. Since then, the FMDV carrier state has been a subject of controversy amongst scientists and policymakers. A fundamental...
Fri Feb 28, 2020 02:00
Pathogens, Vol. 9, Pages 170: Phosphite Application Alleviates Pythophthora infestans by Modulation of Photosynthetic and Physio-Biochemical Metabolites in Potato Leaves Pathogens doi: 10.3390/pathogens9030170 Authors: Mohammadi Han Zhang Xi Boorboori Wang-Pruski Potato late blight (Phytophtora infestans) is among the most severely damaging diseases of potato (Solanum tuberusom L.) worldwide, causing serious damages in potato leaves and tubers. In the present study,...
Fri Feb 28, 2020 02:00
Pathogens, Vol. 9, Pages 166: MmpS5-MmpL5 Transporters Provide Mycobacterium smegmatis Resistance to imidazo[1,2-b][1,2,4,5]tetrazines Pathogens doi: 10.3390/pathogens9030166 Authors: Maslov Shur Vatlin Danilenko The emergence and spread of drug-resistant Mycobacterium tuberculosis strains (including MDR, XDR, and TDR) force scientists worldwide to search for new anti-tuberculosis drugs. We have previously reported a number of imidazo[1,2-b][1,2,4,5]tetrazines –...
Fri Feb 28, 2020 02:00
Environmental Science & Technology LettersDOI: 10.1021/acs.estlett.0c00068
Mon Mar 02, 2020 07:00
Environmental Science & Technology LettersDOI: 10.1021/acs.estlett.0c00019
Fri Feb 28, 2020 07:00
New British Society of Gastroenterology/UK-PSC guidelines have recently discussed the current state-of-the-art on primary sclerosing cholangitis and outlined key elements for the management of this disease. The current lack of effective pharmacological treatments to prevent progression of liver fibrosis to cirrhosis limits our ability to modify the natural history of the disease. However, a personalised approach and structured follow-up could allow earlier diagnosis and management of complications...
Mon Mar 02, 2020 19:00
GoalsOur study aims to define success and complication rates of precut sphincterotomy with the needle-knife and transpancreatic papillary septotomy (TPS) techniques as experienced at a single, high-volume endoscopy centre.BackgroundComplication rates rise with increasing number of failed attempts at biliary cannulation; therefore, early precut sphincterotomy (PS) has been recommended. Selecting the ideal method for PS can be challenging and there is a paucity of data to help guide this decision.StudyWe...
Mon Mar 02, 2020 19:00
ObjectiveRefractory ascites is an established indication for liver transplantation. While transplantation is regarded as the definitive therapy for this condition, many patients are unsuitable due to comorbidity or frailty. Alternatives such as transjugular intrahepatic portosystemic shunt (TIPSS) and large-volume paracentesis can lead to complications, including encephalopathy, circulatory and renal dysfunction, and protein–calorie deficiency that may accelerate sarcopenia. Cost and complication...
Fri Feb 28, 2020 19:00
Abstract The purpose of this study is to investigate the correlation between single-nucleotide polymorphism (SNP) at the 3' end of the untranslated region (UTR) of Sirtuin 2 (SIRT2) gene and the risk of developing Alzheimer’s disease (AD), and to explore its underlying mechanisms. In total, 260 patients with AD and 260 healthy controls were recruited in this study. The genotype of rs2015 and rs2241703 loci of the SIRT2 gene was analyzed by Sanger sequencing for all participants....
Mon Mar 02, 2020 02:00
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