Publication date: Available online 2 March 2020Source: Clinical ImmunologyAuthor(s): S.J. Donohue, A. Midgley, J.C. Davies, R.D. Wright, I. Bruce, M.W. Beresford, C.M. Hedrich, on behalf of the MRC MASTERPLANS Consortium, the UK jSLE Cohort Study and Repository
Mon Mar 02, 2020 19:48
Publication date: Available online 29 February 2020Source: Clinical ImmunologyAuthor(s): Bin Chu, Li Bao, Yutong Wang, Minqiu Lu, Lei Shi, Shan Gao, Lijuan Fang, Qiuqing Xiang, Xi Liu
Sat Feb 29, 2020 18:22
Abstract Introduction HyQvia (Immune Globulin Infusion 10% [Human] with Recombinant Human Hyaluronidase) was developed to combine the advantages of intravenous and subcutaneous immune globulin (SCIG), allowing administration of larger volumes at a single subcutaneous site with less frequent dosing when compared to other SCIG products. Current US prescribing guidelines for HyQvia are limited to adults and do not encompass the flexibility...
Mon Mar 02, 2020 02:00
Abstract Introduction The CIMZIA® AutoClicks® pre-filled pen (CZP PFP) was developed to overcome barriers to self-injection, by improving self-injection confidence, reducing fear associated with needle use, and supporting patients with impaired dexterity. The purpose of this research was to gather feedback on injection experience and the usefulness of training materials. ...
Mon Mar 02, 2020 02:00
Abstract Introduction Prostate cancer (PC) is the second leading cause of cancer death among US men and accounts for considerable healthcare expenditures. We evaluated economic outcomes in men with chemotherapy-naïve metastatic castration-resistant PC (mCRPC) treated with enzalutamide or abiraterone acetate plus prednisone (abiraterone). Methods We performed...
Fri Feb 28, 2020 02:00
Abstract Introduction Pharmacotherapy is a mainstay of treatment for lower limb chronic venous disease (CVD) and its complications. However, therapeutic agents with evidence-based efficacy for the treatment of CVD are limited. Sulodexide (registered as Vessel Due F in Russia) has confirmed therapeutic efficacy in patients with moderately severe or late-stage CVD, but real-world evidence of its use in Russian patients with initial manifestations...
Fri Feb 28, 2020 02:00
Publication date: Available online 2 March 2020Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Fereshteh Sharifi, Shiva Irani, Golrokh Azadegan, Mohamad Pezeshki-Modaress, Mojgan Zandi, Mahdi Saeed
Mon Mar 02, 2020 19:46
Publication date: Available online 2 March 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Siyi He, Mohamed Taha Moutaoufik, Saadul Islam, Amit Persad, Adam Wu, Khaled A. Aly, Humphrey Fonge, Mohan Babu, Francisco S. Cayabyab
Mon Mar 02, 2020 19:46
Publication date: Available online 28 February 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Karlijn van Loon, Julia Yemelyanenko-Lyalenko, Coert Margadant, Arjan W. Griffioen, Elisabeth J.M. Huijbers
Fri Feb 28, 2020 15:43
Abstract Purpose This study aimed to assess the reliability of rectal villous tumors staging between rectal MRI and histological examination used as the Gold Standard and to investigate causes for discrepancies. Methods The rectal 1.5 T MR scans of 40 patients followed for a histologically proven rectal villous adenoma were retrospectively included. Two independent...
Mon Mar 02, 2020 02:00
In this installment of Your Unicorn Career, our columnist shares tips on how to create your very own board of directors
Mon Mar 02, 2020 18:35
Abstract This paper makes a phenomenological contribution to the distinction between personal and subpersonal types of explanation. I expound the little-known fact that Husserl gives an account of personal level explanation via his exposition of our capacity to express the understanding of another’s motivational nexus when we are in the personalistic attitude. I show that Husserl’s unique exposition of the motivational nexus conveys its concrete, internally coherent, and intentional...
Mon Mar 02, 2020 02:00
To investigate the clinical efficacy and mechanism of laparoscopic sleeve gastrectomy (LSG) in improving renal function in obese patients. LSG led to body weight loss and significantly improved serum creatinine, urea and urinary albumin:creatinine ratio values in patients with obesity, which may be related to changes in adipocytokines and inflammatory factors, post‐operatively. LSG is expected to become a new treatment to prevent or treat renal insufficiency caused by obesity. Abstract Background...
Mon Mar 02, 2020 19:37
Mon Mar 02, 2020 19:37
Ileorectal and ileosigmoid anastomoses are typically performed following total colectomy and subtotal colectomy, respectively. There is little focus in the literature on ileorectal and ileosigmoid anastomotic technique, despite these anastomoses having a relatively high complication rate. The purpose of the current study is to describe four standardized ileorectal or ileosigmoid anastomotic configurations, with commentary on specific challenges and theoretical advantages and disadvantages of each....
Mon Mar 02, 2020 19:37
There are almost no international data on the prevalence of arthroplasty in high‐income countries, where these operations are an important component of maintaining musculoskeletal health in older patients. These Australian data link arthroplasty operations with patient‐level data that are linked to the National Death Register and demonstrate that >800 000 Australians are living with at least one joint replacement, including >22% of all Australians aged over 85 years. Furthermore, we show striking...
Mon Mar 02, 2020 19:37
Obtaining exposure of the total mesorectal excision plane via a laparoscopic approach is technically challenging due to instrument limitations. Use of an articulating fan retractor is a relatively simple, cost‐effective and easily accessible instrument that allows the surgeon to gain improved retraction and exposure in what is an otherwise technically challenging dissection.
Mon Mar 02, 2020 19:37
When compared to staged bilateral total knee arthroplasty, simultaneous bilateral total knee arthroplasty patients had faster improvements in pain and function, shorter total acute hospital length of stay and lower health service costs. Abstract Background The advantages of simultaneous bilateral total knee arthroplasty (sim‐BTKA) remain controversial. This study investigated the effects of two‐surgeon sim‐BTKA compared to separate admission staged BTKA regarding intraoperative and post‐operative...
Fri Feb 28, 2020 16:47
This study analysed data from a well‐established and comprehensive peer review audit of surgical deaths in Australian hospitals from 2009 to 2015, focusing on urology cases with identified areas for improvement in patient management. Urological surgical cases with potentially avoidable mortality constitute a small, but important subset of deaths. The analysis of these cases can inform various stakeholders to improve the quality and safety of surgical care. Abstract Background This study...
Fri Feb 28, 2020 16:47
Investigation into the use of social media platforms by surgical training institutions in Australia and New Zealand. This study explores the use of social media, types of content posted, engagement with social media posts and perspectives towards use of social media for surgical education. Abstract Background Social media are an increasingly important tool for educators, although their use for surgical education in Australia and New Zealand (ANZ) has not been quantified. This study aimed...
Fri Feb 28, 2020 16:47
Abstract Although data sharing is one of the primary measures proposed to improve the integrity and quality of published research, studies show it remains the exception not the rule. The current study examines the availability of data in papers reporting the results of analyses of empirical data from original research in high-impact addiction journals. Thirteen high-impact journals with data sharing policies were selected from those included in the substance abuse category of the...
Mon Mar 02, 2020 02:00
Publication date: Available online 2 March 2020Source: Acta HistochemicaAuthor(s): Denis Matrov, Sophie Imbeault, Margus Kanarik, Marianna Shkolnaya, Patricia Schikorra, Ergo Miljan, Ruth Shimmo, Jaanus Harro
Mon Mar 02, 2020 19:35
Publication date: Available online 27 February 2020Source: Acta HistochemicaAuthor(s): Irene Rosa, Mirca Marini, Eleonora Sgambati, Lidia Ibba-Manneschi, Mirko Manetti
Fri Feb 28, 2020 17:44
BackgroundThe idea that individuals are responsible for their health has been the focus of debate in the theoretical literature and in its concrete application to healthcare policy in many countries. Controversies persist regarding the form, substance and fairness of allocating health responsibility to the individual, particularly in universal, need-based healthcare systems.ObjectiveTo examine how personal health responsibility has been framed and rationalised in Norwegian key policy documents on...
Mon Mar 02, 2020 19:00
Abstract Background Internationally, patient access to notes is increasing. This has been driven by respect for patient autonomy, often recognised as a primary tenet of medical ethics: patients should be able to access their records to be fully engaged with their care. While research has been conducted on the impact of patient access to outpatient and primary care records and to patient portals, there is no such review looking at...
Mon Mar 02, 2020 02:00
The fractional telegraph equation is a kind of important evolution equation, which has an important application in signal analysis such as transmission and propagation of electrical signals. However, it is difficult to obtain the corresponding analytical solution, so it is of great practical value to study the numerical solution. In this paper, the alternating segment pure explicit-implicit (PASE-I) and implicit-explicit (PASI-E) parallel difference schemes are constructed for time fractional telegraph...
Mon Mar 02, 2020 16:50
Periodic solutions of the Coulomb equation motion for three equal negative point charges in the field of six equal positive point charges fixed in vertices of a convex octagon are found. The system possesses an equilibrium configuration. The Lyapunov center theorem is applied.
Fri Feb 28, 2020 18:50
Publication date: March 2020Source: Free Radical Biology and Medicine, Volume 149Author(s):
Mon Mar 02, 2020 19:30
Publication date: Available online 1 March 2020Source: Free Radical Biology and MedicineAuthor(s): Andreas Daiber, Stefan Chlopicki
Mon Mar 02, 2020 19:30
Publication date: Available online 1 March 2020Source: Free Radical Biology and MedicineAuthor(s): Yunen Liu, Changci Tong, Yushan Tang, Peifang Cong, Ying Liu, Xiuyun Shi, Lin Shi, Yan Zhao, Hongxu Jin, Jing Li, Mingxiao Hou
Mon Mar 02, 2020 19:30
Publication date: Available online 1 March 2020Source: Free Radical Biology and MedicineAuthor(s): Tony Y. Momma, Javier I. Ottaviani
Sun Mar 01, 2020 17:30
Publication date: Available online 28 February 2020Source: Free Radical Biology and MedicineAuthor(s): Alessandra Pecorelli, Carlo Cervellati, Valeria Cordone, Joussef Hayek, Giuseppe Valacchi
Sat Feb 29, 2020 13:41
Source: Yahoo News - ScienceAn official at the Interior Department embarked on a campaign that has inserted misleading language about climate change—including debunked claims that increased carbon dioxide in the atmosphere is beneficial—into the agency's scientific reports, according to documents reviewed by The New York Times.
Mon Mar 02, 2020 18:27
Source: Yahoo News - Top HeadlinesFor centuries, South Carolina's Charleston was the largest port of entry for the transatlantic slave trade. Now, a billionaire activist named Tom Steyer, is shaking up the state's Democratic primary by advocating slavery reparations for African Americans.
Sat Feb 29, 2020 11:42
Source: Yahoo News - Top HeadlinesThe University of California, Santa Cruz, issued termination letters on Friday to 54 graduate students who have been waging a months-long strike for a cost-of-living-adjustment amid soaring rents. The firings came as graduate students at the University of California, Davis, and University of California, Santa Barbara, began their own cost-of-living strikes in solidarity.
Sat Feb 29, 2020 11:41
Source: Reuters - US NewsWhen graduate student Haobo Zhang decided to design underwear specifically for transgender women, his ambition was more high-minded than simply turning in a project to complete his master's degree in fashion at the University of Delaware.
Sat Feb 29, 2020 11:41
Source: Yahoo News - BusinessWhen Patrick Donohue retired after a 20-year career in customer service at AT&T, he and his wife, Kay, didn't celebrate. Instead, they argued over which pension option was better: obtaining a large portion right away to free themselves from student debt, or scheduling small monthly payments. It’s a situation many U.S. retirees can relate to: people over 60 are the fastest-growing segment of the population with student loan debt.
Sat Feb 29, 2020 11:40
A 14-year-old girl was admitted to our institute with a history of intermittent bilateral ankle swelling, and moderate but progressively worsening pain which has lasted for 2 years.The patient’s history was unremarkable. She did not take medications and was not involved in any sports activity. She reported no fever, gastrointestinal symptoms, fatigue, weight loss, travels abroad or previous infections. She reported moderate pain at night, associated with a sense of heaviness, tightness and general...
Mon Mar 02, 2020 19:00
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