We have read with great interest the article by Jurmeister et al on NGS findings in lung cancer [1]. One of the new findings was that of c-MYC gene abnormalities in most of the studied colloid carcinomas. We had the opportunity to detect c-Myc protein expression in this rare type of lung carcinoma on immunohistochemistry (Fig. 1). The staining intensity was moderate to strong, in more than 50% of the tumor cells. Tumor cells also expressed heterogeneously TTF1, cytokeratin CK20, CK7, CK5/6, CDX2...
Mon Mar 02, 2020 00:00
US public health watchdogs have been failing for years in their legal duty to inform the public about the results of clinical trials, a federal court has found.The US district court for southern New...
Mon Mar 02, 2020 17:11
A senior employee of the US Department of Health and Human Services has filed a whistleblower complaint alleging that untrained staff were sent without proper protective equipment to meet the first...
Mon Mar 02, 2020 17:01
Recently retired doctors may be asked to return to work as part of the UK’s covid-19 response, according to health secretary Matt Hancock.Speaking on The Andrew Marr Show on 1 March, Hancock said...
Mon Mar 02, 2020 16:31
Canada’s government has tabled new legislation that would remove some of the restrictions placed on medical aid in dying, most notably the requirement that applicants suffer from a terminal condition...
Mon Mar 02, 2020 15:16
Two days of talks in Glasgow have shown that UK politicians are as far apart as ever in developing a shared approach to tackling record numbers of drug related deaths.Activists campaigning for better...
Mon Mar 02, 2020 13:46
The covid-19 epidemic is not only viral—it is also digital.1Information spread through social and traditional media, as well as through governmental or health agencies, has reached a huge scale,...
Mon Mar 02, 2020 13:21
What you need to knowLong term use of aspirin may prevent colorectal cancer in people with Lynch syndrome, a group with a high risk of colorectal cancerTreatment options for early rectal cancer...
Mon Mar 02, 2020 13:16
A woman who sued three NHS trusts for negligence for not telling her while she was pregnant that her father had Huntington’s disease has lost her case in the High Court.1The woman, referred to as...
Mon Mar 02, 2020 13:11
Key messagesSpending on clinical negligence is escalating, constituting a major threat to the sustainability of the NHSIn England, payments for negligence awards are resourced from the same funds...
Mon Mar 02, 2020 13:06
bmj;368/feb28_10/m794/FAF1faJohn Wyn Owen approached his death in the same way as his life as director of the NHS in Wales; director general of the New South Wales Health Department in Australia; and...
Fri Feb 28, 2020 16:21
bmj;368/feb28_8/m658/FAF1faNicholas Godlee came from a medical lineage: his great uncle, Sir Rickman Godlee, the first neurosurgeon to successfully remove a brain tumour, was himself the nephew of...
Fri Feb 28, 2020 14:41
bmj;368/feb28_9/m796/FAF1faIain Smith Macdonald was born in Greenock. After graduating, he did national service in North Africa, then qualified in public health medicine and did a spell as a lecturer...
Fri Feb 28, 2020 14:40
The fallout from former health secretary Andrew Lansley’s 2012 reorganisation of the NHS in England is still being felt. The enduring effects have largely been seen in a series of unintended...
Fri Feb 28, 2020 13:31
Covid-19: school closures and bans on mass gatherings will need to be considered, says England’s CMO
School closures and bans on mass gatherings will need to be considered if there is evidence of onward transmission of covid-19 in the UK, England’s chief medical officer has said.Speaking at the...
Fri Feb 28, 2020 13:26
We welcome The BMJ’s thoughtful editorial linking health to the debate on divestment.1 The increasing pressure for divestment from fossil fuels builds on a long tradition of ethical...
Fri Feb 28, 2020 13:21
We welcome Howard’s article on how difficult it is for general practitioners to get the right care for patients with gender dysphoria, and we share the concerns that GPs might be expected to fill the...
Fri Feb 28, 2020 13:16
The health secretary Matt Hancock has vowed to stamp out what he described as the “absurd” and “unwarranted” postcode variations in access to certain clinical services on the NHS.In a keynote speech...
Fri Feb 28, 2020 12:56
Neurosurgeons assess, diagnose, and undertake surgery to treat disorders of the central nervous system, including the brain and spine.The work is varied and challenging. Neurosurgeons deal with...
Fri Feb 28, 2020 12:41
At The BMJ we try to practise what we preach—just as in healthcare, our decisions should be based on solid evidence. Of course, solid evidence can only be generated by solid research that is well...
Fri Feb 28, 2020 12:30
Abstract Massa intermedia (MI) is an inconsistent midline structure in the human brain that is absent in approximately 30% of the population. Absence of MI is seen more frequently in schizophrenia spectrum disorder and bipolar disorder. However, very little is known about the normal role of MI in the human brain. The purpose of this study was to investigate the role of human MI in cortical and subcortical cognitive processing as determined by differences between subjects with and...
Mon Mar 02, 2020 02:00
J. Intell., Vol. 8, Pages 9: How Approaches to Animal Swarm Intelligence Can Improve the Study of Collective Intelligence in Human Teams Journal of Intelligence doi: 10.3390/jintelligence8010009 Authors: Lisa O'Bryan Margaret Beier Eduardo Salas Researchers of team behavior have long been interested in the essential components of effective teamwork. Much existing research focuses on examining correlations between team member traits, team processes, and team outcomes, such as collective...
Mon Mar 02, 2020 02:00
Zusammenfassung Diese Übersichtsarbeit beschreibt die international anerkannten Risikofaktoren für Plattenepithelkarzinome des Ösophagus und des Anus, deren Verbreitung in Deutschland sowie Präventionsansätze. Die Hauptrisikofaktoren für Plattenepithelkarzinome des Ösophagus sind in Deutschland der Tabak- und Alkoholkonsum, vor allem in Kombination miteinander. Ein riskantes Trinkverhalten weisen 14 % der Frauen und 18 % der Männer auf. Ein Rauschtrinken mindestens einmal im Monat...
Mon Mar 02, 2020 02:00
Zusammenfassung Hintergrund Patientenverfügungen und Vorsorgevollmachten sind wichtige Instrumente für eine selbstbestimmte gesundheitliche Vorausplanung. Insbesondere bei fortschreitenden Krebserkrankungen sind auch krankheitsspezifische Aspekte relevant. Ziel der Arbeit Es erfolgen die Darstellung der Rechtslage, kritische Reflexion der Situationsbeschreibungen...
Mon Mar 02, 2020 02:00
Zusammenfassung Hintergrund Die endokrin basierte Therapie ist laut allen nationalen und internationalen Leitlinien die erste Option in der Behandlung des hormonrezeptorpositiven (HR+) metastasierten Mammakarzinoms. Ziel Die Autoren werten die Evidenz der aktuell verfügbaren Substanzen und geben Empfehlungen für den klinischen Alltag. ...
Fri Feb 28, 2020 02:00
Zusammenfassung Hintergrund Checkpointinhibitoren haben sich in den letzten Jahren als Standard bei immunogenen Tumoren etabliert, die häufig durch eine hohe Mutationslast gekennzeichnet sind. Sowohl präklinische als auch klinische Daten beim Mammakarzinom zeigen, dass das Immunsystem nicht nur eine prognostische, sondern auch prädiktive Rolle für das Ansprechen auf eine Chemotherapie oder eine anti-HER2-gerichtete Therapie spielt. Sie...
Fri Feb 28, 2020 02:00
Abstract Purpose Although intra-arterial chemotherapy (IAC) is commonly used for treating intraocular retinoblastoma, it is not a systemic therapy. We aimed to investigate whether the addition of intravenous chemotherapy (IVC) before IAC administration had any effects (whether beneficial or adverse) on patient outcomes. Methods This multicenter retrospective...
Mon Mar 02, 2020 02:00
Abstract Objectives This study was established to investigate whether the chemokines CXCL1, CCL2, and CCL5 are produced in periodontal cells and tissues and, if so, whether their levels are regulated by microbial and/or mechanical signals. Materials and methods The chemokine expression and protein levels in gingival biopsies from patients with and without...
Mon Mar 02, 2020 02:00
Abstract Objectives The main objective of this study was to assess changes in the position of the gingival margin (GM) after performing an aesthetic crown lengthening (ACLP) by means of submarginal incisions, buccal osseous surgery, and a replaced flap after a healing period of 6 months. Methods Twenty-one patients who needed a surgical crown lengthening...
Mon Mar 02, 2020 02:00
ObjectiveTo determine the incidence, demography and prognosis of vitamin D deficiency dilated cardiomyopathy (DCM) in Scotland over the last decade.Study designA retrospective review of cases of vitamin D deficiency DCM presenting to a national paediatric cardiac centre between 1 January 2008 and 1 January 2018. The departmental database and electronic and paper case notes were used to identify patients and extract data.ResultsSix patients were identified (three male), three of whom were Caucasian....
Mon Mar 02, 2020 19:00
The ‘First Thousand Days’ refers to the period from conception to the child’s second birthday. It is increasingly gaining traction as a concept to guide public health policy. It is seen as a crucial window of opportunity for interventions that improve child and population health. This review outlines the origin and growth of the First Thousand Days concept, and the evidence behind it, particularly in the areas of brain development and cognition; mental and emotional health; nutrition and obesity;...
Fri Feb 28, 2020 19:00
ObjectiveTo evaluate the use of cerebrospinal fluid (CSF) ferritin levels in the diagnosis of purulent meningitis (PM).MethodWe studied 81 children between 28 days and 12 years of age who presented with clinical suspicion of meningitis to the emergency department. CSF ferritin levels were measured and compared between diagnostic groups (PM, aseptic meningitis (AM) and no meningitis).ResultsThe median age was 24 (IQR 8–69) months. There were 32 patients with AM (39%), 23 with PM (28%) and 26 with...
Fri Feb 28, 2020 19:00
ConclusionsInpatient treatment of epistaxis seems to be variable in daily routine needing standardization by clinical guidelines and strategies to shorten inpatient treatment and to reduce the risk of readmission. (Source: European Archives of Oto-Rhino-Laryngology)
Mon Mar 02, 2020 00:00
We thank Dr Barabesi and Dr Sartorelli1 for their interest in our article ‘Bronchoalveolar cell differential count and the number of asbestos bodies correlate with survival in patients with asbestosis’, which was published in 2019 in Occupational and Environmental Medicine.2 They have claimed that the use of Cox regression analysis may lead to biased results. In the letter they have referred to an article from McGregor et al3 (published online ahead of print on 25 July 2019) which showed an example...
Mon Mar 02, 2020 19:00
Recently, Keskitalo et al presented a study focused on the association of bronchoalveolar lavage fluid (BALF) cell differential counts (CDCs) with the smoking habits and the number of asbestos bodies (ABs) in a population of patients with asbestosis.1 They also dealt with the dependence between the survival time of the patients and the BALF CDCs, as well as the number of ABs. However, we have serious concerns about the correctness of the statistical analysis used in the study.It is crucial to observe...
Mon Mar 02, 2020 19:00
Publication date: Available online 2 March 2020Source: Clinical ImmunologyAuthor(s): S.J. Donohue, A. Midgley, J.C. Davies, R.D. Wright, I. Bruce, M.W. Beresford, C.M. Hedrich, on behalf of the MRC MASTERPLANS Consortium, the UK jSLE Cohort Study and Repository
Mon Mar 02, 2020 19:48
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