ConclusionsGenetic risk variants inIL1B andIL6 may affect the association between IM and TCL, possibly by influencing T-cell activation, growth, and differentiation in the presence of IM, thereby decreasing risk of immune cell proliferation. (Source: Cancer Causes and Control)
Mon Mar 02, 2020 00:00
ConclusionLate stage presentation, HER2-enriched and triple-negative subtypes, and HIV coinfection were overrepresented in our cohort relative to resource-rich settings and were associated with mortality. These findings highlight robust opportunities for population- and patient-level interventions across the entire cascade of care to improve breast cancer outcomes in low-income countries in SSA. (Source: Cancer Causes and Control)
Mon Mar 02, 2020 00:00
ConclusionOur results suggest that obesity might be an initiator for colon adenomas but not a promoter for colorectal cancer among Black women. (Source: Cancer Causes and Control)
Mon Mar 02, 2020 00:00
Background Research has suggested ideal combinations of sleep, physical activity (PA) and sedentary time (ST) (i.e., optimal sleep/high PA/low ST) are associated with better overall health. Previous research has shown nurses spend more than half their day sedentary, do not generally meet PA guidelines and have difficulty obtaining adequate sleep. There has been no known work to examine how combinations of sleep, PA and ST relate to the work performance and mental health of nurses....
Mon Mar 02, 2020 02:00
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Abstract Recent studies have shown that the level of miR-1202 in peripheral blood is closely related to brain activity and cognitive function in patients with depression, and it is involved in glioma pathological progress. However, the correlation between miR-1202 and neuroinflammation has not been reported. The expressions of miR-1202 and small GTP-ase Rab1a at mRNA level were detected in oxygen-glucose deprivation (OGD)/reoxygenation (R) induced human microglial cells (HM cells)...
Mon Mar 02, 2020 02:00
Abstract Alzheimer's disease (AD) is the most common form of dementia that progressively disrupts neurocognitive function, which has neither cure nor effective treatment. Hypercholesterolemia might be involved in brain alterations that could evolve into AD. The present study aims to evaluate the potential of omega-3, Co-enzyme Q10 (Co-Q10), as well as their combination in ameliorating hypercholesterolemia-initiated AD-like disease. We adapted a hypercholesterolemic (HC) rat model,...
Mon Mar 02, 2020 02:00
Abstract Inflammatory responses play a major role in the pathophysiology of cerebral ischemia. Mesenchymal stem cell-derived exosomes (MSC-exos) have important anti-inflammatory effects on the treatment of organ injury. This study aimed to determine the anti-inflammatory effect and furtherly investigate the potential mechanism of MSC-exos on acute cerebral ischemia. MSC-exos were isolated by ultracentrifugation, characterized by transmission electron microscopy and FACS. Rats subjected...
Fri Feb 28, 2020 02:00
Ocular involvement with disseminated coccidiodal infection is rare. Even rarer is a patient presenting with symptomatic chorioretinitis first, followed weeks later by systemic symptoms of disseminated coccidioidomycosis. This highlights the need for physicians to have a heightened suspicion for testing for valley fever in patients living in endemic regions who present with ocular inflammation so that rapid and timely initiation of antifungal therapy may prevent loss of vision.
Mon Mar 02, 2020 14:20
Cystic echinococcosis (CE) is a neglected helminthic disease and major public health problem in several regions of the world. The zoonosis is caused by the larval stage of different cestode species belonging to the genus Echinococcus. CE can affect any organ with the liver and lungs being most commonly involved. The brain is involved in less than 2% of the cases. We report a case of a CE1 echinococcal cyst of the brain in an Iranian patient.
Sat Feb 29, 2020 17:05
Patients with systemic lupus erythematosus (SLE) are at increased risk for infection including opportunistic infections. Fungal infection in particular can be difficult to diagnose and treat and often can be life-threatening in the immunocompromised patient. We present a case in which a patient with SLE presented to the hospital with shortness of breath and cough. Throughout the hospital course, the patient’s condition continued to decline leading to acute respiratory failure, and eventually, the...
Sat Feb 29, 2020 09:50
Posterior Reversible Encephalopathy Syndrome in a Patient with Hemorrhagic Fever with Renal Syndrome
We presently report the case of hantavirus infection in a 45-year-old male who was hospitalized to our clinic of infectious diseases, with fever, myalgia, vomiting, nausea, headache, and abdominal pain. The physical findings included hepatomegaly, splenomegaly, rash, and conjunctival injection. Eight days before the start of complaints, the patient has cut trees in the mountain. An acute renal failure was observed with an oliguria and an increase of serum creatinine and blood urea nitrogen. Urinalysis...
Sat Feb 29, 2020 09:35
Abstract Purpose Although intra-arterial chemotherapy (IAC) is commonly used for treating intraocular retinoblastoma, it is not a systemic therapy. We aimed to investigate whether the addition of intravenous chemotherapy (IVC) before IAC administration had any effects (whether beneficial or adverse) on patient outcomes. Methods This multicenter retrospective...
Mon Mar 02, 2020 02:00
Abstract Introduction To assess treatment outcome and prognostic factors associated with prolonged survival in patients with brain metastases (BM) treated with stereotactic radiosurgery (SRS) or hypofractionated stereotactic radiotherapy (HFSRT). Methods/Patients This study retrospectively reviewed 200 patients with 324 BM treated with one fraction...
Mon Mar 02, 2020 02:00
Abstract Background The role of DNA damage response (DDR) proteins is poorly understood in uveal melanoma. ATR belongs to one of those proteins that induce DDR by arresting the cell cycle which leads to DNA repair. ATR is localized at position 23 on the same chromosome 3 where BAP1 is located at position 21.1 which is a known poor prognostic marker of UM. The aim of our study is to detect the expression of ATR at the protein and RNA...
Mon Mar 02, 2020 02:00
Abstract Background Dementia represents a key health issue for older adults, with negative consequences on psycho-social and functional status. Treatments that counteract cognitive deficits in mild cognitive impairment (MCI) are needed to prevent or delay it. Aim To describe the experimental protocol of the STRENGTH Project. This study investigates a multimodal...
Mon Mar 02, 2020 02:00
Abstract Necrotizing fasciitis is a rare rapidly progressive, devastating surgical emergency that results in necrosis of superficial fascia, and subcutaneous tissue. It most commonly affects the abdominal wall, extremities and perineum, while the involvement in the head and neck region is relatively rare. Here, we report a successfully treated case of necrotizing fasciitis of the craniofacial region caused by Mucor in an uncontrolled diabetic patient. Early diagnosis, early surgical...
Mon Mar 02, 2020 02:00
JSAN, Vol. 9, Pages 15: The Use of Meta-Surfaces in Vehicular Networks Journal of Sensor and Actuator Networks doi: 10.3390/jsan9010015 Authors: Barbara M. Masini Cristiano M. Silva Ali Balador Mobility as a service is becoming a new paradigm in the direction of travel planning on the basis of the best service offered by the travelled roads. Hence, the environment in which people move will become smarter and more and more connected to grant services along the whole path. This opens...
Mon Mar 02, 2020 02:00
A jury ruled that Bayer and BASF should pay farmer Bill Bader $250 million in punitive damages and $15 million in compensatory damages for pesticide drift. Learn more Slideshow Category: Flex Slider
Mon Mar 02, 2020 19:30
This month, Corteva announced it would stop making chlorpyrifos, a brain-harming pesticide. Though this is generally welcome news — the win feels complicated. Learn more Slideshow Category: Flex Slider
Mon Mar 02, 2020 19:27
Immune checkpoint inhibitors are now established therapies across several cancers including melanoma, renal cell, bladder and non-small cell lung cancer (NSCLC) [1 –4]. Preclinical data and emerging clinical data suggest that the combination of antibodies against programmed death ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) may be a more promising approach because of non-redundant pathway blockade and synergy which in turn, may r esult in more durable anti-tumour activity...
Fri Feb 28, 2020 00:00
Lung cancer remains one of the most frequent and most deadly tumor entities, with 1.6 million tumor-related deaths annually worldwide. Lung cancer in patients who have never smoked has attracted growing interest because of treatable oncogenic alterations and the opportunity for individualized treatment. The identification of activating mutations in EGFR, mostly seen in exon 19 (deletion) or in exon 21 (L858R point mutation), together with an increased sensitivity to EGFR tyrosine kinase inhibitors,...
Fri Feb 28, 2020 00:00
The publisher regrets a correction was not applied before publication of this manuscript. Reference [33] should be as follows: (Source: Lung Cancer)
Thu Feb 27, 2020 00:00
When it comes to food and farming issues, who’s in charge really does make a difference. Learn more Slideshow Category: Flex Slider
Mon Mar 02, 2020 19:23
JNNP 2020—a centenary of publishing neuroscience achievementLate last year, the Journal of Neurology, Neurosurgery and Psychiatry (JNNP) polled readers, asking them to nominate the single most important or transformative development in neurology, neurosurgery or psychiatry in the past 100 years. The response was overwhelming!Would the early foundational work in brain imaging or drug therapies1–4 take centre stage? Did the phenomenal advancements in genetic research5–7 or the discovery of new biological...
Mon Mar 02, 2020 19:00
ObjectiveTo compare the efficacy of fingolimod and natalizumab in preventing regional grey matter (GM) and white matter (WM) atrophy in relapsing-remitting multiple sclerosis (RRMS) over 2 years.MethodsPatients with RRMS starting fingolimod (n=25) or natalizumab (n=30) underwent clinical examination and 3T MRI scans at baseline (month (M) 0), M6, M12 and M24. Seventeen healthy controls were also scanned at M0 and M24. Tensor-based morphometry and SPM12 were used to assess the longitudinal regional...
Fri Feb 28, 2020 15:04
ObjectivesWe aimed to identify existing outcome measures for functional neurological disorder (FND), to inform the development of recommendations and to guide future research on FND outcomes.MethodsA systematic review was conducted to identify existing FND-specific outcome measures and the most common measurement domains and measures in previous treatment studies. Searches of Embase, MEDLINE and PsycINFO were conducted between January 1965 and June 2019. The findings were discussed during two international...
Fri Feb 28, 2020 15:04
Primary intraosseous carcinoma (PIOC), NOS is an odontogenic carcinoma with unknown etiology. Its diagnosis may be used when central jaw carcinoma cannot be categorized as any other type of carcinoma. Further ...
Sat Feb 29, 2020 02:00
A vascularized fibular osteomyocutaneous flap with severe vascular crisis often results in serious consequences. This study aims to examine the clinical effect of non-vascularized fibular graft on patients wit...
Sat Feb 29, 2020 02:00
Total gastrectomy (TG) is a widely accepted procedure for treating gastric stump cancer (GSC). However, subtotal gastrectomy (SG) would benefit elective patients with GSC. The aim of this study was to clarify ...
Thu Feb 27, 2020 02:00
Whether video-assisted thoracoscopic surgery (VATS) segmentectomy and VATS lobectomy provide similar perioperative and oncological outcomes in stage I non–small cell lung cancer (NSCLC) is still controversial.
Thu Feb 27, 2020 02:00
Author: Stanley, Matthew L.; Marsh, Elizabeth J.; Kay, Aaron C. DOI: 10.1037/xge0000752 Publication Date: February 27, 2020
Mon Mar 02, 2020 20:02
David A. Bluemke, MD, PhD, Editor of Radiology discusses two papers recently published in Radiology.
Mon Mar 02, 2020 17:00
Zusammenfassung In den letzten Jahren ist aufgrund technischer Fortschritte mit einer Miniaturisierung der Systeme und Reduktion der postoperativen Komplikationen, Zunahme der Prävalenz der Herzinsuffizienz, dem Spendermangel im Bereich der Transplantation sowie steigender Lebenserwartung eine deutliche Zunahme der Patientenzahl mit permanenten Herzunterstützungssystemen zu verzeichnen. Dieses sehr spezielle Patientenkollektiv kann sowohl akute systemassoziierte Notfälle, wie z. B....
Mon Mar 02, 2020 02:00
A coroner is to write to the UK General Medical Council asking it to reform its procedures after a consultant anaesthetist killed himself within hours of receiving an email telling him he was being...
Mon Mar 02, 2020 18:11
AbstractGuidelines on the treatment of tuberculosis (TB) have essentially remained the same for the past 35 years, but are now starting to change. Ongoing clinical trials will hopefully transform the...
Mon Mar 02, 2020 13:05
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