Abstract Mutations in THAP1 (THAP domain-containing apoptosis-associated protein 1) are responsible for DYT6 dystonia. Until now, more than eighty different mutations in THAP1 gene have been found in patients with primary dystonia, and two third of them are missense mutations. The potential pathogeneses of these missense mutations in human are largely elusive. In the present study, we generated stable transfected human neuronal cell lines expressing wild-type or mutated THAP1 proteins...
Fri Feb 28, 2020 02:00
Notified by Spain on 17/02/2020
Mon Mar 02, 2020 19:15
This 2020 Recommendation Statement from the US Preventive Services Task Force recommends screening for hepatitis C virus infection in adults aged 18 to 79 years (B recommendation).
Mon Mar 02, 2020 02:00
This systematic review to support the 2020 US Preventive Services Task Force Recommendation Statement on screening for hepatitis C virus (HCV) infection summarizes published evidence on the benefits and harms of HCV screening and treatment in adolescents and adults.
Mon Mar 02, 2020 02:00
This JAMA Patient Page describes the recent USPSTF recommendations on screening for hepatitis C virus infection in adults.
Mon Mar 02, 2020 02:00
In this issue of JAMA, the US Preventive Services Task Force (USPSTF) has issued new recommendations for hepatitis C virus (HCV) infection screening in the asymptomatic US population. Based on an updated review of the evidence, the task force now “recommends screening for HCV infection in adults aged 18 to 79 years (B recommendation),” regardless of known risk factors. Adolescents who engage in injection drug use or other behaviors associated with acquisition of HCV should also be screened. Screening...
Mon Mar 02, 2020 02:00
This Viewpoint provides an update on what’s known and not yet known about the coronavirus disease 2019 (COVID-19) epidemic, reviewing advances over the initial weeks of the outbreak in understanding the epidemiology and clinical spectrum of the illness and in approaches to diagnosis, management, and infection control.
Fri Feb 28, 2020 02:00
This Viewpoint proposes that framing climate change as a human health crisis could accelerate climate action, and reviews evidence pointing toward the health benefits of transitioning to renewable energy, plant-based diets, and a global lower carbon footprint.
Fri Feb 28, 2020 02:00
This Viewpoint reviews progress and challenges to date in federal and state efforts to transition combination oral contraceptives (COCs) from being prescription only to over-the-counter status in the US.
Fri Feb 28, 2020 02:00
Abstract Background Pregnant women are largely exposed to medications. However, knowledge is lacking about their effects on pregnancy and the fetus. Objective This study sought to evaluate the potential of high-dimensional propensity scores and high-dimensional disease risk scores for automated signal detection in pregnant women from medico-administrative...
Mon Mar 02, 2020 02:00
Abstract Introduction When a new drug or biologic product enters the market, its full spectrum of side effects is not yet fully understood, as use in the real world often uncovers nuances not suggested within the relatively narrow confines of preapproval preclinical and trial work. Objective We describe a new, phenome-wide association study (PheWAS)- and...
Fri Feb 28, 2020 02:00
CDC defines a traumatic brain injury (TBI) as a disruption in the normal function of the brain that can be caused by a bump, blow, or jolt to the head.If you or someone you care about has experienced a traumatic brain injury (TBI), or concussion and is showing symptoms of aggression, agitation, and irritability, learn more about this research study of an investigational medication for behavioral problems due to TBI.To qualify:you must be between 18-75 years of ageHave been diagnosed with TBI for...
Mon Mar 02, 2020 00:00
If you or a loved one have gastrointestinal stromal tumors (GIST), you may want to learn more about the intrigue clinical research study. What is the purpose of the intrigue study? The purpose of the intrigue study is to evaluate an investigational drug, ripretinib (DCC-2618), as a potential new treatment option for patients living with GIST. The study is being done to learn more about the safety of ripretinib and how well it works against GIST, as compared to Sutent® (sunitinib), in patients...
Mon Mar 02, 2020 00:00
To evaluate the safety, tolerability, and response profile of NYX-783 in a Post-Traumatic Stress Disorder population.Inclusion Criteria:A primary diagnosis of PTSD (DSM-5 criteria, APA 2013) with the primary traumatic event occurring ≥12 months prior to screening.PCL-5 ≥38 at screening.CAPS-5 total score ≥30 at screening.
Fri Feb 28, 2020 00:00
An open-label, long-term, safety study of AXS-05 in patients with major depressive disorder (MDD), including treatment resistant depression.Detailed Description:A multi-center, open-label, long-term study to evaluate the safety and efficacy of AXS-05 in patients with major depressive disorder, including treatment resistant depression, treated for up to one year.Inclusion Criteria:Diagnosis of major depressive disorder, including treatment resistant depressionBody mass index (BMI) between 18 and 40...
Fri Feb 28, 2020 00:00
1) To evaluate the efficacy and safety of cariprazine at a target dose of 3.0 mg/d compared with placebo in prevention of relapse in patients with bipolar I disorder whose current episode (i.e. index episode) is manic or depressive, with or without mixed features; 2) To evaluate the efficacy and safety of cariprazine at a target dose of 1.5 mg/d compared with placebo in prevention of relapse in patients with bipolar I disorder whose current episode (i.e. index episode) is manic or depressive, with...
Fri Feb 28, 2020 00:00
This study will evaluate the efficacy and safety of SPN-812, an extended-release formulation of viloxazine, in adults.Inclusion Criteria:Is male or female, aged 18 to ≤ 65 years at screening.Is able to read and understand the Informed Consent Form (ICF).Written informed consent obtained from the subject (a signed ICF).Weight within the normal or overweight ranges according to accepted values of the Body Mass Index Chart (18.0 to 35 kg/m2).Is able to swallow capsules whole, without crushing, chewing...
Fri Feb 28, 2020 00:00
A clinical study to evaluate the long-term safety and tolerability of an investigational drug in people with schizophrenia.This study is accepting male and female participants between 18 years old -65 years old who have been diagnosed with schizophrenia. This study will be conducted in approximately 50 study centers worldwide. The study will last approximately 57 weeks.Inclusion criteria:The main inclusion criteria include, but are not limited to the following:Male or female subject between 18 to...
Fri Feb 28, 2020 00:00
Circular RNA (circRNA) has been proven to play a significant role in multiple types of cancer. However, the expression and role of circRNAs in epithelial ovarian cancer (EOC) remains elusive. (Source: Molecular Cancer)
Fri Feb 28, 2020 01:00
N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is very limited. We designed this study to investigate the... (Source: Molecular Cancer)
Fri Feb 28, 2020 01:00
Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such ... (Source: Molecular Cancer)
Fri Feb 28, 2020 01:00
The CDKN2A/B locus contains crucial tumor suppressors and a lncRNA gene ANRIL. However, the mechanisms that coordinately regulate their expression levels are not clear. (Source: Molecular Cancer)
Thu Feb 27, 2020 01:00
Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has significant implicati... (Source: Molecular Cancer)
Thu Feb 27, 2020 01:00
A proof of concept (POC) study evaluating the impact of BTRX-335140 relative to placebo on symptoms of major depressive disorder (MDD) in adult subjects with MDD and symptoms of anhedonia and anxiety following 8 weeks of double-blind treatment as assessed by the HAMD-17 Scale.Inclusion Criteria:Are adult men or women 25 to 65 years of age (inclusive) at informed consent, who provide informed consent by signing the appropriate ICFsHave a primary DSM-5 diagnosis of MDD, with prominent symptoms of anhedonia...
Fri Feb 28, 2020 00:00
Pediatric Irritable Bowel Syndrome with Constipation Study being held in Bowling Green, KY. This study is enrolling for children ages 6-17 years old.
Fri Feb 28, 2020 00:00
Oncogene, Published online: 02 March 2020; doi:10.1038/s41388-020-1209-4ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells (Source: Oncogene)
Mon Mar 02, 2020 00:00
Oncogene, Published online: 02 March 2020; doi:10.1038/s41388-020-1237-0XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary (Source: Oncogene)
Mon Mar 02, 2020 00:00
Oncogene, Published online: 28 February 2020; doi:10.1038/s41388-020-1233-4SOX13 promotes colorectal cancer metastasis by transactivating SNAI2 and c-MET (Source: Oncogene)
Fri Feb 28, 2020 00:00
Oncogene, Published online: 28 February 2020; doi:10.1038/s41388-020-1227-2Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104 (Source: Oncogene)
Fri Feb 28, 2020 00:00
Oncogene, Published online: 28 February 2020; doi:10.1038/s41388-020-1223-6Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription (Source: Oncogene)
Fri Feb 28, 2020 00:00
Oncogene, Published online: 27 February 2020; doi:10.1038/s41388-020-1231-6Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint (Source: Oncogene)
Thu Feb 27, 2020 00:00
Oncogene, Published online: 27 February 2020; doi:10.1038/s41388-020-1230-7Capicua restricts cancer stem cell-like properties in breast cancer cells (Source: Oncogene)
Thu Feb 27, 2020 00:00
Oncogene, Published online: 27 February 2020; doi:10.1038/s41388-020-1228-1MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability (Source: Oncogene)
Thu Feb 27, 2020 00:00
Oncogene, Published online: 27 February 2020; doi:10.1038/s41388-020-1224-5Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species (Source: Oncogene)
Thu Feb 27, 2020 00:00
Um dos filmes mais badalados deste início de ano no universo de escalada é “Pretty Strong”. A produção, incluindo filmagem, O post Filme “Pretty Strong” terá exibição em cinema no Brasil apareceu primeiro em Revista Blog de Escalada.
Mon Mar 02, 2020 18:20
O Campeonato Pan-Americano de Escalada, disputado no ginásio de escalada Sender One em Los Angeles (EUA) e encerrado no último O post Canadense e norte-americano ficam com a vaga do continente para as Olimpíadas apareceu primeiro em Revista Blog de Escalada.
Mon Mar 02, 2020 15:21
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