As the standard treatments for cancer, chemotherapy and radiotherapy have been widely applied to clinical practice worldwide. However, the resistance to cancer therapies is a major challenge in clinics and sci... (Source: Molecular Cancer)
Mon Mar 02, 2020 01:00
It is well acknowledged that immune system is deeply involved in cancer initiation and progression, and can exert both pro-tumorigenic and anti-tumorigenic effects, depending on specific microenvironment. With... (Source: Molecular Cancer)
Mon Mar 02, 2020 01:00
Pancreatic cancer is a highly lethal disease with a poor prognosis, and existing therapies offer only limited effectiveness. Mutation gene sequencing has shown several gene associations that may account for it... (Source: Molecular Cancer)
Mon Mar 02, 2020 01:00
Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatmen... (Source: Molecular Cancer)
Mon Mar 02, 2020 01:00
Oncogene, Published online: 27 February 2020; doi:10.1038/s41388-020-1224-5Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species (Source: Oncogene)
Thu Feb 27, 2020 00:00
Um dos filmes mais badalados deste início de ano no universo de escalada é “Pretty Strong”. A produção, incluindo filmagem, O post Filme “Pretty Strong” terá exibição em cinema no Brasil apareceu primeiro em Revista Blog de Escalada.
Mon Mar 02, 2020 18:20
O Campeonato Pan-Americano de Escalada, disputado no ginásio de escalada Sender One em Los Angeles (EUA) e encerrado no último O post Canadense e norte-americano ficam com a vaga do continente para as Olimpíadas apareceu primeiro em Revista Blog de Escalada.
Mon Mar 02, 2020 15:21
O design clássico de três listras da Adidas é uma marca registrada de prestígio esportivo. Basta perguntar aos fãs de O post Livro da semana: “The Adidas Archive” – Christian Habermeier e Sebastian Jäger apareceu primeiro em Revista Blog de Escalada.
Mon Mar 02, 2020 14:15
Nesta semana foi divulgada o trailer do documentário “Nomad: In The Footsteps of Bruce Chatwin”, dirigido por nada menos que O post Vídeo da Semana: “Nomad” – A história de quem revolucionou a literatura de viagem apareceu primeiro em Revista Blog de Escalada.
Fri Feb 28, 2020 16:55
O calçado de montanha é um assunto constante aqui na Revista Blog de Escalada. Já foram explicados muitos aspectos, mas O post Calçados de montanha: O que prestar atenção na hora da compra? apareceu primeiro em Revista Blog de Escalada.
Fri Feb 28, 2020 16:03
Por ignorância, ou por puro desconhecimento, muitas pessoas acreditam que suplementos alimentares configuram doping esportivo. A discussão é antiga e O post Guia prático de vigilância contra doping para atletas amadores apareceu primeiro em Revista Blog de Escalada.
Fri Feb 28, 2020 13:57
O post Realidade ou convicção pessoal: O que faz uma linha de boulder impossível? apareceu primeiro em Revista Blog de Escalada.
Fri Feb 28, 2020 12:49
The original version of this article, published on 05 September 2019, unfortunately contained a mistake. The image of “Jena Valve” in Table 3 was incorrect.
Mon Mar 02, 2020 02:00
Mon Mar 02, 2020 02:00
Abstract Bacillus Calmette–Guérin (BCG) instillation is a key therapy to manage non-muscle invasive bladder cancer (NMIBC). However, intravesical BCG therapy fails in approximately half of the patients, leading to recurrence and progression. We aimed to reveal the genetic variations associated with treatment failure after intravesical BCG therapy for NMIBC. This study included 91 Japanese patients treated with BCG instillation for NMIBC. Genomic DNA was obtained from patient whole-blood...
Mon Mar 02, 2020 02:00
Abstract Bone metastatic prostate cancer (BM-PCa) significantly reduces overall patient survival and is currently incurable. Current standard immunotherapy showed promising results for PCa patients with metastatic, but less advanced, disease (i.e., fewer than 20 bone lesions) suggesting that PCa growth in bone contributes to response to immunotherapy. We found that: (1) PCa stimulates recruitment of neutrophils, the most abundant immune cell in bone, and (2) that neutrophils heavily...
Sat Feb 29, 2020 02:00
Abstract Neuronal nitric oxide synthase (nNOS) catalyses the production of the neurotransmitter nitric oxide. nNOS is expressed in the dorsal raphe nucleus (DRN), a source of ascending serotonergic projections. In this study we examined the distribution nNOS and the function of nitric oxide in the DRN and adjacent median raphe nucleus (MRN) of the rat. We hypothesised that nNOS is differentially expressed across the raphe nuclei and that nitric oxide influences the firing activity of a subgroup...
Mon Mar 02, 2020 19:02
Abstract Objectives This study was established to investigate whether the chemokines CXCL1, CCL2, and CCL5 are produced in periodontal cells and tissues and, if so, whether their levels are regulated by microbial and/or mechanical signals. Materials and methods The chemokine expression and protein levels in gingival biopsies from patients with and...
Mon Mar 02, 2020 02:00
Abstract Objectives The main objective of this study was to assess changes in the position of the gingival margin (GM) after performing an aesthetic crown lengthening (ACLP) by means of submarginal incisions, buccal osseous surgery, and a replaced flap after a healing period of 6 months. Methods Twenty-one patients who needed a surgical crown lengthening...
Mon Mar 02, 2020 02:00
The original article contains an error in Eqs. (2) and (11).
Mon Mar 02, 2020 02:00
Vaccines, Vol. 8, Pages 117: Trends of Adverse Events Following Immunization (AEFI) Reports of Human Papillomavirus Vaccine in the Valencian Community—Spain (2008–2018) Vaccines doi: 10.3390/vaccines8010117 Authors: Cecilia M. Egoavil José Tuells Juan José Carreras Emilia Montagud Eliseo Pastor-Villalba Pablo Caballero Andreu Nolasco Vaccine safety surveillance is essential in vaccination programs. We accomplished a descriptive study of surveillance AEFI-reporting rate...
Mon Mar 02, 2020 02:00
Vaccines, Vol. 8, Pages 116: Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus Vaccines doi: 10.3390/vaccines8010116 Authors: Elisa S. Roesti Christina N. Boyle Daniel T. Zeman Marcos Sande-Melon Federico Storni Gustavo Cabral-Miranda Alexander Knuth Thomas A. Lutz Monique Vogel Martin F. Bachmann Type 2 diabetes mellitus (T2DM) is a chronic progressive disease characterized by insulin resistance...
Mon Mar 02, 2020 02:00
Vaccines, Vol. 8, Pages 113: Low-Energy Electron Irradiation Efficiently Inactivates the Gram-Negative Pathogen Rodentibacter pneumotropicus—A New Method for the Generation of Bacterial Vaccines with Increased Efficacy Vaccines doi: 10.3390/vaccines8010113 Authors: Jasmin Fertey Lea Bayer Sophie Kähl Rukiya M. Haji Anke Burger-Kentischer Martin Thoma Bastian Standfest Jessy Schönfelder Javier Portillo Casado Frank-Holm Rögner Christoph Georg Baums Thomas Grunwald...
Mon Mar 02, 2020 02:00
Vaccines, Vol. 8, Pages 114: Advanced Safety and Genetic Stability in Mice of a Novel DNA-Launched Venezuelan Equine Encephalitis Virus Vaccine with Rearranged Structural Genes Vaccines doi: 10.3390/vaccines8010114 Authors: Dylan M. Johnson Kevin J. Sokoloski Jenny D. Jokinen Tia L. Pfeffer Yong-Kyu Chu Robert S. Adcock Donghoon Chung Irina Tretyakova Peter Pushko Igor S. Lukashevich The safety and genetic stability of V4020, a novel Venezuelan Equine Encephalitis...
Mon Mar 02, 2020 02:00
Vaccines, Vol. 8, Pages 115: Bovine Herpesvirus-4-Vectored Delivery of Nipah Virus Glycoproteins Enhances T Cell Immunogenicity in Pigs Vaccines doi: 10.3390/vaccines8010115 Authors: Miriam Pedrera Francesca Macchi Rebecca K. McLean Valentina Franceschi Nazia Thakur Luca Russo Lobna Medfai Shawn Todd Elma Z. Tchilian Jean-Christophe Audonnet Keith Chappell Ariel Isaacs Daniel Watterson Paul R. Young Glenn A. Marsh Dalan Bailey Simon P. Graham...
Mon Mar 02, 2020 02:00
Vaccines, Vol. 8, Pages 111: Development of Tumor Cell-Based Vaccine with IL-12 Gene Electrotransfer as Adjuvant Vaccines doi: 10.3390/vaccines8010111 Authors: Tinkara Remic Gregor Sersa Katja Ursic Maja Cemazar Urska Kamensek Tumor cell-based vaccines use tumor cells as a source of tumor-associated antigens. In our study, we aimed to develop and test a tumor vaccine composed of tumor cells killed by irradiation combined with in vivo interleukin-12 gene electrotransfer as...
Mon Mar 02, 2020 02:00
Vaccines, Vol. 8, Pages 112: Effect of Influenza Vaccination on Mortality and Risk of Hospitalization in Elderly Individuals with and without Disabilities: A Nationwide, Population-Based Cohort Study Vaccines doi: 10.3390/vaccines8010112 Authors: Yu-Chia Chang Ho-Jui Tung Yu-Tung Huang Chin-Te Lu Ernawaty Ernawaty Szu-Yuan Wu Purpose: The effects of influenza vaccines are unclear for elderly individuals with disabilities. We use a population-based cohort study to estimate...
Mon Mar 02, 2020 02:00
Vaccines, Vol. 8, Pages 110: Effective Activation of Human Antigen-Presenting Cells and Cytotoxic CD8+ T Cells by a Calcium Phosphate-Based Nanoparticle Vaccine Delivery System Vaccines doi: 10.3390/vaccines8010110 Authors: Florian Scheffel Torben Knuschke Lucas Otto Sebastian Kollenda Viktoriya Sokolova Christine Cosmovici Jan Buer Jörg Timm Matthias Epple Astrid M. Westendorf The ability of vaccines to induce T cell responses is crucial for preventing diseases...
Sun Mar 01, 2020 02:00
Vaccines, Vol. 8, Pages 109: Tropomyosin: An Excretory/Secretory Protein from Haemonchus contortus Mediates the Immuno-Suppressive Potential of Goat Peripheral Blood Mononuclear Cells In Vitro Vaccines doi: 10.3390/vaccines8010109 Authors: Muhammad Ehsan Muhammad Haseeb Ruisi Hu Haider Ali Muhammad Ali Memon Ruofeng Yan Lixin Xu Xiaokai Song Xingquan Zhu Xiangrui Li During host-parasite interactions, binding of excretory/secretory proteins (ESPs) on the host...
Sun Mar 01, 2020 02:00
Vaccines, Vol. 8, Pages 108: Characteristics of Seasonal Influenza Virus Activity in a Subtropical City in China, 2013–2019 Vaccines doi: 10.3390/vaccines8010108 Authors: Aiqin Zhu Jianhua Liu Chuchu Ye Jianxing Yu Zhibing Peng Luzhao Feng Liping Wang Ying Qin Yaming Zheng Zhongjie Li Background: To optimize seasonal influenza vaccination programs in regions with potentially complicated seasonal patterns, the epidemiological characteristics of seasonal influenza...
Sun Mar 01, 2020 02:00
Vaccines, Vol. 8, Pages 107: Evaluation of Current Equine Influenza Vaccination Protocols Prior to Shipment, Guided by OIE Standards Vaccines doi: 10.3390/vaccines8010107 Authors: Ann Cullinane Jacinta Gahan Cathal Walsh Manabu Nemoto Johanna Entenfellner Cecilia Olguin-Perglione Marie Garvey Tao Qi Huang Fu Monica Venner Takashi Yamanaka María Barrandeguy Charlene Judith Fernandez To facilitate the temporary importation of horses for competition and...
Sat Feb 29, 2020 02:00
Vaccines, Vol. 8, Pages 106: Broad Protection of Pigs against Heterologous PRRSV Strains by a GP5-Mosaic DNA Vaccine Prime/GP5-Mosaic rVaccinia (VACV) Vaccine Boost Vaccines doi: 10.3390/vaccines8010106 Authors: Junru Cui Caitlin M. O’Connell Connor Hagen Kim Sawicki Joan A. Smyth Paulo H. Verardi Herbert J. Van Kruiningen Antonio E. Garmendia Background: Porcine reproductive and respiratory syndrome (PRRS) viruses are a major cause of disease and economic loss in...
Fri Feb 28, 2020 02:00
Vaccines, Vol. 8, Pages 105: Simple Nanoparticles from the Assembly of Cationic Polymer and Antigen as Immunoadjuvants Vaccines doi: 10.3390/vaccines8010105 Authors: Yunys Pérez-Betancourt Bianca de Carvalho Lins Fernandes Távora Mônica Colombini Eliana L. Faquim-Mauro Ana Maria Carmona-Ribeiro Since antigens are negatively charged, they combine well with positively charged adjuvants. Here, ovalbumin (OVA) (0.1 mg·mL-1) and poly (diallyldimethylammonium chloride)...
Fri Feb 28, 2020 02:00
Y. Chen et al.
Mon Mar 02, 2020 07:00
M. A. Abdulkarim et al.
Mon Mar 02, 2020 07:00
M. V. Saivish et al.
Mon Mar 02, 2020 07:00
T. Arashiro et al.
Mon Mar 02, 2020 07:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου