Related ArticlesDiseases of the Brain, Head and Neck, Spine 2020–2023: Diagnostic Imaging Book. 2020 Authors: Hodler J, Kubik-Huch RA, von Schulthess GK Abstract Tinnitus and hearing loss in the adult can have profound effects on the quality of life. The imaging workup for tinnitus and hearing loss in adults follows otoscopic exam and audiometry testing. CT and MR imaging have different and often complementary roles in the evaluation of tinnitus and hearing loss depending...
Tue Mar 03, 2020 14:45
Related ArticlesDiseases of the Brain, Head and Neck, Spine 2020–2023: Diagnostic Imaging Book. 2020 Authors: Hodler J, Kubik-Huch RA, von Schulthess GK Abstract In the assessment of patients suspected for dementia, neuroimaging plays an important role in establishing the diagnosis and subtyping the underlying cause of the cognitive impairment. This chapter discusses how “normal aging” can be distinguished from neurodegenerative changes on imaging. Next, imaging findings...
Tue Mar 03, 2020 14:45
Related ArticlesDiseases of the Brain, Head and Neck, Spine 2020–2023: Diagnostic Imaging Book. 2020 Authors: Hodler J, Kubik-Huch RA, von Schulthess GK PMID: 32119229
Tue Mar 03, 2020 14:45
GAMMA SPECTRUM STABILIZATION FOR ENVIRONMENTAL RADIATION MONITORING STATIONS USING NAI(TL) DETECTOR.
Related ArticlesGAMMA SPECTRUM STABILIZATION FOR ENVIRONMENTAL RADIATION MONITORING STATIONS USING NAI(TL) DETECTOR. Radiat Prot Dosimetry. 2020 Mar 02;: Authors: Hung DT, Hiep CV, Khang PD, Hai NX, Anh NN, Dinh DA, Hao TVN, Pham V Abstract Gamma spectrum measured by an NaI(Tl) detector is known to be unstable with the in situ temperature. In the present work, an advanced method has been applied to stabilize the gamma spectrum measured by the NaI(Tl)...
Tue Mar 03, 2020 13:15
Related ArticlesLEVELS OF EXPOSURE TO IONIZING RADIATION AMONG THE PERSONNEL ENGAGED IN CYCLOTRON OPERATION AND THE PERSONNEL ENGAGED IN THE PRODUCTION OF RADIOPHARMACEUTICALS, BASED ON RADIATION MONITORING SYSTEM. Radiat Prot Dosimetry. 2020 Mar 02;: Authors: Biegała M, Jakubowska T Abstract This paper aims to determine the levels of exposure to neutron and photon radiation among the personnel engaged in cyclotron operation and the personnel engaged...
Tue Mar 03, 2020 13:15
Related ArticlesExtensive investigation of benzylic N-containing substituents on the pyrrolopyrimidine skeleton as Akt inhibitors with potent anticancer activity. Bioorg Chem. 2020 Feb 16;97:103671 Authors: Liu Y, Zhang Z, Ran F, Guo K, Chen X, Zhao G Abstract Continuous optimization of benzylic substituents on 1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl)-2-phenylethan-1-one structure as Akt inhibitors was described in this paper. Particularly,...
Tue Mar 03, 2020 15:13
Related ArticlesDesign, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site. Bioorg Chem. 2020 Feb 24;97:103695 Authors: Hu X, Li L, Zhang Q, Wang Q, Feng Z, Xu Y, Xia Y, Yu L Abstract A series of 3-(((9H-purin-6-yl) amino) methyl) pyridin-2(1H)-one derivatives were designed, synthesized and confirmed as tubulin polymerization inhibitors. All compounds were evaluated for their anti-proliferative...
Tue Mar 03, 2020 15:13
Related ArticlesStem Cell-Derived Endothelial Cell Model that Responds to Tobacco Smoke Like Primary Endothelial Cells. Chem Res Toxicol. 2020 Mar 02;: Authors: Chu PH, Chen G, Kuo D, Braisted J, Huang R, Wang Y, Simeonov A, Boehm M, Gerhold DL Abstract To clarify how smoking leads to heart attack and stroke, we developed an endothelial cell model (iECs) generated from human induced Pluripotent Stem Cells (iPSC) and evaluated its responses to tobacco...
Tue Mar 03, 2020 15:13
Related ArticlesActin Cytoskeleton-Disrupting and Magnetic Field-Responsive Multivalent Supramolecular Assemblies for Efficient Cancer Therapy. ACS Appl Mater Interfaces. 2020 Mar 02;: Authors: Yu Q, Zhang B, Zhang YM, Liu YH, Liu Y Abstract Actin cytoskeleton disruption is a promising and intriguing anticancer strategy, but their efficiency is frequently compromised by severe side effects of the actin cytoskeleton-disrupting agents. In this study,...
Tue Mar 03, 2020 15:13
Related ArticlesInfrared-A Irradiation-induced Inhibition of Human Keratinocyte Proliferation and Potential Mechanisms. Photochem Photobiol. 2020 Mar 02;: Authors: Shimizu S, Aoki A, Takahashi T, Harano F Abstract Infrared-A (IRA), which can penetrate deeply into the human skin, is a major component of solar radiation and is recognized to promote photoaging of human dermis. To our knowledge, however, the cellular and molecular consequences of human...
Tue Mar 03, 2020 15:13
Related ArticlesPotential Role of Cellular Senescence in Asthma. Front Cell Dev Biol. 2020;8:59 Authors: Wang ZN, Su RN, Yang BY, Yang KX, Yang LF, Yan Y, Chen ZG Abstract Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation. Cellular senescence not only occurs during the natural aging of...
Tue Mar 03, 2020 15:13
Related ArticlesmiR-221-3p Delivered by BMMSC-Derived Microvesicles Promotes the Development of Acute Myelocytic Leukemia. Front Bioeng Biotechnol. 2020;8:81 Authors: Zhang X, Xu Y, Wang J, Zhao S, Li J, Huang X, Xu H, Zhang X, Suo S, Lv Y, Zhang Y, Yu W Abstract Objective: The study aims to investigate the effects of miR-221-3p in bone marrow mesenchymal stem cell (BMMSC)-derived microvesicles (MVs) on cell cycle, proliferation and invasion of acute...
Tue Mar 03, 2020 15:13
Related ArticlesCurcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model. Front Bioeng Biotechnol. 2020;8:50 Authors: Bolat ZB, Islek Z, Demir BN, Yilmaz EN, Sahin F, Ucisik MH Abstract Combination chemotherapy, administrating two chemotherapeutic agents concurrently, comes into prominence, as the heterogeneity or the level of the disease necessitates...
Tue Mar 03, 2020 15:13
Related ArticlesDNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia. Front Oncol. 2020;10:127 Authors: Carr MI, Zimmermann A, Chiu LY, Zenke FT, Blaukat A, Vassilev LT Abstract Despite significant advances in the treatment of acute myeloid leukemia (AML) the long-term prognosis remains relatively poor and there is an urgent need for improved therapies with increased potency and tumor selectivity....
Tue Mar 03, 2020 15:13
Related ArticlesUpregulated Expression of TUBA1C Predicts Poor Prognosis and Promotes Oncogenesis in Pancreatic Ductal Adenocarcinoma via Regulating the Cell Cycle. Front Oncol. 2020;10:49 Authors: Albahde MAH, Zhang P, Zhang Q, Li G, Wang W Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease and has the worst prognosis and survival rate. TUBA1C is a microtubule component implicated in multiple cancers, however,...
Tue Mar 03, 2020 15:13
Related ArticlesExpression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. Oncoimmunology. 2020;9(1):1708065 Authors: Kato S, Okamura R, Kumaki Y, Ikeda S, Nikanjam M, Eskander R, Goodman A, Lee S, Glenn ST, Dressman D, Papanicolau-Sengos A, Lenzo FL, Morrison C, Kurzrock R Abstract Although immunotherapies have achieved remarkable salutary effects...
Tue Mar 03, 2020 15:13
Related ArticlesPhytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice. Front Pharmacol. 2019;10:1614 Authors: Choudhari AS, Mandave PC, Deshpande M, Ranjekar P, Prakash O Abstract Cancer is a severe health problem that continues to be a leading cause of death worldwide. Increasing knowledge of the molecular mechanisms underlying cancer progression has led to the development of a vast number of anticancer drugs. However,...
Tue Mar 03, 2020 15:13
Related ArticlesCellular Senescence in Neurodegenerative Diseases. Front Cell Neurosci. 2020;14:16 Authors: Martínez-Cué C, Rueda N Abstract Cellular senescence is a homeostatic biological process characterized by a permanent state of cell cycle arrest that can contribute to the decline of the regenerative potential and function of tissues. The increased presence of senescent cells in different neurodegenerative diseases suggests the contribution...
Tue Mar 03, 2020 15:13
Related ArticlesSpalt-Like Protein 4 (SALL4) Promotes Angiogenesis by Activating Vascular Endothelial Growth Factor A (VEGFA) Signaling. Med Sci Monit. 2020 Mar 02;26:e920851 Authors: Sun J, Zhao Z, Zhang W, Tang Q, Yang F, Hu X, Liu C, Song B, Zhang B, Wang H Abstract BACKGROUND Spalt-like protein 4 (SALL4) is a nuclear transcription factor central to early embryonic development, especially for regulating pluripotency of embryonic stem cells (ESCs)...
Tue Mar 03, 2020 15:13
Related ArticlesZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells. Oncogene. 2020 Mar 02;: Authors: Redondo Monte E, Wilding A, Leubolt G, Kerbs P, Bagnoli JW, Hartmann L, Hiddemann W, Chen-Wichmann L, Krebs S, Blum H, Cusan M, Vick B, Jeremias I, Enard W, Theurich S, Wichmann C, Greif PA Abstract ZBTB7A is frequently mutated in acute myeloid leukemia (AML) with t(8;21) translocation. However,...
Tue Mar 03, 2020 13:11
Related ArticlesStructural and strategic landscape of PIKK protein family and their inhibitors: an overview. Front Biosci (Landmark Ed). 2020 Mar 01;25:1538-1567 Authors: Angira D, Shaik A, Thiruvenkatam V Abstract Phosphatidylinositol-3 kinase-related kinases (PIKKs) is a class of six unique serine/threonine kinases that are characterized as high molecular mass colossal proteins present in multicellular organisms. They predominantly regulate the...
Tue Mar 03, 2020 13:11
Related ArticlesEvolution of PIKK family kinase inhibitors: A new age cancer therapeutics. Front Biosci (Landmark Ed). 2020 Mar 01;25:1510-1537 Authors: Shaik A, Kirubakaran S Abstract Phosphatidylinositol-3 kinase-related kinases (PIKKs) belong to a family of atypical serine/threonine kinases in humans. They actively participate in a diverse set of cellular functions such as meiotic, V(D)J recombination, chromosome maintenance, DNA damage sensing...
Tue Mar 03, 2020 13:11
Related ArticlesTriacanthine exerts antitumor effects on bladder cancer in vitro and in vivo. Phytomedicine. 2019 Nov;64:153069 Authors: Shin SS, Park YJ, Hwang B, Park SL, Han SW, Park SS, Choi YH, Kim WJ, Moon SK Abstract BACKGROUND: Numerous studies have focused on solvent extracts from locust trees (Gleditsia spp.), which contain diverse bioactive components including saponins, flavonoids, and alkaloids. However, because of the undefined nature...
Tue Mar 03, 2020 13:11
Related ArticlesOvercoming Treatment Toxicity through Sequential Therapy. Cancer Cell. 2019 06 10;35(6):821-822 Authors: Benada J, Ejlertsen B, Sørensen CS Abstract Combined inhibitions of PARP and DNA damage checkpoint have the potential for high anti-cancer efficacy, but concurrent inhibitions have been hampered by intolerable side effects. In this issue of Cancer Cell, Fang and colleagues (Fang et al., 2019) propose that sequential inhibitions of...
Tue Mar 03, 2020 13:11
Related ArticlesThe Urinary Microbiome and Anticancer Immunotherapy: The Potentially Hidden Role of Unculturable Microbes. Target Oncol. 2019 06;14(3):247-252 Authors: Bersanelli M, Santoni M, Ticinesi A, Buti S Abstract Several urinary disorders, including overactive bladder, urinary incontinence, and interstitial cystitis, are often characterized by negative urine cultures. The application of metagenomics (i.e., 16S rRNA microbial profiling or whole-genome...
Tue Mar 03, 2020 13:11
Related ArticlesComplex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition. Blood Adv. 2019 02 26;3(4):552-563 Authors: Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau G Abstract Patients diagnosed with acute myeloid leukemia with complex karyotype (CK AML) have an adverse prognosis using current...
Tue Mar 03, 2020 13:11
Related ArticlesConsortium of Otolaryngology Journal Editors: Collegiality and Contributions. Ann Otol Rhinol Laryngol. 2020 Feb 29;:3489420908365 Authors: Sataloff RT, Chandra R, Fisher EW, Goldenberg D, Hanna EY, Johnson J, Kennedy DW, Kraus DH, Krouse JH, Link M, Lustig LR, Bert W O, Piccirillo JF, Ruben R, Schwartz S, Selesnick SH, Sindwani R, Smith RJ, Stewart MG, Tysome J, Weber PC, Welling DB PMID: 32115987 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 15:10
Related ArticlesCurrarino syndrome presenting as a cerebrospinal fluid leak from the dermal sinus tract: case report. J Neurosurg Pediatr. 2020 Mar 06;:1-5 Authors: Kim RB, Robbins R, Rollins MD, Brockmeyer DL Abstract Currarino syndrome is an autosomal dominant condition with variable expressivity and penetrance that is associated with several classic features: sacral dysgenesis, presacral mass, and/or anorectal anomalies. The authors present a unique...
Tue Mar 03, 2020 13:11
Related ArticlesRenal Contrast on CT Myelography: Diagnostic Value in Patients with Spontaneous Intracranial Hypotension. AJNR Am J Neuroradiol. 2019 02;40(2):376-381 Authors: Kinsman KA, Verdoorn JT, Luetmer PH, Clark MS, Diehn FE Abstract BACKGROUND AND PURPOSE: The significance of renal contrast on CT myelography is uncertain. This project examined different patient populations undergoing CT myelography for the presence of renal contrast to determine...
Tue Mar 03, 2020 13:11
Related ArticlesDevelopment and validation of knowledge, attitude and practice questionnaire for prevention of respiratory tract infections among Malaysian Hajj pilgrims. BMC Public Health. 2020 Mar 02;20(1):189 Authors: Goni MD, Naing NN, Hasan H, Wan-Arfah N, Deris ZZ, Arifin WN, Hussin TMAR, Abdulrahman AS, Baaba AA, Arshad MR Abstract BACKGROUND: Hajj pilgrimage faces numerous challenges including a high prevalence of respiratory tract infection...
Tue Mar 03, 2020 13:10
Related ArticlesTelocytes and lymphatic endothelial cells: Two immunophenotypically distinct and spatially close cell entities. Acta Histochem. 2020 Feb 27;:151530 Authors: Rosa I, Marini M, Sgambati E, Ibba-Manneschi L, Manetti M Abstract Telocytes (TCs) have recently emerged as a peculiar type of stromal cells located in both perivascular and interstitial compartments of multiple anatomical sites in humans, other mammals and vertebrates. Pioneer...
Tue Mar 03, 2020 13:08
Related ArticlesmiR-214-5p suppresses the proliferation, migration and invasion of trophoblast cells in pre-eclampsia by targeting jagged 1 to inhibit notch signaling pathway. Acta Histochem. 2020 Feb 26;:151527 Authors: Gong F, Chai W, Wang J, Cheng H, Shi Y, Cui L, Jia G Abstract MicroRNA-214-5p has been reported to be expressed in placental tissue and suppressed the proliferation and invasion of various tumor cells. However, the role of miR-214-5p...
Tue Mar 03, 2020 13:08
Publication date: Available online 2 March 2020Source: Allergology InternationalAuthor(s): Hiroyuki Nagase, Shigeharu Ueki, Shigeharu Fujieda
Tue Mar 03, 2020 13:06
Related ArticlesCell-Type-Specific Whole-Brain Direct Inputs to the Anterior and Posterior Piriform Cortex. Front Neural Circuits. 2020;14:4 Authors: Wang L, Zhang Z, Chen J, Manyande A, Haddad R, Liu Q, Xu F Abstract The piriform cortex (PC) is a key brain area involved in both processing and coding of olfactory information. It is implicated in various brain disorders, such as epilepsy, Alzheimer's disease, and autism. The PC consists of the anterior...
Tue Mar 03, 2020 16:00
Related ArticlesA Step-by-Step Protocol for Optogenetic Kindling. Front Neural Circuits. 2020;14:3 Authors: Cela E, Sjöström PJ Abstract Electrical kindling, repeated brain stimulation eventually resulting in seizures, is widely used as an animal model of epileptogenesis and epilepsy. However, the stimulation electrode used for electric kindling targets unknown neuronal populations and may introduce tissue damage and inflammation. Optogenetics can be...
Tue Mar 03, 2020 16:00
Related ArticlesUsing Neural Circuit Interrogation in Rodents to Unravel Human Speech Decoding. Front Neural Circuits. 2020;14:2 Authors: Neophytou D, Oviedo HV Abstract The neural circuits responsible for social communication are among the least understood in the brain. Human studies have made great progress in advancing our understanding of the global computations required for processing speech, and animal models offer the opportunity to discover evolutionarily...
Tue Mar 03, 2020 16:00
Related ArticlesDetailed overview on rare malignant ovarian tumors. Bull Cancer. 2020 Feb 27;: Authors: Aust S, Eberst L, Tredan O, Rousset-Jablonski C, Treilleux I, Méeus P, Chopin N, Beurrier F, Charreton A, Véronique D, Hallouz A, Coulon A, Ricoeur A, Mastier C, Bouhamama A, Racadot S, Devouassoux-Shisheboran M, Haddad V, Ray-Coquard I Abstract The group of rare malignant ovarian tumors includes the group of germ cell tumors, sex cords stromal ovarian...
Tue Mar 03, 2020 13:04
Related Articles[When epitranscriptomics meets the ribosome: A new avenue in oncology]. Bull Cancer. 2020 Feb 27;: Authors: Marcel V, Diaz JJ PMID: 32115179 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 13:04
Related Articles[Preoperative breast imaging review: Interests and limits of specialized validation in oncology]. Bull Cancer. 2020 Feb 27;: Authors: Flory V, Lévy G, Viotti J, Schiappa R, Elkind L, Ghez C, Pellegrin A, Occelli A, Dejode M, Delpech Y, Fouché Y, Figl A, Machiavello JC, Haudebourg J, Peyrottes I, Chapellier C, Barranger E Abstract OBJECTIVES: To evaluate the impact of systematic radiological review by breast specialist radiologist of malignant...
Tue Mar 03, 2020 13:04
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