How Price-Based Frequency Regulation Impacts Stability in Power Grids: A Complex Network Perspective
With the deregulation of modern power grids, electricity markets are playing a more and more important role in power grid operation and control. However, it is still questionable how the real-time electricity price-based operation affects power grid stability. From a complex network perspective, here we investigate the dynamical interactions between price-based frequency regulations and physical networks, which results in an interesting finding that a local minimum of network stability occurs when...
Fri Feb 28, 2020 12:50
This paper presents an evolution-based hyperheuristic (EHH) for addressing the capacitated location-routing problem (CLRP) and one of its more practicable variants, namely, CLRP with simultaneous pickup and delivery (CLRPSPD), which are significant and NP-hard model in the complex logistics system. The proposed approaches manage a pool of low-level heuristics (LLH), implementing a set of simple, cheap, and knowledge-poor operators such as “shift” and “swap” to guide the search. Quantum (QS), ant...
Fri Feb 28, 2020 12:50
Based on the Jordan form of system matrix, this paper discusses algebraic conditions for the controllability of the multiagent network system with directed graph from two aspects: leader-follower network attribute and coupling input disturbance. Leader-follower network attribute refers to the topology structure and information communication among agents. Coupling input disturbance includes the number of external coupling inputs and the selection of leader nodes. When the leader-follower network attribute...
Fri Feb 28, 2020 12:50
This paper proposes a new trajectory tracking scheme for the constrained nonlinear underwater vehicle-manipulator system (UVMS). For overcoming the unmodeled uncertainties, external disturbances, and constraints of control inputs in the operation of UVMS, a modified constrained controller with a basic computed-torque controller (CTC) and a new designed nonlinear disturbance observer (NDO) are proposed. The CTC gives the nominal model-based control. The NDO is designed based on the system dynamics...
Fri Feb 28, 2020 12:50
We performed micro-CT imaging of the vascular blood supply in the interscapular area of the brown adipose tissue in three mice with the use of intravascular contrast agent Aurovist™. Resulting 3D data rendering was then adapted into 2D resolution with visualization using false color system and grayscale images. These were then studied for the automatic quantification of the blood vessel density within this area. We found the highest most occurring density within arterioles or venules representing...
Fri Feb 28, 2020 12:50
The purpose of this study was to evaluate the quality of surface contouring of chondromalacic cartilage by bipolar radio frequency energy using different treatment patterns in an animal model, as well as examining the impact of the treatment onto chondrocyte viability by two different methods. Our experiments were conducted on 36 fresh osteochondral sections from the tibia plateau of slaughtered 6-month-old pigs, where the thickness of the cartilage is similar to that of human wrist cartilage. An...
Fri Feb 28, 2020 12:50
Background. Macrophage-derived foam cells play a central role in atherosclerosis, and their ultimate fate includes apoptosis, promotion of vascular inflammation, or migration to other tissues. Nε-Carboxymethyl-lysine (CML), the key active component of advanced glycation end products, induced foam cell formation and apoptosis. Previous studies have shown that the Vav1/Rac1 pathway affects the macrophage cytoskeleton and cell migration, but its role in the pathogenesis of diabetic atherosclerosis is...
Fri Feb 28, 2020 12:20
Garlic has been proven effective in the prevention and treatment of atherosclerosis (AS), which is widely used as a food and medicine by people in daily life. Garlic saponins are the main active nonsulfur compounds of garlic, which have a variety of pharmacological activities against cardiovascular diseases. In this study, the antiatherosclerosis properties and mechanism of total saponins of garlic (TSG) in rats were explored. The AS animal model was established by a combination of high-fat feeding,...
Fri Feb 28, 2020 12:20
Implementation of precision oncology in treatment of pancreatic cancer is difficult. Many reasons exist for this problem: first, a rapidly progressive disease, mandating early induction of systemic therapy if at all possible; second, a relatively low number of actionable genetic variations; and third, disappointing results of the vast majority of trials assessing targeted approaches in a general population of patients with pancreatic ductal adenocarcinoma.1
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These real-world outcomes suggest that the adoption of precision medicine can have a substantial effect on survival in patients with pancreatic cancer, and that molecularly guided treatments targeting oncogenic drivers and the DNA damage response and repair pathway warrant further prospective evaluation.
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Abstract Objective Hepatic sinusoidal angiogenesis owing to dysfunctional liver sinusoidal endothelial cells (LSECs) accompanied by an abnormal angioarchitecture is a symbol related to liver fibrogenesis, which indicates a potential target for therapeutic interventions. However, there are few researches connecting angiogenesis with liver fibrosis, and the deeper mechanism remains to be explored. Materials and Methods Cell angiogenesis and angiogenic protein were examined in primary...
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The cover image is based on the Original Article A novel method to improve the osteogenesis capacity of hUCMSCs with dual‐directional pre‐induction under screened co‐culture conditions by Qiong Rong et al., https://doi.org/10.1111/cpr.12740.
Sat Feb 29, 2020 13:28
Inadequate handovers between hospital and home can lead to adverse health outcomes. A group particularly at risk are patients at the end of life because of complex health problems, frequent care transitions and involvement of many professionals.
Mon Mar 02, 2020 02:00
Empathy is increasingly described as a learnable skill and is included in professionalism requirements for healthcare providers, yet there are few effective tools for developing and practicing empathy skills.
Fri Feb 28, 2020 02:00
Pediatric palliative care aims to achieve the best possible quality of life for children with life-threatening/life-limiting conditions and their families (1). Globally, it is estimated that over 21 million children need palliative care every year (2). In China, pediatric palliative care is in the early stage of development. The importance of pediatric palliative care, and its need are mostly under-recognized. There are sporadic hospital-based services and only a few hospices, which are mostly located...
Fri Feb 28, 2020 02:00
As the outbreak of coronavirus disease 2019 (COVID-19) in China's Hubei province continues and new cases of the disease increase globally,1 there is pressure on historians to show the value of history for policy. How can the past assist in the real-time management of the crisis? What insights can be gleaned from the ongoing epidemic for future disease preparedness and prevention? Lurking in the background of these interrogatives is a more or less explicit accusation: why haven't past lessons been...
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WHO's Eastern Mediterranean region (EMR) is facing emergencies on a scale that is perhaps unprecedented in its history. There is armed conflict in 12 of the region's 22 countries.1,2 The region's 680 million people3 represent 9% of the global population, yet the EMR is home to 43% of those who need humanitarian assistance4 and is the source of 64% of the world's refugees.5
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The number of people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing coronavirus disease 2019 (COVID-19), is dramatically increasing worldwide.1 The first person-to-person transmission in Italy was reported on Feb 21, 2020, and led to an infection chain that represents the largest COVID-19 outbreak outside Asia to date. Here we document the response of the Emergency Medical System (EMS) of the metropolitan area of Milan, Italy, to the COVID-19 outbreak.
Sat Feb 29, 2020 01:30
Abstract Background Current intraoperative methods of visual inspection and tissue palpation by the surgeon, and frozen section analysis cannot reliably prevent inadequate surgical margins in patients treated for oral squamous‐cell carcinoma (OSCC). This study assessed feasibility of MRI for the assessment of surgical resection margins in fresh OSCC specimens. Methods Ten consecutive tongue specimens containing OSCC were scanned using 3 T clinical whole‐body MRI. Two radiologists...
02:11
Local child psychologist indicted on felony child pornography charges Dayton 24/7 Now
Fri Feb 28, 2020 04:12
Abstract Background Little is known about what factors affect patient‐reported swallowing outcome after total laryngectomy. We explored whether patient demographics, surgical variables, use of adjuvant treatment, and time since surgery were associated with patient‐reported swallowing outcome. Methods Cross‐sectional study of laryngectomees in eight UK hospitals. Demographic, treatment, and surgical variables were drawn from medical notes. The swallowing outcomes after laryngectomy...
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Abstract Background This study compared our proposed N classification including the addition of the number of positive lymph node (LN+) and extranodal extension (ENE) with the current and previous American Joint Committee on Cancer (AJCC) N classifications in salivary gland cancer (SGC). Methods This study involved 172 SGC patients who underwent surgery. Cox proportional hazard regression analyses were used to identify factors associated with overall survival (OS) and disease‐free...
Mon Mar 02, 2020 11:03
Abstract Background The objective of this study was to explore the 10‐year plus outcomes of Intensity Modulated Radiotherapy with concomitant chemotherapy (CRT) combined with preventive swallowing rehabilitation (CRT+) for head and neck cancer (HNC). Methods Subjective and objective swallowing, trismus, and speech related outcomes were assessed at 10‐year plus after CRT+. Outcomes were compared to previously published 6‐year results of the same cohort. Results Fourteen of the 22 patients...
Sun Mar 01, 2020 10:56
Abstract Background This study reports long‐term head and neck cancer (HNC) patient‐reported symptoms using the MD Anderson Symptom Inventory Head and Neck Cancer Module (MDASI‐HN) in a large cohort of HNC survivors. Methods MDASI‐HN results were prospectively collected from an institutional survivorship database. Associations with clinicopathologic data were analyzed using χ 2, Mann‐Whitney, and univariate regression. Results Nine hundred and twenty‐eight patients were included....
Sun Mar 01, 2020 10:56
Sat Feb 29, 2020 11:56
Sat Feb 29, 2020 11:56
The Pharmacogenomics Journal, Published online: 03 March 2020; doi:10.1038/s41397-020-0164-3Association of MICA-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis
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Leprosy is endemic in more than 100 countries worldwide, with over 200 000 new diagnoses each year and more than 4 million people living with some form of impairment related to leprosy. The term leprosy, as used in the Bible, designated a multitude of diseases with skin manifestations. Biblical leprosy carried huge stigma and was considered synonymous with impurity and divine punishment. Global actions to eliminate leprosy have been implemented but have yet to succeed, with stigmatisation and discrimination...
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Human infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global health concern.1,2 Currently, human-to-human transmission of the virus accounts for most infections worldwide.3 We report a family cluster of SARS-CoV-2 infection involving 11 patients in Nanjing, China.
Sat Feb 29, 2020 01:30
We determine the correlation of volumetric contraction and layer depth of light‐cured resin cements. We determine the correlation of microporosity and layer depth of light‐cured resin cements. We found that the composition of the cements is determinant for the correlation's coefficients. We determine a correlation between volumetric contraction and microporosity of light‐cured resin cements. Abstract This research aimed to obtain the depth dependence of polymerization contraction and...
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Taxonomy of family Apocynaceae using light Microscopy and scanning electron microscopy techniques. Important micromorphological characteristics for the identification of species of Apocynaceae. Foliar epidermal anatomical characteristics of the family Apocynaceae. Abstract In the present study, we evaluate the importance of foliar epidermal micromorphological characteristics of Apocyanaceae for accurate identification and classification. The species were collected from the University of Peshawar's...
02:01
Schematic presentation of humoral and cellular responses involved in E. tetragonm defense mechanisms upon infection by micro‐organisms. Blue indicates inside the hemocytes steps of phagocytosis and encapsulation. Green indicates lysosomes and the various humoral factors such as antimicrobial peptides, lysosomal hydrolysases, protease inhibitors that also contribute to eliminate pathogenic micro‐organisms. Red symbolizes the invading micro‐organisms. Episesarma tetragonum hemocytes different types...
Fri Feb 28, 2020 16:05
Abstract University students’ health may be adversely affected by exposure to indoor bacterial contaminants on their campuses. This study aims (1) to quantify culturable bacterial concentrations in three indoor environments at a university, (2) to investigate the influence of meteorological factors and gender, to assess the relationship between indoor and outdoor, and (3) to estimate the bacterial dose for university students in different indoor environments. Airborne bacteria...
Mon Mar 02, 2020 02:00
Abstract Aerobiological studies in urban areas are quite abundant in recent decades, but not in rural areas with a high environmental value. In this work, we analyze the airborne levels of pollen and fern spores in year 2012 collected by means of a volumetric sampler located in an ecological vineyard and in the Biosphere Reserve “Sierras de Béjar y Francia.” The results showed a high atmospheric representation of the natural vegetation of the environment, with almost half of the...
Fri Feb 28, 2020 02:00
Cancer Gene Therapy, Published online: 03 March 2020; doi:10.1038/s41417-020-0170-2Transcription factors in ferroptotic cell death
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Stimulated by published reports of potentially inappropriate application of venous procedures, the American Venous Forum and its Ethics Task Force in collaboration with multiple other professional societies including the Society for Vascular Surgery (SVS), American Vein and Lymphatic Society (AVLS), and the Society of Interventional Radiology (SIR) developed the appropriate use criteria (AUC) for chronic lower extremity venous disease to provide clarity to the application of venous procedures, duplex...
Mon Mar 02, 2020 02:00
Superior mesenteric venous thrombosis (MVT) is a poorly understood clinical entity, and as such, outcomes are poorly described. This study aimed to identify predictors of bowel ischemia after MVT and to compare outcomes for patients treated medically (group 1) with those for patients treated with bowel resection (group 2).
Mon Mar 02, 2020 02:00
Surgical intervention for severe lymphedema is reserved for failure of conservative management. The reductive approach aims to remove fibrosclerotic tissue acquired from prolonged lymphatic stasis. One such reductive approach is the modified Charles procedure, direct circumferential excision down to fascia followed by split-thickness skin graft application. The 1-year outcomes in our patients suggest that a multidisciplinary approach to the modified Charles procedure is an effective management option...
Mon Mar 02, 2020 02:00
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