In assessing the validity of medical trials, an inactive control, or placebo, is considered essential in producing high-quality evidence. Randomized double-blind, placebo-controlled studies are, in fact, considered to be the "gold standard," as good as it gets in terms of epidemiologic studies.1 The assumption here is that the placebo is inert, i.e., is a substance that has no effect on your body. The reason this is an assumption is that, typically, the contents of the placebo in a study are not...
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Promises, promises, promises. The toxic world of genetically modified organisms (GMOs) and industrial agriculture is built on false promises. For nearly 30 years we have been listening to the propaganda of the big biotech companies like Monsanto/Bayer, Syngenta, DuPont/Pioneer, BASF and others about how genetic engineering will transform farming and food production. We’ve heard how it will reduce the environmental impact of farming by lowering pesticide use. We’ve been promised that...
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Chemical pesticides have become a mainstay of modern agriculture, despite red flags that they’re slowly destroying ecosystems. (Technically, pesticides are designed to kill insects, while herbicides are used to kill weeds or substances like bacteria or fungi, but when discussing them, the U.S. EPA lumps them all together as “pesticides.”1) Part of what makes assessing the health and environmental risks of pesticides so difficult is that many of the risks remain unknown, and those that are known...
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The largest high-level encyclopedia on molecular medicine is now publishing a topical volume on Nanomedicine. The long awaited volume gives a comprehensive overview on nanomaterials in drug delivery, imaging and as therapeutics.Read More...
Mon Mar 02, 2020 07:00
Abstract Background Cryptotanshinone (CPT), as a major component of Salvia miltiorrhiza Bunge (Danshen), displays many pharmacological activities including anti-inflammatory effects. However, the exact cellular and molecular mechanisms of the anti-inflammatory activities of CPT remain to be elucidated. The present study was aimed to clarify its mechanisms on lipopolysaccharide (LPS)-induced inflammatory responses in mouse macrophages,...
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Abstract Background To address overuse of unnecessary practices, several surgical organizations have participated in the Choosing Wisely® campaign and identified four breast cancer surgical procedures as unnecessary. Despite evidence demonstrating no survival benefit for all four, evidence suggests only two have been substantially de-implemented. Our objective was to understand why surgeons stop performing certain unnecessary cancer operations...
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Abstract Purpose 18F-Fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (18F-FDG PET/CT) is an important diagnostic tool in breast cancer. The utility of maximum standardized uptake values (SUVmax) of primary tumors has been evaluated to predict sentinel node (SN) and non-SN metastasis in clinically node-negative (cN0) patients. Patients and Methods...
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Directed species loss reduces community productivity in a subtropical forest biodiversity experiment
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