Brain Sciences, Vol. 10, Pages 156: Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies Brain Sciences doi: 10.3390/brainsci10030156 Authors: Claudia Brogna Marco Luigetti Giulia Norcia Roberta Scalise Gloria Ferrantini Beatrice Berti Domenico M. Romeo Raffaele Manna Eugenio Mercuri Marika Pane We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher...
Sat Mar 07, 2020 02:00
Brain Sciences, Vol. 10, Pages 154: Depression Treatment Status of Economically Disadvantaged African American Older Adults Brain Sciences doi: 10.3390/brainsci10030154 Authors: Sharon Cobb Mohsen Bazargan Jessica Castro Sandoval Cheryl Wisseh Meghan C. Evans Shervin Assari Background: It is known that depression remains largely untreated in underserved communities. Hence, it is desirable to gain more knowledge on the prevalence and correlates of untreated depression among...
Sat Mar 07, 2020 02:00
Brain Sciences, Vol. 10, Pages 155: Diagnosing Juvenile Huntington’s Disease: An Explorative Study among Caregivers of Affected Children Brain Sciences doi: 10.3390/brainsci10030155 Authors: Oosterloo Bijlsma Die-Smulders Roos Objective: To investigate the reasons for the diagnostic delay of juvenile Huntington’s disease patients in the Netherlands. Methods: This study uses interpretative phenomenological analysis. Eligible participants were parents and caregivers...
Sat Mar 07, 2020 02:00
Brain Sciences, Vol. 10, Pages 152: Effect of Metformin on Doxorubicin-Induced Memory Dysfunction Brain Sciences doi: 10.3390/brainsci10030152 Authors: Ibrahim Alharbi Hindi Alharbi Yasser Almogbel Abdullah Alalwan Ahmad Alhowail Doxorubicin (DOX) is widely used to treat many types of cancer; however, it is associated with chemotherapy-related complications such as cognitive dysfunction, known as chemobrain. Chemobrain affects up to 75% of cancer survivors, and there are...
Sat Mar 07, 2020 02:00
Brain Sciences, Vol. 10, Pages 153: The Role of Sartans in the Treatment of Stroke and Subarachnoid Hemorrhage: A Narrative Review of Preclinical and Clinical Studies Brain Sciences doi: 10.3390/brainsci10030153 Authors: Stefan Wanderer Basil E. Grüter Fabio Strange Sivani Sivanrupan Stefano Di Santo Hans Rudolf Widmer Javier Fandino Serge Marbacher Lukas Andereggen Background: Delayed cerebral vasospasm (DCVS) due to aneurysmal subarachnoid hemorrhage (aSAH)...
Sat Mar 07, 2020 02:00
Brain Sciences, Vol. 10, Pages 151: Developmental Dyslexia: Where Do We Go from Here? Brain Sciences doi: 10.3390/brainsci10030151 Authors: Paul E. Engelhardt This editorial follows an influential review paper published in Brain Sciences in 2018 (What is Developmental Dyslexia? by John Stein). In this editorial, I present a critical look at the arguments in Stein’s review, with a particular view towards “looking ahead”. In looking ahead, I will focus on...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 627: Impaired Anti-Tumor T cell Response in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12030627 Authors: Chaoul Mancarella Lupo Giannelli Dituri Different subsets of lymphocytes have the capacity to promote or counteract the progression of solid cancers, including hepatocellular carcinoma (HCC). Therefore, to determine the infiltrative ability and functional status of major immune cell subtypes into tumor may lead to novel insights from...
Sun Mar 08, 2020 02:00
Cancers, Vol. 12, Pages 625: Preoperative Serum Thyroglobulin and Its Correlation with the Burden and Extent of Differentiated Thyroid Cancer Cancers doi: 10.3390/cancers12030625 Authors: Hosu Kim So Young Park Jun-Ho Choe Jee Soo Kim Soo Yeon Hahn Sun Wook Kim Jae Hoon Chung Jaehoon Jung Tae Hyuk Kim Lymph node metastasis (LNM) in differentiated thyroid cancer (DTC) is usually detected with preoperative ultrasonography; however, this has limited sensitivity for...
Sun Mar 08, 2020 02:00
Cancers, Vol. 12, Pages 624: Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene Cancers doi: 10.3390/cancers12030624 Authors: Alessandro Liquori Mariam Ibañez Claudia Sargas Miguel Ángel Sanz Eva Barragán José Cervera Although acute promyelocytic leukemia (APL) is one of the most characterized forms of acute myeloid leukemia (AML), the molecular mechanisms involved in the development and progression of this disease are...
Sun Mar 08, 2020 02:00
Cancers, Vol. 12, Pages 626: The Pre-Treatment C-Reactive Protein Represents a Prognostic Factor in Patients with Oral and Oropharyngeal Cancer Treated with Radiotherapy Cancers doi: 10.3390/cancers12030626 Authors: Olivia Knittelfelder Daniela Delago Gabriele Jakse Katarzyna Lukasiak Eva-Maria Thurner Dietmar Thurnher Martin Pichler Wilfried Renner Heidi Stranzl-Lawatsch Tanja Langsenlehner The purpose of the present study was to evaluate the prognostic significance...
Sun Mar 08, 2020 02:00
Cancers, Vol. 12, Pages 623: Retinol-Binding Protein 4 Accelerates Metastatic Spread and Increases Impairment of Blood Flow in Mouse Mammary Gland Tumors Cancers doi: 10.3390/cancers12030623 Authors: Diana Papiernik Anna Urbaniak Dagmara Kłopotowska Anna Nasulewicz-Goldeman Marcin Ekiert Marcin Nowak Joanna Jarosz Monika Cuprych Aleksandra Strzykalska Maciej Ugorski Rafał Matkowski Joanna Wietrzyk Retinol-binding protein 4 (RBP4) is proposed as an adipokine...
Sat Mar 07, 2020 02:00
Cancers, Vol. 12, Pages 622: A High-Performing Plasma Metabolite Panel for Early-Stage Lung Cancer Detection Cancers doi: 10.3390/cancers12030622 Authors: Lun Zhang Jiamin Zheng Rashid Ahmed Guoyu Huang Jennifer Reid Rupasri Mandal Andrew Maksymuik Daniel S. Sitar Paramjit S. Tappia Bram Ramjiawan Philippe Joubert Alessandro Russo Christian D. Rolfo David S. Wishart The objective of this research is to use metabolomic techniques to discover and...
Sat Mar 07, 2020 02:00
Cancers, Vol. 12, Pages 620: RNA Immune Signatures from Pan-Cancer Analysis Are Prognostic for High-Grade Serous Ovarian Cancer and Other Female Cancers Cancers doi: 10.3390/cancers12030620 Authors: Wendell D. Jones Chad M. Michener Charles Biscotti Iona Braicu Jalid Sehouli Mahrukh K. Ganapathi Ram N. Ganapathi Immune cell infiltrates within the tumor microenvironment can influence treatment response and outcome in several cancers. In this study, we developed RNA-based...
Sat Mar 07, 2020 02:00
Cancers, Vol. 12, Pages 621: High Prevalence of Alterations in DNA Mismatch Repair Genes of Lynch Syndrome in Pediatric Patients with Adrenocortical Tumors Carrying a Germline Mutation on TP53 Cancers doi: 10.3390/cancers12030621 Authors: Vania Balderrama Brondani Luciana Montenegro Amanda Meneses Ferreira Lacombe Breno Marchiori Magalhães Mirian Yumie Nishi Mariana Ferreira de Assis Funari Amanda de Moraes Narcizo Lais Cavalca Cardoso Sheila Aparecida Coelho Siqueira...
Sat Mar 07, 2020 02:00
Cancers, Vol. 12, Pages 619: Modeling the Efficacy of Oncolytic Adenoviruses In Vitro and In Vivo: Current and Future Perspectives Cancers doi: 10.3390/cancers12030619 Authors: Mary K. McKenna Amanda Rosewell-Shaw Masataka Suzuki Oncolytic adenoviruses (OAd) selectively target and lyse tumor cells and enhance anti- tumor immune responses. OAds have been used as promising cancer gene therapies for many years and there are a multitude of encouraging pre-clinical studies. However,...
Sat Mar 07, 2020 02:00
Cancers, Vol. 12, Pages 618: Primary Thromboprophylaxis in Pancreatic Cancer Patients: Why Clinical Practice Guidelines Should Be Implemented Cancers doi: 10.3390/cancers12030618 Authors: Dominique Farge Barbara Bournet Thierry Conroy Eric Vicaut Janusz Rak George Zogoulous Jefferey Barkun Mehdi Ouaissi Louis Buscail Corinne Frere Exocrine pancreatic ductal adenocarcinoma, simply referred to as pancreatic cancer (PC) has the worst prognosis of any malignancy....
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 617: Oral Capecitabine-Vinorelbine is Associated with Longer Overall Survival When Compared to Single-Agent Capecitabine in Patients with Hormone Receptor-Positive Advanced Breast Cancer Cancers doi: 10.3390/cancers12030617 Authors: Vernieri Prisciandaro Nichetti Lobefaro Peverelli Ligorio Zattarin Cona Sepe Corti Manglaviti Brambilla Re Belfiore Pruneri Celio Mariani Bianchi Rivoltini Capri...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 615: Haprolid Inhibits Tumor Growth of Hepatocellular Carcinoma through Rb/E2F and Akt/mTOR Inhibition Cancers doi: 10.3390/cancers12030615 Authors: Jun Xing Vikas Bhuria Khac Cuong Bui Mai Ly Thi Nguyen Zexi Hu Chih-Jen Hsieh Kathrin Wittstein Marc Stadler Ludwig Wilkens Jun Li Markus Kalesse Przemyslaw Bozko Ruben R. Plentz Background: Hepatocellular carcinoma (HCC) represents a major health burden with limited curative treatment...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 614: EGFR Protein Expression in KRAS Wild-Type Metastatic Colorectal Cancer Is Another Negative Predictive Factor of the Cetuximab Therapy Cancers doi: 10.3390/cancers12030614 Authors: Andrea Uhlyarik Violetta Piurko Zsuzsanna Papai Erzsebet Raso Erika Lahm Edina Kiss Marta Sikter Jozsef Vachaja Istvan Kenessey Jozsef Timar The selection of colorectal cancer patients for anti-epidermal growth factor receptor (EGFR) antibody therapy is...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 616: Radiotherapy Is Associated with an Accelerated Risk of Ischemic Stroke in Oral Cavity Cancer Survivors after Primary Surgery Cancers doi: 10.3390/cancers12030616 Authors: Feng-Che Kuan Kuan-Der Lee Shiang-Fu Huang Ping-Tsung Chen Cih-En Huang Ting-Yao Wang Min-Chi Chen The number of oral cavity carcinoma (OCC) survivors continues to increase due to advances in definitive surgery and radiation therapy (RT), however the risk of ischemic stroke...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 612: Preventing Venous Thromboembolism in Ambulatory Patients with Cancer: A Narrative Review Cancers doi: 10.3390/cancers12030612 Authors: Rossel Robert-Ebadi Marti Venous thromboembolism (VTE) is frequent among patients with cancer. Ambulatory cancer patients starting chemotherapy have a 5% to 10% risk of cancer associated thrombosis (CAT) within the first year after cancer diagnosis. This risk may vary according to patient characteristics, cancer location,...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 610: Human Endogenous Retroviruses (HERVs): Shaping the Innate Immune Response in Cancers Cancers doi: 10.3390/cancers12030610 Authors: Vincent Alcazer Paola Bonaventura Stephane Depil Human Endogenous Retroviruses (HERVs) are accounting for 8% of the human genome. These sequences are remnants from ancient germline infections by exogenous retroviruses. After million years of evolution and multiple integrations, HERVs have acquired many damages rendering...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 611: Age-Dependent Presentation and Clinical Course of 1465 Patients Aged 0 to Less than 18 Years with Ovarian or Testicular Germ Cell Tumors; Data of the MAKEI 96 Protocol Revisited in the Light of Prenatal Germ Cell Biology Cancers doi: 10.3390/cancers12030611 Authors: Gabriele Calaminus Dominik T. Schneider Dietrich von Schweinitz Heribert Jürgens Nacera Infed Stefan Schönberger Thomas A. Olson Peter Albers Christian Vokuhl Raimund Stein...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 613: Globular Adiponectin Inhibits Breast Cancer Cell Growth through Modulation of Inflammasome Activation: Critical Role of Sestrin2 and AMPK Signaling Cancers doi: 10.3390/cancers12030613 Authors: Duc-Vinh Pham Pawan Kumar Raut Mahesh Pandit Jae-Hoon Chang Nikita Katila Dong-Young Choi Jee-Heon Jeong Pil-Hoon Park Adiponectin, an adipokine predominantly derived from adipose tissue, exhibits potent antitumor properties in breast cancer cells....
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 608: Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin Cancers doi: 10.3390/cancers12030608 Authors: Marta Mariniello Raffaella Petruzzelli Luca G. Wanderlingh Raffaele La Montagna Annamaria Carissimo Francesca Pane Angela Amoresano Ekaterina Y. Ilyechova Michael M. Galagudza Federico Catalano Roberta Crispino Ludmila V. Puchkova Diego L. Medina Roman...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 609: Ductal Carcinoma In Situ of the Breast: An Update with Emphasis on Radiological and Morphological Features as Predictive Prognostic Factors Cancers doi: 10.3390/cancers12030609 Authors: Lucia Salvatorelli Lidia Puzzo Giada Maria Vecchio Rosario Caltabiano Valentina Virzì Gaetano Magro Ductal carcinoma in situ (DCIS) shows overlapping epidemiology with invasive ductal carcinoma of the breast, sharing similar risk factorssuch as age, mammographic...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 606: Combined wIRA-Hyperthermia and Hypofractionated Re-Irradiation in the Treatment of Locally Recurrent Breast Cancer: Evaluation of Therapeutic Outcome Based on a Novel Size Classification Cancers doi: 10.3390/cancers12030606 Authors: Markus Notter Andreas R. Thomsen Mirko Nitsche Robert M. Hermann Hendrik A. Wolff Gregor Habl Karin Münch Anca-L. Grosu Peter Vaupel Effective tumor control in patients suffering from unresectable locally...
Fri Mar 06, 2020 02:00
Cancers, Vol. 12, Pages 607: Prognostic Value of Lymph Node-To-Primary Tumor Standardized Uptake Value Ratio in Esophageal Squamous Cell Carcinoma Treated with Definitive Chemoradiotherapy Cancers doi: 10.3390/cancers12030607 Authors: Chia-Hsin Lin Tsung-Min Hung Yu-Chuan Chang Chia-Hsun Hsieh Ming-Chieh Shih Shih-Ming Huang Chan-Keng Yang Ching-Fu Chang Sheng-Chieh Chan Wing-Keen Yap We aimed to investigate the prognostic value of the relative maximum standardized...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 656: Vascular Smooth Muscle Cell-Specific Progerin Expression Provokes Contractile Impairment in a Mouse Model of Hutchinson-Gilford Progeria Syndrome that Is Ameliorated by Nitrite Treatment Cells doi: 10.3390/cells9030656 Authors: Lara del Campo Amanda Sánchez-López Cristina González-Gómez María Jesús Andrés-Manzano Beatriz Dorado Vicente Andrés Cardiovascular disease (CVD) is the main cause of death worldwide, and aging is its leading risk factor....
Sun Mar 08, 2020 02:00
Cells, Vol. 9, Pages 655: Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation Cells doi: 10.3390/cells9030655 Authors: Maria E. Vega Birgit Kastberger Bernhard Wehrle-Haller Jean E. Schwarzbauer Diabetic nephropathy, a devastating consequence of diabetes mellitus, is characterized by the accumulation of extracellular matrix (ECM) that disrupts the kidney’s filtration apparatus. Elevated glucose levels increase the deposition of a fibronectin (FN) matrix by mesangial...
Sun Mar 08, 2020 02:00
Cells, Vol. 9, Pages 654: Bone Regeneration: A Novel Osteoinductive Function of Spongostan by the Interplay between Its Nano- and Microtopography Cells doi: 10.3390/cells9030654 Authors: Thomas Vordemvenne Dirk Wähnert Julian Koettnitz Madlen Merten Nadine Fokin Andreas Becker Björn Büker Asaria Vogel Daniel Kronenberg Richard Stange Günther Wittenberg Johannes FW Greiner Andreas Hütten Christian Kaltschmidt Barbara Kaltschmidt Scaffold materials...
Sat Mar 07, 2020 02:00
Cells, Vol. 9, Pages 651: Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers Cells doi: 10.3390/cells9030651 Authors: Carina Herman-de-Sousa Ana Rita Pinheiro Diogo Paramos-de-Carvalho Maria Adelina Costa Fátima Ferreirinha Teresa Magalhães-Cardoso Severino Ribeiro Julie Pelletier Jean Sévigny Paulo Correia-de-Sá Human subcutaneous fibroblasts (HSCF) challenged with inflammatory mediators...
Sat Mar 07, 2020 02:00
Cells, Vol. 9, Pages 652: Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells Cells doi: 10.3390/cells9030652 Authors: Verónica Uribe-Etxebarria Patricia García-Gallastegui Miguel Pérez-Garrastachu María Casado-Andrés Igor Irastorza Fernando Unda Gaskon Ibarretxe Nerea Subirán Dental pulp stem cells (DPSCs) from adult teeth show the expression of a very complete repertoire of stem pluripotency core factors and a high plasticity for cell reprogramming....
Sat Mar 07, 2020 02:00
Cells, Vol. 9, Pages 653: Dynamic Signatures of the Epigenome: Friend or Foe? Cells doi: 10.3390/cells9030653 Authors: Marta Machnik Urszula Oleksiewicz Highly dynamic epigenetic signaling is influenced mainly by (micro)environmental stimuli and genetic factors. The exact mechanisms affecting particular epigenomic patterns differ dependently on the context. In the current review, we focus on the causes and effects of the dynamic signatures of the human epigenome as evaluated with...
Sat Mar 07, 2020 02:00
Cells, Vol. 9, Pages 649: A Unique GSK-3β inhibitor B10 Has a Direct Effect on Aβ, Targets Tau and Metal Dyshomeostasis, and Promotes Neuronal Neurite Outgrowth Cells doi: 10.3390/cells9030649 Authors: Xiao-Long Shi Ning Yan Ying-Jie Cui Zhao-Peng Liu Due to the complicated pathogenesis of Alzheimer’s disease (AD), the development of multitargeted agents to simultaneously interfere with multiple pathological processes of AD is a potential choice. Glycogen synthase...
Sat Mar 07, 2020 02:00
Cells, Vol. 9, Pages 650: Mechanical Forces and Their Effect on the Ribosome and Protein Translation Machinery Cells doi: 10.3390/cells9030650 Authors: Lisa J. Simpson John S. Reader Ellie Tzima Mechanical forces acting on biological systems, at both the macroscopic and microscopic levels, play an important part in shaping cellular phenotypes. There is a growing realization that biomolecules that respond to force directly applied to them, or via mechano-sensitive signalling pathways,...
Sat Mar 07, 2020 02:00
Cells, Vol. 9, Pages 647: ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma Cells doi: 10.3390/cells9030647 Authors: Dimas Carolina Belisario Muhlis Akman Martina Godel Virginia Campani Maria Pia Patrizio Lorena Scotti Claudia Maria Hattinger Giuseppe De Rosa Massimo Donadelli Massimo Serra Joanna Kopecka Chiara Riganti The ATP Binding Cassette transporter B1 (ABCB1) induces chemoresistance in osteosarcoma, because it effluxes...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 646: FAK Deficiency in Bone Marrow Stromal Cells Alters Their Homeostasis and Drives Abnormal Proliferation and Differentiation of Haematopoietic Stem Cells Cells doi: 10.3390/cells9030646 Authors: Yuenv Wu Lydia Campos Elisabeth Daguenet Zhiguo He Tiphanie Picot Emmanuelle Tavernier-Tardy Gilbert Soglu Denis Guyotat Carmen-Mariana Aanei Emerging evidence indicates that in myelodysplastic syndromes (MDS), the bone marrow (BM) microenvironment...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 645: MicroRNAs in Small Extracellular Vesicles Indicate Successful Embryo Implantation during Early Pregnancy Cells doi: 10.3390/cells9030645 Authors: Qiang Tan Shuang Shi Jingjie Liang Xiaowei Zhang Dingren Cao Zhengguang Wang Synchronous communication between the developing embryo and the receptive endometrium is crucial for embryo implantation. Thus, uterine receptivity evaluation is vital in managing recurrent implantation failure (RIF). The potential...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 644: Ameloblastomas Exhibit Stem Cell Potential, Possess Neurotrophic Properties, and Establish Connections with Trigeminal Neurons Cells doi: 10.3390/cells9030644 Authors: Pagella Catón Meisel Mitsiadis Ameloblastomas are locally invasive and aggressive odontogenic tumors treated via surgical resection, which results in facial deformity and significant morbidity. Few studies have addressed the cellular and molecular events of ameloblastoma onset and...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 648: The Peroxisome Proliferator-Activated Receptor α- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections Cells doi: 10.3390/cells9030648 Authors: Yi Sak Kim Jin Kyung Kim Bui Thi Bich Hanh Soo Yeon Kim Hyeon Ji Kim Young Jae Kim Sang Min Jeon Cho Rong Park Goo Taeg Oh June-Woo Park Jin-Man Kim Jichan Jang Eun-Kyeong Jo Peroxisome proliferator-activated receptor α (PPARα) shows promising...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 642: Fabrication of Dentin-Pulp-Like Organoids Using Dental-Pulp Stem Cells Cells doi: 10.3390/cells9030642 Authors: Sang Yun Jeong Soonchul Lee Woo Hee Choi Joo Hyun Jee Hyung-Ryong Kim Jongman Yoo We developed a novel dentin-pulp-like organoid. It has both stem-cell and odontoblast characteristics using a mesenchymal cell lineage of human dental-pulp stem cells (hDPSCs). The mixture of hDPSCs and Matrigel was transferred into the maintenance medium...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 643: HMGB1 Translocation in Neurons after Ischemic Insult: Subcellular Localization in Mitochondria and Peroxisomes Cells doi: 10.3390/cells9030643 Authors: Wang Liu Fukuyasu Teshigawara Fu Wake Ohtsuka Nishibori High mobility group box-1 (HMGB1), a nonhistone chromatin DNA-binding protein, is released from neurons into the extracellular space under ischemic, hemorrhagic, and traumatic insults. However, the details of the time-dependent...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 641: Molecular Rewiring of the Jasmonate Signaling Pathway to Control Auxin-Responsive Gene Expression Cells doi: 10.3390/cells9030641 Authors: Li Cao Miu Cao Peng Wan Huang The plant hormone jasmonic acid (JA) has an important role in many aspects of plant defense response and developmental process. JA triggers interaction between the F-box protein COI1 and the transcriptional repressors of the JAZ family that leads the later to proteasomal...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 640: Effective Synergy of Sorafenib and Nutrient Shortage in Inducing Melanoma Cell Death through Energy Stress Cells doi: 10.3390/cells9030640 Authors: Antunes Pereira Saito Buri Gagliardi Bincoletto Chammas Fimia Piacentini Corazzari Smaili Skin melanoma is one of the most aggressive and difficult-to-treat human malignancies, characterized by poor survival rates, thus requiring urgent novel therapeutic approaches. Although...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 637: Induction of Cyclooxygenase-2 by Overexpression of the Human NADPH Oxidase 5 (NOX5) Gene in Aortic Endothelial Cells Cells doi: 10.3390/cells9030637 Authors: Javier Marqués Adriana Cortés Álvaro Pejenaute Eduardo Ansorena Gloria Abizanda Felipe Prósper Juan José Martínez-Irujo Carlos de Miguel Guillermo Zalba Oxidative stress is a main molecular mechanism that underlies cardiovascular diseases. A close relationship between reactive oxygen...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 638: CDK7 Inhibition is Effective in all the Subtypes of Breast Cancer: Determinants of Response and Synergy with EGFR Inhibition Cells doi: 10.3390/cells9030638 Authors: Martina S.J. McDermott Amanda C. Sharko Jessica Munie Susannah Kassler Theresa Melendez Chang-uk Lim Eugenia V. Broude CDK7, a transcriptional cyclin-dependent kinase, is emerging as a novel cancer target. Triple-negative breast cancers (TNBC) but not estrogen receptor-positive...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 636: Human Tonsil-Derived Mesenchymal Stromal Cells Maintain Proliferating and ROS-Regulatory Properties via Stanniocalcin-1 Cells doi: 10.3390/cells9030636 Authors: Seo Shin Ahn Oh Shin Yang Park Shin Kwon Kim Sung Park Lee Kim Mesenchymal stromal cells (MSCs) from various sources exhibit different potential for stemness and therapeutic abilities. Recently, we reported a unique MSCs from human palatine tonsil...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 639: Vascular Smooth Muscle Cell-Derived Exosomal MicroRNAs Regulate Endothelial Cell Migration Under PDGF Stimulation Cells doi: 10.3390/cells9030639 Authors: Jeongyeon Heo Hee Cheol Yang Won Jong Rhee Hara Kang Intercellular communication between vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) is essential for the maintenance of vascular homeostasis. The presence of exosomes, a recently discovered player in vascular cell communication,...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 635: Three-Dimensional Cell Culture Based on Magnetic Fields to Assemble Low-Grade Ovarian Carcinoma Cell Aggregates Containing Lymphocytes Cells doi: 10.3390/cells9030635 Authors: Caroline Natânia de Souza-Araújo Cláudia Rodrigues Tonetti Marcella Regina Cardoso Liliana Aparecida Lucci de Angelo Andrade Rodrigo Fernandes da Silva Luís Gustavo Romani Fernandes Fernando Guimarães There is a limited number of established ovarian cancer cell lines...
Fri Mar 06, 2020 02:00
Cells, Vol. 9, Pages 634: Stress Erythropoiesis is a Key Inflammatory Response Cells doi: 10.3390/cells9030634 Authors: Robert F. Paulson Baiye Ruan Siyang Hao Yuanting Chen Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen. Despite the enormous capacity of the bone marrow to produce erythrocytes, there are times when it is unable...
Fri Mar 06, 2020 02:00
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