Antibiotics, Vol. 9, Pages 115: Understanding General Practitioners’ Antibiotic Prescribing Decisions in Out-of-Hours Primary Care: A Video-Elicitation Interview Study Antibiotics doi: 10.3390/antibiotics9030115 Authors: Infections are the most common reason why patients consult out-of-hours (OOH) primary care. Too often there is an overprescribing of antibiotics for self-limiting infections and general practitioners (GPs) do not always choose the guideline recommended antibiotics. To improve...
Sat Mar 07, 2020 02:00
Antibiotics, Vol. 9, Pages 114: Impact of Strain Competition on Bacterial Resistance in Immunocompromised Populations Antibiotics doi: 10.3390/antibiotics9030114 Authors: DeNegre Myers Fefferman Despite the risk of emerging drug resistance that occurs with the frequent use of antimicrobial agents, targeted and prophylactic antibiotics have been considered crucial to opportunistic infection management among the HIV/AIDS-immunocompromised. As we recently demonstrated, the disrupted...
Sat Mar 07, 2020 02:00
Antibiotics, Vol. 9, Pages 113: Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Simulation of Piperacillin/Tazobactam for Dosing Optimization in Late Elderly Patients with Pneumonia Antibiotics doi: 10.3390/antibiotics9030113 Authors: Ishihara Nishimura Ikawa Karino Miura Tamaki Yano Isobe Morikawa Naora The aim of this study was to develop a population pharmacokinetic model for piperacillin (PIPC)/tazobactam (TAZ) in late...
Fri Mar 06, 2020 02:00
Antibiotics, Vol. 9, Pages 112: Fosfomycin Resistance in Escherichia coli Isolates from South Korea and in vitro Activity of Fosfomycin Alone and in Combination with Other Antibiotics Antibiotics doi: 10.3390/antibiotics9030112 Authors: Hyeri Seok Ji Young Choi Yu Mi Wi Dae Won Park Kyong Ran Peck Kwan Soo Ko We investigated fosfomycin susceptibility in Escherichia coli clinical isolates from South Korea, including community-onset, hospital-onset, and long-term care facility...
Fri Mar 06, 2020 02:00
Antibodies, Vol. 9, Pages 6: Special Issue: Nanobody Antibodies doi: 10.3390/antib9010006 Authors: Chames Rothbauer Since their first description in 1993 [1], single-domain antibody fragments derived from heavy-chain-only antibodies of camelids have received increasing attention as highly versatile binding molecules in the fields of biotechnology and medicine [...]
Fri Mar 06, 2020 02:00
Antioxidants, Vol. 9, Pages 222: Accumulation of Ascorbic Acid in Tomato Cell Culture: Influence of the Genotype, Source Explant and Time of In Vitro Cultivation Antioxidants doi: 10.3390/antiox9030222 Authors: Maria Minutolo Pasquale Chiaiese Antonio Di Matteo Angela Errico Giandomenico Corrado The production and commercialization of natural antioxidants is gaining increasing importance due to their wide range of biological effects and applications. In vitro cell culture...
Sat Mar 07, 2020 02:00
Antioxidants, Vol. 9, Pages 221: Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise Antioxidants doi: 10.3390/antiox9030221 Authors: Shuen Yee Lee Stephen F. Burns Kenneth K.C. Ng David J. Stensel Liang Zhong Frankie H.Y. Tan Kar Ling Chia Kai Deng Fam Margaret M.C. Yap Kwee Poo Yeo Eric P.H. Yap Chin Leong Lim Fibroblast growth factor 21 (FGF21) and adiponectin increase the expression of genes...
Sat Mar 07, 2020 02:00
Antioxidants, Vol. 9, Pages 220: The Possibility of Using Genotoxicity, Oxidative Stress and Inflammation Blood Biomarkers to Predict the Occurrence of Late Cutaneous Side Effects after Radiotherapy Antioxidants doi: 10.3390/antiox9030220 Authors: Samia Chaouni Delphine Dumont Lecomte Dinu Stefan Alexandre Leduc Victor Barraux Alexandra Leconte Jean-Michel Grellard Jean-Louis Habrand Marilyne Guillamin François Sichel Carine Laurent Despite the progresses...
Sat Mar 07, 2020 02:00
Antioxidants, Vol. 9, Pages 219: Efficacy of Antioxidant Supplementation on Conventional and Advanced Sperm Function Tests in Patients with Idiopathic Male Infertility Antioxidants doi: 10.3390/antiox9030219 Authors: Mohamed Arafa Ashok Agarwal Ahmad Majzoub Manesh Kumar Panner Selvam Saradha Baskaran Ralf Henkel Haitham Elbardisi Antioxidants are used in the empirical treatment of infertile men. The aim of this study was to evaluate the effects of antioxidant therapy...
Fri Mar 06, 2020 02:00
Atmosphere, Vol. 11, Pages 269: Differences and Similarities of Central Asian, African, and Arctic Dust Composition from a Single Particle Perspective Atmosphere doi: 10.3390/atmos11030269 Authors: Konrad Kandler Kilian Schneiders Johannes Heuser Andebo Waza Sudharaj Aryasree Dietrich Althausen Julian Hofer Sabur F. Abdullaev Abduvosit N. Makhmudov Mineral dust composition affects a multitude of processes in the atmosphere and adjacent compartments. Dust dry deposition...
Sun Mar 08, 2020 02:00
Atmosphere, Vol. 11, Pages 267: Precipitation Nowcasting with Orographic Enhanced Stacked Generalization: Improving Deep Learning Predictions on Extreme Events Atmosphere doi: 10.3390/atmos11030267 Authors: Gabriele Franch Daniele Nerini Marta Pendesini Luca Coviello Giuseppe Jurman Cesare Furlanello One of the most crucial applications of radar-based precipitation nowcasting systems is the short-term forecast of extreme rainfall events such as flash floods and severe...
Sat Mar 07, 2020 02:00
Atmosphere, Vol. 11, Pages 268: Long-Term Observations of Atmospheric Speciated Mercury at a Coastal Site in the Northern Gulf of Mexico during 2007–2018 Atmosphere doi: 10.3390/atmos11030268 Authors: Xinrong Ren Winston T. Luke Paul Kelley Mark D. Cohen Mark L. Olson Jake Walker Ronald Cole Michael Archer Richard Artz Ariel A. Stein Atmospheric mercury species (gaseous elemental mercury (GEM), gaseous oxidized mercury (GOM), and particulate-bound mercury (PBM)),...
Sat Mar 07, 2020 02:00
Atmosphere, Vol. 11, Pages 266: Evidence of Ozone-Induced Visible Foliar Injury in Hong Kong Using Phaseolus Vulgaris as a Bioindicator Atmosphere doi: 10.3390/atmos11030266 Authors: Felix Leung Jacky Y. S. Pang Amos P. K. Tai Timothy Lam Donald K. C. Tao Katrina Sharps (1) Background: Hong Kong is one of the most densely populated cities in the world, with millions of people exposed to severe air pollution. Surface ozone, mostly produced photochemically from anthropogenic...
Sat Mar 07, 2020 02:00
Atmosphere, Vol. 11, Pages 265: Participation and Engagement of Public Health Stakeholders in Climate and Health Adaptation Atmosphere doi: 10.3390/atmos11030265 Authors: Erika Austhof Vjollca Berisha Ben McMahan Gigi Owen Ladd Keith Matthew Roach Heidi E. Brown Stakeholder participation at the intersection of climate and health is essential to assess and plan for the human health impacts of current and projected climate-sensitive hazards. Using the Maricopa County...
Sat Mar 07, 2020 02:00
Atmosphere, Vol. 11, Pages 263: Source Contributions to Rural Carbonaceous Winter Aerosol in North-Eastern Poland Atmosphere doi: 10.3390/atmos11030263 Authors: Kristensson Ausmeel Pauraite Eriksson Ahlberg Byčenkienė Degórska Concentrations of aerosol particles in Poland and their sources are rarely discussed in peer-reviewed journal articles despite serious air quality issues. A source apportionment of carbonaceous aerosol particles was performed during winter...
Fri Mar 06, 2020 02:00
Atmosphere, Vol. 11, Pages 264: Retrieval and Analysis of the Strongest Mixed Layer in the Troposphere Atmosphere doi: 10.3390/atmos11030264 Authors: Sheng Zhou He In this article, Thorpe analysis, which often retrieves the characteristics of mixing in the free atmosphere from balloon sounding data, is applied to the data of the Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC). We find that the COSMIC data can well retrieve the strongest mixed...
Fri Mar 06, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 66: Schwartz Value Clusters in Modern University Students Behavioral Sciences doi: 10.3390/bs10030066 Authors: Olga V. Maslova Dmitry A. Shlyakhta Mikhail S. Yanitskiy People differ in their value hierarchies, i.e., in the importance they attach to basic personal values. A large number of studies were performed to establish similarities and differences between national, ethnic, or professional groups in terms of Schwartz’s values structure....
Sun Mar 08, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 65: Exploring the Effects of Guided vs. Unguided Art Therapy Methods Behavioral Sciences doi: 10.3390/bs10030065 Authors: Costa Alves Castro Vicente Silva Art therapy has become known by its psychosocial and affective impact, but not so much by its effects on cognitive functioning. Based on a comparison between art therapy and music-making programs, we hypothesized that guided methods—dominant in music-making programs and...
Sat Mar 07, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 64: The Relationship between Self-Compassion and Sleep Quality: An Overview of a Seven-Year German Research Program Behavioral Sciences doi: 10.3390/bs10030064 Authors: Sebastian Butz Dagmar Stahlberg Poor sleep quality is highly prevalent in modern societies and negatively linked to various health outcomes. While previous research has demonstrated preliminary evidence for self-compassion as a tool for improving sleep quality, this review provides...
Fri Mar 06, 2020 02:00
Beverages, Vol. 6, Pages 16: Determination of Macroelements, Transition Elements, and Anionic Contents of Commercial Roasted Ground Coffee Available in Jordanian Markets Beverages doi: 10.3390/beverages6010016 Authors: Sati Y. Al-Dalain Moawiya A. Haddad Salvatore Parisi Mousa Atallah Al-Tarawneh Haitham Qaralleh Coffee is one of the most common drinks worldwide. Due to the variability of elements composition, coffee is important for human health. The aim of this study is...
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Biology, Vol. 9, Pages 50: Understanding Unreported Cases in the COVID-19 Epidemic Outbreak in Wuhan, China, and the Importance of Major Public Health Interventions Biology doi: 10.3390/biology9030050 Authors: Zhihua Liu Pierre Magal Ousmane Seydi Glenn Webb We develop a mathematical model to provide epidemic predictions for the COVID-19 epidemic in Wuhan, China. We use reported case data up to 31 January 2020 from the Chinese Center for Disease Control and Prevention and the...
Sun Mar 08, 2020 02:00
Biology, Vol. 9, Pages 49: Commercial Formulation of Chlorpyrifos Alters Neurological Behaviors and Fertility Biology doi: 10.3390/biology9030049 Authors: Kudavidanage Dissanayake Keerthirathna Nishshanke Peiris Pesticides are known to result in toxic insult. We aimed to evaluate Judo 40, the commercial formulation of chlorpyrifos on the neurological activities, fertility, and hormone levels of male rats. Male Wistar rats were treated orally with 1 mL of 20 or 50 mg/kg...
Sat Mar 07, 2020 02:00
Biology, Vol. 9, Pages 48: Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study Biology doi: 10.3390/biology9030048 Authors: Tatiana V. Kirichenko Veronika A. Myasoedova Alessio L. Ravani Igor A. Sobenin Varvara A. Orekhova Elena B. Romanenko Paolo Poggio Wei-Kai Wu Alexander N. Orekhov This randomized double-blinded, placebo-controlled clinical trial...
Fri Mar 06, 2020 02:00
Biomedicines, Vol. 8, Pages 55: New Insights into Mechanisms of Long-term Protective Anti-tumor Immunity Induced by Cancer Vaccines Modified by Virus Infection Biomedicines doi: 10.3390/biomedicines8030055 Authors: Volker Schirrmacher The topic is how to achieve long-term protective anti-tumor immunity by anti-cancer vaccination and what are its mechanisms. Cancer vaccines should instruct the immune system regarding relevant cancer targets and contain signals for innate immunity activation....
Fri Mar 06, 2020 02:00
Biomolecules, Vol. 10, Pages 421: Machine Learning-Guided Prediction of Antigen-Reactive In Silico Clonotypes Based on Changes in Clonal Abundance through Bio-Panning Biomolecules doi: 10.3390/biom10030421 Authors: Yoo Lee Jung Han Lee Han Kim Chae Ryu Chung c-Met is a promising target in cancer therapy for its intrinsic oncogenic properties. However, there are currently no c-Met-specific inhibitors available in the clinic. Antibodies blocking the...
Sun Mar 08, 2020 02:00
Biomolecules, Vol. 10, Pages 419: Comparison of Fatty Acid Contents in Major Lipid Classes of Seven Salmonid Species from Siberian Arctic Lakes Biomolecules doi: 10.3390/biom10030419 Authors: Nadezhda N. Sushchik Olesia N. Makhutova Anastasia E. Rudchenko Larisa A. Glushchenko Svetlana P. Shulepina Anzhelika A. Kolmakova Michail I. Gladyshev Long-chain omega-3 polyunsaturated fatty acids (LC-PUFA) essential for human nutrition are mostly obtained from wild-caught fish....
Sun Mar 08, 2020 02:00
Biomolecules, Vol. 10, Pages 420: Role of p53 in the Regulation of Cellular Senescence Biomolecules doi: 10.3390/biom10030420 Authors: Mahmut Mijit Valentina Caracciolo Antonio Melillo Fernanda Amicarelli Antonio Giordano The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity....
Sun Mar 08, 2020 02:00
Biomolecules, Vol. 10, Pages 416: Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles Biomolecules doi: 10.3390/biom10030416 Authors: Addinsall Forgan McRae Kelly McDonald McNeill McCulloch Stupka Aberrant extracellular matrix synthesis and remodeling contributes to muscle degeneration and weakness in Duchenne muscular dystrophy (DMD). ADAMTS-5, a secreted metalloproteinase...
Sat Mar 07, 2020 02:00
Biomolecules, Vol. 10, Pages 418: Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[b]furans against Multiple Targets Linked to Type 2 Diabetes Biomolecules doi: 10.3390/biom10030418 Authors: Malose J. Mphahlele Yee Siew Choong Marole M. Maluleka Samantha Gildenhuys The 5-acetyl-2-aryl-6-hydroxybenzo[b]furans 2a–h have been evaluated through in vitro enzymatic assay against targets which are linked to type 2 diabetes (T2D),...
Sat Mar 07, 2020 02:00
Biomolecules, Vol. 10, Pages 417: A Protein in the Yeast Saccharomyces cerevisiae Presents DNA Binding Homology to the p53 Checkpoint Protein and Tumor Suppressor Biomolecules doi: 10.3390/biom10030417 Authors: Kanwal Farooqi Marjan Ghazvini Leah D. Pride Louis Mazzella David White Ajay Pramanik Jill Bargonetti Carol Wood Moore Saccharomyces cerevisiae does not contain a p53 homolog. Utilizing this yeast as an in vivo test tube model, our aim was to investigate if...
Sat Mar 07, 2020 02:00
Biomolecules, Vol. 10, Pages 415: TP53 Mutations in Serum Circulating Cell-Free Tumor DNA As Longitudinal Biomarker for High-Grade Serous Ovarian Cancer Biomolecules doi: 10.3390/biom10030415 Authors: Silvia R. Vitale Floris H. Groenendijk Ronald van Marion Corine M. Beaufort Jean C. Helmijr Hendrikus Jan Dubbink Winand N. M. Dinjens Patricia C. Ewing-Graham Ramon Smolders Helena C. van Doorn Ingrid A. Boere Els M. J. J. Berns Jozien Helleman Maurice...
Sat Mar 07, 2020 02:00
Biomolecules, Vol. 10, Pages 414: Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention Biomolecules doi: 10.3390/biom10030414 Authors: Samir F. de A. Cavalcante Alessandro B. C. Simas Marcos C. Barcellos Victor G. M. de Oliveira Roberto B. Sousa Paulo A. de M. Cabral Kamil Kuča Tanos C. C. França This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and...
Sat Mar 07, 2020 02:00
Biomolecules, Vol. 10, Pages 413: Adsorption of Fibrinogen on Silica Surfaces—The Effect of Attached Nanoparticles Biomolecules doi: 10.3390/biom10030413 Authors: Kristin Hyltegren Mats Hulander Martin Andersson Marie Skepö When a biomaterial is inserted into the body, proteins rapidly adsorb onto its surface, creating a conditioning protein film that functions as a link between the implant and adhering cells. Depending on the nano-roughness of the surface, proteins will adsorb...
Fri Mar 06, 2020 02:00
Biomolecules, Vol. 10, Pages 409: Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metabolites with Human Serum Albumin and Cytochrome P450 Enzymes Biomolecules doi: 10.3390/biom10030409 Authors: Mohos Fliszár-Nyúl Lemli Zsidó Hetényi Mladěnka Horký Pour Poór Flavonoids are abundant polyphenols in nature. They are extensively biotransformed in enterocytes and hepatocytes, where conjugated (methyl, sulfate, and glucuronide) metabolites...
Fri Mar 06, 2020 02:00
Biomolecules, Vol. 10, Pages 411: System-Wide Analysis of Protein Acetylation and Ubiquitination Reveals a Diversified Regulation in Human Cancer Cells Biomolecules doi: 10.3390/biom10030411 Authors: Kozuka-Hata Kitamura Hiroki Aizawa Tsumoto Inoue Oyama Post-translational modifications are known to be widely involved in the regulation of various biological processes, through the extensive diversification of each protein function at the cellular network level....
Fri Mar 06, 2020 02:00
Biomolecules, Vol. 10, Pages 410: Cmfhp Gene Mediates Fruiting Body Development and Carotenoid Production in Cordyceps militaris Biomolecules doi: 10.3390/biom10030410 Authors: Lou Zhao Chen Yu Tang Ye Lin Guo Cordyceps militaris fruiting bodies contain a variety of bioactive components that are beneficial to the human body. However, the low yield of fruiting bodies and the low carotenoid content in C. militaris have seriously hindered the development of...
Fri Mar 06, 2020 02:00
Biomolecules, Vol. 10, Pages 412: Origanum majorana Essential Oil Triggers p38 MAPK-Mediated Protective Autophagy, Apoptosis, and Caspase-Dependent Cleavage of P70S6K in Colorectal Cancer Cells Biomolecules doi: 10.3390/biom10030412 Authors: Athamneh Alneyadi Alsamri Alrashedi Palakott El-Tarabily Eid Al Dhaheri Iratni Colorectal cancer (CRC) is the third most common type of cancer in terms of incidence and mortality worldwide. Here we have investigated...
Fri Mar 06, 2020 02:00
Biomolecules, Vol. 10, Pages 408: A Preliminary Study of Cu Exposure Effects upon Alzheimer’s Amyloid Pathology Biomolecules doi: 10.3390/biom10030408 Authors: Alexander Pilozzi Zhanyang Yu Isabel Carreras Kerry Cormier Dean Hartley Jack Rogers Alpaslan Dedeoglu Xudong Huang A large body of evidence indicates that dysregulation of cerebral biometals (Fe, Cu, Zn) and their interactions with amyloid precursor protein (APP) and Aβ amyloid may contribute to...
Fri Mar 06, 2020 02:00
Biomolecules, Vol. 10, Pages 406: Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase Biomolecules doi: 10.3390/biom10030406 Authors: Hyvönen Keinänen Nuraeva Yanvarev Khomutov Khurs Kochetkov Vepsäläinen Zhgun Khomutov The biogenic polyamines, spermine, spermidine (Spd) and putrescine (Put) are present at micro-millimolar concentrations in eukaryotic and prokaryotic cells (many prokaryotes have no spermine), participating...
Fri Mar 06, 2020 02:00
Biomolecules, Vol. 10, Pages 407: The Molten Globule, and Two-State vs. Non-Two-State Folding of Globular Proteins Biomolecules doi: 10.3390/biom10030407 Authors: Kuwajima From experimental studies of protein folding, it is now clear that there are two types of folding behavior, i.e., two-state folding and non-two-state folding, and understanding the relationships between these apparently different folding behaviors is essential for fully elucidating the molecular mechanisms of protein...
Fri Mar 06, 2020 02:00
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