Protein restriction (PR) has turned out to be a very inquisitive field to understand various trade-offs and phenotypes like body size, weight and wing length in Drosophila melanogaster. However, the long-term effect of PR diet on these phenotypes is unclaimed and hence, we subjected the flies to PR50 & PR70 (50% & 70% protein content present in control food respectively) for 20 generations from the pre-adult stage. The PR fed flies have lower body weight, smaller normal & dry body size,...
Mon Mar 02, 2020 02:00
The discovery of cruciviruses revealed the most explicit example of a common protein homologue between DNA and RNA viruses to date. Cruciviruses are a novel group of circular Rep-encoding ssDNA (CRESS-DNA) viruses that encode capsid proteins (CPs) that are most closely related to those encoded by RNA viruses in the family Tombusviridae. The apparent chimeric nature of the two core proteins encoded by crucivirus genomes suggests horizontal gene transfer of CP genes between DNA and RNA viruses. Here,...
Sun Mar 01, 2020 02:00
In Blasi et al. (2019) we have shown, through a series of statistical analyses and models, that human sound systems have been affected by a transition in bite configuration starting from the Neolithic. Tarasov and Uyeda (2020) (henceforth T&U) raise a number of observations in relation to our article. We appreciate T&Us engagement with our work and their sharing of the code and data of the analyses reported. In brief, their technical comment involves five analyses: O_LIBinomial Causal...
Sun Mar 01, 2020 02:00
Key PointsIntestinal DCs migrate to RLN on ReA onset.TNFRp55 deficiency promotes CCR7 expression.FTY720 reduces DC migration and suppresses ReA.
Mon Mar 02, 2020 17:15
Key PointsThe UBC-GFP transgene is inserted next to the MHC locus on mouse chromosome 17.UBC-GFP BALB/cBy congenic mice retain their founder UBC-GFP C57BL/6 MHC haplotype.
Mon Mar 02, 2020 17:15
Key PointsTCR stimulation induces intracellular iron flux that correlates with proliferation.Iron fuels proliferation by contributing to IL-2R signaling in activated T cells.Iron is required for proper mitochondrial function after T cell activation.
Mon Mar 02, 2020 17:15
Key PointsPosttranslationally methylated peptides can be recognized by human T cells.Methyl lysines are part of the T cell epitope on heparin-binding hemagglutinin.Methylated peptides induce IFN- secretion upon M. tuberculosis infection.
Mon Mar 02, 2020 17:15
Key PointsIntravaginal neomycin can pull CD8 T cells to the vaginal mucosa.Neomycin-recruited CD8 T cells become tissue resident and protect mice from HSV-2.Neomycin can replace recombinant chemokine CXCL10 in prime and pull vaccine.
Mon Mar 02, 2020 17:15
Key PointsTolerizing liposomes encapsulate a high-affinity islet CD4+ mimotope with calcitriol.Liposome administration s.c. at onset of hyperglycemia suppresses diabetes progression.Mimotope-specific T cells cross-regulate IGRP-specific CD8+ T cells in PLN.
Fri Feb 28, 2020 18:15
Key PointsGSDMEb is an evolutionary pyroptosis executor downstream of caspy2 in zebrafish.Caspy2–GSDMEb signaling activation drives proximal renal tubular damage.GSDMEb cleavage-mediated pyroptosis enhances septic AKI in vivo.
Fri Feb 28, 2020 18:15
Key PointsKIR genes evolved rapidly in closely related macaque species and their populations.Hybrid KIR genes in macaques are generated frequently by recombination.
Fri Feb 28, 2020 18:15
Key PointsReduced IL-37 was associated with the pathogenesis of MG.Tfh and B cells highly express IL-37 receptor SIGIRR.IL-37 represses the activation of Tfh and B cells via STAT3 signaling.
Fri Feb 28, 2020 18:15
Dtsch med Wochenschr 2020; 145: 306-312DOI: 10.1055/a-0944-8835Biliary stenoses represent a differential diagnostic challenge. Diagnostic methods to clarify the underlying dignity are often invasive, and provide high specificity beside insufficient sensitivity. In many cases, an accurate diagnosis is only possible over time, and therefore limits curative treatment options. This article provides an overview of the diagnostic challenges and treatment options for unclear biliary stenosis.[...]© Georg...
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 284-284DOI: 10.1055/a-1075-5749© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 277-277DOI: 10.1055/a-1037-5656© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 338-338DOI: 10.1055/a-1066-5700© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 277-277DOI: 10.1055/a-1037-5667© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 287-295DOI: 10.1055/a-0944-8655Gallstones develop in the gallbladder or the bile ducts. According to their chemical composition, gallstones can be divided into cholesterol stones, which are common, and the rare bile pigment stones. Altogether, up to 20 % of all adults develop gallstones and more than 20 % of them symptoms or complications. Female sex, age, pregnancy, physical inactivity, obesity, overnutrition and genetic factors such as ABCB4 deficiency of the hepatic...
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 277-277DOI: 10.1055/a-1037-5678© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 318-326DOI: 10.1055/a-0999-0101The 12-lead resting ECG remains an indispensable diagnostic tool in patients with acute chest pain. This is particularly important as the identification of ST-segment elevations leads to the diagnosis of ST-segment elevation myocardial infarction (STEMI) and subsequent, immediate coronary reperfusion (usually via primary PCI). However, correct interpretation of the 12-lead ECG in patients with acute chest pain remains challenging. Apart...
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 277-277DOI: 10.1055/a-1037-5689© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 282-284DOI: 10.1055/a-1038-6590© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 277-277DOI: 10.1055/a-1037-5700© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 285-286DOI: 10.1055/a-1081-7742© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 277-277DOI: 10.1055/a-1037-5711© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 296-305DOI: 10.1055/a-0944-8805Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are rare, autoimmune mediated cholestatic liver diseases. Other auto-immune diseases are often associated with PBC and PSC, and inflammatory bowel disease is present in the majority of PSC patients. In the course of disease, chronic inflammation in the liver leads to fibrotic restructuring and ultimately cirrhosis. The diagnosis of PBC is confirmed serologically...
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 279-280DOI: 10.1055/a-1084-4798© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 314-317DOI: 10.1055/a-1038-9291 Anamnese und klinischer Befund Eine Patientin mit T1DM, Panikstörung und Hypoglykämieangst (Diabetesdauer 4 Jahre, BMI 25,6) wurde in der Tagesklinik Psychosomatik mit einem multimodalen Behandlungsansatz behandelt. Sie berichtet von ausgeprägter Angst vor Hypoglykämie und von wiederholten Hypoglykämien. Aus Angst vor Hypoglykämien veränderte die Patientin ihr Diabetes-Selbstmanagement und erlebte damit Einschränkungen in...
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 280-282DOI: 10.1055/a-1075-5450© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 327-335DOI: 10.1055/a-1065-4516The declaration and investigation of death cases is a non-delegable task of medical doctors and should be mastered in the same quality as all examinations on living patients. A person is death when at least one sign of death is established (livores mortis, rigor mortis, putrefaction, injuries incompatible with life, brain death). In all other cases of unconscious patients a sufficient cardiopulmonary resuscitation should be started.If...
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 339-339DOI: 10.1055/a-1099-8023© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Dtsch med WochenschrDOI: 10.1055/a-1034-5963 Hintergrund Ziel der Untersuchung war die Abbildung von Motiven zur hausärztlichen Niederlassung aus der aktuellen Sicht nach Niederlassung (Erwartungen erfüllt) sowie vor Niederlassung (Motivation). Zudem sollten hinderliche bzw. förderliche Faktoren einer Niederlassung identifiziert werden. Methoden Mittels Mixed-Methods-Ansatz (Fokusgruppen, Einzelinterviews) der Zielgruppe wurden Erfahrungen, Meinungen und Motivationen zur hausärztlichen...
Mon Mar 02, 2020 01:00
Dtsch med Wochenschr 2020; 145: 273-273DOI: 10.1055/a-0952-9479© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Mar 02, 2020 01:00
Abstract Introduction Bruxism is often indicated as a risk factor for the occurrence of temporomandibular disorders (TMD). Despite the frequent co‐occurrence of bruxism and TMD, the exact relationship between these phenomena has not been thoroughly explained, and their causal relationship is still considered controversial. Aim The aim of this study was to evaluate the distribution of TMD among sleep bruxers and non‐bruxers. Materials and methods The participants of this...
04:46
Abstract Objective To perform the content and construct validation of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Axis I, for children 7 to 11 years old. Materials and Methods A Delphi process was used to perform the content validity of the DC/TMD Axis I. One hundred eighty nine 7‐11 years old children were assessed with the adapted instrument. Confirmatory factor analysis (CFA) was used to investigate construct validity of the DC/TMD for children. A baseline...
Mon Mar 02, 2020 16:24
As an alternative to hair transplantation for lowering the overly high hairline, hairline-lowering/forehead-reduction surgery has several advantages, including unsurpassed density and immediate results. Appropriate candidates for this surgery must have a stable frontal hairline (thus excluding most men) and a fairly to very mobile scalp that will permit sufficient advancement to warrant this more “invasive” approach. The main objective of this surgery is the lowering of the hairline. The authors’...
Mon Mar 02, 2020 02:00
Platelet-rich plasma (PRP) is a promising treatment for hair restoration in patients with androgenic alopecia. Created from a platelet concentrate from an autologous blood draw, PRP is a safe therapeutic option for patients with hair loss. It is used alone or in conjunction with topical and oral therapies. Most studies of hair restoration with PRP report positive outcomes. Further research to optimize PRP preparation/administration procedures and identify patient populations that benefit most from...
Mon Mar 02, 2020 02:00
Purpose: Several aggressive pediatric cancers harbor alterations in SMARCB1, including rhabdoid tumors, epithelioid sarcoma and chordoma. As tumor profiling has become more routine in clinical care, we investigated the relationship between SMARCB1 genetic variants identified by next-generation sequencing (NGS) and INI1 protein expression. Therapeutic approaches for INI1-deficient tumors are limited. Early reports suggest a potential role for immune checkpoint inhibition in these patients. Thus, we...
Mon Mar 02, 2020 16:20
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