Brain Sciences, Vol. 10, Pages 150: Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABAA Receptors Brain Sciences doi: 10.3390/brainsci10030150 Authors: Jing-Jing Lian Yan-Qing Cao Yu-Lei Li Gang Yu Rui-Bin Su Gamma-aminobutyric acid, type A (GABAA) receptors are complex heterogeneous pentamers with various drug binding sites. Several lines of evidence suggest that benzodiazepines modulate certain GABAA receptors in a flumazenil-insensitive manner,...
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Molecules, Vol. 25, Pages 1148: Magnetic Solid-Phase Extraction of Organic Compounds Based on Graphene Oxide Nanocomposites Molecules doi: 10.3390/molecules25051148 Authors: Natalia Manousi Erwin Rosenberg Eleni Deliyanni George A. Zachariadis Victoria Samanidou Graphene oxide (GO) is a chemical compound with a form similar to graphene that consists of one-atom-thick two-dimensional layers of sp2-bonded carbon. Graphene oxide exhibits high hydrophilicity and dispersibility....
Wed Mar 04, 2020 02:00
Molecules, Vol. 25, Pages 1150: Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms Molecules doi: 10.3390/molecules25051150 Authors: Agustín Cota-Coronado Jennifer C. Durnall Néstor Fabián Díaz Lachlan H. Thompson N. Emmanuel Díaz-Martínez Human induced pluripotent stem cells (hiPSCs) have transformed conventional drug discovery pathways in recent years. In particular, recent advances in hiPSC biology, including organoid technologies,...
Wed Mar 04, 2020 02:00
Molecules, Vol. 25, Pages 1140: Zinc and Calcium Cations Combination in the Production of Floating Alginate Beads as Prednisolone Delivery Systems Molecules doi: 10.3390/molecules25051140 Authors: Paola Russo Silvana Morello Aldo Pinto Pasquale Del Gaudio Giulia Auriemma Rita P. Aquino The aim of this research was to verify the application of alginate in combination with Ca2+ and Zn2+ ions to produce a floating and prolonged release system for the oral administration of...
Wed Mar 04, 2020 02:00
Molecules, Vol. 25, Pages 1145: Characterization of Ethyl Acetate and Trichloromethane Extracts from Phoebe zhennan Wood Residues and Application on the Preparation of UV Shielding Films Molecules doi: 10.3390/molecules25051145 Authors: Pan Chen He Jiang Qi Xiao Chen Huang Hu Tu Lin Chen Hao Xiao Xie In this work, ethyl acetate (EA) and trichloromethane (TR) extracts were extracted from Phoebe zhennan wood residues and the extracts...
Wed Mar 04, 2020 02:00
Molecules, Vol. 25, Pages 1147: Calculation of the Isobaric Heat Capacities of the Liquid and Solid Phase of Organic Compounds at 298.15K by Means of the Group-Additivity Method Molecules doi: 10.3390/molecules25051147 Authors: Rudolf Naef The calculation of the isobaric heat capacities of the liquid and solid phase of molecules at 298.15 K is presented, applying a universal computer algorithm based on the atom-groups additivity method, using refined atom groups. The atom groups are...
Wed Mar 04, 2020 02:00
Molecules, Vol. 25, Pages 1141: High-Valent NiIII and NiIV Species Relevant to C–C and C–Heteroatom Cross-Coupling Reactions: State of the Art Molecules doi: 10.3390/molecules25051141 Authors: Nebra Ni catalysis constitutes an active research arena with notable applications in diverse fields. By analogy with its parent element palladium, Ni catalysts provide an appealing entry to build molecular complexity via cross-coupling reactions. While Pd catalysts typically involve a M0/MII redox...
Wed Mar 04, 2020 02:00
Molecules, Vol. 25, Pages 1144: Systematic Investigations of Annealing and Functionalization of Carbon Nanotube Yarns Molecules doi: 10.3390/molecules25051144 Authors: Scholz Hayashi Eckert Khavrus Leonhardt Büchner Mertig Hampel Carbon nanotube yarns (CNY) are a novel carbonaceous material and have received a great deal of interest since the beginning of the 21st century. CNY are of particular interest due to their useful heat conducting, electrical conducting,...
Wed Mar 04, 2020 02:00
Molecules, Vol. 25, Pages 1143: Reducing-End Functionalization of 2,5-Anhydro-d-mannofuranose-Linked Chitooligosaccharides by Dioxyamine: Synthesis and Characterization Molecules doi: 10.3390/molecules25051143 Authors: Maxence Coudurier Jimmy Faivre Agnès Crépet Catherine Ladavière Thierry Delair Christophe Schatz Stéphane Trombotto The nitrous acid depolymerization of chitosan enables the synthesis of singular chitosan oligosaccharides (COS) since their reducing-end...
Wed Mar 04, 2020 02:00
Molecules, Vol. 25, Pages 1142: One-Pot Production of RNA in High Yield and Purity Through Cleaving Tandem Transcripts Molecules doi: 10.3390/molecules25051142 Authors: Hannes Feyrer Raluca Munteanu Lorenzo Baronti Katja Petzold There is an increasing demand for efficient and robust production of short RNA molecules in both pharmaceutics and research. A standard method is in vitro transcription by T7 RNA polymerase. This method is sequence-dependent on efficiency and is limited...
Wed Mar 04, 2020 02:00
Molecules, Vol. 25, Pages 1138: A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process Molecules doi: 10.3390/molecules25051138 Authors: Yongxi Liang Mei-Lin Tang Zhipeng Huo Chenchen Zhang Xun Sun An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This...
Wed Mar 04, 2020 02:00
Nanomaterials, Vol. 10, Pages 464: Visible-Light-Excited Room Temperature Phosphorescent Carbon Dots
Nanomaterials, Vol. 10, Pages 464: Visible-Light-Excited Room Temperature Phosphorescent Carbon Dots Nanomaterials doi: 10.3390/nano10030464 Authors: Hu Jiang Wang Wang Li Lin Carbon dots (CDs) with a room temperature phosphorescent (RTP) feature have attracted considerable interest in recent years due to their fundamental importance and promising applications. However, the reported matrix-free RTP CDs only show short-wavelength (green to yellow) emissions and have...
Wed Mar 04, 2020 02:00
Nanomaterials, Vol. 10, Pages 459: Zinc Oxide Films with High Transparency and Crystallinity Prepared by a Low Temperature Spatial Atomic Layer Deposition Process Nanomaterials doi: 10.3390/nano10030459 Authors: Zhao Sun Hsu Huang Zhang Wu Gao Qiu Lien Zhu Zinc oxide (ZnO) attracts much attention owing to its remarkable electrical and optical properties for applications in optoelectronics. In this study, ZnO thin films were prepared by spatial atomic...
Wed Mar 04, 2020 02:00
Nanomaterials, Vol. 10, Pages 463: Porous Si Microparticles Infiltrated with Magnetic Nanospheres Nanomaterials doi: 10.3390/nano10030463 Authors: Chistè Ischia Gerosa Marzola Scarpa Daldosso Porous silicon (pSi) microparticles obtained by porosification of crystalline silicon wafers have unique optical properties that, together with biodegradability, biocompatibility and absence of immunogenicity, are fundamental characteristics to candidate them as tracers in optical...
Wed Mar 04, 2020 02:00
Nanomaterials, Vol. 10, Pages 460: Precise Surface State Control of Carbon Quantum Dots to Enhance Charge Extraction for Solar Cells Nanomaterials doi: 10.3390/nano10030460 Authors: Yang Yang Zhang Ge Yang Yang Dye-sensitized solar cells are regarded as promising candidates to resolve the energy and environmental issues in recent years, arising from their solution-processable fabrication technology and high power conversion efficiency. However, there are still several...
Wed Mar 04, 2020 02:00
Nanomaterials, Vol. 10, Pages 461: Controllable Synthesis of Mn3O4 Nanowires and Application in the Treatment of Phenol at Room Temperature Nanomaterials doi: 10.3390/nano10030461 Authors: Han Min Liu Zhang Xie Sui Nanosized Mn3O4 nanowires are prepared with KMnO4 and ethanol in mild conditions by facile hydrothermal method. Hydrothermal reaction temperature is optimized to get uniform nanowires. The prepared Mn3O4 nanowires exhibit high activity in the treatment...
Wed Mar 04, 2020 02:00
Nanomaterials, Vol. 10, Pages 462: Ultraviolet Photoactivated Room Temperature NO2 Gas Sensor of ZnO Hemitubes and Nanotubes Covered with TiO2 Nanoparticles Nanomaterials doi: 10.3390/nano10030462 Authors: Choi Kwon Lee Im Kim Noh Park Oh Kim Prolonged exposure to NO2 can cause lung tissue inflammation, bronchiolitis fibrosa obliterans, and silo filler’s disease. In recent years, nanostructured semiconducting metal oxides have been widely...
Wed Mar 04, 2020 02:00
Nanomaterials, Vol. 10, Pages 458: Ultraviolet Photodetecting and Plasmon-to-Electric Conversion of Controlled Inkjet-Printing Thin-Film Transistors Nanomaterials doi: 10.3390/nano10030458 Authors: Cheng-Jyun Wang Hsin-Chiang You Jen-Hung Ou Yun-Yi Chu Fu-Hsiang Ko Direct ink-jet printing of a zinc-oxide-based thin-film transistor (ZnO-based TFT) with a three-dimensional (3-D) channel structure was demonstrated for ultraviolet light (UV) and visible light photodetection....
Wed Mar 04, 2020 02:00
Nanomaterials, Vol. 10, Pages 457: Self-Compliance and High Performance Pt/HfOx/Ti RRAM Achieved through Annealing Nanomaterials doi: 10.3390/nano10030457 Authors: Lei Wu Hongxia Liu Jinfu Lin Shulong Wang A self-compliance resistive random access memory (RRAM) achieved through thermal annealing of a Pt/HfOx/Ti structure. The electrical characteristic measurements show that the forming voltage of the device annealing at 500 °C decreased, and the switching ratio and uniformity...
Wed Mar 04, 2020 02:00
Nanomaterials, Vol. 10, Pages 456: Manganese and Graphene Included Titanium Dioxide Composite Nanowires: Fabrication, Characterization and Enhanced Photocatalytic Activities Nanomaterials doi: 10.3390/nano10030456 Authors: Jun-Cheol Lee Anantha-Iyengar Gopalan Gopalan Saianand Kwang-Pill Lee Wha-Jung Kim We report the detailed microstructural, morphological, optical and photocatalytic studies of graphene (G) and manganese (Mn) co-doped titanium dioxide nanowires (TiO2(G–Mn)...
Wed Mar 04, 2020 02:00
Nanomaterials, Vol. 10, Pages 455: Nanopharmaceutics: Part II—Production Scales and Clinically Compliant Production Methods Nanomaterials doi: 10.3390/nano10030455 Authors: Souto Silva Dias-Ferreira Zielinska Ventura Durazzo Lucarini Novellino Santini Due the implementation of nanotechnologies in the pharmaceutical industry over the last few decades, new type of cutting-edge formulations—nanopharmaceutics—have been proposed. These...
Wed Mar 04, 2020 02:00
Nutrients, Vol. 12, Pages 691: Efficacy of Vitamin D3 Buccal Spray Supplementation Compared to Other Delivery Methods: A Systematic Review of Superiority Randomized Controlled Trials Nutrients doi: 10.3390/nu12030691 Authors: Grammatikopoulou Gkiouras Nigdelis Bogdanos Goulis (1) Background: Vitamin D deficiency is an important public health concern and supplementation is common for this deficiency. Many different modes of delivering supplementation have been proposed...
Wed Mar 04, 2020 02:00
Nutrients, Vol. 12, Pages 692: The Effects of Endoplasmic-Reticulum-Resident Selenoproteins in a Nonalcoholic Fatty Liver Disease Pig Model Induced by a High-Fat Diet Nutrients doi: 10.3390/nu12030692 Authors: Wang Lu He Shi Lei Shan The present study aimed to investigate the intervention of selenium in the oxidative stress and apoptosis of pig livers, which were induced by a high-fat diet, and the effects of four endoplasmic reticulum (ER)-resident selenoproteins...
Wed Mar 04, 2020 02:00
Nutrients, Vol. 12, Pages 690: Physical Activity, Nutritional Status, and Autonomic Nervous System Activity in Healthy Young Adults with Higher Levels of Depressive Symptoms and Matched Controls without Depressive Symptoms: A Cross-Sectional Study Nutrients doi: 10.3390/nu12030690 Authors: Tsujita Akamatsu Nishida Hayashi Moritani The aim of the present study was to comprehensively investigate physical activity (PA), nutritional status, and autonomic nervous system (ANS)...
Wed Mar 04, 2020 02:00
Nutrients, Vol. 12, Pages 693: Stearoyl-CoA Desaturase-1 Enzyme Inhibition by Grape Skin Extracts Affects Membrane Fluidity in Human Colon Cancer Cell Lines Nutrients doi: 10.3390/nu12030693 Authors: Tutino Gigante Scavo Refolo Nunzio Milella Caruso Notarnicola The polyphenolic compounds present in grape extracts have chemopreventive and anticancer properties. Here, we studied the ability of two grape skin extracts (GSEs), Autumn Royal and Egnatia, to influence...
Wed Mar 04, 2020 02:00
Nutrients, Vol. 12, Pages 689: Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study Nutrients doi: 10.3390/nu12030689 Authors: Sara Castro-Barquero Anna Tresserra-Rimbau Facundo Vitelli-Storelli Mónica Doménech Jordi Salas-Salvadó Vicente Martín-Sánchez María Rubín-García Pilar Buil-Cosiales Dolores Corella Montserrat Fitó Dora Romaguera Jesús Vioque Ángel...
Wed Mar 04, 2020 02:00
Nutrients, Vol. 12, Pages 688: Effects of an Alkalizing or Acidizing Diet on High-Intensity Exercise Performance under Normoxic and Hypoxic Conditions in Physically Active Adults: A Randomized, Crossover Trial Nutrients doi: 10.3390/nu12030688 Authors: Mirjam Limmer Juliane Sonntag Markus de Marées Petra Platen Pre-alkalization caused by dietary supplements such as sodium bicarbonate improves anaerobic exercise performance. However, the influence of a base-forming nutrition...
Wed Mar 04, 2020 02:00
Nutrients, Vol. 12, Pages 687: Pituitary Glycoprotein Hormones in Human Milk before and after Pasteurization or Refrigeration Nutrients doi: 10.3390/nu12030687 Authors: Réka A. Vass Robert D. Roghair Edward F. Bell Tarah T. Colaizy Karen J. Johnson Mendi L. Schmelzel Jacky R. Walker Tibor Ertl Our aims were to investigate the presence of pituitary glycoprotein hormones in preterm and donor milk, and to examine the effects of Holder pasteurization and refrigeration...
Wed Mar 04, 2020 02:00
Pathogens, Vol. 9, Pages 186: Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks Pathogens doi: 10.3390/pathogens9030186 Authors: Hossam M. Ashour Walid F. Elkhatib Md. Masudur Rahman Hatem A. Elshabrawy Coronaviruses (CoVs) are RNA viruses that have become a major public health concern since the Severe Acute Respiratory Syndrome-CoV (SARS-CoV) outbreak in 2002. The continuous evolution of coronaviruses was further highlighted...
Wed Mar 04, 2020 02:00
Pathogens, Vol. 9, Pages 189: Bartonella spp. Prevalence (Serology, Culture, and PCR) in Sanitary Workers in La Rioja Spain Pathogens doi: 10.3390/pathogens9030189 Authors: Aránzazu Portillo Ricardo Maggi José A. Oteo Julie Bradley Lara García-Álvarez Montserrat San-Martín Xavier Roura Edward Breitschwerdt Bartonella spp. are increasingly implicated in association with a spectrum of zoonotic infectious diseases. One hundred sanitary workers in La Rioja, Spain completed...
Wed Mar 04, 2020 02:00
Pathogens, Vol. 9, Pages 187: Different Cell Wall-Degradation Ability Leads to Tissue-Specificity between Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola Pathogens doi: 10.3390/pathogens9030187 Authors: Jianbo Cao Chuanliang Chu Meng Zhang Limin He Lihong Qin Xianghua Li Meng Yuan Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc) lead to the devastating rice bacterial diseases and have a very close genetic relationship....
Wed Mar 04, 2020 02:00
Pathogens, Vol. 9, Pages 188: Development of a High-Throughput Serum Neutralization Test Using Recombinant Pestiviruses Possessing a Small Reporter Tag Pathogens doi: 10.3390/pathogens9030188 Authors: Madoka Tetsuo Keita Matsuno Tomokazu Tamura Takasuke Fukuhara Taksoo Kim Masatoshi Okamatsu Norbert Tautz Yoshiharu Matsuura Yoshihiro Sakoda A serum neutralization test (SNT) is an essential method for the serological diagnosis of pestivirus infections, including...
Wed Mar 04, 2020 02:00
Pathogens, Vol. 9, Pages 185: Large-Scale Screening of 239 Traditional Chinese Medicinal Plant Extracts for Their Antibacterial Activities against Multidrug-Resistant Staphylococcus aureus and Cytotoxic Activities Pathogens doi: 10.3390/pathogens9030185 Authors: Gowoon Kim Ren-You Gan Dan Zhang Arakkaveettil Kabeer Farha Olivier Habimana Vuyo Mavumengwana Hua-Bin Li Xiao-Hong Wang Harold Corke Novel alternative antibacterial compounds have been persistently explored...
Wed Mar 04, 2020 02:00
Pathogens, Vol. 9, Pages 184: Transformation of Helicobacter pylori into Coccoid Forms as a Challenge for Research Determining Activity of Antimicrobial Substances Pathogens doi: 10.3390/pathogens9030184 Authors: Paweł Krzyżek Rossella Grande Morphological variability is one of the phenotypic features related to adaptation of microorganisms to stressful environmental conditions and increased tolerance to antimicrobial substances. Helicobacter pylori, a gastric mucosal pathogen, is...
Wed Mar 04, 2020 02:00
Pharmaceutics, Vol. 12, Pages 228: Development of Novel Silica-based Formulation of α-Lipoic Acid: Evaluation of Photo and Thermal Stability of the Encapsulated Drug Pharmaceutics doi: 10.3390/pharmaceutics12030228 Authors: Ekaterina S. Dolinina Elizaveta Yu. Akimsheva Elena V. Parfenyuk Powerful antioxidant α-lipoic acid (LA) is easily degraded under light and heating. This creates difficulties in its manufacture, storage and reduces efficiency and safety of the drug....
Wed Mar 04, 2020 02:00
Pharmaceutics, Vol. 12, Pages 227: Hierarchical Porous Carbon—PLLA and PLGA Hybrid Nanoparticles for Intranasal Delivery of Galantamine for Alzheimer’s Disease Therapy Pharmaceutics doi: 10.3390/pharmaceutics12030227 Authors: Stavroula G. Nanaki Konstantinos Spyrou Chryssa Bekiari Pelagia Veneti Turki N. Baroud Niki Karouta Ioannis Grivas Georgios C. Papadopoulos Dimitrios Gournis Dimitrios N. Bikiaris In the present study, poly(l-lactic acid) (PLLA) and poly(lactide-co-glycolide)...
Wed Mar 04, 2020 02:00
Pharmaceutics, Vol. 12, Pages 226: Cow Milk and Intestinal Epithelial Cell-derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery Pharmaceutics doi: 10.3390/pharmaceutics12030226 Authors: Greta Carobolante Julia Mantaj Enrico Ferrari Driton Vllasaliu Ingestion is the preferred way for drug administration. However, many drugs have poor oral bioavailability, warranting the use of injections. Extracellular vesicles (EVs) from cow milk have shown potential utility...
Wed Mar 04, 2020 02:00
Pharmacy, Vol. 8, Pages 30: Safety and Efficacy of Direct Oral Anticoagulants for Atrial Fibrillation in Patients with Renal Impairment Pharmacy doi: 10.3390/pharmacy8010030 Authors: Soo Min Jang Khaled Bahjri Huyentran Tran Direct oral anticoagulants (DOACs) are gaining popularity for patients with nonvalvular atrial fibrillation (AF) for stroke prevention. Less bleeding risk with comparable stroke prevention compared to warfarin was shown. DOACs have predictable anticoagulant...
Wed Mar 04, 2020 02:00
Pharmacy, Vol. 8, Pages 29: The COPHELA (Cooperation in Quality Assurance for Pharmacy Education and Training between Europe and Latin America) Project Pharmacy doi: 10.3390/pharmacy8010029 Authors: Antonio Sánchez-Pozo Afonso Miguel Cavaco Paolo Blasi Mariana Ortiz Reynoso Carlos Tomas Quirino-Barreda Patricia Acuña Johnson Fernando Torres Moscoso Selma Rodrigues de Castilho Claudia Fegadolli Sergio Slan Zarwar Jeffrey Atkinson COPHELA (Cooperation in Quality...
Wed Mar 04, 2020 02:00
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