Abstract Staphylocoagulase (Coa) is a virulence factor of Staphylococcus aureus (S. aureus) that promotes blood coagulation by activating prothrombin to convert fibrinogen to fibrin. Coa plays a crucial role in disease pathogenesis and is a promising target for the treatment of S. aureus infections. Here, we identified that isoquercitrin, a natural flavonol compound, can markedly reduce the activity of Coa at concentrations that have no effect on bacterial growth. Mechanistic...
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Abstract Porcine parvovirus (PPV) virus-like particles (VLPs) are a potential vaccine candidate for the prevention of parvovirus-induced reproductive failure in pregnant sows. Currently, the Escherichia coli (E. coli) expression system is the most cost-efficient to express recombinant proteins. To overcome the limitations of protein misfolding and to prepare soluble highly bioactive antigen and high yields of protein, we optimized the PPV-VP2 gene, subcloned it into pET24a, pET26b,...
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Related ArticlesThe "broken escalator" phenomenon: Vestibular dizziness interferes with locomotor adaptation. J Vestib Res. 2020 Feb 26;: Authors: Patel M, Roberts E, Arshad Q, Bunday K, Golding JF, Kaski D, Bronstein AM Abstract BACKGROUND: Although vestibular lesions degrade postural control we do not know the relative contributions of the magnitude of the vestibular loss and subjective vestibular symptoms to locomotor adaptation. OBJECTIVE:...
Tue Mar 03, 2020 14:51
Publication date: Available online 3 March 2020Source: Journal of Neuroscience MethodsAuthor(s): Lili Shen, Zhijian Liu, Yueping Li
Tue Mar 03, 2020 14:50
Publication date: Available online 2 March 2020Source: Journal of Neuroscience MethodsAuthor(s): Ingrid Reverte, Stephen Volz, Fahd H. Alhazmi, Mihwa Kang, Keith Kaufman, Sue Chan, Claudia Jou, Mihaela D. Iordanova, Guillem R. Esber
Tue Mar 03, 2020 14:50
Publication date: Available online 2 March 2020Source: Journal of Neuroscience MethodsAuthor(s): Svetnik Vladimir, Wa Ting-Chuan, Xu Yuting, J. Hansen Bryan, V. Fox Steven
Tue Mar 03, 2020 14:50
Versorgung von Defekten der Nasenspitze und des Nasenstegs. Laryngorhinootologie. 2020 Mar;99(3):195-196 Authors: Rettinger G PMID: 32120443 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 14:50
Fragen für die Facharztprüfung. Laryngorhinootologie. 2020 Mar;99(3):192-193 Authors: PMID: 32120442 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 14:50
Related Articles[Imaging of the Inner Ear Before Cochlear Implantation]. Laryngorhinootologie. 2020 Mar;99(3):181-191 Authors: Mack MG, Suckfüll MM Abstract If sufficient speech understanding can no longer be achieved with conventional hearing aids, the indication for a cochlear implant is very often present. Imaging plays an important preoperative role, as it is the only way to decide whether a cochlear implant is possible or not. The preoperative evaluation...
Tue Mar 03, 2020 14:50
Related Articles[Statement of the German Society of Otorhinolaryngology, Head and Neck Surgery on the execution of a tonsillotomy]. Laryngorhinootologie. 2020 Mar;99(3):176-180 Authors: Guntinas-Lichius O, Windfuhr J, Deitmer T, Delank KW PMID: 32120440 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 14:50
Related ArticlesTraumatologie des Gesichtsschädels im Kindesalter. Laryngorhinootologie. 2020 Mar;99(3):155-165 Authors: Freudlsperger C, Hoffmann J, Ristow O Abstract Associated injuries are a common feature in pediatric facial fractures, which reinforce the importance of a complete initial assessment of a child with facial trauma.Particular kinds of fracture tend to occur at specific anatomic sites in children, with the severity and extent of the fracture...
Tue Mar 03, 2020 14:50
Related Articles[Nutrition in Cancer: Effective in Prevention and Treatment?] Laryngorhinootologie. 2020 Mar;99(3):149-154 Authors: Arends J Abstract Nutritional effects on cancer occurrence and on treatment outcome in cancer patients may depend on food preferences and on the quantity of foods supplied. However, it has been difficult to reliably show beneficial effects of specific dietary concepts on cancer incidence. On the other hand, obesity as a...
Tue Mar 03, 2020 14:50
Related Articles[Mucoepidermoidcarcinoma - Importance in molecular pathology]. Laryngorhinootologie. 2020 Mar;99(3):144-148 Authors: Nachtsheim L, Arolt C, Dreyer T, Meyer MF, Brobeil A, Gamerdinger U, Gattenlöhner S, Grosheva M, Wittekindt C, Klußmann JP Abstract Mucoepidermoid carcinoma is the most common primary salivary gland malignancy and its tumor grading has an important prognostic significance. The 5 year overall survival rate is significantly...
Tue Mar 03, 2020 14:50
Vokalisatrophie. Laryngorhinootologie. 2020 Mar;99(3):142-143 Authors: PMID: 32120436 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 14:50
Medialisierungsthyroplastik: Effekt der Platzierung auf Phonation. Laryngorhinootologie. 2020 Mar;99(3):140-141 Authors: PMID: 32120435 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 14:50
Elastizität der Nasenspitze nach Tongue-in-Groove-Technik und Columella-Strut-Transplantation. Laryngorhinootologie. 2020 Mar;99(3):139-140 Authors: PMID: 32120434 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 14:50
Hörerhalt nach Cochlea-Implantation mit Slim-Modiolar-Elektrode. Laryngorhinootologie. 2020 Mar;99(3):138-139 Authors: PMID: 32120433 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 14:50
Liebe Leserinnen und Leser der LRO. Laryngorhinootologie. 2020 Mar;99(3):135-136 Authors: Stöckli S PMID: 32120432 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 14:50
Related ArticlesEffects of Sleep-Related Disorders on the Prognosis of Amyotrophic Lateral Sclerosis. Neurodegener Dis. 2020 Feb 28;:1-7 Authors: Reyhani A, Benbir Senel G, Karadeniz D Abstract BACKGROUND/OBJECTIVE: In this study, we demonstrated the effects of obstructive sleep apnea syndrome (OSAS) on the prognosis of amyotrophic lateral sclerosis (ALS). However, the effects of sleep-related disorders other than breathing problems are still waiting...
Tue Mar 03, 2020 14:48
Related ArticlesInductive conformal prediction for silent speech recognition. J Neural Eng. 2020 Mar 02;: Authors: Zhang M, Wang Y, Wei Z, Yang M, Luo Z, Li G Abstract OBJECTIVE: Silent speech recognition based on surface electromyography has been studied for years. Though some progress in feature selection and classification has been achieved, one major problem remains: how to provide confident or reliable prediction. APPROACH: Inductive conformal...
Tue Mar 03, 2020 14:42
Related ArticlesActivation robustness with directional leads and multi-lead configurations in deep brain stimulation. J Neural Eng. 2020 Feb 28;: Authors: Janson AP, Anderson DN, Butson CR Abstract OBJECTIVE: Clinical outcomes from deep brain stimulation (DBS) can be highly variable, and two critical factors underlying this variability are the location and type of stimulation. In this study we quantified how robustly DBS activates a target region when...
Tue Mar 03, 2020 14:42
Related ArticlesDiagnosis and treatment of low-risk superficial basal cell carcinoma in a single visit. J Dermatolog Treat. 2020 Mar 02;:1-14 Authors: Hattier GA, Duffy RF, Finkelstein MJ, Beggs SM, Lee JB Abstract Introduction: Surgical excision remains the most commonly utilized treatment for superficial basal cell carcinoma (sBCC). In the era of cost containment of healthcare, the rising incidence of BCC and the high cost of excision require a continuous...
Tue Mar 03, 2020 14:42
Related ArticlesA Comprehensive Review of Treatment Options for Recalcitrant Nongenital Cutaneous Warts. J Dermatolog Treat. 2020 Mar 02;:1-51 Authors: Leerunyakul K, Thammarucha S, Suchonwanit P, Rutnin S Abstract Introduction: The treatment of recalcitrant nongenital cutaneous warts has always been challenging for dermatologists as they often recur and relapse. Multiple treatment options have been investigated to improve the outcome. This review provides...
Tue Mar 03, 2020 14:42
Related ArticlesEfficacy of an anti-TNF-alpha agent in refractory livedoid vasculopathy: a retrospective analysis. J Dermatolog Treat. 2020 Mar 02;:1-18 Authors: Gao Y, Jin H Abstract BACKGROUND: Livedoid vasculopathy is a recurrent thrombo-occlusive vasculopathy of cutaneous blood vessels and its standard or first-line therapy is still controversial. Besides hypercoagulability, inflammatory factors may also play a secondary role in pathogenesis of this...
Tue Mar 03, 2020 14:42
Related ArticlesOff-Label Dermatologic Uses of IL-17 Inhibitors. J Dermatolog Treat. 2020 Mar 02;:1-24 Authors: Wu KK, Dao H Abstract IL-17 inhibitors, including secukinumab, brodalumab, and ixekizumab, have been U.S. Food and Drug Administration (FDA) approved for the treatment of psoriasis. In addition to psoriasis, IL-17 has been implicated in the pathophysiology of other inflammatory skin conditions. This review aims to synthesize and interpret the...
Tue Mar 03, 2020 14:42
Publication date: Available online 3 March 2020Source: American Journal of Infection ControlAuthor(s): Geneva Wilson, Virgil Jackson, Linda Boyken, Mireia Puig-Asensio, Alexandre R. Marra, Eli Perencevich, Marin L. Schweizer, Daniel Diekema, Patrick Breheny, Christine Petersen
Tue Mar 03, 2020 14:41
Related ArticlesGlucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages. J Cell Physiol. 2020 Mar 01;: Authors: Watanabe S, Usui-Kawanishi F, Karasawa T, Kimura H, Kamata R, Komada T, Inoue Y, Mise N, Kasahara T, Takahashi M Abstract Although the intimate linkage between hypoxia and inflammation is well known, the mechanism underlying this linkage has not been fully understood. Nucleotide-binding oligomerization domain-like receptor...
Tue Mar 03, 2020 14:41
Related ArticlesProteomics reveals different pathological processes of adipose tissue, liver, and skeletal muscle under insulin resistance. J Cell Physiol. 2020 Mar 01;: Authors: Li Y, Ma Q, Li P, Wang J, Wang M, Fan Y, Wang T, Wang C, Wang T, Zhao B Abstract Type 2 diabetes mellitus is the most common type of diabetes, and insulin resistance (IR) is its core pathological mechanism. Proteomics is an ingenious and promising Omics technology that can comprehensively...
Tue Mar 03, 2020 14:41
Related ArticlesSerum Androgens are Independent Predictors of Insulin Clearance But Not of Insulin Secretion in Women With Pcos. J Clin Endocrinol Metab. 2020 Mar 02;: Authors: Tosi F, Dal Molin F, Zamboni F, Saggiorato E, Salvagno GL, Fiers T, Kaufman JM, Bonora E, Moghetti P Abstract CONTEXT/OBJECTIVE: In insulin resistant subjects, hyperinsulinemia is a key compensatory mechanism, aimed at maintaining glucose homeostasis. Increased secretion and reduced...
Tue Mar 03, 2020 14:40
Related ArticlesInterleukin-6 (IL-6) activates the NOTCH1 signaling pathway through E-proteins in endometriotic lesions. J Clin Endocrinol Metab. 2020 Mar 02;: Authors: Song Y, Su RW, Joshi NR, Kim TH, Lessey BA, Jeong JW, Fazleabas AT Abstract CONTEXT: NOTCH signaling is activated in endometriotic lesions, but the exact mechanisms remains unclear. Interleukin-6 (IL-6), which is increased in the peritoneal fluid of women with endometriosis, induces NOTCH1...
Tue Mar 03, 2020 14:40
Related ArticlesResting energy expenditure in obese women with primary hypothyroidism and appropriate levothyroxine replacement therapy. J Clin Endocrinol Metab. 2020 Mar 02;: Authors: Muraca E, Ciardullo S, Oltolini A, Zerbini F, Bianconi E, Perra S, Villa M, Cannistraci R, Castoldi G, Pizzi P, Manzoni G, Lattuada G, Perseghin G Abstract CONTEXT: Growing evidence suggests that appropriate levothyroxine (LT4) replacement therapy may not correct the full...
Tue Mar 03, 2020 14:40
Related ArticlesRecharacterizing The Metabolic State of Energy Balance in Thrifty and Spendthrift Phenotypes. J Clin Endocrinol Metab. 2020 Mar 02;: Authors: Hollstein T, Basolo A, Ando T, Votruba SB, Walter M, Krakoff J, Piaggi P Abstract PURPOSE: The human thrifty phenotype hypothesis presupposes that lower 24-hour energy expenditure (24EE) during famine preserves body mass and promotes survival. The prevailing view defines thrifty individuals as having...
Tue Mar 03, 2020 14:40
Related ArticlesDifferential frequency of CYP2R1 variants across populations reveals pathway selection for vitamin D homeostasis. J Clin Endocrinol Metab. 2020 Mar 02;: Authors: Casella A, Long C, Zhou J, Lai M, O'Lear L, Caplan I, Levine MA, Roizen JD Abstract CONTEXT: Normal vitamin D homeostasis is necessary to ensure optimal mineral metabolism. Dietary insufficiency of vitamin D and lack of sunlight each have well understood roles in vitamin D deficiency;...
Tue Mar 03, 2020 14:40
Related ArticlesHormonal profiles of menstrual bleeding patterns during the luteal-follicular transition. J Clin Endocrinol Metab. 2020 Mar 02;: Authors: Jacobson MH, Howards PP, Kesner JS, Meadows JW, Dominguez CE, Spencer JB, Darrow LA, Terrell ML, Marcus M Abstract CONTEXT: Menstrual cycle function is determined by a complex endocrine axis that controls the ovaries and endometrium. While the late luteal phase is characterized by declining progesterone...
Tue Mar 03, 2020 14:40
Related ArticlesVideo Head Impulse Test Results in Patients With a Vestibular Schwannoma-Sensitivity and Correlation With Other Vestibular System Function Tests, Hearing Acuity, and Tumor Size. Otol Neurotol. 2020 Feb 28;: Authors: West N, Sass H, Klokker M, Cayé-Thomasen P Abstract OBJECTIVE: No previous studies have investigated a vestibular function test battery combining the Video Head Impulse Test (VHIT), the caloric test, and the cervical vestibular...
Tue Mar 03, 2020 14:39
Related ArticlesThe controversial role of Bevacizumab in the treatment of patients with intracranial meningioma: a comprehensive literature review. Expert Rev Anticancer Ther. 2020 Mar 02;: Authors: Scerrati A, Mongardi L, Visani J, Lofrese G, Cavallo MA, Fiorentino A, De Bonis P Abstract Introduction: Meningiomas represent the most common primary intracranial tumors. Today, surgical resection, followed by radiotherapy when indicated, is still the treatment...
Tue Mar 03, 2020 14:39
Related ArticlesAdvancements in predicting outcomes in patients with glioma: a surgical perspective. Expert Rev Anticancer Ther. 2020 Mar 02;:1-11 Authors: Jakola AS, Sagberg LM, Gulati S, Solheim O Abstract Introduction: Diffuse glioma is a challenging neurosurgical entity. Although surgery does not provide a cure, it may greatly influence survival, brain function, and quality of life. Surgical treatment is by nature highly personalized and outcome...
Tue Mar 03, 2020 14:39
31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/03/03PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Mar 03, 2020 14:36
31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/03/03PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Mar 03, 2020 13:36
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