Microorganisms, Vol. 8, Pages 380: Beneficial Propionibacteria within a Probiotic Emmental Cheese: Impact on Dextran Sodium Sulphate-Induced Colitis in Mice Microorganisms doi: 10.3390/microorganisms8030380 Authors: Houem Rabah Fillipe Luiz Rosa do Carmo Rodrigo Dias de Oliveira Carvalho Barbara Fernandes Cordeiro Sara Heloisa da Silva Emiliano Rosa Oliveira Luisa Lemos Denise Carmona Cara Ana Maria Caetano Faria Gilles Garric Marielle Harel-Oger Yves Le Loir...
Microorganisms, Vol. 8, Pages 377: Fitness Cost of blaNDM-5-Carrying p3R-IncX3 Plasmids in Wild-Type NDM-Free Enterobacteriaceae Microorganisms doi: 10.3390/microorganisms8030377 Authors: Tengfei Ma Jiani Fu Ning Xie Shizhen Ma Lei Lei Weishuai Zhai Yingbo Shen Chengtao Sun Shaolin Wang Zhangqi Shen Yang Wang Timothy R. Walsh Jianzhong Shen The wide dissemination of New Delhi metallo-β-lactamase genes (blaNDM) has resulted in the treatment...
Microorganisms, Vol. 8, Pages 376: Effect of Thermal Drying and Chemical Treatments with Wastes on Microbiological Contamination Indicators in Sewage Sludge Microorganisms doi: 10.3390/microorganisms8030376 Authors: Andreia F. Santos Cátia P. Santos Ana M. Matos Olga Cardoso Margarida J. Quina This work aims to evaluate the microbiological contamination of sewage sludge (SS) collected in urban wastewater treatment plants (WWTP) from Portugal. Two types of SS were considered:...
Microorganisms, Vol. 8, Pages 375: Spatio-Temporal Distribution of Acinetobacter baumannii in Germany—A Comprehensive Systematic Review of Studies on Resistance Development in Humans (2000–2018) Microorganisms doi: 10.3390/microorganisms8030375 Authors: Gamal Wareth Christian Brandt Lisa D. Sprague Heinrich Neubauer Mathias W. Pletz Acinetobacter (A.) baumannii has gained global notoriety as a significant nosocomial pathogen because it is frequently associated with multi-drug...
Microorganisms, Vol. 8, Pages 371: Targeted Combination Antibiotic Therapy Induces Remission in Treatment-Naïve Crohn’s Disease: A Case Series Microorganisms doi: 10.3390/microorganisms8030371 Authors: Gaurav Agrawal Annabel Clancy Rijata Sharma Roy Huynh Sanjay Ramrakha Thomas Borody Prospective trials of anti-mycobacterial antibiotic therapy (AMAT) have proven efficacious in Crohn’s disease (CD) but use as first-line treatment in CD has not been evaluated....
Microorganisms, Vol. 8, Pages 373: The Nature and Extent of Plasmid Variation in Chlamydia trachomatis Microorganisms doi: 10.3390/microorganisms8030373 Authors: Jones Hadfield Thomson Cleary Marsh Clarke O’Neill Chlamydia trachomatis is an obligate intracellular pathogen of humans, causing both the sexually transmitted infection, chlamydia, and the most common cause of infectious blindness, trachoma. The majority of sequenced C. trachomatis clinical isolates...
Microorganisms, Vol. 8, Pages 372: The Complexity of the Holobiont in the Red Sea Coral Euphyllia paradivisa under Heat Stress Microorganisms doi: 10.3390/microorganisms8030372 Authors: Meron Maor-Landaw Eyal Elifantz Banin Loya Levy The recognition of the microbiota complexity and their role in the evolution of their host is leading to the popularization of the holobiont concept. However, the coral holobiont (host and its microbiota) is still enigmatic and unclear....
Microorganisms, Vol. 8, Pages 374: Detection of Wood Mice (Apodemus sylvaticus) Carrying Non-Tuberculous Mycobacteria Able to Infect Cattle and Interfere with the Diagnosis of Bovine Tuberculosis Microorganisms doi: 10.3390/microorganisms8030374 Authors: Lucía Varela-Castro Olalla Torrontegi Iker A. Sevilla Marta Barral Mycobacterial infections caused by the Mycobacterium tuberculosis complex (MTC) and non-tuberculous mycobacteria (NTM) are of great medical and veterinary relevance....
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Molbank, Vol. 2020, Article M1119: 8-Fluoro-N-2-Isobutyryl-2′-Deoxyguanosine: Synthesis and Reactivity Molbank doi: 10.3390/M1119 Authors: Solodinin Helmkay Ollivier Yan 3′,5′-O-Bis(tert-butyldimethylsilyl)-8-fluoro-N-2-isobutyryl-2′-deoxyguanosine was synthesized from 3′,5′-O-bis(tert-butyldimethylsilyl)-N-2-isobutyryl-2′-deoxyguanosine by the treatment with N-fluorobenzenesulfonimide. A similar fluorination reaction...
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Molecules, Vol. 25, Pages 1218: An Overview of Self-Consistent Field Calculations Within Finite Basis Sets Molecules doi: 10.3390/molecules25051218 Authors: Susi Lehtola Frank Blockhuys Christian Van Van Alsenoy A uniform derivation of the self-consistent field equations in a finite basis set is presented. Both restricted and unrestricted Hartree–Fock (HF) theory as well as various density functional approximations are considered. The unitary invariance of the HF and...
Molecules, Vol. 25, Pages 1217: New Strategy to Preserve Phosphate by Ionic Liquid Matrices in Matrix-Assisted Laser Desorption/Ionization: A Case of Adenosine Nucleotides Molecules doi: 10.3390/molecules25051217 Authors: Lin Lee Wu Lu Adenosine -5′-triphosphate (ATP) plays a valuable role in metabolic activity to produce adequate energy in a biosystem. A high ATP/AMP ratio has a correlation with diabetes that induces suppression of AMP-activated protein kinase...
Molecules, Vol. 25, Pages 1215: The Oxygen Consumption Kinetics of Commercial Oenological Tannins in Model Wine Solution and Chianti Red Wine Molecules doi: 10.3390/molecules25051215 Authors: Jelena Jeremic Isara Vongluanngam Arianna Ricci Giuseppina Paola Parpinello Andrea Versari One property of oenological tannins, oxygen reactivity, is commonly exploited in winemaking. The reactivity is mediated by the presence of catalysts (i.e., transition metals and sulfur dioxide)...
Molecules, Vol. 25, Pages 1216: Inducing Intermediates in Biotransformation of Natural Polyacetylene and A Novel Spiro-γ-Lactone from Red Ginseng by Solid Co-Culture of Two Gut Chaetomium globosum and The Potential Bioactivity Modification by Oxidative Metabolism Molecules doi: 10.3390/molecules25051216 Authors: Bang-Yan Wang Chen-Hao Zhu Xue-Qiong Yang Ming Hu Ting-Ting Xu Xue-Yin Wang Shuang Yang Ya-Bin Yang Zhong-Tao Ding The ω-hydroxyl-panaxytriol...
Molecules, Vol. 25, Pages 1214: Direct Evidence of Salinity and pH Effects on the Interfacial Interactions of Asphaltene-Brine-Silica Systems Molecules doi: 10.3390/molecules25051214 Authors: Fanghui Liu Hui Yang Ting Chen Shanmeiyu Zhang Danfeng Yu Yongqiang Chen Quan Xie The hydraulic fracturing technique remains essential to unlock fossil fuel from shale oil reservoirs. However, water imbibed by shale during hydraulic fracturing triggers environmental and technical...
Molecules, Vol. 25, Pages 1213: Mesoscale Assembly of Bisteroidal Esters from Terephthalic Acid Molecules doi: 10.3390/molecules25051213 Authors: Gabriel Guerrero-Luna María Guadalupe Hernández-Linares Sylvain Bernès Alan Carrasco-Carballo Diana Montalvo-Guerrero María A. Fernández-Herrera Jesús Sandoval-Ramírez A new series of bisteroidal esters was synthesized using a spacer group, sterols and sapogenins as substrates. Steroidal dimers were prepared in high yields...
Molecules, Vol. 25, Pages 1212: A Cyclodextrin-Based Controlled Release System in the Simulation of In Vitro Small Intestine Molecules doi: 10.3390/molecules25051212 Authors: Danni Zheng Liuxi Xia Hangyan Ji Zhengyu Jin Yuxiang Bai A novel cyclodextrin (CD)-based controlled release system was developed in the small intestine to control the rate of drug release, on the premise of enteric-coated tablets. The system was designed based on the enzymes exogenous β-cyclodextrin...
Molecules, Vol. 25, Pages 1211: Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction Molecules doi: 10.3390/molecules25051211 Authors: Anastasia Beloglazkina Nikolai Zyk Alexander Majouga Elena Beloglazkina This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53– Mouse double minute 2 homolog (MDM2) protein–protein interaction. The main focus is placed on synthetic approaches to such molecules,...
Molecules, Vol. 25, Pages 1210: Blue Emitting Star-Shaped and Octasilsesquioxane-Based Polyanions Bearing Boron Clusters. Photophysical and Thermal Properties Molecules doi: 10.3390/molecules25051210 Authors: Justo Cabrera-González Mahdi Chaari Francesc Teixidor Clara Viñas Rosario Núñez High boron content systems were prepared by the peripheral functionalisation of 1,3,5-triphenylbenzene (TPB) and octavinylsilsesquioxane (OVS) with two different anionic boron clusters: closo-dodecaborate...
Molecules, Vol. 25, Pages 1208: Evaluation of Organo [18F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers Molecules doi: 10.3390/molecules25051208 Authors: Sofia Otaru Surachet Imlimthan Mirkka Sarparanta Kerttuli Helariutta Kristiina Wähälä Anu J. Airaksinen Fluorine-18 is the most widely used positron emission tomography (PET) radionuclide currently in clinical application, due to its optimal nuclear properties. The synthesis of 18F-labeled...
Molecules, Vol. 25, Pages 1207: Hierarchically Porous Silk/Activated-Carbon Composite Fibres for Adsorption and Repellence of Volatile Organic Compounds Molecules doi: 10.3390/molecules25051207 Authors: Aled D. Roberts Jet-Sing M. Lee Adrián Magaz Martin W. Smith Michael Dennis Nigel S. Scrutton Jonny J. Blaker Fabrics comprised of porous fibres could provide effective passive protection against chemical and biological (CB) threats whilst maintaining high air permeability...
Molecules, Vol. 25, Pages 1206: Comparison of Sample Preparation and Determination of 60 Veterinary Drug Residues in Flatfish Using Liquid Chromatography-Tandem Mass Spectrometry Molecules doi: 10.3390/molecules25051206 Authors: Kim Park Kang Cho Oh This study was performed to optimize the analytical method for multi-residues of 60 compounds in flatfish samples. Three sample preparation methods were tested to identify the optimal recovery conditions for target analytes....
Molecules, Vol. 25, Pages 1209: Novel Steroidal 5α,8α-Endoperoxide Derivatives with Semicarbazone/Thiosemicarbazone Side-chain as Apoptotic Inducers through an Intrinsic Apoptosis Pathway: Design, Synthesis and Biological Studies Molecules doi: 10.3390/molecules25051209 Authors: Liwei Ma Haijun Wang Jing Wang Lei Liu Song Zhang Ming Bu A series of novel steroidal 5α,8α-endoperoxide derivatives bearing semicarbazone (7a–g) or thiosemicarbazone...
Molecules, Vol. 25, Pages 1205: Targeting Genome Integrity in Mycobacterium Tuberculosis: From Nucleotide Synthesis to DNA Replication and Repair Molecules doi: 10.3390/molecules25051205 Authors: Riccardo Miggiano Castrese Morrone Franca Rossi Menico Rizzi Mycobacterium tuberculosis (MTB) is the causative agent of tuberculosis (TB), an ancient disease which still today causes 1.4 million deaths worldwide per year. Long-term, multi-agent anti-tubercular regimens can lead to the...
Molecules, Vol. 25, Pages 1204: Salvinorin A Does Not Affect Seizure Threshold in Mice Molecules doi: 10.3390/molecules25051204 Authors: Katarzyna Socała Urszula Doboszewska Piotr Wlaź The κ-opioid receptor has recently gained attention as a new molecular target in the treatment of many psychiatric and neurological disorders including epilepsy. Salvinorin A is a potent plant-derived hallucinogen that acts as a highly selective κ-opioid receptor agonist. It has...
Molecules, Vol. 25, Pages 1203: Nanocomposite Films of Chitosan-Grafted Carbon Nano-Onions for Biomedical Applications Molecules doi: 10.3390/molecules25051203 Authors: Carlos David Grande Tovar Jorge Iván Castro Carlos Humberto Valencia Diana Paola Navia Porras José Herminsul Mina Hernandez Mayra Eliana Valencia Zapata Manuel N. Chaur The design of scaffolding from biocompatible and resistant materials such as carbon nanomaterials and biopolymers has become very important,...
Molecules, Vol. 25, Pages 1201: Compact and Highly Sensitive NO2 Photoacoustic Sensor for Environmental Monitoring Molecules doi: 10.3390/molecules25051201 Authors: Yufeng Pan Lei Dong Xukun Yin Hongpeng Wu A nitrogen dioxide (NO2) photoacoustic sensor for environmental monitoring was developed using a low-cost high-power laser diode emitting at 450 nm. A compact low-noise photoacoustic detection module was designed to reduce the sensor size and to suppress noise. A LabVIEW-based...
Molecules, Vol. 25, Pages 1202: Enzyme and Biological Activities of the Water Extracts from the Plants Aesculus hippocastanum, Olea europaea and Hypericum perforatum That Are Used as Folk Remedies in Turkey Molecules doi: 10.3390/molecules25051202 Authors: Sarikurkcu Locatelli Tartaglia Ferrone Juszczak Ozer Tepe Tomczyk Phenolic compounds are secondary metabolites that are found ubiquitously in plants, fruits, and vegetables. Many studies have shown that...
Molecules, Vol. 25, Pages 1200: The Influence of Halogenated Hypercarbon on Crystal Packing in the Series of 1-Ph-2-X-1,2-dicarba-closo-dodecaboranes (X = F, Cl, Br, I) Molecules doi: 10.3390/molecules25051200 Authors: Havránek Samsonov Holub Růžičková Drož Růžička Fanfrlík Hnyk Although 1-Ph-2-X-closo-1,2-C2B10H10 (X = F, Cl, Br, I) derivatives had been computed to have positive values of the heat of formation, it was possible to prepare them. The corresponding...
Molecules, Vol. 25, Pages 1199: Flexible and Reusable Ag Coated TiO2 Nanotube Arrays for Highly Sensitive SERS Detection of Formaldehyde Molecules doi: 10.3390/molecules25051199 Authors: Tong Zhu Hang Wang Libin Zang Sila Jin Shuang Guo Eungyeong Park Zhu Mao Young Mee Jung Quantitative analysis of formaldehyde (HCHO, FA), especially at low levels, in various environmental media is of great importance for assessing related environmental and human health risks. A...
Molecules, Vol. 25, Pages 1197: Deciphering Pathways for Carotenogenesis in Haloarchaea Molecules doi: 10.3390/molecules25051197 Authors: Micaela Giani Jose María Miralles-Robledillo Gloria Peiró Carmen Pire Rosa María Martínez-Espinosa Bacterioruberin and its derivatives have been described as the major carotenoids produced by haloarchaea (halophilic microbes belonging to the Archaea domain). Recently, different works have revealed that some haloarchaea synthetize other...
Molecules, Vol. 25, Pages 1196: The Effects of Houttuynia cordata Thunb and Piper ribesioides Wall Extracts on Breast Carcinoma Cell Proliferation, Migration, Invasion and Apoptosis Molecules doi: 10.3390/molecules25051196 Authors: Subhawat Subhawa Teera Chewonarin Ratana Banjerdpongchai Houttuynia cordata Thunb. (HCT) and Piper ribesioides Wall. (PR) are common herbs that are widely distributed throughout East Asia and possess various biological properties including anti-cancer...
Molecules, Vol. 25, Pages 1198: A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides Molecules doi: 10.3390/molecules25051198 Authors: Florian Nachon Terrone L. Rosenberry Israel Silman Joel L. Sussman Over recent decades, crystallographic software for data processing and structure refinement has improved dramatically,...
Molecules, Vol. 25, Pages 1195: Structure and Aggregation Mechanisms in Amyloids Molecules doi: 10.3390/molecules25051195 Authors: Zaida L. Almeida Rui M. M. Brito The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and deposition into insoluble plaques and intracellular inclusions is the hallmark of several misfolding diseases known as amyloidoses. Alzheimer′s, Parkinson′s and Huntington’s diseases are some of the approximately...
Molecules, Vol. 25, Pages 1189: Simplification of Natural β-Carboline Alkaloids to Obtain Indole Derivatives as Potent Fungicides against Rice Sheath Blight Molecules doi: 10.3390/molecules25051189 Authors: Zeng Zhang Zhu Jiang Zhong The increasing resistance of rice sheath blight caused by Rhizoctonia solani highlights the need for highly effective and environmentally benign agents. Natural β-carboline alkaloids were simplified to obtain a series of indole...
Molecules, Vol. 25, Pages 1194: Emerging Role of the Macrophage Migration Inhibitory Factor Family of Cytokines in Neuroblastoma. Pathogenic Effectors and Novel Therapeutic Targets? Molecules doi: 10.3390/molecules25051194 Authors: Eugenio Cavalli Rosella Ciurleo Maria Cristina Petralia Paolo Fagone Rita Bella Katia Mangano Ferdinando Nicoletti Placido Bramanti Maria Sofia Basile Neuroblastoma (NB) is the most frequent extracranial pediatric tumor. Despite the...
Molecules, Vol. 25, Pages 1190: Antioxidant Content of Frozen, Convective Air-Dried, Freeze-Dried, and Swell-Dried Chokecherries (Prunus virginiana L.) Molecules doi: 10.3390/molecules25051190 Authors: Téllez-Pérez Cardador-Martínez Tejada-Ortigoza Soria-Mejía Balderas-León Alonzo-Macías Chokecherry (Prunus virginiana L.) is rich in bioactive molecules as phenolics, which can act as antioxidants, anti-inflammatory, anticancer, among others; however, due to its high...
Molecules, Vol. 25, Pages 1191: Performance of Fluorescence and Diffuse Reflectance Hyperspectral Imaging for Characterization of Lutefisk: A Traditional Norwegian Fish Dish Molecules doi: 10.3390/molecules25051191 Authors: Abdo Hassoun Karsten Heia Stein-Kato Lindberg Heidi Nilsen Lutefisk is a traditional Norwegian fish dish made from dried fish, such as cod or other whitefish. In Norway and other Nordic countries, lutefisk is considered among the most popular dishes served...
Molecules, Vol. 25, Pages 1193: Chemometric Analysis of Low-field 1H NMR Spectra for Unveiling Adulteration of Slimming Dietary Supplements by Pharmaceutical Compounds Molecules doi: 10.3390/molecules25051193 Authors: Nao Wu Stéphane Balayssac Saïda Danoun Myriam Malet-Martino Véronique Gilard The recent introduction of compact or low-field (LF) NMR spectrometers that use permanent magnets, giving rise to proton (1H) NMR frequencies between 40 and 80 MHz, have opened up new...
Molecules, Vol. 25, Pages 1192: Antioxidant Properties of Camphene-Based Thiosemicarbazones: Experimental and Theoretical Evaluation Molecules doi: 10.3390/molecules25051192 Authors: Lijuan Yang Haochuang Liu Dasha Xia Shifa Wang The thiosemicarbazone derivatives have a wide range of biological activities, such as antioxidant activity. In this study, the antiradical activities of six camphene-based thiosemicarbazones (TSC-1~6) were investigated by 2,2-diphenyl-1-picrylhydrazyl...
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