IJMS, Vol. 21, Pages 1851: The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21051851 Authors: Lee Lee Kim Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation...
Sun Mar 08, 2020 02:00
IJMS, Vol. 21, Pages 1850: Transcriptional Profiling of Advanced Urothelial Cancer Predicts Prognosis and Response to Immunotherapy International Journal of Molecular Sciences doi: 10.3390/ijms21051850 Authors: Seung-Woo Baek In-Hwan Jang Seon-Kyu Kim Jong-Kil Nam Sun-Hee Leem In-Sun Chu Recent investigations reported that some subtypes from the Lund or The Cancer Genome Atlas (TCGA) classifications were most responsive to PD-L1 inhibitor treatment. However, the association...
Sun Mar 08, 2020 02:00
IJMS, Vol. 21, Pages 1848: LY75 Ablation Mediates Mesenchymal-Epithelial Transition (MET) in Epithelial Ovarian Cancer (EOC) Cells Associated with DNA Methylation Alterations and Suppression of the Wnt/β-Catenin Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21051848 Authors: Sadia Mehdi Magdalena Bachvarova Marie-Pier Scott-Boyer Arnaud Droit Dimcho Bachvarov Growing evidence demonstrates that epithelial–mesenchymal transition (EMT) plays...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1849: Downregulation of Placental Amino Acid Transporter Expression and mTORC1 Signaling Activity Contributes to Fetal Growth Retardation in Diabetic Rats International Journal of Molecular Sciences doi: 10.3390/ijms21051849 Authors: Xu Wang Cao Jia Huang Cai Lu Zhu Alterations in placental transport may contribute to abnormal fetal intrauterine growth in pregnancies complicated by diabetes, but it is not clear whether the placental...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1847: Antibiotic Resistance, Virulence Factors, Phenotyping, and Genotyping of Non–Escherichia coli Enterobacterales from the Gut Microbiota of Healthy Subjects International Journal of Molecular Sciences doi: 10.3390/ijms21051847 Authors: Alberto Amaretti Lucia Righini Francesco Candeliere Eliana Musmeci Francesca Bonvicini Giovanna Angela Gentilomi Maddalena Rossi Stefano Raimondi Non-Escherichia coli Enterobacterales (NECE) can colonize the...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1845: Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21051845 Authors: Qian Zhao Hong-Ping Zhu Xin Xie Qing Mao Yan-Qing Liu Xiang-Hong He Cheng Peng Qing-Lin Jiang Wei Huang Melanoma is the deadliest form of skin cancer, and its incidence has continuously increased over the past...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1841: Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer’s Disease Progression International Journal of Molecular Sciences doi: 10.3390/ijms21051841 Authors: Laura Gil Sandra A. Niño Erika Chi-Ahumada Ildelfonso Rodríguez-Leyva Carmen Guerrero Ana Belén Rebolledo José A. Arias María E. Jiménez-Capdeville Background. Recent reports point to a nuclear origin of Alzheimer’s disease...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1844: Chronic Exposure to Low Concentration Lead Chloride-Induced Anxiety and Loss of Aggression and Memory in Zebrafish International Journal of Molecular Sciences doi: 10.3390/ijms21051844 Authors: Ngoc Hieu Bui Thi Ngoc Anh Nguyen Thi Gilbert Audira Petrus Siregar Sung-Tzu Liang Jong-Chin Huang Chung-Der Hsiao Lead and lead-derived compounds have been extensively utilized in industry, and their chronic toxicity towards aquatic animals has not...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1843: Clinical Significance of Cytoplasmic IgE-Positive Mast Cells in Eosinophilic Chronic Rhinosinusitis International Journal of Molecular Sciences doi: 10.3390/ijms21051843 Authors: Yuka Gion Mitsuhiro Okano Takahisa Koyama Tokie Oura Asami Nishikori Yorihisa Orita Tomoyasu Tachibana Hidenori Marunaka Takuma Makino Kazunori Nishizaki Yasuharu Sato Cross-linking of antigen-specific IgE bound to the high-affinity IgE receptor (FcεRI)...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1842: Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase from Schistosoma mansoni, a Platyhelminth Parasite Responsible for Schistosomiasis International Journal of Molecular Sciences doi: 10.3390/ijms21051842 Authors: Andrea Angeli Mariana Pinteala Stelian S. Maier Bogdan C. Simionescu Akram A. Da’dara Patrick J. Skelly Claudiu T. Supuran Schistosomiasis is a debilitating infection provoked by parasitic flatworms called schistosomes. The...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1846: High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression International Journal of Molecular Sciences doi: 10.3390/ijms21051846 Authors: Lei Xu Hua Xia Dongsheng Ni Yanxia Hu Jianing Liu Yao Qin Qin Zhou Qiying Yi Yajun Xie High-dose dexamethasone (DEX) is used to treat chemotherapy-induced nausea and vomiting or to control immunotherapy-related autoimmune diseases in clinical...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1840: Does the Pre-Ovulatory Pig Oviduct Rule Sperm Capacitation In Vivo Mediating Transcriptomics of Catsper Channels? International Journal of Molecular Sciences doi: 10.3390/ijms21051840 Authors: Cristina A. Martinez Manuel Alvarez-Rodriguez Dominic Wright Heriberto Rodriguez-Martinez Spermatozoa need to conduct a series of biochemical changes termed capacitation in order to fertilize. In vivo, capacitation is sequentially achieved during sperm transport...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1839: Curcumin as an Anticancer Agent in Malignant Mesothelioma: A Review International Journal of Molecular Sciences doi: 10.3390/ijms21051839 Authors: Alfonso Baldi Antonio De Luca Patrizia Maiorano Costantino D’Angelo Antonio Giordano Malignant mesothelioma is an infrequent tumor that initiates from the mesothelial cells lining of body cavities. The great majority of mesotheliomas originate in the pleural cavity, while the remaining cases initiate...
Sat Mar 07, 2020 02:00
IJMS, Vol. 21, Pages 1838: Mitochondrial Epigenetics: Non-Coding RNAs as a Novel Layer of Complexity
IJMS, Vol. 21, Pages 1838: Mitochondrial Epigenetics: Non-Coding RNAs as a Novel Layer of Complexity International Journal of Molecular Sciences doi: 10.3390/ijms21051838 Authors: Giovanna C. Cavalcante Leandro Magalhães Ândrea Ribeiro-dos-Santos Amanda F. Vidal Mitochondria are organelles responsible for several functions involved in cellular balance, including energy generation and apoptosis. For decades now, it has been well-known that mitochondria have their own genetic...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1837: In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF-β1 Signaling Pathway in Asthma International Journal of Molecular Sciences doi: 10.3390/ijms21051837 Authors: Ieva Janulaityte Andrius Januskevicius Virginija Kalinauskaite-Zukauske Ieva Bajoriuniene Kestutis Malakauskas Eosinophils infiltration and releasing TGF-β1 in the airways has been implicated in the pathogenesis...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1832: Biological Activities and Molecular Docking of Brassinosteroids 24-Norcholane Type Analogs International Journal of Molecular Sciences doi: 10.3390/ijms21051832 Authors: Katy Díaz Luis Espinoza Rodrigo Carvajal Marcos Conde-González Vladimir Niebla Andrés F. Olea Yamilet Coll The quest and design of new brassinosteroids analogs is a matter of current interest. Herein, the effect of short alkyl side chains and the configuration at C22 on the...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1833: In Vitro Vascular Network Modified to Function as Culture Platform and Angiogenic Induction Potential Test for Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21051833 Authors: Outi Huttala Synnöve Staff Tuula Heinonen Johanna Mäenpää Minna Tanner Timo Ylikomi Drug treatments have been designed to inhibit tumor angiogenesis in hope of stopping tumor growth. However, not all tumor types respond to this type of treatment....
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1834: Induction of Antitumor Immunity by Exosomes Isolated from Cryopreserved Cord Blood Monocyte-Derived Dendritic Cells International Journal of Molecular Sciences doi: 10.3390/ijms21051834 Authors: Uyen Thi Trang Than Huyen Thi Le Diem Huong Hoang Xuan-Hung Nguyen Cuong Thi Pham Khanh Thi Van Bui Hue Thi Hong Bui Phong Van Nguyen Tu Dac Nguyen Thu Thi Hoai Do Thao Thi Chu Anh Viet Bui Liem Thanh Nguyen Nhung Thi My Hoang (1)...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1836: Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress International Journal of Molecular Sciences doi: 10.3390/ijms21051836 Authors: Kaiyue Sun Yingting Sun Heyang Li Dongyao Han Yuting Bai Rong Zhao Zijiao Guo We aimed to study the effects of an ethyl acetate fraction of Physalis alkekengi (PAE) on d-galactose (d-gal)-induced senescence...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1827: The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21051827 Authors: Yahima Frión-Herrera Daniela Gabbia Michela Scaffidi Letizia Zagni Osmany Cuesta-Rubio Sara De De Martin Maria Carrara The majority of deaths related to colorectal cancer (CRC) are associated with the metastatic process. Alternative therapeutic...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1829: Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR International Journal of Molecular Sciences doi: 10.3390/ijms21051829 Authors: Yuji Tokunaga Thibault Viennet Haribabu Arthanari Koh Takeuchi Solution NMR spectroscopy is a unique and powerful technique that has the ability to directly connect the structural dynamics of proteins in physiological conditions to their activity and function. Here,...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1828: JA-Ile-macrolactone 5b Induces Tea Plant (Camellia sinensis) Resistance to Both Herbivore Ectropis obliqua and Pathogen Colletotrichum camelliae International Journal of Molecular Sciences doi: 10.3390/ijms21051828 Authors: Songbo Lin Yanan Dong Xiwang Li Yuxian Xing Miaomiao Liu Xiaoling Sun Jasmonates (JAs), the group of lipid-derived hormones, were found to control the defense responses in a myriad of plants. Meaningfully, the macrolactones...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1830: Stem Cell Aging in Skeletal Muscle Regeneration and Disease International Journal of Molecular Sciences doi: 10.3390/ijms21051830 Authors: Hiroyuki Yamakawa Dai Kusumoto Hisayuki Hashimoto Shinsuke Yuasa Skeletal muscle comprises 30–40% of the weight of a healthy human body and is required for voluntary movements in humans. Mature skeletal muscle is formed by multinuclear cells, which are called myofibers. Formation of myofibers depends on...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1826: Similarities in the General Chemical Composition of Colon Cancer Cells and Their Microvesicles Investigated by Spectroscopic Methods-Potential Clinical Relevance International Journal of Molecular Sciences doi: 10.3390/ijms21051826 Authors: Joanna Depciuch Bartosz Klębowski Małgorzata Stec Rafał Szatanek Kazimierz Węglarczyk Monika Baj-Krzyworzeka Magdalena Parlińska-Wojtan Jarek Baran Colon cancer constitutes 33% of all cancer cases in...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1824: The Role of Gibberellins in Regulation of Nitrogen Uptake and Physiological Traits in Maize Responding to Nitrogen Availability International Journal of Molecular Sciences doi: 10.3390/ijms21051824 Authors: Yubin Wang Qingqing Yao Yushi Zhang Yuexia Zhang Jiapeng Xing Benzhou Yang Guohua Mi Zhaohu Li Mingcai Zhang Modified gibberellin (GA) signaling leads to semi-dwarfism with low nitrogen (N) use efficiency (NUE) in crops. An understanding...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1831: A Meta-Analysis of Multiple Whole Blood Gene Expression Data Unveils a Diagnostic Host-Response Transcript Signature for Respiratory Syncytial Virus International Journal of Molecular Sciences doi: 10.3390/ijms21051831 Authors: Ruth Barral-Arca Alberto Gómez-Carballa Miriam Cebey-López Xabier Bello Federico Martinón-Torres Antonio Salas Respiratory syncytial virus (RSV) is one of the major causes of acute lower respiratory tract infection worldwide....
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1835: The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms21051835 Authors: Anastasia Poznyak Andrey V. Grechko Paolo Poggio Veronika A. Myasoedova Valentina Alfieri Alexander N. Orekhov Diabetes mellitus comprises a group of carbohydrate metabolism disorders that share a common main feature of chronic hyperglycemia that results...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1821: Bisphenol S Impaired Human Granulosa Cell Steroidogenesis in Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21051821 Authors: Sarah Amar Aurélien Binet Ophélie Téteau Alice Desmarchais Pascal Papillier Marlène Z. Lacroix Virginie Maillard Fabrice Guérif Sebastien Elis Bisphenol S (BPS) is a structural analog of the endocrine disruptor bisphenol A (BPA); it is the main BPA replacement in the plastics industry. Previous...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1823: Interaction of the Coffee Diterpenes Cafestol and 16-O-Methyl-Cafestol Palmitates with Serum Albumins International Journal of Molecular Sciences doi: 10.3390/ijms21051823 Authors: Federico Berti Luciano Navarini Elena Guercia Ana Oreški Alessandra Gasparini Jeremy Scoltock Cristina Forzato The main coffee diterpenes cafestol, kahweol, and 16-O-methylcafestol, present in the bean lipid fraction, are mostly esterified with fatty acids. They...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1825: Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions International Journal of Molecular Sciences doi: 10.3390/ijms21051825 Authors: Francesca Arruga Benjamin Baffour Gyau Andrea Iannello Nicoletta Vitale Tiziana Vaisitti Silvia Deaglio Representing the major cause of morbidity and mortality for chronic lymphocytic leukemia (CLL) patients, immunosuppression is a common feature...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1817: Exploring Diverse-Ring Analogues on Combretastatin A4 (CA-4) Olefin as Microtubule-Targeting Agents International Journal of Molecular Sciences doi: 10.3390/ijms21051817 Authors: Ming-Yu Song Qiu-Rui He Yi-Lin Wang Hao-Ran Wang Tian-Cheng Jiang Jiang-Jiang Tang Jin-Ming Gao Combretastatin-4 (CA-4) as a tubulin polymerization inhibitor draws extensive attentions. However, due to its weak stability of cis-olefin and poor metabolic stability,...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1820: Chromosomal Distribution of Genes Conferring Tolerance to Abiotic Stresses Versus That of Genes Controlling Resistance to Biotic Stresses in Plants International Journal of Molecular Sciences doi: 10.3390/ijms21051820 Authors: Richard R.-C. Wang Tolerance to abiotic stresses caused by environmental conditions can prevent yield loss in crops for sustaining agricultural productivity [...]
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1822: A Brief Review of Nutraceutical Ingredients in Gastrointestinal Disorders: Evidence and Suggestions International Journal of Molecular Sciences doi: 10.3390/ijms21051822 Authors: Xiang Gao Jingwen Liu Li Li Wei Liu Meiyan Sun The dietary effect on gut health has long been recognized through the empirical practice of soothing gastric discomfort with certain types of food, and recently the correlation between specific diets with lower incidences of...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1816: Structural Characterization of an Archaeal Lipid Bilayer as a Function of Hydration and Temperature International Journal of Molecular Sciences doi: 10.3390/ijms21051816 Authors: Marta Salvador-Castell Bruno Demé Philippe Oger Judith Peters Archaea, the most extremophilic domain of life, contain ether and branched lipids which provide extraordinary bilayer properties. We determined the structural characteristics of diether archaeal-like phospholipids...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1818: DNA Methylation Profiling for Diagnosing Undifferentiated Sarcoma with Capicua Transcriptional Receptor (CIC) Alterations International Journal of Molecular Sciences doi: 10.3390/ijms21051818 Authors: Evelina Miele Rita De De Vito Andrea Ciolfi Lucia Pedace Ida Russo Maria Debora De De Pasquale Angela Di Di Giannatale Alessandro Crocoli Biagio De Angelis Marco Tartaglia Rita Alaggio Giuseppe Maria Milano Undifferentiated soft...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1819: Genetic and Global Epigenetic Modification, Which Determines the Phenotype of Transgenic Rice? International Journal of Molecular Sciences doi: 10.3390/ijms21051819 Authors: Xiaoru Fan Jingguang Chen Yufeng Wu CheeHow Teo Guohua Xu Xiaorong Fan Transgenic technologies have been applied to a wide range of biological research. However, information on the potential epigenetic effects of transgenic technology is still lacking. Here, we show that...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1815: Gibberellin Signaling Repressor LlDELLA1 Controls the Flower and Pod Development of Yellow Lupine (Lupinus luteus L.) International Journal of Molecular Sciences doi: 10.3390/ijms21051815 Authors: Katarzyna Marciniak Krzysztof Przedniczek Precise control of generative organ development is of great importance for the productivity of crop plants, including legumes. Gibberellins (GAs) play a key role in the regulation of flowering, and fruit setting and development....
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1814: Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts of Acacia dealbata International Journal of Molecular Sciences doi: 10.3390/ijms21051814 Authors: Cátia S. D. Oliveira Patrícia Moreira Judite Resende Maria T. Cruz Cláudia M. F. Pereira Artur M. S. Silva Sónia A. O. Santos Armando J. D. Silvestre Acacia dealbata biomass, either from forest exploitation or from the management of invasive...
Fri Mar 06, 2020 02:00
IJMS, Vol. 21, Pages 1812: Global Characterization of GH10 Family Xylanase Genes in Rhizoctonia cerealis and Functional Analysis of Xylanase RcXYN1 During Fungus Infection in Wheat International Journal of Molecular Sciences doi: 10.3390/ijms21051812 Authors: Lin Lu Yongwei Liu Zengyan Zhang Wheat (Triticum aestivum L.) is an important staple crop. Rhizoctonia cerealis is the causal agent of diseases that are devastating to cereal crops, including wheat. Xylanases play an important...
Fri Mar 06, 2020 02:00
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