Related ArticlesBioactivity of Biphasic Calcium Phosphate Granules, the Control of a Needle-Like Apatite Layer Formation for Further Medical Device Developments. Front Bioeng Biotechnol. 2019;7:462 Authors: d'Arros C, Rouillon T, Veziers J, Malard O, Borget P, Daculsi G Abstract Biphasic calcium phosphate (BCP) bioceramics (hydroxyapatite/tricalcium phosphate, or HA/TCP) for tissue engineering and drug delivery systems is a unique know-how. A mechanical...
Tue Mar 03, 2020 17:23
Related ArticlesBest Practice in Surgical Treatment of Malignant Head and Neck Tumors. Front Oncol. 2020;10:140 Authors: Simon C, Nicolai P, Paderno A, Dietz A Abstract Purpose of review: Defining the best practice of surgical care for patients affected by malignant head and neck tumors is of great importance. In this review we aim to describe the evolution of "best practice" guidelines in the context of quality-of-care measures and discuss current evidence...
Tue Mar 03, 2020 17:23
Related ArticlesRole of fibrillin-2 in the control of TGF-β activation in tumor angiogenesis and connective tissue disorders. Biochim Biophys Acta Rev Cancer. 2020 Feb 28;:188354 Authors: van Loon K, Yemelyanenko-Lyalenko J, Margadant C, Griffioen AW, Huijbers EJM Abstract Fibrillins constitute a family of large extracellular glycoproteins which multimerize to form microfibrils, an important structure in the extracellular matrix. It has long been assumed...
Tue Mar 03, 2020 14:22
Related ArticlesCancer patients' experiences with immune checkpoint modulators: A qualitative study. Cancer Med. 2020 Mar 02;: Authors: Ala-Leppilampi K, Baker NA, McKillop C, Butler MO, Siu LL, Spreafico A, Abdul Razak AR, Joshua AM, Hogg D, Bedard PL, Leighl N, Oza AM, Parsons JA, Hansen AR Abstract BACKGROUND: Minimal qualitative data exist on the experiences of cancer patients treated with immune checkpoint inhibitors or costimulatory antibodies....
Tue Mar 03, 2020 14:22
Related ArticlesWelcome to Volume 9 of CNS Oncology. CNS Oncol. 2020 Mar 02;:CNS49 Authors: Straiton J PMID: 32118489 [PubMed - as supplied by publisher]
Tue Mar 03, 2020 14:22
Related ArticlesNorepinephrine-CREB1-miR-373 axis promotes progression of colon cancer. Mol Oncol. 2020 Mar 02;: Authors: Han J, Jiang Q, Ma R, Zhang H, Tong D, Tang K, Wang X, Ni L, Miao J, Duan B, Yang Y, Chen Y, Wu F, Han J, Wang M, Hou N, Huang C Abstract The adrenergic system contributes to the stress-induced onset and progression of cancer. Adrenergic fibers are the primary source of norepinephrine (NE). The underlying mechanisms involved in NE-induced...
Tue Mar 03, 2020 14:22
Related ArticlesA Review of Precision Oncology Knowledgebases for Determining the Clinical Actionability of Genetic Variants. Front Cell Dev Biol. 2020;8:48 Authors: Li X, Warner JL Abstract The increased availability of tumor genetic testing and targeted cancer therapies contributes to the advancement of precision medicine in the field of oncology. Precision oncology knowledgebases provide a way of organizing clinically relevant genetic information...
Tue Mar 03, 2020 14:22
Related ArticlesFat Wasting Is Damaging: Role of Adipose Tissue in Cancer-Associated Cachexia. Front Cell Dev Biol. 2020;8:33 Authors: Sun X, Feng X, Wu X, Lu Y, Chen K, Ye Y Abstract Loss of body weight, especially loss of adipose tissue and skeletal muscle weight, characterizes cancer-associated cachexia (CAC). Clinically, therapeutic options for CAC are limited due to the complicated signaling between cancer and other organs. Recent research advances...
Tue Mar 03, 2020 14:22
Related ArticlesA Cost-Effectiveness and Quality of Life Analysis of Different Approaches to the Management and Treatment of Localized Prostate Cancer. Front Oncol. 2020;10:103 Authors: Harat A, Harat M, Martinson M Abstract The aim of this study was to compare the cost-effectiveness and quality-adjusted life years (QALYs) of active monitoring (AM), radical prostatectomy (PR), and external-beam radiotherapy with neoadjuvant hormone therapy (RT) for localized...
Tue Mar 03, 2020 14:22
Related ArticlesImpact of Radiochemotherapy on Immune Cell Subtypes in High-Grade Glioma Patients. Front Oncol. 2020;10:89 Authors: Dutoit V, Philippin G, Widmer V, Marinari E, Vuilleumier A, Migliorini D, Schaller K, Dietrich PY Abstract Glioblastoma is a dreadful disease with very poor prognosis, median overall survival being <2 years despite standard-of-care treatment. This has led to the development of alternative strategies, among which immunotherapy...
Tue Mar 03, 2020 14:22
Related ArticlesSPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human. Front Oncol. 2020;10:20 Authors: Etienne F, Berthaud M, Nguyen F, Bernardeau K, Maurel C, Bodet-Milin C, Diab M, Abadie J, Gouilleux-Gruart V, Vidal A, Bourgeois M, Chouin N, Ibisch C, Davodeau F Abstract Antibodies directed against CD22 have been used in radioimmunotherapy (RIT) clinical trials...
Tue Mar 03, 2020 14:22
Related ArticlesComputational Prediction and Validation of Tumor-Associated Neoantigens. Front Immunol. 2020;11:27 Authors: Roudko V, Greenbaum B, Bhardwaj N Abstract Tumor progression is typically accompanied by an accumulation of driver and passenger somatic mutations. A handful of those mutations occur in protein coding genes which introduce non-synonymous polymorphisms. Certain substitutions may give rise to novel, tumor-associated antigens or neoantigens,...
Tue Mar 03, 2020 14:22
Related ArticlesSystems analysis of benign bladder disorders: insights from omics analysis. Am J Physiol Renal Physiol. 2020 Mar 02;: Authors: Hashemi Gheinani A, Bigger-Allen A, Wacker A, Adam RM Abstract The signaling pathways and effectors that drive the response of the bladder to non-malignant insults or injury are incompletely defined. Interrogation of biological systems has been revolutionized by the ability to generate high content datasets that...
Tue Mar 03, 2020 14:22
Related ArticlesSetting a research agenda for vascular Ehlers-Danlos syndrome using a patient and stakeholder engagement model. J Vasc Surg. 2020 Feb 27;: Authors: Sage L, Russo ML, Byers PH, Demasi J, Morris SA, Puryear LN, Fulton DS, Shalhub S, Vascular Ehlers-Danlos Syndrome Research Collaborative Abstract OBJECTIVE: Vascular Ehlers-Danlos syndrome (vEDS) is a rare, syndromic, heritable condition with life-threatening complications that include aortic...
Tue Mar 03, 2020 13:22
Related ArticlesNeurosurgical training and global health education: systematic review of challenges and benefits of in-country programs in the care of neural tube defects. Neurosurg Focus. 2020 Mar 01;48(3):E14 Authors: Gandy K, Castillo H, Rocque BG, Bradko V, Whitehead W, Castillo J Abstract OBJECTIVE: The recognition that neurosurgeons harbor great potential to advocate for the care of individuals with neural tube defects (NTDs) globally has sounded...
Tue Mar 03, 2020 13:22
Related ArticlesPatient-reported outcomes at discontinuation of anti-angiogenesis therapy in the randomized trial of chemotherapy with bevacizumab for advanced cervical cancer: an NRG Oncology Group study. Int J Gynecol Cancer. 2020 Feb 28;: Authors: Chase D, Huang HQ, Monk BJ, Ramondetta LM, Penson RT, Gil K, Landrum LM, Leitao M, Oaknin A, Huh WK, Pulaski HL, Robison K, Guntupalli SR, Richardson D, Salani R, Sill MW, Wenzel LB, Tewari KS Abstract INTRODUCTION:...
Tue Mar 03, 2020 13:22
Related ArticlesDNA methylation of the TERT promoter and its impact on human cancer. Curr Opin Genet Dev. 2020 Feb 27;60:17-24 Authors: Lee DD, Komosa M, Nunes NM, Tabori U Abstract Telomere maintenance is a hallmark of human cancer that enables replicative immortality. Most cancer cells acquire telomere maintenance by telomerase activation through expression of telomerase reverse transcriptase (TERT), a rate-limiting component of the telomerase holoenzyme....
Tue Mar 03, 2020 13:22
Related ArticlesOral Lichen Planus-Associated Oral Cavity Squamous Cell Carcinoma Is Associated With Improved Survival and Increased Risk of Recurrence. J Oral Maxillofac Surg. 2020 Feb 05;: Authors: Best DL, Herzog C, Powell C, Braun T, Ward BB, Moe J Abstract PURPOSE: We investigated the overall survival (OS), disease-specific survival (DSS), and disease-free survival among patients with oral lichen planus-associated oral cavity squamous cell carcinoma...
Tue Mar 03, 2020 13:22
Related ArticlesA User's Guide to Novel Therapies for Acute Myeloid Leukemia. Clin Lymphoma Myeloma Leuk. 2020 Jan 30;: Authors: Patel SA, Gerber JM Abstract Few diseases have been marked by a 40-year period of stagnation with regard to therapeutic advances and United States Food and Drug Administration (FDA) approvals, as has been the case for acute myeloid leukemia (AML). Cytarabine and anthracyclines were introduced for the treatment of AML in the...
Tue Mar 03, 2020 13:22
Related ArticlesA Phase II Study of Pembrolizumab in Combination With Palliative Radiotherapy for Hormone Receptor-positive Metastatic Breast Cancer. Clin Breast Cancer. 2020 Jan 30;: Authors: Barroso-Sousa R, Krop IE, Trippa L, Tan-Wasielewski Z, Li T, Osmani W, Andrews C, Dillon D, Richardson ET, Pastorello RG, Winer EP, Mittendorf EA, Bellon JR, Schoenfeld JD, Tolaney SM Abstract BACKGROUND: The purpose of this study was to investigate whether combining...
Tue Mar 03, 2020 13:22
Related ArticlesWhole-person care in general practice: The doctor-patient relationship. Aust J Gen Pract. 2020 03;49(3):139-144 Authors: Thomas H, Best M, Mitchell G Abstract BACKGROUND AND OBJECTIVES: Whole-person care (WPC) is a defining feature of general practice, but it may not be consistently implemented. These authors conducted a qualitative study to define WPC and determine factors that influence its provision. Part one of this series suggested...
Tue Mar 03, 2020 13:22
Related ArticlesThe Urinary Microbiome and Anticancer Immunotherapy: The Potentially Hidden Role of Unculturable Microbes. Target Oncol. 2019 06;14(3):247-252 Authors: Bersanelli M, Santoni M, Ticinesi A, Buti S Abstract Several urinary disorders, including overactive bladder, urinary incontinence, and interstitial cystitis, are often characterized by negative urine cultures. The application of metagenomics (i.e., 16S rRNA microbial profiling or whole-genome...
Tue Mar 03, 2020 13:22
Related ArticlesCorrelation of Milestone Restricted Mean Survival Time Ratio With Overall Survival Hazard Ratio in Randomized Clinical Trials of Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019 05 03;2(5):e193433 Authors: Wang ZX, Wu HX, Xie L, Wang YN, Yang LP, He MM, Luo HY, Ding PR, Xie D, Chen G, Li YH, Wang F, Xu RH Abstract Importance: Immune checkpoint inhibitors (ICIs) have unique patterns of response...
Tue Mar 03, 2020 13:22
Introduction: Noise-induced hearing loss (NIHL) is a common occupational disease that represents an irreversible hearing damage to the auditory system. It has been identified as a complicated disease involving both environmental and genetic factors. More efforts need to be made to explore the genes associated with susceptibility to NIHL. The main aim of this research is to detect the associations between SIK3 polymorphisms and NIHL susceptibility in Han people in China. Methods: A case-control study...
Tue Mar 03, 2020 12:03
Related Articles5-Fluorouracil-induced hyperammonaemic encephalopathy: A French national survey. Eur J Cancer. 2020 Feb 28;129:32-40 Authors: Boilève A, Thomas L, Lillo-Le Louët A, Gaboriau L, Chouchana L, Ducreux M, Malka D, Boige V, Hollebecque A, Hillaire-Buys D, Jozwiak M Abstract BACKGROUND: 5-Fluorouracil (5-FU)-induced hyperammonaemic encephalopathy is a rare but serious 5-FU adverse drug reaction (ADR). Given the growing number of cancers treated...
Tue Mar 03, 2020 14:19
Related ArticlesMutational and transcriptomic landscapes of a rare human prostate basal cell carcinoma. Prostate. 2020 Mar 02;: Authors: Su X, Long Q, Bo J, Shi Y, Zhao LN, Lin Y, Luo Q, Ghazanfar S, Zhang C, Liu Q, Wang L, He K, He J, Cui X, Yang JYH, Han ZG, Yang G, Sha JJ Abstract BACKGROUND: As a rare subtype of prostate carcinoma, basal cell carcinoma (BCC) has not been studied extensively and thus lacks systematic molecular characterization. ...
Tue Mar 03, 2020 14:19
Related Articlesvon Hippel-Lindau Syndrome: Genetic Study of Case With a Rare Pathogenic Variant With Optic Nerve Hemangioblastoma, a Rare Phenotypic Expression. Front Oncol. 2020;10:139 Authors: Boratto SDF, Cardoso PAS, Priolli DG, Botelho RV, Goldenberg A, Bianco B, Waisberg J Abstract von Hippel-Lindau syndrome (VHLS) is a rare, autosomal dominant genetic disease with high penetrance and variable phenotypic expression caused by variants in the VHL...
Tue Mar 03, 2020 14:19
Related ArticlesFrom the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine. Front Oncol. 2020;10:117 Authors: Rao SR, Somarelli JA, Altunel E, Selmic LE, Byrum M, Sheth MU, Cheng S, Ware KE, Kim SY, Prinz JA, Devos N, Corcoran DL, Moseley A, Soderblom E, Hsu SD, Eward WC Abstract Cancer drug discovery is an inefficient process, with...
Tue Mar 03, 2020 14:19
Related ArticlesIntracranial Metastases Originating From Pediatric Primary Spinal Cord Glioblastoma Multiforme: A Case Report and Literature Review. Front Oncol. 2020;10:99 Authors: Song D, Xu D, Gao Q, Hu P, Guo F Abstract Primary spinal cord glioblastoma multiforme (scGBM) is an uncommon entity in pediatrics, and intracranial metastasis originating in spinal cord gliomas is very rare. A 7-year-old female presented with weakness in the limbs, paralysis...
Tue Mar 03, 2020 14:19
Related ArticlesAtrial Myxoma, a Rare Cause of Sudden Cardiac Death: A Case Report and Review of Literature. Cureus. 2020 Jan 19;12(1):e6704 Authors: Hasan M, Abdelmaseih R, Faluk M, Chacko J, Nasser H Abstract Despite the huge improvement in cardiovascular care over the past several decades and the decline in cardiovascular deaths, sudden cardiac death (SCD) continues to present a nationwide health problem accounting to more than half of all deaths...
Tue Mar 03, 2020 14:19
Related ArticlesMalignant melanoma of the breast: controversies in the diagnosis and therapeutic management of a rare nosologic entity. Int J Dermatol. 2020 Mar 02;: Authors: Mastoraki A, Schizas D, Giannakodimos I, Rebakos A, Margaris I, Katsaros I, Vagios I, Vassiliu P, Pikoulis E Abstract Melanoma of the breast is an infrequent entity, presenting as either primary or metastatic from extramammary solid neoplasms. Depending on the involvement of the...
Tue Mar 03, 2020 13:18
Related ArticlesHistory of Japan Clinical Oncology Group (JCOG) Lung Cancer Study Group. Jpn J Clin Oncol. 2020 Mar 02;: Authors: Horinouchi H, Ohe Y Abstract The Japan Clinical Oncology Group Lung Cancer Study Group has been carrying out clinical studies, exploring new strategies of treatment, supportive therapies (antiemetics, etc.), etc., for a variety of cancers, including not only small cell lung cancer and non-small cell lung cancer but also rare...
Tue Mar 03, 2020 13:18
Related ArticlesDiffuse Large B-Cell Lymphoma Arising from the Lesion of Chronic Lobar Atelectasis. Tohoku J Exp Med. 2020;250(2):129-135 Authors: Fujita N, Ando M, Goto A, Sakata M, Ogata M, Usagawa Y, Yoshikawa H, Yamasue M, Komiya K, Umeki K, Nureki SI, Kadota JI Abstract Pulmonary lymphoma is rare, accounting for < 1% of primary lung cancers. Most primary pulmonary lymphomas (PPL) are low-grade mucosa-associated lymphoid tissue (MALT)-type, and...
Tue Mar 03, 2020 13:18
Related ArticlesCytopathology of classic type epithelioid sarcoma: a series of 20 cases and review of the literature. J Am Soc Cytopathol. 2020 Feb 06;: Authors: Wakely PE Abstract INTRODUCTION: As a rare soft tissue malignancy, epithelioid sarcoma (EpS) is infrequently subjected to cytopathologic analysis. With the exception of a few series, the cytology literature regarding EpS is largely limited to single case reports. Our purpose was to evaluate...
Tue Mar 03, 2020 13:18
Related ArticlesGenetic and histopathological analysis of a case of primary intraosseous carcinoma, NOS with features of both ameloblastic carcinoma and squamous cell carcinoma. World J Surg Oncol. 2020 Feb 29;18(1):45 Authors: Yukimori A, Tsuchiya M, Wada A, Michi Y, Kayamori K, Sakamoto K, Ikeda T Abstract BACKGROUND: Primary intraosseous carcinoma (PIOC), NOS is an odontogenic carcinoma with unknown etiology. Its diagnosis may be used when central...
Tue Mar 03, 2020 13:18
Related Articles[Large-cell neuroendocrine carcinoma of the lung - challenges of diagnosis and treatment]. Orv Hetil. 2020 Feb;161(8):313-319 Authors: Zombori T, Juhász-Nagy G, Tiszlavicz L, Cserni G, Furák J, Szalontai K, Pálföldi R Abstract Small-cell lung carcinoma (SCLC) and the rare large-cell neuroendocrine carcinoma belong to the high grade pulmonary neuroendocrine carcinomas. Making the correct diagnosis and selection of treatment modalities...
Tue Mar 03, 2020 13:18
Related Articles[Osteoid osteoma of the hand - Diagnostics and operative treatment]. Orv Hetil. 2020 Feb;161(7):263-268 Authors: Balog L, Szakács N, Kiss J, Hetthéssy JR Abstract Introduction: Osteoid osteoma is a rare benign bone tumor displaying typical clinical symptoms and radiological signs in most cases. Characteristic symptoms are nocturnal pain alleviated by non-steroid antiinflammatory drugs. Radiological findings are also characteristic, the...
Tue Mar 03, 2020 13:18
Related Articles[A Case of Primary Central Nervous System Lymphomatoid Granulomatosis that was Completely Ameliorated by Corticosteroid Treatment]. Brain Nerve. 2020 Feb;72(2):159-165 Authors: Nakao T, Izumoto S, Tsuyuguchi N, Kato A, Yokoo H, Enoki E Abstract Lymphomatoid granulomatosis (LYG) is an angiocentric, angiodestructive lymphoreticular proliferative disease that usually affects the lungs but it has been speculated to also effect the central...
Tue Mar 03, 2020 13:18
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