Antibiotics, Vol. 9, Pages 111: Abundant Extractable Metabolites from Temperate Tree Barks: The Specific Antimicrobial Activity of Prunus Avium Extracts Antibiotics doi: 10.3390/antibiotics9030111 Authors: Abedini Colin Hubert Charpentier Angelis Bounasri Bertaux Kotland Reffuveille Nuzillard Renault Gangloff Tree barks are mainly considered as wood wastes from forestry activities, but represent valuable resources as they may contain antimicrobial...
Wed Mar 04, 2020 02:00
Antioxidants, Vol. 9, Pages 211: Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells Antioxidants doi: 10.3390/antiox9030211 Authors: Francesco Ciccarese Vittoria Raimondi Evgeniya Sharova Micol Silic-Benussi Vincenzo Ciminale Reactive oxygen species (ROS) constitute a homeostatic rheostat that modulates signal transduction pathways controlling cell turnover. Most oncogenic pathways activated in cancer cells drive a sustained increase in ROS production, and...
Wed Mar 04, 2020 02:00
Antioxidants, Vol. 9, Pages 210: Combining Medicinal Plant In Vitro Culture with Machine Learning Technologies for Maximizing the Production of Phenolic Compounds Antioxidants doi: 10.3390/antiox9030210 Authors: García-Pérez Lozano-Milo Landín Gallego We combined machine learning and plant in vitro culture methodologies as a novel approach for unraveling the phytochemical potential of unexploited medicinal plants. In order to induce phenolic compound biosynthesis, the in...
Wed Mar 04, 2020 02:00
Arts, Vol. 9, Pages 33: Galician Female Architects—A Critical Approach to Inequality in the Architectural Profession (1931–1986) Arts doi: 10.3390/arts9010033 Authors: María Novas-Ferradás María Carreiro-Otero Cándido López-González The remoteness of Galicia, a cultural and linguistic bridge between Portugal and Spain, did not prevent it from playing a significant role in the history of female architects in the Iberian Peninsula. Nine Galician pioneers have carved the path since...
Wed Mar 04, 2020 02:00
Atmosphere, Vol. 11, Pages 256: Kinetic Measurements of Cl Atom Reactions with C5–C8 Unsaturated Alcohols Atmosphere doi: 10.3390/atmos11030256 Authors: Grira Amarandei Romanias El Dib Canosa Arsene Bejan Olariu Coddeville Tomas The reactions of five structurally similar unsaturated alcohols, i.e., (Z)-2-penten-1-ol, (E)-2-hexen-1-ol, (E)-3-hexen-1-ol, (Z)-3-hexen-1-ol, and 1-octen-3-ol, with Cl atoms in the gas phase, were investigated at 296 ±...
Wed Mar 04, 2020 02:00
Atmosphere, Vol. 11, Pages 255: Changes in the Dynamics of the Northern Hemisphere Atmospheric Circulation and the Relationship to Surface Temperature in the 20th and 21st Centuries Atmosphere doi: 10.3390/atmos11030255 Authors: Nina K. Kononova Anthony R. Lupo This study examines the long-term fluctuations in the Northern Hemisphere (NH) and global atmospheric circulation, teleconnections, including blocking, and surface temperature over the period 1899–2018. The teleconnection...
Wed Mar 04, 2020 02:00
Bioengineering, Vol. 7, Pages 24: Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2 Bioengineering doi: 10.3390/bioengineering7010024 Authors: Martin Koller During the two years that have passed since the first volume of “Advances in Polyhydroxyalkanoate (PHA) production” was published, the progress in PHA-related research was indeed tremendous, calling for the next, highly bioprocess- and bioengineering-oriented volume. This editorial paper summarizes and...
Wed Mar 04, 2020 02:00
Biomedicines, Vol. 8, Pages 54: Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine Biomedicines doi: 10.3390/biomedicines8030054 Authors: Casado López-de-Eguileta Fonseca Muñoz Demetrio Gordo-Vega Cerveró In hydroxychloroquine (HCQ) retinopathy, early detection of asymptomatic retinal changes and the interruption of the drug are essential to prevent permanent vision loss. Our purpose was to investigate the roles of ganglion...
Wed Mar 04, 2020 02:00
Biomedicines, Vol. 8, Pages 50: Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease Biomedicines doi: 10.3390/biomedicines8030050 Authors: Jiang Zhang Kusumanchi Han Yang Liangpunsakul Once ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal...
Wed Mar 04, 2020 02:00
Biomedicines, Vol. 8, Pages 53: Reversal of Hyperglycemia and Suppression of Type 1 Diabetes in the NOD Mouse with Apoptotic DNA Immunotherapy™ (ADi™), ADi-100 Biomedicines doi: 10.3390/biomedicines8030053 Authors: David G. Alleva Melika Rezaee Linda Yip Gang Ren Jarrett Rosenberg Waldo Concepcion Alan Escher Shahrokh Shabahang Avnesh S. Thakor The antigen-specific apoptotic DNA immunotherapeutic, ADi-100, is designed to suppress type 1 diabetes and consists of...
Wed Mar 04, 2020 02:00
Biomedicines, Vol. 8, Pages 51: Effects of an 8-Week Protein Supplementation Regimen with Hyperimmunized Cow Milk on Exercise-Induced Organ Damage and Inflammation in Male Runners: A Randomized, Placebo Controlled, Cross-Over Study Biomedicines doi: 10.3390/biomedicines8030051 Authors: Ma Tominaga Kanda Sugama Omae Hashimoto Aoyama Yoshikai Suzuki Prolonged strenuous exercise may induce inflammation, cause changes in gastrointestinal permeability, and...
Wed Mar 04, 2020 02:00
Biomedicines, Vol. 8, Pages 52: Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I Biomedicines doi: 10.3390/biomedicines8030052 Authors: N. David Åberg Gustaf Gadd Daniel Åberg Peter Hällgren Christian Blomstrand Katarina Jood Michael Nilsson Fredrick R. Walker Johan Svensson Christina Jern Jörgen Isgaard Physical activity (PA) and insulin-like growth factor I (IGF-I) have beneficial effects for...
Wed Mar 04, 2020 02:00
Biomolecules, Vol. 10, Pages 399: A Novel T Cell-Engaging Bispecific Antibody for Treating Mesothelin-Positive Solid Tumors Biomolecules doi: 10.3390/biom10030399 Authors: Yoon Lee Lee Lim Park Song Kim Kim Lim As mesothelin is overexpressed in various types of cancer, it is an attractive target for therapeutic antibodies. T-cell bispecific antibodies bind to target cells and engage T cells via binding to CD3, resulting in target cell killing by T-cell...
Wed Mar 04, 2020 02:00
Biomolecules, Vol. 10, Pages 400: Phenols and Melanoidins as Natural Antioxidants in Beer. Structure, Reactivity and Antioxidant Activity Biomolecules doi: 10.3390/biom10030400 Authors: Martinez-Gomez Caballero Blanco Beer is one of the most consumed drinks around the world, containing a variety of compounds that offer both appreciated sensorial characteristics and health advantages. Important healthy compounds in beer are those with antioxidant properties that attenuate the...
Wed Mar 04, 2020 02:00
Biomolecules, Vol. 10, Pages 401: The Biomolecular Spectrum Drives Microbial Biology and Functions in Agri-Food-Environments Biomolecules doi: 10.3390/biom10030401 Authors: Sharma Singh Rangappa Stadler Mishra Silva Prasad Gupta Microbial biomolecules have huge commercial and industrial potential. In nature, biological interactions are mostly associated with biochemical and biological diversity, especially with the discovery of associated biomolecules from...
Wed Mar 04, 2020 02:00
Biomolecules, Vol. 10, Pages 396: Hypothalamic NAD+-Sirtuin Axis: Function and Regulation Biomolecules doi: 10.3390/biom10030396 Authors: Roh Kim The rapidly expanding elderly population and obesity endemic have become part of continuing global health care problems. The hypothalamus is a critical center for the homeostatic regulation of energy and glucose metabolism, circadian rhythm, and aging-related physiology. Nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase sirtuins...
Wed Mar 04, 2020 02:00
Biomolecules, Vol. 10, Pages 397: A Bioorthogonally Applicable, Fluorogenic, Large Stokes-Shift Probe for Intracellular Super-Resolution Imaging of Proteins Biomolecules doi: 10.3390/biom10030397 Authors: Németh Knorr Németh Kele Herein, we present the synthesis and application of a fluorogenic, large Stokes-shift (>100 nm), bioorthogonally conjugatable, membrane-permeable tetrazine probe, which can be excited at common laser line 488 nm and detected at around 600...
Wed Mar 04, 2020 02:00
Biomolecules, Vol. 10, Pages 395: An Oral Rinse Active Matrix Metalloproteinase-8 Point-of-Care Immunotest May Be Less Accurate in Patients with Crohn’s Disease Biomolecules doi: 10.3390/biom10030395 Authors: Rautava Gürsoy Kullström Könönen Sorsa Tervahartiala Gürsoy The diagnostic accuracy of point-of-care (PoC) applications may be compromised in individuals with additional inflammatory conditions. This cross-sectional study examined the performance of a commercial...
Wed Mar 04, 2020 02:00
Biomolecules, Vol. 10, Pages 394: Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, in Coronary Artery Disease Biomolecules doi: 10.3390/biom10030394 Authors: Julius Nikorowitsch Francisco Ojeda Karl J. Lackner Renate B. Schnabel Stefan Blankenberg Tanja Zeller Mahir Karakas Risk stratification among patients with coronary artery disease (CAD) is of considerable interest...
Wed Mar 04, 2020 02:00
Biomolecules, Vol. 10, Pages 398: Protective Effects of Chromium Picolinate Against Diabetic-Induced Renal Dysfunction and Renal Fibrosis in Streptozotocin-Induced Diabetic Rats Biomolecules doi: 10.3390/biom10030398 Authors: Qi Zheng Jiang Yuan Dong Diabetic nephropathy (DN) is one of the most important complications of diabetes， and the leading cause of end-stage renal disease (ESRD). While Chromium picolinate (CrPic) supplementation has...
Wed Mar 04, 2020 02:00
Biosensors, Vol. 10, Pages 22: Molecularly Imprinted Nanoparticles Based Sensor for Cocaine Detection Biosensors doi: 10.3390/bios10030022 Authors: D’Aurelio Chianella Goode Tothill The development of a sensor based on molecularly imprinted polymer nanoparticles (nanoMIPs) and electrochemical impedance spectroscopy (EIS) for the detection of trace levels of cocaine is described in this paper. NanoMIPs for cocaine detection, synthesized using a solid phase, were applied as...
Wed Mar 04, 2020 02:00
Brain Sciences, Vol. 10, Pages 149: Erratum: Chén “The Roles of Statistics in Human Neuroscience”, Brain Sci. 2019, 9 (8), 194 Brain Sciences doi: 10.3390/brainsci10030149 Authors: Chén The author wishes to make an erratum to the published version of his paper [...]
Wed Mar 04, 2020 02:00
Brain Sciences, Vol. 10, Pages 147: Abnormal Emotional Processing and Emotional Experience in Patients with Peripheral Facial Nerve Paralysis: An MEG Study Brain Sciences doi: 10.3390/brainsci10030147 Authors: Mina Kheirkhah Stefan Brodoehl Lutz Leistritz Theresa Götz Philipp Baumbach Ralph Huonker Otto W. Witte Gerd Fabian Volk Orlando Guntinas-Lichius Carsten M. Klingner Abnormal emotional reactions of the brain in patients with facial nerve paralysis have...
Wed Mar 04, 2020 02:00
Brain Sciences, Vol. 10, Pages 148: The Brain Differentially Prepares Inner and Overt Speech Production: Electrophysiological and Vascular Evidence Brain Sciences doi: 10.3390/brainsci10030148 Authors: Stephan Saalbach Rossi Speech production not only relies on spoken (overt speech) but also on silent output (inner speech). Little is known about whether inner and overt speech are processed differently and which neural mechanisms are involved. By simultaneously applying electroencephalography...
Wed Mar 04, 2020 02:00
Brain Sciences, Vol. 10, Pages 145: The Relation between Sustained Attention and Incidental and Intentional Object-Location Memory Brain Sciences doi: 10.3390/brainsci10030145 Authors: Efrat Barel Orna Tzischinsky The role of attention allocation in object-location memory has been widely studied through incidental and intentional encoding conditions. However, the relation between sustained attention and memory encoding processes has scarcely been studied. The present study aimed to...
Wed Mar 04, 2020 02:00
Brain Sciences, Vol. 10, Pages 144: Cognitive and Emotional Aspects of Cupping Therapy Brain Sciences doi: 10.3390/brainsci10030144 Authors: Hong Lee Ryu Kim Chae Cupping therapy has recently gained public attention and is widely used in many regions. Some patients are resistant to being treated with cupping therapy, as visually unpleasant marks on the skin may elicit negative reactions. This study aimed to identify the cognitive and emotional components of cupping therapy....
Wed Mar 04, 2020 02:00
Brain Sciences, Vol. 10, Pages 146: Analyzing the Open/Deep Web to Better Understand the New/Novel Psychoactive Substances (NPS) Scenarios: Suggestions from CASSANDRA and NPS.Finder Research Projects Brain Sciences doi: 10.3390/brainsci10030146 Authors: Fabrizio Schifano New/novel psychoactive substances (NPS) are defined as new narcotic/psychotropic drugs which are not controlled by the United Nations’ 1961 Narcotic Drugs/1971 Psychotropic Substances conventions, but which...
Wed Mar 04, 2020 02:00
Cancers, Vol. 12, Pages 589: Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer Cancers doi: 10.3390/cancers12030589 Authors: Narisa Dewi Maulany Darwis Takahiro Oike Hidemasa Kawamura Masahiro Kawahara Nobuteru Kubo Hiro Sato Yuhei Miyasaka Hiroyuki Katoh Hitoshi Ishikawa Hiroshi Matsui Yoshiyuki Miyazawa Kazuto Ito Kazuhiro Suzuki Soehartati Gondhowiardjo Takashi Nakano Tatsuya Ohno This study aimed to...
Wed Mar 04, 2020 02:00
Cancers, Vol. 12, Pages 587: TLD1433 Photosensitizer Inhibits Conjunctival Melanoma Cells in Zebrafish Ectopic and Orthotopic Tumour Models Cancers doi: 10.3390/cancers12030587 Authors: Quanchi Chen Vadde Ramu Yasmin Aydar Arwin Groenewoud Xue-quan Zhou Martine J. Jager Houston Cole Colin G. Cameron Sherri A. McFarland Sylvestre Bonnet B. Ewa Snaar-Jagalska The ruthenium-based photosensitizer (PS) TLD1433 has completed a phase I clinical trial for photodynamic...
Wed Mar 04, 2020 02:00
Cancers, Vol. 12, Pages 586: The Current Status of Immune Checkpoint Inhibitors in Neuro-Oncology: A Systematic Review Cancers doi: 10.3390/cancers12030586 Authors: Cyrillo G. Brahm Myra E. van Linde Roelien H. Enting Maaike Schuur René H.J. Otten Martijn W. Heymans Henk M.W. Verheul Annemiek M.E. Walenkamp The introduction of immune checkpoint inhibitors (ICI), as a novel treatment modality, has transformed the field of oncology with unprecedented successes. However,...
Wed Mar 04, 2020 02:00
Cancers, Vol. 12, Pages 588: Lymph Node and Bone Marrow Micrometastases Define the Prognosis of Patients with pN0 Esophageal Cancer Cancers doi: 10.3390/cancers12030588 Authors: Karstens Ghadban Effenberger Sauter Pantel Izbicki Vashist König Reeh Background: Pathological routine lymph node staging is postulated to be the main oncological prognosticator in esophageal cancer (EC). However, micrometastases in lymph nodes (LNMM) and bone marrow (BNMM) are...
Wed Mar 04, 2020 02:00
Cells, Vol. 9, Pages 622: The G Protein-Coupled Estrogen Receptor (GPER) Expression Correlates with Pro-Metastatic Pathways in ER-Negative Breast Cancer: A Bioinformatics Analysis Cells doi: 10.3390/cells9030622 Authors: Marianna Talia Ernestina Marianna De Francesco Damiano Cosimo Rigiracciolo Maria Grazia Muoio Lucia Muglia Antonino Belfiore Marcello Maggiolini Andrew H. Sims Rosamaria Lappano The G protein-coupled estrogen receptor (GPER, formerly known as...
Wed Mar 04, 2020 02:00
Cells, Vol. 9, Pages 621: Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy Cells doi: 10.3390/cells9030621 Authors: Bo Zhang Xuelin Zhong Moira Sauane Yihong Zhao Zhi-Liang Zheng Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control. Our prior work has shown...
Wed Mar 04, 2020 02:00
Cells, Vol. 9, Pages 623: Hybrid Epithelial/Mesenchymal State in Cancer Metastasis: Clinical Significance and Regulatory Mechanisms Cells doi: 10.3390/cells9030623 Authors: Liao Yang Epithelial-mesenchymal transition (EMT) has been well recognized for its essential role in cancer progression as well as normal tissue development. In cancer cells, activation of EMT permits the cells to acquire migratory and invasive abilities and stem-like properties. However, simple categorization...
Wed Mar 04, 2020 02:00
Cells, Vol. 9, Pages 619: Valproic Acid Promotes Early Neural Differentiation in Adult Mesenchymal Stem Cells Through Protein Signalling Pathways Cells doi: 10.3390/cells9030619 Authors: Santos Hubert Milthorpe Regenerative medicine is a rapidly expanding area in research and clinical applications. Therapies involving the use of small molecule chemicals aim to simplify the creation of specific drugs for clinical applications. Adult mesenchymal stem cells have recently shown...
Wed Mar 04, 2020 02:00
Cells, Vol. 9, Pages 618: Immunotherapy, Inflammation and Colorectal Cancer Cells doi: 10.3390/cells9030618 Authors: Charles Robert Lichtenstern Rachael Katie Ngu Shabnam Shalapour Michael Karin Colorectal cancer (CRC) is the third most common cancer type, and third highest in mortality rates among cancer-related deaths in the United States. Originating from intestinal epithelial cells in the colon and rectum, that are impacted by numerous factors including genetics, environment...
Wed Mar 04, 2020 02:00
Cells, Vol. 9, Pages 620: Response to Stimulations Inducing Circadian Rhythm in Human Induced Pluripotent Stem Cells Cells doi: 10.3390/cells9030620 Authors: Kaneko Kaitsuka Tomizawa Regenerative medicine and disease modeling are expanding rapidly, through the development of human-induced pluripotent stem cells (hiPSCs). Many exogeneous supplements are often used for the directed differentiation of hiPSCs to specific lineages, such as chemicals and hormones. Some of these are...
Wed Mar 04, 2020 02:00
Cells, Vol. 9, Pages 613: The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP Cells doi: 10.3390/cells9030613 Authors: Ambjørner Wiese Köhler Svindt Lund Gajhede Saaby Brodin Rump Weigt Brünner Stenvang ATP-binding cassette (ABC) transporters, such as breast cancer resistance protein (BCRP), are key players in resistance to multiple anti-cancer drugs, leading to cancer treatment failure and...
Wed Mar 04, 2020 02:00
Cells, Vol. 9, Pages 616: Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation Cells doi: 10.3390/cells9030616 Authors: Zhao Ma Qiu Wang Zhang Chen Su Zhang Li Ma Yang Chen Yin Tian Hu Li Zhang Wu Qian Microtubule actin crosslinking factor 1 (MACF1) is a large crosslinker that contributes to cell integrity and cell differentiation. Recent studies show that MACF1 is involved in multiple...
Wed Mar 04, 2020 02:00
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