Abstract The molecular mechanisms underlying colon cancer lesions at different sites are not entirely clear. Herein, we aimed to explore location-specific gene profiles related to the pathogenesis of colon cancer and to identify their function. The robust rank aggregation (RRA) method was used to integrate colon cancer microarray datasets and screen differentially expressed gene (DEG) profiles between left- and right-sided colon cancers. Then, weighted gene co-expression network...
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Abstract Rationale Metacognitions, beliefs that monitor or control thoughts and coping, are considered to be important components for development and maintenance of obsessive–compulsive disorder (OCD). Objectives This study prospectively investigated whether metacognitive beliefs can predict early treatment response after serotonin reuptake inhibitor (SRI)...
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Abstract Objective Patients with schizophrenia are at higher risk of cardiovascular morbidity and mortality than healthy individuals. This study was conducted to compare the effect of lurasidone and olanzapine on cardiometabolic parameters in unmedicated patients with schizophrenia. Methods The present study was a randomized open-label, parallel design, active-controlled...
Sat Aug 01, 2020 03:00
Abstract To assess the surgical outcomes in patients who underwent femtosecond laser-assisted lamellar keratoplasty with double continuous suture for keratoconus, 100 patients (102 eyes) with keratoconus in advanced stages undergoing femtosecond laser-assisted lamellar keratoplasty in Shandong Eye Hospital were studied. In the management of keratoconus, 50 patients (52 eyes) received double continuous suture, and 50 patients (50 eyes) underwent interrupted suture. The follow-up...
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Abstract Background Advanced computer-aided design and computer-aided manufacturing (CAD-CAM) technology led to the introduction of an increasing number of machinable materials suitable for dental prostheses. One of these materials is polyetheretherketone (PEEK), a high performance polymer recently used in dentistry with favorable physical, mechanical and chemical properties. The purpose of this study was to review the current...
Sun Aug 02, 2020 03:00
Abstract Background Dental anxiety (DA) has an impact on the quality of dental treatment and may have long-lasting implications for children. A recent study introducing experiential learning (EL) into children’s oral health promotion resulted in better oral hygiene. The purpose of the study is to evaluate whether EL can reduce children’s DA. Methods ...
Fri Jul 31, 2020 03:00
Publication date: Available online 1 August 2020Source: Magnetic Resonance ImagingAuthor(s): Ya-Nan Zhang, Yi-Ran Huang, Jun-Lian Liu, Feng-Quan Zhang, Bing-Yue Zhang, Jun-Chen Wu, Ying Ma, Jing Xia, Ying Hao, Jian-Wei Huo
Sun Aug 02, 2020 16:55
Publication date: Available online 1 August 2020Source: Sleep MedicineAuthor(s): Robert Joseph Thomas, Matt Travis Bianchi
Sun Aug 02, 2020 16:31
Related Articles Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review. BMC Surg. 2020 Jul 31;20(1):173 Authors: Hu J, Lu D, Ren J, Wen Q, Zhou J, Gan W, Liu J, Liu S, Yang H, Zou J Abstract BACKGROUND: Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx. CASE PRESENTATION:...
Sun Aug 02, 2020 16:11
Related Articles Evaluation of a Cervical Stabilization Exercise Program for Pain, Disability, and Physical Impairments in University Violinists with Nonspecific Neck Pain. Int J Environ Res Public Health. 2020 Jul 28;17(15): Authors: Kuo YL, Lee TH, Tsai YJ Abstract Cervical stabilization exercises are frequently used to reduce pain, maximize function, and improve physical impairments for people with nonspecific neck pain. We conducted a single...
Sat Aug 01, 2020 15:43
Related Articles Does a simple hematological examination predict the response and side effects in patients undergoing induction chemotherapy and/or neoadjuvant chemotherapy? J Chin Med Assoc. 2020 02;83(2):107-108 Authors: Lee WL, Chan IS, Wang PH PMID: 31868856 [PubMed - indexed for MEDLINE]
Sat Aug 01, 2020 15:43
Particle Therapy: Protons and Heavy Ions. Adv Otorhinolaryngol. 2020;84:87-105 Authors: Jensen AD Abstract Particle therapy is a comparatively new radiotherapy treatment form allowing the application of extremely conformal treatment plans. In head and neck malignancies, especially in the paranasal sinus and anterior skull base, this technology is very valuable in order to maintain normal tissue tolerance of critical structures while still applying...
Fri Jul 31, 2020 15:14
Future Perspectives in the Management of Tumors of the Anterior Skull Base. Adv Otorhinolaryngol. 2020;84:246-250 Authors: Nicolai P, Bradley PJ, Bossi P, Ferrari M Abstract In the coming years, further developments can be expected in the field of diagnosis and management of tumors involving the anterior skull base, and especially malignant tumors of the sinonasal tract, which account for the majority of lesions affecting this anatomic area....
Fri Jul 31, 2020 15:14
Treatment Options for Recurrent Anterior Skull Base Tumors. Adv Otorhinolaryngol. 2020;84:231-245 Authors: Orlandi E, Iacovelli NA, Ingargiola R, Resteghini C, Bossi P, Licitra L, Ferrari M, Nicolai P Abstract Malignancies of the anterior skull base are rare and recur in 40-80% of treated cases, varying with substantial variance according to histology, stage at primary diagnosis, and other factors. Most recurrences manifest within 2-5 years...
Fri Jul 31, 2020 15:14
Related Articles Bhopal Technique of Cochlear Implantation: A Surgical Review of 50 Cases. Indian J Otolaryngol Head Neck Surg. 2020 Sep;72(3):375-380 Authors: Dubey S, Singh J, Bhardwaj B Abstract Cochlear Implant is the new age treatment for profound deafness especially in children who are unable to hear since birth. This is a life changing technology where in a surgically implanted device can stimulate the auditory nerve through electrical...
Fri Jul 31, 2020 15:14
Related Articles NIR Photodynamic Destruction of PDAC and HNSCC Nodules Using Triple-Receptor-Targeted Photoimmuno-Nanoconjugates: Targeting Heterogeneity in Cancer. J Clin Med. 2020 Jul 27;9(8): Authors: Bano S, Obaid G, Swain JWR, Yamada M, Pogue BW, Wang K, Hasan T Abstract Receptor heterogeneity in cancer is a major limitation of molecular targeting for cancer therapeutics. Single-receptor-targeted treatment exerts selection pressures that...
Fri Jul 31, 2020 15:14
Psychological stress is a prevalent factor in inflammatory bowel disease (IBD) with detrimental effects on patients’ quality of life and possibly disease course. Although the aetiology of symptom exacerbation ...
Sat Aug 01, 2020 03:00
Behavioural weight management programmes are effective in assisting people with overweight or obesity to lose excess body weight. Yet, many still struggle to attain their weight loss goals in such programmes. ...
Thu Jul 30, 2020 03:00
Neuroendocrine carcinoma (NEC) is an aggressive malignant tumor that rarely arises from the gallbladder. Here, we investigated the clinicopathologic and immunohistochemical characteristics of 34 NECs of the gallbladder. The patients were predominantly women (68%) with a median age of 63 years (range, 37 to 82 y). NECs frequently occurred in the fundus (44%) as mass-forming lesions (66%). Histologically, 17 tumors were of small cell type, and another 17 were of large cell type. Twenty-three cases...
Wed Jul 29, 2020 03:00
Abstract Purpose To assess the effect of gadobenate dimeglumine on magnetic resonance cholangiopancreatography (MRCP) and determine an appropriate time frame for performing MRCP sequences. Materials and methods 2D MRCP sequences obtained after intravenous administration of gadobenate dimeglumine or gadobutrol over 14 months were reviewed retrospectively in...
Sun Aug 02, 2020 03:00
Abstract Purpose To compare computed diffusion-weighted imaging (cDWI) feasibility with that of directly acquired DWI for visualizing pancreatic ductal adenocarcinoma (PDAC) and focal autoimmune pancreatitis (AIP). Methods From April 2012 to January 2017, 135 patients with PDAC (n = 111) or focal AIP (n = 24) were retrospectively enrolled. They underwent...
Sat Aug 01, 2020 03:00
Abstract Purpose To evaluate the association between texture parameters based on bi-parametric MRI and Gleason score (GS) in patients with prostate cancer (PCa) and to evaluate diagnostic performance of any significant parameter for discriminating clinically significant cancer (CSC, GS ≥ 7) from non-CSC. Methods A total of 116 patients who had been confirmed...
Sat Aug 01, 2020 03:00
Abstract Objective To investigate the relationship between imaging findings and S100A4 overexpression in pancreatic ductal adenocarcinoma (PDAC) and to determine imaging biomarkers of S100A4 overexpression from whole-tumor evaluation with MRI and texture analysis. Methods A total of 60 patients with pathologically confirmed PDAC were included in the study....
Sat Aug 01, 2020 03:00
Purpose of review The rising global burden of allergic diseases, particularly in the pediatric population, is of serious concern. Ocular allergy is one of the most common ocular pathologies met in clinical practice. A large proportion of children and adolescents suffer from allergic eye diseases (AEDs), which affect their quality of life. The available treatments and surgical modalities have their limitations and side effects. Therefore, the development of novel and alternate strategies is the...
Mon Jul 27, 2020 03:00
No abstract available
Mon Jul 27, 2020 03:00
Purpose of review Chemokines are a large group of low molecular weight cytokines that attract and activate leukocytes throughout the body and therefore have a key role in the framework of late-phase allergic responses. The purpose of this article is to provide an overview of the main chemokines involved in allergic conjunctivitis, their primary functions and their physiological roles, and therapies targeted at chemokines and their receptors for ocular allergic diseases. Recent findings In...
Mon Jul 27, 2020 03:00
Purpose of review Information on the natural history of hypersensitivity reactions is helpful for deciding which patient urgently needs a venom immunotherapy (VIT). Recent findings The frequency of self-reported systemic allergic reactions (SAR) to Hymenoptera stings is approximately 3–7% in the Northern Hemisphere. About 25% of SAR are severe (anaphylactic shock). Fatal sting reactions are very rare. The most important risk factor for severe insect sting anaphylaxis is mast cell disease....
Mon Jul 27, 2020 03:00
Purpose of review Ocular allergic contact dermatitis is a common yet challenging and frequently misdiagnosed condition. Inappropriate or delayed treatment can contribute to a variety of clinical symptoms such as tearing and itching with signs such as ptosis and cicatricial ectropion, resulting in deterioration of disease, for which the topical medication was originally prescribed to resolve. Recent findings Understanding previously unrecognized pathogenic mechanisms involving ocular contact...
Mon Jul 27, 2020 03:00
Purpose of review Epinephrine is the agreed-upon first line treatment for anaphylaxis, yet it continues to be underused by patients/caregivers and providers alike. Recent findings There are unfortunately limited data on how epinephrine can best be utilized in anaphylaxis, which hinders how best to inform patients and providers. Studies reporting underuse suggest various barriers and themes on why this may happen. Summary Continued education of patients, caregivers, and providers is needed;...
Mon Jul 27, 2020 03:00
Abstract Ehlers–Danlos syndromes (EDS) are a group of inherited connective tissue disorders with an impaired quality of life in association with fatigue, pain, and kinesiophobia. A retrospective evaluation of the effects of an outpatient rehabilitation program (RP) was performed in Ehlers–Danlos syndrome hypermobile type (hEDS) patients. The 6‐minute walk test (6MWT) was used to evaluate functional capacity. Kinesiophobia, fatigue, pain, and quality of life were self‐evaluated at the start, at the...
Sat Aug 01, 2020 13:30
Abstract Objective This study investigated the effects of bolus consistency on pharyngeal volume during swallowing using three‐dimensional kinematic analysis. Methods Eight subjects (2 males, 6 females, mean ± SD 44± 10 years old) underwent a 320‐row area detector scan during swallows of 10‐ml of honey‐thick liquid and thin liquid. Critical event timing (hyoid, soft palate, UES) and volume of pharyngeal cavity and bolus were measured and compared between two swallows. Results The...
Sat Aug 01, 2020 16:58
Abstract Lead by the original idea to perform noninvasive optical biopsies of various tissue, optical coherence tomography found numerous medical applications within the last two decades. The interference based imaging technique opens the possibility to visualise subcellular morphology up to an imaging depth of 3 mm and up to micron level axial and lateral resolution. The birefringence properties of the tissue are visualised with enhanced contrast using polarisation sensitive or cross polarised...
Sat Aug 01, 2020 14:43
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Ovarian vein thrombosis (OVT) was first described in 1956 and is well known for its association with gynecological malignancy, pregnancy, postpartum, pelvic diseases, surgeries, and other thrombophilic etiologies. Most commonly OVT presents on the right ovarian vein. We report a rare case of a 47-year-old Caucasian female G7P7 with no significant past medical history who presented to the emergency...
Sat Aug 01, 2020 15:45
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Acute interstitial nephritis (AIN) is a relatively common cause of acute kidney injury with etiologies that include drug therapy, infections, and systemic diseases. Of these etiologies, drug therapy accounts for ~70% of AIN cases. Although any drug can cause AIN, there are no reported cases of AIN caused by omalizumab, a humanized monoclonal antibody that binds to and inhibits circulating immunoglobulin...
Sat Aug 01, 2020 15:45
Background. Minipuberty of infancy refers to the transient activation of the hypothalamic-pituitary-gonadal (HPG) axis during the first few months of life. Studies have documented a more exaggerated and prolonged gonadotropin surge in preterm infants compared with term infants. We present a case of minipuberty presenting with vaginal bleeding at the corrected age of 3 months of life. Case Presentation. A former 23 + 6-week infant presented with intermittent vaginal bleeding in the diaper at the corrected...
Sat Aug 01, 2020 18:20
Abstract The peculiar biotechnological applications of Oleispira spp. in the natural cleansing of oil-polluted marine systems stimulated the study of the phenotypic characteristics of the Oleispira antarctica RB-8(T) strain and modifications of these characteristics in relation to different growth conditions. Bacterial abundance, cell size and morphology variations (by image analysis) and hydrocarbon degradation (by gas chromatography with flame ionization detection, GC-FID) were...
Sat Aug 01, 2020 03:00
Abstract The underlying principles influencing bacteria community assembly have long been of interest in the field of microbial ecology. Environmental heterogeneity is believed to be important in controlling the uniqueness and variability of communities. However, little is known about the influence of the host macrophytes on epiphytic bacteria assembly. In this study, we used two contrasting artificial water environments (eutrophic and oligotrophic) for reciprocal transplant experiment...
Sat Aug 01, 2020 03:00
The leading factors of paediatric, pedestrian road traffic injuries (PPRTIs) are associated with the characteristics of immediate environment. Spatial analysis of data related to PPRTIs could provide useful kn...
Fri Jul 31, 2020 03:00
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