Background: Neuro-oncology care is becoming increasingly complex and patients often see multiple specialists. Multidisciplinary clinic (MDC) is a patient-centric option to allow multiple specialists to be involved where patients see multiple providers on the same day. Objective: The objective of this study was to evaluate the role of a neuro-oncology MDC on patient outcomes. Materials and Methods: Retrospective study was performed on consecutive patients who received radiosurgery...
Mon Aug 24, 2020 03:00
Purpose: Radiotherapy (RT) is an effective treatment for localized gastric mucosa-associated lymphoid tissue (MALT) lymphomas unresponsive to antibiotic therapy; however, irradiating the stomach can result in significant radiation to the heart, a risk factor for cardiac disease. We analyzed the Surveillance, Epidemiology, and End Results database to evaluate outcomes related to cardiac disease among patients treated with RT for stage I gastric MALT. Materials and Methods: We identified...
Mon Aug 24, 2020 03:00
British Journal of Cancer, Published online: 26 August 2020; doi:10.1038/s41416-020-01037-7Differential association of CD68+ and CD163+ macrophages with macrophage enzymes, whole tumour gene expression and overall survival in advanced melanoma
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British Journal of Cancer, Published online: 26 August 2020; doi:10.1038/s41416-020-01030-0Bowel inflammation in cancer patients: the microbiome, antibiotics and interleukin-9
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Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Aug 21, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Aug 21, 2020 10:00
Long Noncoding RNA NEAT1 Promotes the Progression of Breast Cancer by Regulating miR-138-5p/ZFX Axis
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Aug 21, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Fri Aug 21, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Thu Aug 20, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Thu Aug 20, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Thu Aug 20, 2020 10:00
Publication date: Available online 24 August 2020Source: Cancer/RadiothérapieAuthor(s): A. Laville, A. Coutte, P. Blanchard, R. Sun, E. Deutsch, I. Latorzeff
Tue Aug 25, 2020 13:20
Publication date: Available online 24 August 2020Source: Cancer/RadiothérapieAuthor(s): C. Chargari, S. Supiot, C. Hennequin, A. Chapel, J.-M. Simon
Tue Aug 25, 2020 13:20
Purpose: We explored the prognostic effect of PIK3CA mutation in HER2-positive patients enrolled in the ShortHER trial. Experimental Design: The ShortHER trial randomized 1253 patients with HER2-positive breast cancer to 9-weeks or 1-year of adjuvant trastuzumab combined with chemotherapy. PIK3CA hot-spot mutations in exon 9 and 20 were analysed by Pyrosequencing. Expression of 60 genes, including PAM50 genes was measured using the nCounter platform. Results: A mutation of the PIK3CA gene was detected...
Tue Aug 25, 2020 15:56
Publication date: October 2020Source: European Journal of Cancer, Volume 138Author(s): Meta H.M. Diekstra, Ruben Malmberg, Stefan Sleijfer, Roelof W.F. van Leeuwen
Tue Aug 25, 2020 13:15
Publication date: Available online 25 August 2020Source: European Journal of Surgical OncologyAuthor(s): Martin Hübner, Shigeki Kusamura, Laurent Villeneuve, Ahmed Al-Niaimi, Mohammad Alyami, Konstantin Balonov, John Bell, Robert Bristow, Delia Cortés Guiral, Anna Fagotti, Luiz Fernando R. Falcão, Olivier Glehen, Laura Lambert, Lloyd Mack, Tino Muenster, Pompiliu Piso, Marc Pocard, Beate Rau, Olivia Sgarbura, S.P. Somashekkar
Tue Aug 25, 2020 13:30
Publication date: Available online 25 August 2020Source: European Journal of Surgical OncologyAuthor(s): Masayuki Okuno, Yoshikuni Kawaguchi, Mario De Bellis, Eduardo A. Vega, Steven Y. Huang, Kamran Ahrar, Sanjay Gupta, Jean-Nicolas Vauthey, Bruno C. Odisio
Tue Aug 25, 2020 13:30
Publication date: Available online 25 August 2020Source: European Journal of Surgical OncologyAuthor(s): Niharika Rajan Garach, Shigeki Kusamura, Marcello Guaglio, Valentina Bartolini, Marcello Deraco, Dario Baratti
Tue Aug 25, 2020 13:30
Publication date: Available online 25 August 2020Source: European Journal of Surgical OncologyAuthor(s): S. Rostoft, Barbara van Leeuwen
Tue Aug 25, 2020 13:30
Publication date: Available online 24 August 2020Source: European Journal of Surgical OncologyAuthor(s): Tomoaki Takahashi, Hideya Kawaji, Yasuhiro Murakawa, Yoshihide Hayashizaki, Takashi Murakami, Yasuhiro Yabushita, Yuki Homma, Takafumi Kumamoto, Ryusei Matsuyama, Itaru Endo
Tue Aug 25, 2020 13:30
Abstract Considerable controversies exist regarding whether elderly patients with early‐stage breast cancer receiving breast conserving surgery (BCS) should forgo radiotherapy. We utilized the National Cancer Database to analyze data of 115 516 women aged ≥70 years, treated with BCS for T1‐2N0‐1M0 breast cancer between 2004 and 2014. Multivariable Cox proportional hazards model was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for mortality 3‐, 5‐ and 10‐years after 90‐days...
Mon Aug 24, 2020 12:11
Abstract Low selenium status may be associated with increased risk of prostate cancer (PC), particularly aggressive PC, and variation in selenoprotein genes may constitute an important modifying factor. We aimed to investigate the association between two selenium status biomarkers [toenail selenium, plasma selenoprotein P (SELENOP)] and risk of advanced, high‐grade, and advanced‐stage PC. We further studied whether variations in selenoprotein genes were associated with PC risk and selenium biomarker...
Mon Aug 24, 2020 11:14
Abstract Immune checkpoint inhibitors (CPIs) have radically changed outcomes for patients diagnosed with metastatic melanoma globally in the last 10 years, based on evidence of overall survival (OS) benefits generated from international randomised controlled trials (RCTs). Since RCTs don’t always reflect real‐world prescribing, we interrogated established national databases to track prescribing of CPIs approved for first line treatment of metastatic melanoma patients in England since 2014 and determined...
Mon Aug 24, 2020 11:03
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Thu Aug 20, 2020 10:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Thu Aug 20, 2020 10:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Wed Aug 19, 2020 10:00
Abstract Racial/ethnic minorities face stark inequalities in lung cancer incidence, treatment, survival, and mortality compared with US born non-Hispanic Whites. Lung cancer screening (LCS) with low-dose computed tomography (LDCT) is effective at reducing lung cancer mortality in high-risk current and former smokers and is recommended by the US Preventive Services Task Force (USPSTF). This study sought to assess primary care providers’ (PCPs’) knowledge, attitudes, beliefs, and...
Tue Aug 25, 2020 03:00
Abstract Straight line scoring (SLS), defined as trainee assessments with the same score for all evaluation items, is statistically improbable and potentially indicates inaccurate assessment. Factors contributing to higher SLS rates are unknown, and knowledge of SLS prevalence within oncologic training is lacking. SLS frequency was measured for evaluations from all Accreditation Council for Graduate Medical Education (ACGME)-accredited programs at a single cancer care institution...
Tue Aug 25, 2020 03:00
cAMP responsive element binding protein 5 (CREB5) is a transcriptional activator in eukaryotic cells that can regulate gene expression. Previously, we found that CREB5 was involved in the occurrence and develo...
Tue Aug 25, 2020 03:00
Abstract Sal‐like protein 4 (SALL4) is overexpressed in breast cancer and might contribute to breast cancer progression, but the molecular mechanism remains unknown. Here, we found that within a group of 371 ethnic Chinese breast cancer patients, SALL4 was associated with lower grade (P = .002) and progesterone receptor positivity (P = .004) for overall cases; lower Ki67 (P = .045) and high vimentin (P = .007) for luminal cases. Patients with high SALL4 expression in lymph node metastasis showed...
Mon Aug 24, 2020 20:54
Publication date: Available online 24 August 2020Source: Practical Radiation OncologyAuthor(s): Lukasz M. Mazur, Robert Adams, Prithima R. Mosaly, Joseph Nuamah, Karthik Adapa, Lawrence B. Marks
Tue Aug 25, 2020 19:46
The past decade has seen the standard of care (SoC) for metastatic prostate cancer (MPC) expand beyond lifelong androgen deprivation therapy (ADT). Multiple randomized control trials (RCTs) have demonstrated improvements in overall survival by intensifying systemic therapy [1-8]. Such care has produced excellent outcomes for an advanced malignancy. In the most recent RCTs, newly diagnosed metastatic hormone sensitive prostate cancer (mHSPC) patients have 3-year overall survival rates between 65-80%.
Tue Aug 25, 2020 03:00
Over the past 15 years, evidence has accumulated that radiotherapy for breast cancer can increase the risk of subsequent heart disease. Parts of this evidence come from studies comparing left- with right-sided radiotherapy. Since the heart is located in the left side of the chest, the radiation dose to the heart tends to be larger for left- than for right-sided breast cancer. An increased risk of heart disease comparing left- with right-sided radiotherapy has been interpreted as evidence of radiation-induced...
Tue Aug 25, 2020 03:00
In vitro, Drosophila melanogaster Dicer-2 (Dcr-2) uses its helicase domain to initiate processing of dsRNA with blunt (BLT) termini, and its Platform•PAZ domain to initiate processing of dsRNA with 3’ overhangs (ovrs). To understand the relationship of these in vitro observations to roles of Dcr-2 in vivo, we compared in vitro effects of two helicase mutations to their impact on production of endogenous and viral siRNAs in flies. Consistent with the importance of the helicase domain in processing...
Tue Aug 25, 2020 22:59
The Fibro-purF motif is a putative structured noncoding RNA domain that was discovered previously in species of Fibrobacter by employing comparative sequence analysis methods. An updated bioinformatics search yielded a total of only 30 unique-sequence representatives, exclusively found upstream of the purF gene that codes for the enzyme amidophosphoribosyltransferase. This enzyme synthesizes the compound 5-phospho-D-ribosylamine (PRA), which is the first committed step in purine biosynthesis. The...
Tue Aug 25, 2020 19:31
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