Related Articles Finding a Jill for JAK: Assessing Past, Present, and Future JAK Inhibitor Combination Approaches in Myelofibrosis. Cancers (Basel). 2020 Aug 14;12(8): Authors: Kuykendall AT, Horvat NP, Pandey G, Komrokji R, Reuther GW Abstract Myelofibrosis (MF) is a myeloproliferative neoplasm hallmarked by the upregulation of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway with associated extramedullary...
Sun Aug 23, 2020 14:07
Related Articles The Clinical Significance of RAS, PIK3CA, and PTEN Mutations in Non-Small Cell Lung Cancer Using Cell-Free DNA. J Clin Med. 2020 Aug 14;9(8): Authors: Chang WJ, Sung JS, Lee SY, Kang EJ, Kwon NJ, Kim HM, Shin SW, Choi JY, Choi YJ, Kim JW, Park KH, Kim YH Abstract Mutations in the EGFR gene downstream signaling pathways may cause receptor-independent pathway activation, making tumors unresponsive to EGFR inhibitors. However,...
Sun Aug 23, 2020 14:07
Related Articles Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population. Int J Environ Res Public Health. 2020 Aug 13;17(16): Authors: Noreen Z, Loffredo CA, Bhatti A, Simhadri JJ, Nunlee-Bland G, Nnanabu T, John P, Khan JS, Ghosh S Abstract The epidemic of type 2 diabetes mellitus (T2DM) is an important global health concern. Our earlier epidemiological investigation in Pakistan prompted...
Sun Aug 23, 2020 14:07
From Patient Engagement to Precision Oncology: Leveraging Informatics to Advance Cancer Care. Yearb Med Inform. 2020 Aug;29(1):235-242 Authors: Griffin AC, Topaloglu U, Davis S, Chung AE Abstract OBJECTIVES: Conduct a survey of the literature for advancements in cancer informatics over the last three years in three specific areas where there has been unprecedented growth: 1) digital health; 2) machine learning; and 3) precision oncology. We...
Sat Aug 22, 2020 14:05
Effect of virtual reality therapy in reducing pain and anxiety for cancer related medical procedures: A systematic narrative review. J Pain Symptom Manage. 2020 Aug 18;: Authors: Chow H, Hon J, Chua W, Chuan A Abstract CONTEXT: Virtual reality (VR) has emerged as a novel form of non-pharmacological analgesia therapy. We wished to review the use of VR to treat pain and anxiety in cancer related medical procedures and chemotherapy. OBJECTIVE:...
Sat Aug 22, 2020 14:05
Related Articles [Artificial intelligence : What do urologists need to know?] Urologe A. 2020 Aug 21;: Authors: Schreiber A, Hahn H, Wenzel M, Loch T Abstract In the past 10 years, the methods of artificial intelligence (AI) have experienced breakthroughs that have opened up a multitude of new fields of application for information technology. AI is particularly strong in those areas where patterns have to be recognized and conclusions and forecasts...
Sat Aug 22, 2020 14:05
Related Articles Why natural killer cells in triple negative breast cancer? World J Clin Oncol. 2020 Jul 24;11(7):464-476 Authors: Abdel-Latif M, Youness RA Abstract The triple-negative subtype of breast cancer (TNBC) has the bleakest prognosis, owing to its lack of either hormone receptor as well as human epidermal growth factor receptor 2. Henceforth, immunotherapy has emerged as the front-runner for TNBC treatment, which avoids potentially...
Sat Aug 22, 2020 14:05
Related Articles Endocrine Therapy Plus Anti-HER2 Therapy as Adjuvant Systemic Therapy for Luminal HER2-Positive Breast Cancer: An Analysis of the National Cancer Database. Breast Cancer (Auckl). 2020;14:1178223420945694 Authors: Nahleh ZA, Elimimian EB, Elson LC, Hobbs B, Wei W, Blake CN Abstract Background: Guidelines regarding the usage of adjuvant systemic therapy in patients with small human epidermal growth factor receptor 2 (HER2)-positive...
Sat Aug 22, 2020 14:05
Related Articles Development of chemotherapeutics for unresectable advanced esophageal cancer. Expert Rev Anticancer Ther. 2020 Aug 21;: Authors: Imazeki H, Kato K Abstract INTRODUCTION: The prognosis of unresectable advanced esophageal squamous cell carcinoma (ESCC) has gradually improved due to efforts for the development of systemic chemotherapy or concurrent chemoradiotherapy. Areas covered: Chemotherapeutic agents such as cytotoxic agents,...
Sat Aug 22, 2020 14:05
Related Articles Decreased level of peripheral CD8+CD28+ T cells is associated with lymph node metastasis in patients with breast cancer. Future Oncol. 2020 Aug 21;: Authors: Li Y, Qian T, Zhao H, Zhang Z, Ming Y, Qiao G, Liu J Abstract Background: Lymph node metastasis (LNM) is an independent risk factor for prognosis in patients with early breast cancer (EBC). Here we explored whether peripheral lymphocyte subtypes could be used as surrogate...
Sat Aug 22, 2020 14:05
Related Articles Gastric Cancer: Where Are We Heading? Dig Dis. 2020;38(4):280-285 Authors: Petryszyn P, Chapelle N, Matysiak-Budnik T Abstract BACKGROUND: Despite its decreasing incidence, gastric cancer (GC) remains one of the leading cancers in the world and an important global healthcare problem due to its overall high prevalence and high mortality rate. SUMMARY: GC is a consequence of Helicobacter pylori infection in 90% of cases,...
Sat Aug 22, 2020 14:05
Related Articles Reagent-Free and Rapid Assessment of T Cell Activation State Using Diffraction Phase Microscopy and Deep Learning. Anal Chem. 2019 03 05;91(5):3405-3411 Authors: Karandikar SH, Zhang C, Meiyappan A, Barman I, Finck C, Srivastava PK, Pandey R Abstract CD8+ T cells constitute an essential compartment of the adaptive immune system. During immune responses, naı̈ve T cells become functional, as they are primed with their cognate...
Sat Aug 22, 2020 14:05
Polygenic risk score-analysis of thromboembolism in patients with acute lymphoblastic leukemia. Thromb Res. 2020 Aug 12;196:15-20 Authors: Jarvis KB, Nielsen RL, Gupta R, Hede FD, Huttunen P, Jónsson ÓG, Rank CU, Ranta S, Saks K, Trakymiene SS, Tuckuviene R, Tulstrup M, INVENT consortium, Ruud E, Schmiegelow K, LeBlanc M Abstract INTRODUCTION: Thromboembolism (TE) is a common and serious toxicity of acute lymphoblastic leukemia (ALL) treatment,...
Fri Aug 21, 2020 21:47
Related Articles Cutaneous viral infections associated with ultraviolet radiation exposure. Int J Cancer. 2020 Aug 20;: Authors: Zhao Y, Amorrortu RP, Fenske NA, Cherpelis B, Messina JL, Sondak VK, Giuliano AR, Schell MJ, Waterboer T, Pawlita M, McKay-Chopin S, Gheit T, Tommasino M, Rollison DE Abstract The complex interplay between ultraviolet radiation (UVR) and cutaneous viral infections in the context of cancer etiology is challenging to...
Fri Aug 21, 2020 21:47
Related Articles Bidirectional interaction between intestinal microbiome and cancer: opportunities for therapeutic interventions. Biomark Res. 2020;8:31 Authors: Dutta D, Lim SH Abstract Gut microbiota composition influences the balance between human health and disease. Increasing evidence suggests the involvement of microbial factors in regulating cancer development, progression, and therapeutic response. Distinct microbial species have been...
Fri Aug 21, 2020 21:47
Related Articles Novel platform leveraging electronic medical record (EMR) to triage patients admitted with high-grade immune-related adverse events (irAEs) to the immune-toxicity (ITOX) service. J Immunother Cancer. 2020 Aug;8(2): Authors: Abu-Shawer O, Singh P, Yenulevich E, Brito A, Ni J, Abdulnour RE, Grover S, Manos M, Bowling P, LeBoeuf NR, Ott P, Stephen Hodi F, Jacobson J, Rahma O Abstract BACKGROUND: The incidence of high-grade immune-related...
Fri Aug 21, 2020 21:47
Related Articles A 3-gene signature based on MYC, BCL-2 and NFKBIA improves risk stratification in diffuse large B-cell lymphoma. Haematologica. 2020 Aug 13;: Authors: Derenzini E, Mazzara S, Melle F, Motta G, Fabbri M, Bruna R, Agostinelli C, Cesano A, Corsini CA, Chen N, Righi S, Sabattini E, Chiappella A, Calleri A, Fiori S, Tabanelli V, Cabras A, Pruneri G, Vitolo U, Gianni AM, Rambaldi A, Corradini P, Zinzani PL, Tarella C, Pileri S Abstract ...
Fri Aug 21, 2020 21:47
Related Articles A pedigree-based prediction model identifies carriers of deleterious de novo mutations in families with Li-Fraumeni syndrome. Genome Res. 2020 Aug 18;: Authors: Gao F, Pan X, Dodd-Eaton EB, Recio CV, Montierth MD, Bojadzieva J, Mai PL, Zelley K, Johnson VE, Braun D, Nichols KE, Garber JE, Savage SA, Strong LC, Wang W Abstract De novo mutations (DNMs) are increasingly recognized as rare disease causal factors. Identifying DNM...
Fri Aug 21, 2020 21:47
Related Articles How I treat neuroendocrine tumours. ESMO Open. 2020 Aug;5(4): Authors: Kiesewetter B, Raderer M Abstract Neuroendocrine tumours (NETs) constitute a heterogeneous group of neoplasms characterised by variable endocrine activity and somatostatin receptor expression, with the latter allowing the use of targeted therapeutic concepts. Currently accepted treatment strategies for advanced well-differentiated NET include somatostatin...
Fri Aug 21, 2020 21:47
Related Articles Current status and future potential of predictive biomarkers for immune checkpoint inhibitors in gastric cancer. ESMO Open. 2020 Aug;5(4): Authors: Kang BW, Chau I Abstract Immunotherapy is revolutionising cancer treatment and has already emerged as standard treatment for patients with recurrent or metastatic gastric cancer (GC). Recent research has been focused on identifying robust predictive biomarkers for GC treated with...
Fri Aug 21, 2020 21:47
Related Articles Moving Beyond BRCA - Incorporating Molecular Assays into Ovarian Cancer trials. Clin Cancer Res. 2020 Aug 14;: Authors: McMullen M, Karakasis K, Oza AM Abstract PrOTYPE is a locked down assay validated to Institute of Medicine standards, using NanoString technology to classify High Grade Serous Ovarian Cancer into four subgroups. Future directions will include prospective-retrospective analysis and prospective clinical validation...
Fri Aug 21, 2020 21:47
Related Articles Angiogenic and immune-related biomarkers and outcomes following axitinib/pembrolizumab treatment in patients with advanced renal cell carcinoma. Clin Cancer Res. 2020 Aug 18;: Authors: Martini JF, Plimack ER, Choueiri TK, McDermott DF, Puzanov I, Fishman MN, Cho DC, Vaishampayan U, Rosbrook B, Fernandez KC, Tarazi JC, George S, Atkins MB Abstract PURPOSE: Combined axitinib/pembrolizumab is approved for advanced renal cell carcinoma...
Fri Aug 21, 2020 21:47
Related Articles Pregnancy in Breast Cancer Survivors. Adv Exp Med Biol. 2020;1252:165-174 Authors: Bjelic-Radisic V, Esfandbod M, Alipour S Abstract Safety of pregnancy occurring after breast cancer treatment has been studied largely, but it is still debatable. These studies have generally showed that overall and disease-free survival in breast cancer survivors with subsequent pregnancy is not less than those without future pregnancy . Also,...
Fri Aug 21, 2020 21:47
Related Articles Premalignant Disorders of the Breast in Pregnancy and Lactation. Adv Exp Med Biol. 2020;1252:63-72 Authors: Omranipour R, Alipour S, Ensani F, Nakhlis F Abstract Papillomas, atypical hyperplasias, and lobular carcinoma in situ of the breast are not malignant tumors, but present serious management challenges when they are diagnosed in a breast biopsy . Upgrading after excision and increased possibility of future cancer are risks...
Fri Aug 21, 2020 21:47
Related Articles Cisplatin and carboplatin pharmacokinetics in a pediatric patient with hepatoblastoma receiving peritoneal dialysis. Cancer Chemother Pharmacol. 2020 Aug 20;: Authors: Nijstad AL, van Eijkelenburg NKA, Kraal KCJM, Meijs MJM, de Kanter CTMM, Lilien MR, Huitema ADR Abstract PURPOSE: Cisplatin and carboplatin are frequently used drugs in the treatment of pediatric hepatoblastoma. Dosing guidelines for these drugs in children requiring...
Fri Aug 21, 2020 21:47
Related Articles Breast cancer surgery after the COVID-19 pandemic. Future Oncol. 2020 Aug 20;: Authors: Tsang-Wright F, Tasoulis MK, Roche N, MacNeill F PMID: 32815421 [PubMed - as supplied by publisher]
Fri Aug 21, 2020 21:47
Related Articles The combination of histone deacetylase inhibitors and radiotherapy: a promising novel approach for cancer treatment. Future Oncol. 2020 Aug 20;: Authors: Shirbhate E, Patel P, Patel VK, Veerasamy R, Sharma PC, Rajak H Abstract HDAC inhibitors (HDACi) play an essential role in various cellular processes, such as differentiation and transcriptional regulation of key genes and cytostatic factors, cell cycle arrest and apoptosis...
Fri Aug 21, 2020 21:47
Related Articles A Systematic Literature Review of Animal-Assisted Interventions in Oncology (Part I): Methods and Results. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420943278 Authors: Holder TRN, Gruen ME, Roberts DL, Somers T, Bozkurt A Abstract Animal-assisted interventions (AAIs) use human-animal interactions to positive effect in various contexts including cancer care. As the first installment of a 2-part series, this systematic literature...
Fri Aug 21, 2020 21:47
Related Articles Favorable therapeutic response after anti-Mesothelin antibody-drug conjugate treatment requires high expression of Mesothelin in tumor cells. Arch Gynecol Obstet. 2020 Aug 19;: Authors: Lazzerini L, Jöhrens K, Sehouli J, Cichon G Abstract PURPOSE: The cell surface glycoprotein Mesothelin is overexpressed in ovarian, fallopian tube, endometrial, cervical and primary peritoneal cancer and, therefore, might become a particular...
Fri Aug 21, 2020 21:47
Related Articles When and How to Use PARP Inhibitors in Prostate Cancer: A Systematic Review of the Literature with an Update on On-Going Trials. Eur Urol Oncol. 2020 Aug 17;: Authors: Antonarakis ES, Gomella LG, Petrylak DP Abstract CONTEXT: The goal of precision oncology is to use the underlying genomic characteristics of the patient and the cancer to select the optimal treatment at a given time. The recent Food and Drug Administration (FDA)...
Fri Aug 21, 2020 21:47
Related Articles How shall we treat locally advanced triple negative breast cancer? F1000Res. 2019;8:1649 Authors: Luz P, Dias D, Fortuna A, Bretes L, Gosalbez B Abstract Triple negative breast cancer (TNBC) has been shown to respond to neoadjuvant chemotherapy (NACT). It has been established that achieving pathological complete response (pCR) for certain aggressive subtypes of breast cancer, including HER-2 (over-expressed) and TNBC, provides...
Fri Aug 21, 2020 21:47
Related Articles Correction: Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5. Oncotarget. 2020 Aug 04;11(31):3025 Authors: Al-Jameel W, Gou X, Forootan SS, Fayi MSA, Rudland PS, Forootan FS, Zhang J, Cornford PA, Hussain SA, Ke Y Abstract [This corrects the article DOI: 10.18632/oncotarget.16055.]. PMID: 32821347 [PubMed - as supplied by publisher]
Sat Aug 22, 2020 13:15
Related Articles Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma. Oncotarget. 2020 Aug 04;11(31):3013-3024 Authors: Turcios L, Marti F, Watt DS, Kril LM, Khurana A, Chapelin F, Liu C, Zwischenberger JB, Evers BM, Gedaly R Abstract BACKGROUND: Hepatocellular Carcinoma (HCC) is the third most common cause of cancer related death worldwide. Adequate treatment options for patients with advanced...
Sat Aug 22, 2020 13:15
Related Articles Ewing sarcoma family of tumors-derived small extracellular vesicle proteomics identify potential clinical biomarkers. Oncotarget. 2020 Aug 04;11(31):2995-3012 Authors: Samuel G, Crow J, Klein JB, Merchant ML, Nissen E, Koestler DC, Laurence K, Liang X, Neville K, Staggs V, Ahmed A, Atay S, Godwin AK Abstract PURPOSE: Ewing Sarcoma Family of Tumors (ESFT), the second most common pediatric osseous malignancy, are characterized...
Sat Aug 22, 2020 13:15
Related Articles Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma. Oncotarget. 2020 Aug 04;11(31):2982-2994 Authors: Fujiwara-Tani R, Sasaki T, Fujii K, Luo Y, Mori T, Kishi S, Mori S, Matsushima-Otsuka S, Nishiguchi Y, Goto K, Kawahara I, Kondoh M, Sho M, Kuniyasu H Abstract High morbidity and mortality of cancer, especially colorectal cancer (CRC), in diabetic...
Sat Aug 22, 2020 13:15
Related Articles Sirolimus-eluting stents: opposite in vitro effects on the clonogenic cell potential on a long-term exposure. Oncotarget. 2020 Aug 04;11(31):2973-2981 Authors: Vasuri F, Degiovanni A, Gargiulo M, Thilly WG, Gostjeva EV, Pasquinelli G, Fittipaldi S Abstract We evaluated the long-term effects of sirolimus on three different cell in vitro models, cultured in physiological conditions mimicking sirolimus-eluted stent, in order...
Sat Aug 22, 2020 13:15
Related Articles Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells. Oncotarget. 2020 Aug 04;11(31):2959-2972 Authors: Ballout F, Monzer A, Fatfat M, Ouweini HE, Jaffa MA, Abdel-Samad R, Darwiche N, Abou-Kheir W, Gali-Muhtasib H Abstract The high recurrence rates of colorectal cancer have been associated with a small population of cancer stem cells (CSCs) that are resistant...
Sat Aug 22, 2020 13:15
Related Articles Otolaryngology Match 2020-21: Survey of Prospective Applicants in the Setting of COVID-19. Ann Otol Rhinol Laryngol. 2020 Aug 19;:3489420952470 Authors: Izreig S, Torabi SJ, Kasle DA, Rahmati RW, Manes RP Abstract OBJECTIVES: To capture the perspectives of candidates applying for otolaryngology residency positions in the 2020-21 cycle, in the context of disruption caused by the coronavirus disease 2019 (COVID-19) pandemic....
Fri Aug 21, 2020 21:27
Related Articles Epithelioid Sarcoma of the Tongue: An Unusual Tumor Mimic for Squamous Cell Carcinoma. Ann Otol Rhinol Laryngol. 2020 Aug 19;:3489420952473 Authors: Kazi AA, Vahidi NA, Wiles AB, Reiter ER Abstract INTRODUCTION: Epithelioid sarcoma is a rare soft tissue malignancy that usually presents in the distal extremities along fascial planes, aponeuroses or tendon sheaths. Very rarely, it presents as a primary or metastatic lesion...
Fri Aug 21, 2020 21:27
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