A 10‐year‐old girl presented with ileus, urinary retention, dry mouth, lack of tears, fixed dilated pupils, and diffuse anhidrosis 7‐days after a febrile illness. We hypothesized that her syndrome was due to autoimmunity against muscarinic acetylcholine receptors, blocking their activation. Using an indirect enzyme‐linked immunosorbent assay for all five muscarinic receptors (M1‐M5) we identified in the patient's serum antibodies that selectively bound to M3 receptors. In‐vitro functional studies...
Mon Aug 24, 2020 18:40
Objective Disturbed sleep is common in epilepsy. The direct influence of nocturnal epileptic activity on sleep fragmentation remains poorly understood. Stereo‐electroencephalography paired with polysomnography is the ideal tool to study this relationship. We investigated whether sleep‐related epileptic activity is associated with sleep disruption. Methods We visually marked sleep stages, arousals, seizures and epileptic bursts in 36 patients with focal drug‐resistant epilepsy who underwent...
Mon Aug 24, 2020 16:02
Publication date: Available online 25 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Kang Min Park, Kyung Ran Jun, Ho-Joon Lee, Seongho Park, Sung Eun Kim
Tue Aug 25, 2020 19:18
Publication date: Available online 25 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): David Chachkhiani, Michael Y. Soliman, Delphi Barua, Marine Isakadze, Nicole R. Villemarette-Pittman, Deidre J. Devier, Jesus F. Lovera
Tue Aug 25, 2020 19:18
Publication date: April 2021Source: Current Opinion in Neurobiology, Volume 67Author(s): Lotte J Herstel, Corette J Wierenga
Tue Aug 25, 2020 19:41
No abstract available
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
Abstract: Neurocysticercosis is the most common disease of the nervous system caused by a parasite. Ophthalmological manifestations of cysticercosis typically are due to direct intraorbital or intraocular involvement, parenchymal brainstem involvement, or secondary to hydrocephalus or increased intracranial pressure. We describe a patient with a unilateral fourth nerve palsy, a rare presentation of neurocyticercosis.
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
Abstract: The initiation and continuation of immune-based therapies to treat and prevent complications of inflammatory neuro-ophthalmologic disorders during the 2019 novel coronavirus (COVID-19) pandemic is the subject of considerable debate. In each case, a treatment decision must be reached based on best clinical practices for the disorder, patient comorbidities, the current state of knowledge about the pathogenesis and infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),...
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
Background: The purpose of the study was to examine 5-year changes in eyes with optic disc drusen at baseline on optical coherence tomography (OCT) scans and the relation of incident drusen to hyperreflective prelaminar lines. Methods: The study included children who presented at baseline, when participants were aged 11–12 years, and again 5 years later. Grading for optic disc drusen was made in all. Grading for prelaminar lines was made in all children at follow-up and in eyes with optic...
Tue Aug 25, 2020 21:04
Abstract: A 63-year-old man with a history of high-grade bladder cancer was admitted to the intensive care unit (ICU) with renal failure and methicillin-susceptible Staphylococcus aureus bacteremia originating from his nephrostomy tube. While in the ICU, he had painless, severe loss of vision in the right eye followed by his left eye 12 hours later. Visual acuity was no light perception in each eye. He was anemic, and before each eye lost vision, there was a significant decrease in blood pressure....
Tue Aug 25, 2020 21:04
Background: To analyze the final visual acuity (VA) of neuro-ophthalmologic injuries (NOI) in combat ocular trauma and to study the association of NOI with systemic neurologic injury (SNI) and traumatic brain injury (TBI). Methods: The Walter Reed Ocular Trauma Database was reviewed. Inclusion criteria were any US service member and Department of Defense civilians who suffered NOI, SNI, or TBI in Operation Iraqi Freedom or Operation Enduring Freedom. The primary outcome measure was the rate...
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
Background: Nonarteritic anterior ischemic optic neuropathy (NAION) is a common cause of acute optic neuropathy in adults and is associated with vascular risk factors. Owing to the overlapping risk factor profiles between NAION and cerebral stroke, previous studies have produced conflicting results with regard to NAION as an independent risk factor for stroke. Methods: A retrospective chart review was conducted using the Rochester Epidemiology Project database to identify all cases of NAION...
Tue Aug 25, 2020 21:04
Background: Acute nonarteritic central retinal artery occlusion (CRAO) is an eye stroke with poor visual prognosis and no proven effective therapies. Given advances in acute stroke care, thrombolysis in CRAO merits critical re-examination. We review the evidence for intravenous (IV) and intra-arterial (IA) tissue plasminogen activator (tPA) in CRAO management. Evidence Acquisition: MEDLINE, Scopus, and Cochrane online databases were systematically searched from 1960 to present, for reports...
Tue Aug 25, 2020 21:04
Background: The visual, ocular motor and vestibular systems have intimate neural and close anatomical relationship that dictates their assessment in a patient with dizziness and vertigo. Results: Recognition of the pearls and pitfalls of a targeted clinical examination HINTS/HINTS “Plus” allows the clinician to probe at the bedside the most crucial hypothesis in a patient with acute isolated vestibular syndrome, “Is this a stroke?” Conclusion: By applying a methodical approach to examination...
Tue Aug 25, 2020 21:04
Background: During the COVID-19 pandemic, telehealth modalities have come to prominence as a strategy for providing patient care when in-person care provision opportunities are limited. The degree of adoption by neuro-ophthalmologists has not been quantified. Methods: Telehealth utilization pre–COVID-19 and peri–COVID-19 was surveyed among practicing neuro-ophthalmologists in and outside the United States using an online platform. Demographics, perceived benefits, barriers, and utility for...
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
Background: Nonarteritic anterior ischemic optic neuropathy (NA-AION) associated with optic disc drusen (ODD) is termed ODD-AION, where NA-AION with no evidence of ODD is simply termed NA-AION. Patients with ODD-AION have been found to be younger than those with NA-AION but with similar vascular risk factors. This study compares the known risk factors for NA-AION between a group with ODD-AION and a similarly aged group with NA-AION. Methods: A case–control study of 13 patients with ODD-AION...
Tue Aug 25, 2020 21:04
Abstract: Postoperative hemorrhages are relatively common complications of surgical procedures including craniotomies, and these typically occur at or near the operative site. Bleeding in remote areas (e.g., posterior fossa) after supratentorial craniotomy can occur and may be associated with a high morbidity and mortality. Although remote cerebellar hemorrhage after craniotomy is well described, remote pontine hemorrhage is less common. We describe a bilateral internuclear ophthalmoplegia due...
Tue Aug 25, 2020 21:04
Background: Some reports have indicated that when a cause for Horner syndrome can be determined, it is most often chest and neck tumors and stroke. Others have suggested that Horner syndrome is more frequently caused by surgical procedures in the neck and chest. These differences may be explained by disparate accrual methods. Therefore, we decided to compare the cause of Horner syndrome in cases where the diagnosis was confirmed by apraclonidine testing conducted by ophthalmologists to cases in...
Tue Aug 25, 2020 21:04
Abstract: A 70 year-old man presented with insidiously progressing central visual acuity loss in both eyes over several years. Objectively the only abnormality identified on the exam was questionable granularity in the fovea in each eye. Extensive work up which included neuro-imaging, screening blood work for toxic and nutritional causes of optic neuropathy as well as electroretinogram and fluorescein angiography to rule out subtle maculopathy was all unrevealing. When vision continued to deteriorate...
Tue Aug 25, 2020 21:04
Background: The relation of retinal thickness to neuropsychological indexes of cognitive impairment in patients with Alzheimer disease (AD) remains an area of investigation. The scope of this investigation was to compare volume and thickness changes of neuronal retinal layers in subjects with AD with those of age-matched healthy controls and to estimate the relation between cognitive functioning evaluated by neuropsychological assessment and thickness changes of the retina. Methods: This...
Tue Aug 25, 2020 21:04
In this issue of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD, and Mark L. Moster, MD will discuss the following 6 articles:
Tue Aug 25, 2020 21:04
Background: Telehealth provides health care to a patient from a provider at a distant location. Before the COVID-19 pandemic, adoption of telehealth modalities was increasing slowly but steadily. During the public health emergency, rapid widespread telehealth implementation has been encouraged to promote patient and provider safety and preserve access to health care. Evidence Acquisition: Evidence was acquired from English language Internet searches of the medical and business literature...
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
Background: Over the past decade, there has been a remarkable advancement in the understanding of autoimmune etiologies of encephalitis. The first identified generation of paraneoplastic encephalitis tends to occur in older populations, responds poorly to immunotherapy, and is mediated by T-cell damage with antibodies directed toward intracellular antigens. A new generation of autoimmune encephalitides has been described, which are mediated by antibodies to cell-surface proteins, tend to occur...
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
Background: To describe the various neuro-ophthalmic presentations, key exam features, and clinical findings associated with 5 common primary and secondary intracranial malignancies. Evidence Acquisition: Retrospective PubMed search and review of published case reports, case series, observational studies, book chapters, and review articles examining the neuro-ophthalmic features of intracranial malignancies including primary glial neoplasms (e.g., glioblastoma multiforme), primary and secondary...
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
No abstract available
Tue Aug 25, 2020 21:04
State-of-the-art bionic hands incorporate hi-tech devices which try to overcome limitations of conventional single grip systems. Unfortunately, their complexity often limits mechanical robustness and intuitive...
Tue Aug 25, 2020 03:00
Publication date: Available online 25 August 2020Source: Journal of Neuroscience MethodsAuthor(s): Lauren N. Hirth, Christopher J. Stanley, Diane L. Damiano, Thomas C. Bulea
Tue Aug 25, 2020 14:50
Publication date: Available online 25 August 2020Source: Journal of Neuroscience MethodsAuthor(s): Drishti Yadav, Shilpee Yadav, Karan Veer
Tue Aug 25, 2020 14:50
Publication date: October 2020Source: Brain Research Bulletin, Volume 163Author(s):
Tue Aug 25, 2020 18:22
Publication date: Available online 25 August 2020Source: Brain Research BulletinAuthor(s): Yati Sharma, Debapriya Garabadu
Tue Aug 25, 2020 18:22
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Shigeomi Yokoya, Hideki Oka, Naoto Shiomi, Akihiko Hino, Masahito Fujimoto
Tue Aug 25, 2020 17:12
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Joyce Antony, Anna Jolly Neriamparambil, Norman Ma
Tue Aug 25, 2020 17:12
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Timothy H. Ung, Mellissa R. Delcont, Salih Colakoglu, Joshua Seinfeld, Brooke French, C. Corbett Wilkinson
Tue Aug 25, 2020 17:12
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Huaiyu Sun, Yue Wang, Shihai Yu, Zifan Li, Tingzhong Wang
Tue Aug 25, 2020 17:12
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Rimlee Dutta, Mehar Chand Sharma, Vaishali Suri, Chitra Sarkar, Ajay Garg, Achal Srivastava, Vivek Tandon
Tue Aug 25, 2020 17:12
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Marta Pastor-Cabeza, Antonio González-Crespo, Manel Tardáguila, Alberto Blanco Ibañez de Opacua, Sebastián Remollo, Carlos J. Domínguez, Jordi M. Rimbau, Ana Rodríguez-Hernández
Tue Aug 25, 2020 17:12
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