Publication date: Available online 20 August 2020Source: European Journal of CancerAuthor(s): Pankaj K. Garg, Pallvi Kaul, Deepti Choudhary
Fri Aug 21, 2020 13:13
Future Oncology, Ahead of Print.
Fri Aug 21, 2020 13:54
Related Articles Decreased level of peripheral CD8+CD28+ T cells is associated with lymph node metastasis in patients with breast cancer. Future Oncol. 2020 Aug 21;: Authors: Li Y, Qian T, Zhao H, Zhang Z, Ming Y, Qiao G, Liu J Abstract Background: Lymph node metastasis (LNM) is an independent risk factor for prognosis in patients with early breast cancer (EBC). Here we explored whether peripheral lymphocyte subtypes could be used as surrogate...
Sat Aug 22, 2020 14:45
Related Articles Breast cancer surgery after the COVID-19 pandemic. Future Oncol. 2020 Aug 20;: Authors: Tsang-Wright F, Tasoulis MK, Roche N, MacNeill F PMID: 32815421 [PubMed - as supplied by publisher]
Fri Aug 21, 2020 22:55
Related Articles The combination of histone deacetylase inhibitors and radiotherapy: a promising novel approach for cancer treatment. Future Oncol. 2020 Aug 20;: Authors: Shirbhate E, Patel P, Patel VK, Veerasamy R, Sharma PC, Rajak H Abstract HDAC inhibitors (HDACi) play an essential role in various cellular processes, such as differentiation and transcriptional regulation of key genes and cytostatic factors, cell cycle arrest and apoptosis...
Fri Aug 21, 2020 22:55
Abstract Endometrial stromal nodule (ESN) and low‐grade endometrial stromal sarcoma (LG‐ESS) are rare uterine tumors known as endometrial stromal tumors (ESTs). In addition to their similarity in morphological features, recent studies have shown that these two tumors share common genetic alterations. In particular, JAZF1‐SUZ12 fusion is found with high frequency in both ESN and LG‐ESS. In LG‐ESS, some minor fusions have also been described, which include rearrangements involving PHF1 and its partner...
Thu Aug 20, 2020 18:33
Abstract The complex interplay between ultraviolet radiation (UVR) and cutaneous viral infections in the context of cancer etiology is challenging to unravel, given the limited information on the independent association between UVR and cutaneous viral infections. Using multiple biomarkers of infection with 21 types of cutaneous human papillomavirus (HPV) and 4 types of polyomaviruses (HPyV), we investigated cross‐sectional associations with recent UVR exposure, using skin pigmentation measured by...
Thu Aug 20, 2020 11:43
Abstract The cystine/glutamate antiporter, system xc −, is essential for the efficient uptake of cystine into cells. Interest into the mechanisms of system xc − function soared with the recognition that system xc − presents the most upstream node of ferroptosis, a recently described form of regulated necrosis relevant for degenerative diseases and cancer. Since targeting system xc − hold the great potential to efficiently combat tumor growth and metastasis of certain tumors, we disrupted the...
Thu Aug 20, 2020 11:43
Abstract Gaps in the translation of research findings to clinical management have been recognised for decades. They exist for the diagnosis as well as the management of cancer. The international standards for cancer diagnosis are contained within the World Health Organization (WHO) Classification of Tumours, published by the International Agency for Research on Cancer (IARC) and known worldwide as the WHO Blue Books. In addition to their relevance to individual patients, these volumes provide a...
Thu Aug 20, 2020 11:43
Abstract Analysis of routine population‐based data has previously shown that patterns of surgical treatment for colorectal cancer can vary widely but there is limited evidence available to determine if such variation is also seen in the use of chemotherapy. This study quantified variation in adjuvant chemotherapy across both England using cancer registry data, and in more detail across the representative Yorkshire and Humber region. Individuals with stage II and III colorectal cancer who underwent...
Thu Aug 20, 2020 11:42
ABSTRACT Complete surgical resection of pulmonary metastatic disease in patients with osteosarcoma is crucial to long‐term survival. Open thoracotomy allows palpation of nodules not identified on imaging but the impact on survival is unknown. The objective of this study was to compare overall survival (OS) and pulmonary disease‐free survival (DFS) in children who underwent thoracotomy versus thoracoscopic surgery for pulmonary metastasectomy. A multi‐institutional collaborative group retrospectively...
Thu Aug 20, 2020 11:40
Abstract Virtual reality (VR) presents opportunities for innovative patient educational methods. This study used a combination of subjective questionnaires and objective physiological measures to investigate the impact of a VR radiotherapy (RT) educational system on patients’ understanding and anxiety prior to commencing RT. Sixty patients were randomized to control (n = 30) and intervention (n = 30) groups prior to initiating RT. The control group received the standard nursing...
Sat Aug 22, 2020 03:00
Abstract Early diagnosis of oral cancer results in less aggressive treatment and improves the quality of life and overall 5-year survival rate. Well-trained dental professionals can play a crucial role in the early detection of oral cancers. The present study aims to determine the effectiveness of the training program “OralDETECT”, a spaced repetitive, test-enhanced learning tool with a corrective feedback mechanism for early detection of oral cancer. Thirty-two dentists and 259...
Fri Aug 21, 2020 03:00
An amendment to this paper has been published and can be accessed via the original article.
Fri Aug 21, 2020 03:00
Abstract For solid tumors, extravasation of cancer cells and their survival in circulation represents a critical stage of the metastatic process that lacks complete understanding. Gaining insight into interactions between circulating tumor cells (CTCs) and other peripheral blood mononuclear cells (PBMCs) may provide valuable prognostic information. The purpose of this study was to use single‐cell RNA‐sequencing (scRNA‐seq) of liquid biopsies from breast cancer patients to begin defining intravascular...
Fri Aug 21, 2020 17:00
Abstract Chemoresistance to gemcitabine (GEM)—a frontline chemotherapeutic, resulting from its dysfunctional uptake and metabolism in cancer cells, is a major contributing factor for failed therapy in pancreatic cancer (PanC) patients. Therefore, there is an urgent need for agents that could reverse GEM resistance and allow continued chemosensitivity to the drug. We employed natural nontoxic agent (with anti‐PanC potential) bitter melon juice (BMJ) and GEM to examine their combinatorial benefits...
Thu Aug 20, 2020 18:08
Publication date: Available online 20 August 2020Source: Practical Radiation OncologyAuthor(s): William Clinkscales, Matthew Spence, John Gleysteen, Neil Hayes, Enrique Izaguirre, Daniel Wakefield, David Schwartz, Isaac Rhea, Cristobal Risquez, Ankur Sharma
Fri Aug 21, 2020 18:12
Online adaptive radiotherapy is intended to prevent plan degradation caused by inter-fractional tumor volume and shape changes, but time limitations make online re-planning challenging. The aim of this study w...
Fri Aug 21, 2020 03:00
In head and neck cancer (HNC), the relationship between a delay in starting radiotherapy (RT) and the outcome is unclear. The aim of the present study was to determine the impact of the amount of time before t...
Thu Aug 20, 2020 03:00
Radiotherapy for breast cancer (BC) and its resulting cardiac exposure are associated with subclinical left ventricular dysfunction characterized by early decrease of global longitudinal strain (LS) measuremen...
Thu Aug 20, 2020 03:00
Publication date: Available online 22 August 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Naveen Mummudi, Asfiya Khan, Anil Tibdewal, Rajiv Kumar, Sabita Jiwnani, George Karimundackal, C.S. Pramesh, Jai Prakash Agarwal
Sun Aug 23, 2020 19:46
Publication date: Available online 21 August 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Paulina Czajka-Francuz, Tomasz Francuz, Sylwia Cisoń-Jurek, Aleksander Czajka, Marcin Fajkis, Bożena Szymczak, Maciej Kozaczka, Krzysztof Piotr Malinowski, Wojciech Zasada, Jerzy Wojnar, Jerzy Chudek
Sat Aug 22, 2020 23:56
Ribonucleic acids (RNAs) play essential roles in living cells. Many of them fold into defined three-dimensional (3D) structures to perform functions. Recent advances in single-particle cryo-electron microscopy (cryo-EM) have enabled structure determinations of RNA to atomic resolutions. However, most RNA molecules are structurally flexible, limiting the resolution of their structures solved by cryo-EM. In modeling these molecules, several computational methods are limited by the requirement of massive...
Fri Aug 21, 2020 22:00
Publication date: October 2020Source: Cancer Epidemiology, Volume 68Author(s): Christine M. White, Salih Bakhiet, Mark Bates, Carmel Ruttle, Loretto J. Pilkington, Helen Keegan, Sharon A. O’Toole, Linda Sharp, Ruth O’Kelly, Prerna Tewari, Grainne Flannelly, Cara M. Martin, John J. O’Leary, On behalf of the CERVIVA consortium
Sun Aug 23, 2020 19:36
Abstract “Radiomics,” as it refers to the extraction and analysis of a large number of advanced quantitative radiological features from medical images using high-throughput methods, is perfectly suited as an engine for effectively sifting through the multiple series of prostate images from before, during, and after radiotherapy (RT). Multiparametric (mp)MRI, planning CT, and cone beam CT (CBCT) routinely acquired throughout RT and the radiomics pipeline are developed for extraction...
Fri Aug 21, 2020 03:00
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