Objective Medial temporal lobe epilepsy (TLE) is the most common form of medication‐resistant focal epilepsy in adults. Despite removal of medial temporal structures, over a third of patients continue to have disabling seizures post‐operatively. Seizure refractoriness implies that extra‐medial regions are capable of influencing the brain network and generating seizures. We tested whether abnormalities of structural network integration could be associated with surgical outcomes. Methods Presurgical...
Sat Aug 22, 2020 13:59
Objective To determine whether priming with 1 Hz or 25 Hz repetitive transcranial magnetic stimulation (rTMS) will enhance the benefits from treadmill training up to three‐month post‐intervention in people with Parkinson's disease (PD), and to evaluate the underlying changes in cortical excitability. Methods This randomized double‐blind, placebo‐controlled trial was conducted between Oct 2016 and Dec 2018. Fifty‐one participants with PD were randomized to receive 12 sessions of rTMS (25 Hz,...
Sat Aug 22, 2020 13:46
Objective Deep brain stimulation (DBS) is a treatment alternative for refractory chronic Cluster headache (CCH). Despite several recent prospective case series reporting on good outcome, the effectiveness and the optimal stimulation target of DBS for CCH remain unclear. We aimed to obtain precise estimates and predictors of long‐term pain relief in an individual patient data meta‐analysis. Further, we aimed to construct a probabilistic stimulation map of effective DBS. Methods We invited investigators...
Sat Aug 22, 2020 13:45
Objective We sought to evaluate the impact of implantable cardiac monitoring (ICM) in the prevention of stroke recurrence after a cryptogenic ischemic stroke or transient ischemic attack (TIA). Methods We evaluated consecutive patients with cryptogenic ischemic stroke or TIA admitted in a comprehensive stroke center during an eight‐year period. We compared the baseline characteristics and outcomes between patients receiving conventional cardiac monitoring with repeated 24‐hour Holter‐monitoring...
Sat Aug 22, 2020 13:29
Publication date: Available online 22 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Yadi Wang, Hongwei Wang, Zhanbiao He, Yang Gao, Jianbo Li, Guorong Zhang, Jun Yin
Sun Aug 23, 2020 15:35
Publication date: Available online 22 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Chuzhong Li, Haibo Zhu, Xuyi Zong, Xinsheng Wang, Songbai Gui, Peng Zhao, Jiwei Bai, Chunhui Liu, Lei Cao, Zhenye Li, Yazhuo Zhang
Sun Aug 23, 2020 15:35
Publication date: Available online 22 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Mohammed Ali Alvi, Desmond Brown, Yagiz Ugur Yolcu, Jad Zreik, Mohamad Bydon, Jeremy K. Cutsforth-Gregory, Jonathan Graff-Radford, David T. Jones, Neill R. Graff-Radford, Benjamin D. Elder
Sun Aug 23, 2020 15:35
Publication date: Available online 22 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Charbel Moussalem, Louna Ftouni, Zaki Abou Mrad, Ali Amine, Dima Hamideh, Wassim Baassiri, Bassel Bali, Marwan Najjar
Sun Aug 23, 2020 15:35
Publication date: Available online 22 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Rosemary Behmer Hansen, Justin Gold, Meeki Lad, Raghav Gupta, Somnath Ganapa, Antonios Mammis
Sun Aug 23, 2020 15:35
Publication date: Available online 22 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Sebastian Sanchez, Yesica Campos, Angel Cadena, Sara Habib, Maureen Deprince, Nohra Chalouhi, Matthew Vibbert, Jacqueline Urtecho, M. Kamran Athar, Diana Tzeng, Lori Sheehan, Rodney Bell, Stravoupoula Tjoumakaris, Pascal Jabbour, Robert Rosenwasser, Fred Rincon
Sun Aug 23, 2020 15:35
Publication date: Available online 22 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Kaiyuan Lin, Kehan Song, Shengxing Wang, Libo Jiang, Huiren Wang, Jian Dong
Sun Aug 23, 2020 15:35
Publication date: Available online 22 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Narayanam Anantha Sai Kiran, Laxminadh Sivaraju, Sunil Valentine Furtado, Kanneganti Vidyasagar, Vivek Raj, Sarita Aryan, Sumit Thakar, Dilip Mohan, Alangar S. Hegde
Sat Aug 22, 2020 18:49
Publication date: Available online 22 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): M. Pegoli, Z. Zurlo, F. Bilotta
Sat Aug 22, 2020 18:49
Publication date: Available online 22 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Paolo Missori, Simone Peschillo, Angela Ambrosone, Stefano Martini, Emanuela Rastelli, Cristina Mancarella, Massimo Vigliotta, Sergio Paolini
Sat Aug 22, 2020 18:49
Publication date: Available online 21 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Pedro Tadao Hamamoto Filho, Lucas Braz Gonçalves, Nicholas Falcomer Koetz, Aline Silvestrin, Aderaldo Costa Alves Júnior, Lilian Aline Rocha, Gabriel Pinheiro Módolo, Marla Andreia Garcia de Avila, Luis Cuadrado Martin, Hermann Neugebauer, Marco Antônio Zanini, Rodrigo Bazan
Fri Aug 21, 2020 16:51
Publication date: Available online 20 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Fioravante Capone, Antonio De Vincentis, Elisabetta Ferraro, Mariagrazia Rossi, Francesco Motolese, Antonio Picardi, Barbara Giannetti, Giancarlo Di Battista, Umberto Vespasiani-Gentilucci, Vincenzo Di Lazzaro
Fri Aug 21, 2020 16:51
Traumatic Brain Injury (TBI) is a leading cause of fatality and disability worldwide, partly due to the occurrence of secondary injury and late interventions. Correct diagnosis and timely monitoring ensure eff...
Fri Aug 21, 2020 03:00
Regular body-powered (BP) prosthesis training facilitates the acquisition of skills through repeated practice but requires adequate time and motivation. Therefore, auxiliary tools such as indirect training may...
Thu Aug 20, 2020 03:00
Publication date: Available online 21 August 2020Source: Journal of Neuroscience MethodsAuthor(s): Gabriella Ugolini
Sat Aug 22, 2020 18:04
Publication date: Available online 21 August 2020Source: Journal of Neuroscience MethodsAuthor(s): D.A. Pinotsis
Fri Aug 21, 2020 21:27
Objective Focal cortical dysplasia (FCD) accounts for nearly half of all cases of medically refractory epilepsy in the pediatric and adult patient populations. This neurological disorder stems from localized malformations in cortical brain tissue due to impaired neuronal proliferation, differentiation, and migration patterns. Recent studies in animal models have highlighted the potential role of the Fragile X mental retardation protein (FMRP) levels in FCD. The purpose of this study was to investigate...
Thu Aug 20, 2020 03:00
Background With an increase in the number of spinal cord injuries (SCIs) in China, severe dysfunction of the limb below the injured segment is prominent. Among the studies centered on the factors inducing SCIs, inflammatory response has a dramatic input on the pathogenesis of SCIs. Objectives This study aimed to investigate the effects of Tricholoma matsutake polysaccharides (TMP) on function recovery following SCIs. Methods The cell viability, neurite growth, NF-kappa B, TNFα...
Thu Aug 20, 2020 03:00
Background: An isolated oculomotor nerve (CN III) palsy is a diagnostic concern because of the potential for serious morbidity or life-threatening causes. We present 5 unusual causes of oculomotor nerve palsy that escaped initial diagnosis in order to raise awareness of their associated features that will facilitate correct diagnosis. Methods: This study consisted of a retrospective analysis of clinical features and imaging of 5 patients who were referred for neuro-ophthalmologic evaluation...
Wed Aug 19, 2020 03:00
No abstract available
Wed Aug 19, 2020 03:00
Background: Wernicke encephalopathy (WE) is classically described by a clinical triad consisting of confusion, ataxia, and ophthalmoplegia, but recent reports emphasize a history of malnutrition along with 2 elements of the WE triad (Caine's criteria) to enhance diagnostic sensitivity. The ophthalmoplegia, vestibular, and auditory expeditious improvement with intravenous thiamine usually confirms the diagnosis; serum levels generally provide additional diagnostic certainty. Methods: ...
Wed Aug 19, 2020 03:00
No abstract available
Wed Aug 19, 2020 03:00
Abstract: A 6-year-old boy was referred for constant right gaze deviation. Rather than a gaze deviation, he constantly seemed to look on the left side of any displayed target. Examination revealed the association of a highly positive angle Kappa and an esotropia of equal values. He also exhibited signs of ocular albinism with no associated infantile nystagmus syndrome. The X-linked ocular albinism was confirmed genetically, explaining the presence of a positive angle Kappa. A highly positive...
Wed Aug 19, 2020 03:00
Background: Diagnostic error is prevalent and costly, occurring in up to 15% of US medical encounters and affecting up to 5% of the US population. One-third of malpractice payments are related to diagnostic error. A complex and specialized diagnostic process makes neuro-ophthalmologic conditions particularly vulnerable to diagnostic error. Evidence Acquisition: English-language literature on diagnostic errors in neuro-ophthalmology and neurology was identified through electronic search...
Wed Aug 19, 2020 03:00
No abstract available
Wed Aug 19, 2020 03:00
No abstract available
Wed Aug 19, 2020 03:00
Abstract: Spinal cord tumors (SCTs) may rarely cause increased intracranial pressure without hydrocephalus (IICPWH). A review of the English literature published after 1970 revealed 29 cases of IICPWH secondary to SCT. The following data were acquired: demographics, tumor characteristics, ophthalmic and neurological manifestations, and cerebral spinal fluid (CSF) features. We summarize the existing literature regarding various theories of pathophysiology, spinal imaging recommendations, and...
Wed Aug 19, 2020 03:00
Abstract: Idiopathic intracranial hypertension (IIH) is a syndrome associated with increased intracranial pressure without a clear underlying cause that is classically seen in young women. Patients typically present with headache and ocular findings, including disc edema and, less frequently, an abduction deficit. To make a diagnosis of IIH, other than cranial nerve 6 or 7 dysfunction, patients must have a normal neurologic examination. When cranial nerve 7 is affected patients can present with...
Wed Aug 19, 2020 03:00
Normal cerebral ventricular volume growth in childhood. J Neurosurg Pediatr. 2020 Aug 21;:1-8 Authors: Cutler NS, Srinivasan S, Aaron BL, Anand SK, Kang MS, Altshuler DB, Schermerhorn TC, Hollon TC, Maher CO, Khalsa SSS Abstract OBJECTIVE: Normal percentile growth charts for head circumference, length, and weight are well-established tools for clinicians to detect abnormal growth patterns. Currently, no standard exists for evaluating normal...
Sat Aug 22, 2020 14:26
Purpose: This study aimed to evaluate the safety and efficacy of multiple cycles of 177Lu-DOTA-EB-TATE peptide receptor radionuclide therapy (PRRT) at escalating doses in neuroendocrine tumors (NETs). Methods: A total of 32 NET patients were randomly divided into 3 groups and treated with escalating doses: group A (1.17 ± 0.09 GBq/cycle); group B (1.89 ± 0.53 GBq/cycle); group C (3.97 ± 0.84 GBq/cycle). The treatment was planned up to three cycles. Treatment-related adverse events (AEs) were graded...
Sat Aug 22, 2020 00:34
CD20 over-expressed non-Hodgkin lymphoma typically shows progressive malignancy. Obinutuzumab (obi) is a next-generation FDA-approved humanized monoclonal antibody that targets CD20. Previous studies with 89Zr-labeled obi has successfully imaged CD20 in vivo. However, delayed tumor uptake and increased radioactive exposure caused by long blood circulation limits its clinical translation. This study aims to develop 64Cu-labeled F(ab')2 fragments of obi for imaging CD20 in lymphoma xenograft tumor...
Sat Aug 22, 2020 00:34
Rationale: With the successful development and increased use of targeted radionuclide therapy for treating cancer comes the increased risk of radiation injury to bone marrow—both direct suppression and stochastic effects, leading to neoplasia. Herein, we report a novel radioprotector drug, a liposomal formulation of gamma-tocotrienol (GT3), or GT3-Nano for short, to mitigate bone marrow radiation damage during targeted radionuclide therapy (TRT). Methods: GT3 was loaded into liposomes using...
Sat Aug 22, 2020 00:34
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): I. Jonathan Pomeraniec, Panagiotis Mastorakos, Daniel Raper, Min S. Park
Sat Aug 22, 2020 21:47
Publication date: November 2020Source: World Neurosurgery, Volume 143Author(s): Guilu He, Yehai Li, Jianhao Lin, Xiuming Zhou, Jing Ye, Fobao Huang, Ruirui Yun, Qiao Li, Liang Zhang
Fri Aug 21, 2020 19:47
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