MPs, Vol. 3, Pages 60: Metastasis Model of Cancer Stem Cell-Derived Tumors Methods and Protocols doi: 10.3390/mps3030060 Authors: Hager Mansour Ghmkin Hassan Said M. Afify Ting Yan Akimasa Seno Masaharu Seno Metastasis includes the dissemination of cancer cells from a malignant tumor and seed in distant sites inside the body forming secondary tumors. Metastatic cells from the primary tumor can move even before the cancer is detected. Therefore, metastases are responsible...
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1284: Recent Advances in Novel Antiviral Therapies against Human Adenovirus Microorganisms doi: 10.3390/microorganisms8091284 Authors: Bratati Saha Robin J. Parks Human adenovirus (HAdV) is a very common pathogen that typically causes minor disease in most patients. However, the virus can cause significant morbidity and mortality in certain populations, including young children, the elderly, and those with compromised immune systems. Currently, there...
Sat Aug 22, 2020 03:00
Microorganisms, Vol. 8, Pages 1286: Influences of Semaphorin 3A Expression on Clinicopathological Features, Human Papillomavirus Status, and Prognosis in Oropharyngeal Carcinoma Microorganisms doi: 10.3390/microorganisms8091286 Authors: Pham Kondo Endo Wakisaka Aoki Nakanishi Kase Mizokami Kano Ueno Hatano Moriyama-Kita Sugimoto Yoshizaki Human papillomavirus (HPV) infection is now identified as a major etiologic factor for oropharyngeal...
Sat Aug 22, 2020 03:00
Microorganisms, Vol. 8, Pages 1282: Novel Psychrophiles and Exopolymers from Permafrost Thaw Lake Sediments Microorganisms doi: 10.3390/microorganisms8091282 Authors: Ilaria Finore Adrien Vigneron Warwick F. Vincent Luigi Leone Paola Di Donato Aniello Schiano Moriello Barbara Nicolaus Annarita Poli Thermokarst lakes are one of the most abundant types of microbial ecosystems in the circumpolar North. These shallow basins are formed by the thawing and collapse of ice-rich...
Sat Aug 22, 2020 03:00
Microorganisms, Vol. 8, Pages 1283: The Impact of the Postpartum “Doing-the-Month” Practice on Human Milk Microbiota: A Pilot Study in Taiwan Microorganisms doi: 10.3390/microorganisms8091283 Authors: Po-Wen Chen Yu-Hsien Kuo Yi-Ling Lin Human milk microorganisms could benefit the healthy development of the immune system in infants. In Asia, the practice of “doing-the-month” indicates a month-long period of postpartum recuperation for new mothers. This is composed...
Sat Aug 22, 2020 03:00
Microorganisms, Vol. 8, Pages 1281: Composition and Metabolic Functions of the Microbiome in Fermented Grain during Light-Flavor Baijiu Fermentation Microorganisms doi: 10.3390/microorganisms8091281 Authors: Xiaoning Huang Yi Fan Ting Lu Jiamu Kang Xiaona Pang Beizhong Han Jingyu Chen The metabolism and accumulation of flavor compounds in Chinese Baijiu are driven by microbiota succession and their inter-related metabolic processes. Changes in the microbiome composition...
Sat Aug 22, 2020 03:00
Microorganisms, Vol. 8, Pages 1285: Repurposing Anti-Diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa Microorganisms doi: 10.3390/microorganisms8091285 Authors: Wael A. H. Hegazy Maan T. Khayat Tarek S. Ibrahim Majed S. Nassar Muhammed A. Bakhrebah Wesam H. Abdulaal Nabil A. Alhakamy Mahmoud M. Bendary Pseudomonas aeruginosa is a significant human pathogen, it possesses almost all of the known antimicrobial resistance mechanisms. Quorum sensing...
Sat Aug 22, 2020 03:00
Microorganisms, Vol. 8, Pages 1279: Colistin Heteroresistance among Extended Spectrum β-lactamases-Producing Klebsiella pneumoniae Microorganisms doi: 10.3390/microorganisms8091279 Authors: Felipe Morales-León Celia A. Lima Gerardo González-Rocha Andrés Opazo-Capurro Helia Bello-Toledo Colistin-heteroresistant (CST-HR) Enterobacterales isolates have been identified recently, challenging the clinical laboratories since routine susceptibility tests fail to detect this phenotype....
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1278: Effect of Sample Collection (Manual Expression vs. Pumping) and Skimming on the Microbial Profile of Human Milk Using Culture Techniques and Metataxonomic Analysis Microorganisms doi: 10.3390/microorganisms8091278 Authors: Maricela Rodríguez-Cruz Claudio Alba Marina Aparicio María Ángeles Checa Leonides Fernández Juan Miguel Rodríguez Human milk microbiota is a unique bacterial community playing a relevant role in infant health, but...
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1280: Recent Molecular Evolution of Human Metapneumovirus (HMPV): Subdivision of HMPV A2b Strains Microorganisms doi: 10.3390/microorganisms8091280 Authors: Naganori Nao Miwako Saikusa Ko Sato Tsuyoshi Sekizuka Shuzo Usuku Nobuko Tanaka Hidekazu Nishimura Makoto Takeda Human metapneumovirus (HMPV) is a major etiological agent of acute respiratory infections in humans. HMPV has been circulating worldwide for more than six decades and...
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1270: The Role of the Bacterial Community in Producing a Peculiar Smell in Chinese Fermented Sour Soup Microorganisms doi: 10.3390/microorganisms8091270 Authors: Liangjing Lin Jinyuan Wu Xi Chen Libiao Huang Xiaoyong Zhang Xiangyang Gao In this paper, the volatile flavour constituents and the bacterial diversity in characteristic Chinese fermented sour soup were analysed, and the dynamics of bacteria associated with the odour were characterized....
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1273: Regulation of Microbial Activity Rates by Organic Matter in the Ross Sea during the Austral Summer 2017 Microorganisms doi: 10.3390/microorganisms8091273 Authors: Renata Zaccone Cristina Misic Filippo Azzaro Maurizio Azzaro Giovanna Maimone Olga Mangoni Gianna Fusco Alessandro Ciro Rappazzo Rosabruna La Ferla The active prokaryotic communities proliferate in the ecosystems of the Antarctic Ocean, participating in biogeochemical...
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1275: Biosulfidogenesis Mediates Natural Attenuation in Acidic Mine Pit Lakes Microorganisms doi: 10.3390/microorganisms8091275 Authors: van der Graaf Sánchez-España Yusta Ilin Shetty Bale Villanueva Stams Sánchez-Andrea Acidic pit lakes are abandoned open pit mines filled with acid mine drainage (AMD)—highly acidic, metalliferous waters that pose a severe threat to the environment and are rarely properly remediated....
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1274: Processing Wastewaters from Spanish-Style cv. Chalkidiki Green Olives: A Potential Source of Enterococcus Casseliflavus and Hydroxytyrosol Microorganisms doi: 10.3390/microorganisms8091274 Authors: Papadaki Botsaris Athanasiadi Mantzouridou The purpose of this study was to examine the isolation of indigenous lactic acid bacteria (LAB) with functional properties from Spanish-style cv. Chalkidiki green olive processing wastewaters (GOW)....
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1276: Impact of Surfactant Protein-A Variants on Survival in Aged Mice in Response to Klebsiella pneumoniae Infection and Ozone: Serendipity in Action Microorganisms doi: 10.3390/microorganisms8091276 Authors: Nithyananda Thorenoor David S. Phelps Padma Kala Radhika Ravi Andreas Floros Phelps Todd M. Umstead Xuesheng Zhang Joanna Floros Innate immune molecules, SP-A1 (6A2, 6A4) and SP-A2 (1A0, 1A3), differentially affect young mouse...
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1272: Probiotic Effects on Multispecies Biofilm Composition, Architecture, and Caries Activity In Vitro Microorganisms doi: 10.3390/microorganisms8091272 Authors: Zhihui Chen Sebastian Schlafer Gerd Göstemeyer Falk Schwendicke While probiotics have been tested for their anti-caries effect in vitro and also clinically, there is a lack of understanding of their effects on complex dental biofilms. We assessed two probiotics, Lactobacillus reuteri and...
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1271: The Role of Pea (Pisum sativum) Seeds in Transmission of Entero-Aggregative Escherichia coli to Growing Plants Microorganisms doi: 10.3390/microorganisms8091271 Authors: Leonard S. van Overbeek Carin Lombaers-van der Plas Patricia van der Zouwen Crop plants can become contaminated with human pathogenic bacteria in agro-production systems. Some of the transmission routes of human pathogens to growing plants are well explored such as water, manure...
Fri Aug 21, 2020 03:00
Microorganisms, Vol. 8, Pages 1277: A First Insight into the Structural and Functional Comparison of Environmental Microbiota in Freshwater Turtle Chinemys reevesii at Different Growth Stages under Pond and Greenhouse Cultivation Microorganisms doi: 10.3390/microorganisms8091277 Authors: Aiguo Zhou Shaolin Xie Di Sun Pan Zhang Han Dong Zhiheng Zuo Xiang Li Jixing Zou The microbial community structure of water is an important indicator for evaluating the water quality...
Fri Aug 21, 2020 03:00
Molecules, Vol. 25, Pages 3835: Box–Behnken Response Surface Design of Polysaccharide Extraction from Rhododendron arboreum and the Evaluation of Its Antioxidant Potential Molecules doi: 10.3390/molecules25173835 Authors: Ajaz Ahmad Muneeb U. Rehman Adil Farooq Wali Hamed A. El-Serehy Fahad A. Al-Misned Saleh N. Maodaa Hossam M. Aljawdah Tahir Maqbool Mir Parvaiz Ahmad In the present investigation, the ultrasound-assisted extraction (UAE) conditions and optimization...
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Molecules, Vol. 25, Pages 3832: Simultaneous Natural Deep Eutectic Solvent-Based Ultrasonic-Assisted Extraction of Bioactive Compounds of Cinnamon Bark and Sappan Wood as a Dipeptidyl Peptidase IV Inhibitor Molecules doi: 10.3390/molecules25173832 Authors: Islamudin Ahmad Ayun Erwina Arifianti Aditya Sindu Sakti Fadlina Chany Saputri Abdul Mun’im Cinnamon bark (Cinnamomum burmannii) and sappan wood (Caesalpinia sappan) have been reported to be beneficial for Type-2 Diabetes...
Sun Aug 23, 2020 03:00
Molecules, Vol. 25, Pages 3834: Exacerbated LPS/GalN-Induced Liver Injury in the Stress-Sensitive Wistar Kyoto Rat Is Associated with Changes in the Endocannabinoid System Molecules doi: 10.3390/molecules25173834 Authors: Marykate Killilea Daniel M. Kerr Beth M. Mallard Michelle Roche Antony M. Wheatley Acute liver injury (ALI) is a highly destructive and potentially life-threatening condition, exacerbated by physical and psychological stress. The endocannabinoid system plays...
Sun Aug 23, 2020 03:00
Molecules, Vol. 25, Pages 3833: Effect of γ-Aminobutyric Acid (GABA) on the Metabolome of Two Strains of Lasiodiplodia theobromae Isolated from Grapevine Molecules doi: 10.3390/molecules25173833 Authors: Maria Michela Salvatore Carina Félix Fernanda Lima Vanessa Ferreira Ana Sofia Duarte Francesco Salvatore Artur Alves Ana Cristina Esteves Anna Andolfi The effect of γ-aminobutyric acid (GABA) on the metabolome of two strains of Lasiodiplodia theobromae...
Sun Aug 23, 2020 03:00
Molecules, Vol. 25, Pages 3831: Caesalpinia ferrea C. Mart. (Fabaceae) Phytochemistry, Ethnobotany, and Bioactivities: A Review Molecules doi: 10.3390/molecules25173831 Authors: Nair Silva Macêdo Zildene de Sousa Silveira Antonio Henrique Bezerra José Galberto Martins da Costa Henrique Douglas Melo Coutinho Barbara Romano Raffaele Capasso Francisco Assis Bezerra da Cunha Márcia Vanusa da da Silva Caesalpinia ferrea C. Mart., popularly known as “Jucá”...
Sun Aug 23, 2020 03:00
Molecules, Vol. 25, Pages 3830: Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method Molecules doi: 10.3390/molecules25173830 Authors: Milan Sencanski Vladimir Perovic Snezana B. Pajovic Miroslav Adzic Slobodan Paessler Sanja Glisic The SARS-CoV-2 outbreak caused an unprecedented global public health threat, having a high transmission rate with currently no drugs or vaccines approved. An alternative powerful additional approach...
Sun Aug 23, 2020 03:00
Molecules, Vol. 25, Pages 3829: Biorefinery of Biomass of Agro-Industrial Banana Waste to Obtain High-Value Biopolymers Molecules doi: 10.3390/molecules25173829 Authors: Redondo-Gómez Rodríguez Quesada Vallejo Astúa Murillo Zamora Lopretti Vega-Baudrit On a worldwide scale, food demand is increasing as a consequence of global population growth. This makes companies push their food supply chains’ limits with a consequent increase in generation of large amounts...
Sun Aug 23, 2020 03:00
Molecules, Vol. 25, Pages 3828: The Electronic Property Differences between dA::dG and dA::dGoxo. A Theoretical Approach Molecules doi: 10.3390/molecules25173828 Authors: Boleslaw T. Karwowski The dA::dGoxo pair appearing in nucleic ds-DNA can lead to a mutation in the genetic information. Depending on the dGoxo source, an AT→GC and GC→AC transversion might be observed. As a result, glycosylases are developed during the evolution, i.e., OGG1 and MutY. While the former...
Sun Aug 23, 2020 03:00
Molecules, Vol. 25, Pages 3827: Structural and Energetic Insights on Two Dye Compounds: 1-Acetyl-2-naphthol and 2-Acetyl-1-naphthol Molecules doi: 10.3390/molecules25173827 Authors: Vera L. S. Freitas Maria D. M. C. Ribeiro da Silva The energy involved in the structural switching of acyl and hydroxyl substituents in the title compounds was evaluated combining experimental and computational studies. Combustion calorimetry and Knudsen effusion techniques were used to determine the enthalpies...
Sat Aug 22, 2020 03:00
Molecules, Vol. 25, Pages 3826: Identification of the Effects of Aspirin and Sulindac Sulfide on the Inhibition of HMGA2-Mediated Oncogenic Capacities in Colorectal Cancer Molecules doi: 10.3390/molecules25173826 Authors: Titus Ime Ekanem Wei-Lun Tsai Yi-Hsuan Lin Wan-Qian Tan Hsin-Yi Chang Tsui-Chin Huang Hsin-Yi Chen Kuen-Haur Lee Distant metastatic colorectal cancer (CRC) is present in approximately 25% of patients at initial diagnosis, and eventually half of...
Sat Aug 22, 2020 03:00
Molecules, Vol. 25, Pages 3825: k-Oligocarrageenan Promoting Growth of Hybrid Maize: Influence of Molecular Weight Molecules doi: 10.3390/molecules25173825 Authors: Pham Trung San Chau Minh Khanh Huynh Hoang Nhu Khanh Truong Anh Khoa Nguyen Hoang Le Thi Nhung Nguyen Thi Kieu Trinh Thanh-Danh Nguyen k-Oligocarrageenan (OC) is an effective biostimulator and a protector against disease infections for plants. However, the effect of OC molecular weight (MW) on plant growth...
Sat Aug 22, 2020 03:00
Molecules, Vol. 25, Pages 3821: Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei Molecules doi: 10.3390/molecules25173821 Authors: Jih Ru Hwu Avijit Panja Srinivasan Jayakumar Shwu-Chen Tsay Kui-Thong Tan Wen-Chieh Huang Yu-Chen Hu Pieter Leyssen Johan Neyts The modern world has no available drugs for the treatment of enteroviruses (EV), which affect millions of people worldwide each year. The EV71 is a major causative disease for hand, foot,...
Sat Aug 22, 2020 03:00
Molecules, Vol. 25, Pages 3824: Integral Representation of Electrostatic Interactions Inside a Lipid Membrane Molecules doi: 10.3390/molecules25173824 Authors: Guilherme Volpe Bossa Sylvio May Interactions between charges and dipoles inside a lipid membrane are partially screened. The screening arises both from the polarization of water and from the structure of the electric double layer formed by the salt ions outside the membrane. Assuming that the membrane can be represented as...
Sat Aug 22, 2020 03:00
Molecules, Vol. 25, Pages 3823: Cyanidin-3-O-Glucoside-Rich Haskap Berry Administration Suppresses Carcinogen-Induced Lung Tumorigenesis in A/JCr Mice Molecules doi: 10.3390/molecules25173823 Authors: Madumani Amararathna David W. Hoskin H. P. Vasantha Rupasinghe In our previous study, we demonstrated that cyanidin-3-O-glucoside (C3G)-rich haskap (Lonicera caerulea L.) berry extracts can attenuate the carcinogen-induced DNA damage in normal lung epithelial cells in vitro. Here,...
Sat Aug 22, 2020 03:00
Molecules, Vol. 25, Pages 3822: In Silico Identification of Potential Natural Product Inhibitors of Human Proteases Key to SARS-CoV-2 Infection Molecules doi: 10.3390/molecules25173822 Authors: R.P. Vivek-Ananth Abhijit Rana Nithin Rajan Himansu S. Biswal Areejit Samal Presently, there are no approved drugs or vaccines to treat COVID-19, which has spread to over 200 countries and at the time of writing was responsible for over 650,000 deaths worldwide. Recent studies have...
Sat Aug 22, 2020 03:00
Molecules, Vol. 25, Pages 3820: Photoluminescence as a Complementary Tool for UV-VIS Spectroscopy to Highlight the Photodegradation of Drugs: A Case Study on Melatonin Molecules doi: 10.3390/molecules25173820 Authors: Monica Daescu N’ghaya Toulbe Mihaela Baibarac Alin Mogos Adam Lőrinczi C. Logofatu In this work, a complementary ultraviolet-visible (UV-VIS) spectroscopy and photoluminescence (PL) study on melatonin (MEL) hydrolysis in the presence of alkaline aqueous solutions...
Sat Aug 22, 2020 03:00
Molecules, Vol. 25, Pages 3819: Site-Specific Tryptophan Labels Reveal Local Microsecond–Millisecond Motions of Dihydrofolate Reductase Molecules doi: 10.3390/molecules25173819 Authors: Morgan B. Vaughn Chloe Biren Qun Li Ashwin Ragupathi R. Brian Dyer Many enzymes are known to change conformations during their catalytic cycle, but the role of these protein motions is not well understood. Escherichia coli dihydrofolate reductase (DHFR) is a small, flexible enzyme that is...
Sat Aug 22, 2020 03:00
Molecules, Vol. 25, Pages 3817: Bioinspired Heterocyclic Partnership in a Cyanine-Type Acidichromic Chromophore Molecules doi: 10.3390/molecules25173817 Authors: Maria Laura Alfieri Lucia Panzella Marco d’Ischia Alessandra Napolitano A new red hair-inspired 1,4-benzothiazine-based scaffold is disclosed herein, built upon a modular D-π-A architecture via condensation of the easily accessible 3-phenyl-2H-1,4-benzothiazine with indole-3-carboxaldehyde. The compound was obtained...
Fri Aug 21, 2020 03:00
Molecules, Vol. 25, Pages 3818: Varietal and Geographical Discrimination of Greek Monovarietal Extra Virgin Olive Oils Based on Squalene, Tocopherol, and Fatty Acid Composition Molecules doi: 10.3390/molecules25173818 Authors: Theano Mikrou Elisavet Pantelidou Niki Parasyri Andreas Papaioannou Maria Kapsokefalou Chrysavgi Gardeli Athanasios Mallouchos Extra virgin olive oil (EVOO) is an important component of the Mediterranean diet and a highly priced product. Despite...
Fri Aug 21, 2020 03:00
Molecules, Vol. 25, Pages 3816: Thermal Conductivities of Choline Chloride-Based Deep Eutectic Solvents and Their Mixtures with Water: Measurement and Estimation Molecules doi: 10.3390/molecules25173816 Authors: Taleb H. Ibrahim Muhammad A. Sabri Nabil Abdel Jabbar Paul Nancarrow Farouq S. Mjalli Inas AlNashef The thermal conductivities of selected deep eutectic solvents (DESs) were determined using the modified transient plane source (MTPS) method over the temperature...
Fri Aug 21, 2020 03:00
Molecules, Vol. 25, Pages 3814: Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents Molecules doi: 10.3390/molecules25173814 Authors: Cristina Chircov Angela Spoială Cătălin Păun Luminița Crăciun Denisa Ficai Anton Ficai Ecaterina Andronescu Ștefan Claudiu Turculeƫ In recent years, researchers focused their attention on mesoporous silica nanoparticles (MSNs) owing to the considerable advancements of the characterization...
Fri Aug 21, 2020 03:00
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