Clinical Neurophysiology

Cerebral preparation of spontaneous movements: an EEG study

Publication date: Available online 25 August 2020Source: Clinical NeurophysiologyAuthor(s): Elise Houdayer, Sae-Jin Lee, Mark Hallett

Clinical Neurophysiology

Tue Aug 25, 2020 20:20

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 Experimental Physiology

Mitochondrial dysfunction in skeletal muscle of fukutin deficient mice is resistant to exercise‐ and AICAR‐induced rescue

New Findings What is the central question of this study ? Does fukutin deficiency in skeletal muscle cause mitochondrial dysfunction, and if so, can AMPK stimulation via AICAR attenuate this through regulation of mitochondrial biogenesis and autophagy? What is the main finding and its importance? Mitochondrial dysfunction is associated with fukutin deficiency and AMPK stimulation may benefit muscle contractility to a greater extent than mitochondrial function. Abstract Disruptions...

Experimental Physiology

Mon Aug 24, 2020 16:10

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 Psychophysiology

Cerebrovascular function in hypertension: Does high blood pressure make you old?

Abstract The majority of individuals over an age of 60 have hypertension. Elevated blood pressure and older age are associated with very similar changes in brain structure and function. We review the parallel brain changes associated with increasing age and blood pressure. This review focuses on joint associations of aging and elevated blood pressure with neuropsychological function, regional cerebral blood flow responses to cognitive and metabolic challenges, white matter disruptions, grey matter...

Psychophysiology

Mon Aug 24, 2020 13:25

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 The Journal of Physiology

Fatigue‐induced change in T‐system excitability and its major cause in rat fast‐twitch skeletal muscle in vivo

Key points By using a mechanically‐skinned fibre of rat, we investigated i) a transverse tubular‐system (T‐system) excitability after high‐intensity contractions, and ii) mechanisms undelying the fatigue‐induced alteration of the T‐system excitability. T‐system excitability estimated by using skinned fibre, which is highly regulated by T‐system Na+‐K+ ATPase, was decreased after muscle contractions, but it was fully restored by the treatment with dithiothreitol. The S‐glutathionylation of Na+‐K+...

The Journal of Physiology

Mon Aug 24, 2020 17:18

Tracking the motion of KV1.2 voltage sensor reveals the molecular perturbations caused by a de novo mutation in a case of epilepsy

Key points KV1.2 channels, encoded by the KCNA2 gene, regulate neuronal excitability by conducting K+ upon depolarization. A new KCNA2 missense variant was discovered in a patient with epilepsy, causing amino‐acid substitution F302L at helix S4, in the KV1.2 voltage‐sensing domain. Immunocytochemistry and flow cytometry showed that F302L does not impair KCNA2 subunit surface trafficking. Molecular dynamics simulations indicated that F302L alters the exposure of S4 residues to membrane lipids....

The Journal of Physiology

Mon Aug 24, 2020 17:18

Good things come in small packages…except after spinal injury

The Journal of Physiology

Mon Aug 24, 2020 16:14

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