Osteoporosis, a bone disease characterized by bone loss and microarchitectural deterioration, is one of the most disabling consequences of aging. As the population ages, the incidence and associated costs of osteoporotic fractures will rise dramatically. These fractures lead to substantial…
Thu Aug 20, 2020 03:00
Approximately 850 million persons worldwide have chronic kidney disease, and almost 4 million receive renal replacement therapy. Among these 4 million, more than 520,000 Americans are undergoing dialysis, and fewer than 225,000 have a functioning kidney transplant. To improve treatment and outcomes…
Thu Aug 20, 2020 03:00
Randomized clinical trials have shown that bariatric surgery is more effective than medical therapy for treatment of type 2 diabetes. Moreover, several studies suggest that surgical procedures that involve bypass of the upper gastrointestinal tract, such as Roux-en-Y gastric bypass, have unique…
Thu Aug 20, 2020 03:00
Homozygous familial hypercholesterolemia is a rare genetic disorder of lipid metabolism affecting approximately 1 in 300,000 persons. The condition is most often caused by the presence of loss-of-function variants in the low-density lipoprotein (LDL) receptor, which leads to low or absent hepatic…
Thu Aug 20, 2020 03:00
Presentation of Case. Dr. Meridale V. Baggett (Medicine): A 60-year-old woman presented to this hospital with altered mental status during the pandemic of coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The patient had been in…
Thu Aug 20, 2020 03:00
Trigeminal neuralgia, traditionally called tic douloureux, is a chronic neuropathic pain disorder characterized by spontaneous and elicited paroxysms of electric shock–like or stabbing pain in a region of the face. A poor quality of life and suicide in severe cases have been attributed to the…
Thu Aug 20, 2020 03:00
To the Editor: The discoverers of ivermectin, a broad-spectrum parasiticide that is widely used in humans and animals, were awarded the Nobel Prize in Physiology or Medicine in 2015. This drug is reputed to be remarkably safe thanks to its ability to be effluxed by the ATP-binding cassette…
Thu Aug 20, 2020 03:00
Adiposity-based chronic disease is probably the greatest noninfectious epidemic of the 21st century. In the United States alone, more than 1 in 3 adults are obese. More than 40 chronic diseases, including type 2 diabetes mellitus, cancer, and atherosclerosis, are associated with obesity. Yet…
Thu Aug 20, 2020 03:00
"Lost something, Doctor?" "I think my nice pen slipped under your sheets," I explain. Groaning at the thought of moving his diabetic legs, the patient says, "Maybe you should keep your nice pens at home." People have been telling me that for years. My first nice pen was a Sheaffer, a medical school…
Thu Aug 20, 2020 03:00
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